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Article ; Online: Chameleonic Reactivity of Imidoyl Sulfoxonium Ylides: Access to Functionalized Pyrroles and Dihydro-pyridines.

Xu, Jingnan / Yang, Ren-Yin / Xu, Bo

Organic letters

2024 Volume 26, Issue 1, Page(s) 62–67

Abstract: We have found a chameleonic reactivity of imidoyl sulfoxonium ylides. On the one hand, imidoyl sulfoxonium ylides react with electron-deficient reagents, such as alkynyl esters, to lead to the formation of 1,2-dihydro-pyridines. The methyl group attached ...

Abstract	We have found a chameleonic reactivity of imidoyl sulfoxonium ylides. On the one hand, imidoyl sulfoxonium ylides react with electron-deficient reagents, such as alkynyl esters, to lead to the formation of 1,2-dihydro-pyridines. The methyl group attached to the sulfur atom acts as a methylene donor. On the other hand, imidoyl sulfoxonium ylides react with pyridinium 1,4-zwitterionic thiolates, which leads to the formation of functionalized pyrroles. Both transformations feature mild reaction conditions and good functional group tolerance.
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.3c03625
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Article ; Online: A review of hazards in meat products: Multiple pathways, hazards and mitigation of polycyclic aromatic hydrocarbons.

Lu, Jingnan / Zhang, Yunkai / Zhou, Hui / Cai, Kezhou / Xu, Baocai

Food chemistry

2024 Volume 445, Page(s) 138718

Abstract: Polycyclic aromatic hydrocarbons (PAHs) are stable carcinogens that are widely distributed in the environment and food, and humans are exposed to PAHs primarily through the respiratory tracts, dermal contact, and dietary intake. Meat products are an ... ...

Abstract	Polycyclic aromatic hydrocarbons (PAHs) are stable carcinogens that are widely distributed in the environment and food, and humans are exposed to PAHs primarily through the respiratory tracts, dermal contact, and dietary intake. Meat products are an essential part of the human diet, and the formation of PAHs during meat processing is unavoidable. Therefore, a comprehensive understanding of PAHs in meat products can be a contribution to the minimization of human exposure dose. The aim of this review is to provide a comprehensive description of the toxicological analysis of PAHs intake and the various production pathways. The distribution of different PAHs in various meat products, including poultry and aquatic products, is analyzed. The discussion focuses on controlling PAHs through the use of endogenous marinades and antioxidants as well as reducing exogenous particulate matter-PAHs attachment. In addition, potential strategies for PAHs reduction and possible directions for future research are proposed.
MeSH term(s)	Humans ; Polycyclic Aromatic Hydrocarbons/toxicity ; Polycyclic Aromatic Hydrocarbons/analysis ; Meat Products ; Food Contamination/analysis ; Diet ; Meat/analysis
Chemical Substances	Polycyclic Aromatic Hydrocarbons
Language	English
Publishing date	2024-02-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.138718
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Article ; Online: The Supervision Mechanism of Residents’ Waste Separation Behavior

Mengge Hao / Shichun Xu / Jingnan Zhang / Xiaona Meng

Journal of Environmental and Public Health, Vol

Analysis Using a Tripartite Evolutionary Game Model

2023 Volume 2023

Abstract: To promote residents’ waste separation behavior, waste separation supervision has been a crucial need. This paper aims to explore the supervision mechanism of residents’ waste separation behavior using a tripartite evolutionary game model. The ... ...

