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Article: Commentary on "Cognitive Function and Urologic Medications for Lower Urinary Tract Symptoms".

Birder, Lori

2020 Volume 24, Issue 3, Page(s) 295

Language	English
Publishing date	2020-09-30
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2584447-7
ISSN	2093-6931 ; 2093-4777
ISSN (online)	2093-6931
ISSN	2093-4777
DOI	10.5213/inj.2040286.143
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Urothelial Layers: Not All Created Equal.

Birder, Lori

The Journal of urology

2016 Volume 195, Issue 3, Page(s) 544–545

MeSH term(s)	Animals ; Mitomycin/pharmacokinetics ; Ureter/metabolism ; Urinary Bladder/metabolism ; Urothelium/metabolism
Chemical Substances	Mitomycin (50SG953SK6)
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2015.12.033
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Article ; Online: Soluble Guanylate Cyclase Activators to Treat Benign Prostatic Hyperplasia and associated LUTS.

Kanai, A J / Andersson, K-E / Birder, L A / Fry, C H

Continence (Amsterdam, Netherlands)

2023 Volume 6

Abstract: This review summarises the presentations during a workshop session entitled "The Use of Soluble Guanylate Cyclase Activators to Treat Benign Prostatic Hyperplasia, Obstruction and Fibrosis - Mechanistic Concepts and Clinical Implications" at the ... ...

Abstract	This review summarises the presentations during a workshop session entitled "The Use of Soluble Guanylate Cyclase Activators to Treat Benign Prostatic Hyperplasia, Obstruction and Fibrosis - Mechanistic Concepts and Clinical Implications" at the International Continence Society (ICS) 2021 Melbourne Virtual meeting. Benign prostatic hyperplasia (BPH) is a highly prevalent condition that can result in bladder outflow obstruction (BOO) and development of lower urinary tract symptoms (LUTS), and by 80 years of age is present in about 75% of men. Current pharmacological therapies include
Language	English
Publishing date	2023-05-17
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-9737
ISSN (online)	2772-9737
DOI	10.1016/j.cont.2023.100699
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Article: Oxidative Stress Biomarkers in Age-Related Lower Urinary Tract Disorders: A Systematic Review.

Khosla, Lakshay / Gong, Susan / Weiss, Jeffrey P / Birder, Lori A

International neurourology journal

2022 Volume 26, Issue 1, Page(s) 3–19

Abstract: Purpose: To conduct a systematic review of preclinical and clinical peer-reviewed evidence linking alterations in oxidative stress biomarkers or outcome measures that were also prevalent in specific age-related lower urinary tract (LUT) disorders.: ... ...

Abstract	Purpose: To conduct a systematic review of preclinical and clinical peer-reviewed evidence linking alterations in oxidative stress biomarkers or outcome measures that were also prevalent in specific age-related lower urinary tract (LUT) disorders. Methods: PubMed, Scopus, CINAHL, and Embase were searched for peer-reviewed studies published between January 2000 and March 2021. Animal and human studies that reported on the impact of oxidative stress in age-related LUT disorders through structural or functional changes in the LUT and changes in biomarkers were included. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) protocol was followed. Results: Of 882 articles identified, 21 studies (13 animal; 8 human) met inclusion criteria. Across LUT disorders, common structural changes were increased bladder and prostate weights, ischemic damage, nerve damage and detrusor muscle hypertrophy; common functional changes included decreased bladder contraction, increased bladder sensation and excitability, decreased perfusion, and increased inflammation. The disorders were associated with increased levels of biomarkers of oxidative stress that provided evidence of either molecular damage, protective mechanisms against oxidative stress, neural changes, or inflammation. In all cases, the effect on biomarkers and enzymes was greater in aged groups compared to younger groups. Conclusion: Increased oxidative stress, often associated with mitochondrial dysfunction, plays a significant role in the pathogenesis of age-related LUT disorders and may explain their increasing prevalence. This systematic review identifies potential markers of disease progression and treatment opportunities; further research is warranted to evaluate these markers and the mechanisms by which these changes may lead to age-related LUT disorders.
Language	English
Publishing date	2022-03-31
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2584447-7
ISSN	2093-6931 ; 2093-4777
ISSN (online)	2093-6931
ISSN	2093-4777
DOI	10.5213/inj.2142188.094
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Article: Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome.