Abstract	To promote residents’ waste separation behavior, waste separation supervision has been a crucial need. This paper aims to explore the supervision mechanism of residents’ waste separation behavior using a tripartite evolutionary game model. The evolutionary stability conditions of resident, property service enterprise, and the government were analyzed. The influences of the main parameters on the strategy of three stakeholders were explored through numerical simulation. The results show that the regulatory mechanism of waste separation will reach the optimal stable strategy when the following conditions are satisfied: (1) the penalty for nonclassification is higher than the difference between classification cost and the total benefit of classification; (2) the subsidy to property services enterprise is greater than the total cost of positive participation management. Residents’ behaviors are mainly influenced by rewards and punishments. The behavioral strategies of property service companies are more sensitive to subsidies than penalties. In the early stage of mandatory waste separation, it is important to reduce the cost of residents’ separation, develop the publics’ environmental awareness, and increase the willingness of properties to participate in management. This paper presents a new perspective and theoretical guidelines for the local government and communities to supervise residents’ waste separation behaviors in China and other developing countries and offers useful insights into waste separation management for other countries.
Keywords	Public aspects of medicine ; RA1-1270
Subject code	710
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Author Correction: Identification of MyoD-Responsive Transcripts Reveals a Novel Long Non-coding RNA (lncRNA-AK143003) that Negatively Regulates Myoblast Differentiation.

Guo, Yiwen / Wang, Jingnan / Zhu, Mingfei / Zeng, Rui / Xu, Zaiyan / Li, Guoliang / Zuo, Bo

Scientific reports

2023 Volume 13, Issue 1, Page(s) 1937

Language	English
Publishing date	2023-02-02
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-28986-2
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Article ; Online: The Supervision Mechanism of Residents' Waste Separation Behavior: Analysis Using a Tripartite Evolutionary Game Model.

Hao, Mengge / Xu, Shichun / Zhang, Jingnan / Meng, Xiaona

Journal of environmental and public health

2023 Volume 2023, Page(s) 2551973

Abstract: To promote residents' waste separation behavior, waste separation supervision has been a crucial need. This paper aims to explore the supervision mechanism of residents' waste separation behavior using a tripartite evolutionary game model. The ... ...

Abstract	To promote residents' waste separation behavior, waste separation supervision has been a crucial need. This paper aims to explore the supervision mechanism of residents' waste separation behavior using a tripartite evolutionary game model. The evolutionary stability conditions of resident, property service enterprise, and the government were analyzed. The influences of the main parameters on the strategy of three stakeholders were explored through numerical simulation. The results show that the regulatory mechanism of waste separation will reach the optimal stable strategy when the following conditions are satisfied: (1) the penalty for nonclassification is higher than the difference between classification cost and the total benefit of classification; (2) the subsidy to property services enterprise is greater than the total cost of positive participation management. Residents' behaviors are mainly influenced by rewards and punishments. The behavioral strategies of property service companies are more sensitive to subsidies than penalties. In the early stage of mandatory waste separation, it is important to reduce the cost of residents' separation, develop the publics' environmental awareness, and increase the willingness of properties to participate in management. This paper presents a new perspective and theoretical guidelines for the local government and communities to supervise residents' waste separation behaviors in China and other developing countries and offers useful insights into waste separation management for other countries.
MeSH term(s)	Waste Management/methods ; China
Language	English
Publishing date	2023-01-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2526611-1
ISSN	1687-9813 ; 1687-9813
ISSN (online)	1687-9813
ISSN	1687-9813
DOI	10.1155/2023/2551973
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Article ; Online: Hematite Hollow-Sphere-Array Photoanodes for Efficient Photoelectrochemical Water Splitting.

Yang, Rongge / Xiao, Shuang / Zhang, Jingnan / Tang, Songtao / Xu, Ruimei / Tong, Yexiang

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2310752

Abstract: Constructing 3D nanophotonic structures is regarded as an effective method to realize efficient solar-to-hydrogen conversion. These photonic structures can enhance the absorbance of photoelectrodes by the light trapping effect, promote the charge ... ...

Abstract	Constructing 3D nanophotonic structures is regarded as an effective method to realize efficient solar-to-hydrogen conversion. These photonic structures can enhance the absorbance of photoelectrodes by the light trapping effect, promote the charge separation by designable charge transport pathway and provide a high specific surface area for catalytic reaction. However, most 3D structures reported so far mainly focused on the influence of light absorption and lacked a systematic investigation of the overall water splitting process. Herein, hematite hollow-sphere-array photoanodes are fabricated through a facile hydrothermal method with polystyrene templates. Validating by simulations and experiments, the hollow sphere array is proved to enhance the efficiency of light harvesting, charge separation and surface reaction at the same time. With an additional annealing treatment in oxygen, a photocurrent density of 2.26 mA cm
Language	English
Publishing date	2024-02-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202310752
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Article ; Online: Clinicopathological features, endoscopic features, and treatment analysis of gastric neuroendocrine neoplasms.

Huang, Ju / Wu, Xi / Xu, Tianming / Li, Jingnan

Chinese medical journal

2022 Volume 135, Issue 20, Page(s) 2497–2499

MeSH term(s)	Humans ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/therapy ; Stomach Neoplasms/pathology ; Neuroendocrine Tumors/diagnosis ; Neuroendocrine Tumors/therapy ; Neuroendocrine Tumors/pathology ; Endoscopy ; Retrospective Studies ; Prognosis
Language	English
Publishing date	2022-10-20
Publishing country	China
Document type	Letter
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000002437
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Article ; Online: Taste properties and mechanism of umami peptides from fermented goose bones based on molecular docking and molecular dynamics simulation using umami receptor T1R1/T1R3.

Feng, Xinrui / Wang, Ran / Lu, Jingnan / Du, Qingfei / Cai, Kezhou / Zhang, Bao / Xu, Baocai

Food chemistry

2024 Volume 443, Page(s) 138570

Abstract: Umami peptides are valuable taste substances due to their exceptional taste and beneficial properties. In this study, purification of fermented goose bone broth was performed using continuous chromatography and sensory analysis, and after identification ... ...

Abstract	Umami peptides are valuable taste substances due to their exceptional taste and beneficial properties. In this study, purification of fermented goose bone broth was performed using continuous chromatography and sensory analysis, and after identification through nano-LC-MS/MS, four umami peptides were screened out by umami activity prediction and molecular docking, which are VGYDAE, GATGRDGAR, GETGEAGER, and GETGEAGERG derived from collagen. Sensory analysis indicated that they were also umami-enhancing, with thresholds ranging from 0.41 to 1.15 mmol/L, among which GER9 was the best. Combining the results of docking and molecular dynamics simulation, it was known that hydrogen bond and electrostatic interactions were vital in driving the umami formation. Moreover, Glu, Ser, and Asp of umami receptor T1R1/T1R3 were the key residues for the binding between four umami peptides and T1R1/T1R3. These findings provide novel insights into the high-value utilization of goose bones and offer profound theoretical guidance for understanding the umami mechanism.
MeSH term(s)	Animals ; Molecular Docking Simulation ; Receptors, G-Protein-Coupled/metabolism ; Geese/metabolism ; Molecular Dynamics Simulation ; Taste ; Tandem Mass Spectrometry ; Peptides/chemistry
Chemical Substances	Receptors, G-Protein-Coupled ; Peptides
Language	English
Publishing date	2024-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.138570
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Article ; Online: Effects of freezing on the gelation behaviors of liquid egg yolks affected by saccharides: thermal behaviors and rheological and structural changes.

Ma, Zihong / Qing, Mingmin / Zang, Jingnan / Xu, Yonghao / Gao, Xin / Chi, Yuan / Chi, Yujie

Poultry science

2024 Volume 103, Issue 6, Page(s) 103657

Abstract: Monitoring and controlling the freezing process and thermal properties of foods is an important means to understand and maintain product quality. Saccharides were used in this study to regulate the gelation of liquid egg yolks induced by freeze‒thawing; ... ...

Abstract	Monitoring and controlling the freezing process and thermal properties of foods is an important means to understand and maintain product quality. Saccharides were used in this study to regulate the gelation of liquid egg yolks induced by freeze‒thawing; the selected saccharides included sucrose, L-arabinose, xylitol, trehalose, D-cellobiose, and xylooligosaccharides. The regulatory effects of saccharides on frozen egg yolks were investigated by characterizing their thermal and rheological properties and structural changes. The results showed that L-arabinose and xylitol were effective gelation regulators. After freeze‒thawing, the sugared egg yolks exhibited a lower consistency index and fewer rheological units than those without saccharides, indicating controlled gelation. Weaker aggregation of egg yolk proteins was confirmed by smaller aggregates observed by confocal laser scanning microscopy and smaller particle sizes. Saccharides alleviated the freeze-induced conversion of α-helices to β-sheets in egg yolk proteins, exposing fewer Trp residues. Overall, L-arabinose showed the greatest improvement in regulating the gelation of egg yolks, followed by xylitol, which is correlated with its low molecular weight.
Language	English
Publishing date	2024-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2024.103657
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Article ; Online: The effects of anticoagulant therapy re-initiation after gastrointestinal bleeding: A systematic review and meta-analysis.

Bingzheng, Xu / Jingnan, Ren / Ligang, Bao / Jianping, Chen

Journal of clinical pharmacy and therapeutics

2021 Volume 46, Issue 6, Page(s) 1509–1518

Abstract: What is known and objective: Long-term anticoagulant/antithrombotic therapy is widely used for the management of thromboembolic conditions. Gastrointestinal bleeding is a common collateral manifestation of anticoagulant/antithrombotic therapy that ... ...

Abstract	What is known and objective: Long-term anticoagulant/antithrombotic therapy is widely used for the management of thromboembolic conditions. Gastrointestinal bleeding is a common collateral manifestation of anticoagulant/antithrombotic therapy that complicates its administration. The continuation or discontinuation of anticoagulant/antithrombotic therapy after an episode of gastrointestinal bleeding has been a matter of debate. Despite recent positive reports from retrospective cohort studies suggesting a reduction in morbidity- and mortality-related outcomes with continued administration of anticoagulant/antithrombotic agents (even after gastrointestinal bleeding), no consensus or comparisons about the efficacies of continued or discontinued antithrombotic administration exist. Therefore, we developed this current state-of-evidence analysis evaluating the comparative effects of continuation and discontinuation of anticoagulant/antithrombotic drugs after gastrointestinal bleeding on the overall incidences of gastrointestinal bleeding, thromboembolic events and mortality events. Methods: We performed a systematic academic literature search according to the PRISMA guidelines across five databases: Web of Science, Embase, CENTRAL, Scopus and MEDLINE. Moreover, we conducted a random effect meta-analysis to compare the effects of continuation and discontinuation of anticoagulant/antithrombotic drugs after an event of gastrointestinal bleeding on the overall incidences of gastrointestinal bleeding, thromboembolic events and mortality events. Results: We found seven eligible studies (from 1397 candidates) with 2532 participants (mean age, 73.1 ± 4.1 years). Our meta-analysis revealed lower odds of thromboembolic events (OR, -0.21), mortality outcomes (OR, -0.39) and an increase in the incidence of gastrointestinal bleeding (OR, 2.4) in the group with continued anticoagulant/antithrombotic therapy than in the group discontinuing the therapy. What is new and conclusion: We provide an updated evidence on the comparative effects between continuation and discontinuation of anticoagulant/antithrombotic drugs after gastrointestinal bleeding events based on the overall incidences of gastrointestinal bleeding, thromboembolic events and mortality events. This study reports confirm an overall lower incidence of thromboembolic events and mortality outcomes for the continuation group than for the discontinuation group.
MeSH term(s)	Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Drug Administration Schedule ; Fibrinolytic Agents/therapeutic use ; Gastrointestinal Hemorrhage/chemically induced ; Humans ; Platelet Aggregation Inhibitors/therapeutic use ; Risk Factors ; Thrombosis/prevention & control
Chemical Substances	Anticoagulants ; Fibrinolytic Agents ; Platelet Aggregation Inhibitors
Language	English
Publishing date	2021-06-07
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	639006-7
ISSN	1365-2710 ; 0269-4727
ISSN (online)	1365-2710
ISSN	0269-4727
DOI	10.1111/jcpt.13442
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