Birder, Lori / Andersson, Karl-Erik

International neurourology journal

2018 Volume 22, Issue Suppl 1, Page(s) S3–9

Abstract: The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to ... ...

Abstract	The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1) bladder-centric models, (2) models with complex mechanisms, and (3) psychological and physical stressors/natural disease models. It is obvious that all aspects of the human disease cannot be mimicked by a single model. It may be the case that several models, each contributing to a piece of the puzzle, are required to recreate a reasonable picture of the pathophysiology and time course of the disease(s) diagnosed as IC/BPS, and thus to identify reasonable targets for treatment.
Language	English
Publishing date	2018-01-31
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2584447-7
ISSN	2093-6931 ; 2093-4777
ISSN (online)	2093-6931
ISSN	2093-4777
DOI	10.5213/inj.1835062.531
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Article: Current Pharmacologic Approaches in Painful Bladder Research: An Update.

Andersson, Karl-Erik / Birder, Lori

International neurourology journal

2017 Volume 21, Issue 4, Page(s) 235–242

Abstract: The symptoms of interstitial cystitis (IC)/bladder pain syndrome (BPS) may have multiple causes and involve many contributing factors. Traditional treatments (intravesical instillations) have had a primary focus on the bladder as origin of symptoms ... ...

Abstract	The symptoms of interstitial cystitis (IC)/bladder pain syndrome (BPS) may have multiple causes and involve many contributing factors. Traditional treatments (intravesical instillations) have had a primary focus on the bladder as origin of symptoms without adequately considering the potential influence of other local (pelvic) or systemic factors. Systemic pharmacological treatments have had modest success. A contributing factor to the low efficacy is the lack of phenotyping the patients. Individualized treatment based on is desirable, but further phenotype categorization is needed. There seems to be general agreement that IC is a unique disease and that BPS is a syndrome with multiple pathophysiologies, but this has so far not been not been well reflected in preclinical research with the aim of finding new pharmacological treatments. Current research approaches, including anti-nerve growth factor treatment, anti-tumor necrosis factor-α treatment, activation of SHIP1 (AQX-1125), and P2X3 receptor antagonists, and α
Language	English
Publishing date	2017-12-31
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2584447-7
ISSN	2093-6931 ; 2093-4777
ISSN (online)	2093-6931
ISSN	2093-4777
DOI	10.5213/inj.1735022.511
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Article ; Online: Lifelong LUTS: Understanding the bladder's role and implications across transition phases, a comprehensive review.

Kheir, George Bou / Verbakel, Irina / Wyndaele, Michel / Monaghan, Thomas F / Sinha, Sanjay / Larsen, Tove Holm / Van Laecke, Erik / Birder, Lori / Hervé, François / Everaert, Karel

Neurourology and urodynamics

2024

Abstract: Introduction: Lower urinary tract symptoms (LUTSs) are a diverse array of urinary and pelvic dysfunctions that can emerge from childhood, extend through adulthood, and persist into older age. This narrative review aims to provide a comprehensive ... ...

Abstract	Introduction: Lower urinary tract symptoms (LUTSs) are a diverse array of urinary and pelvic dysfunctions that can emerge from childhood, extend through adulthood, and persist into older age. This narrative review aims to provide a comprehensive perspective on the continuum of LUTS and shed light on the underlying mechanisms and clinical implications that span across the lower urinary tract. Methods: A panel of five experts from Belgium, the Netherlands, India, Denmark, and the United States participated in an intensive research to explore and pinpoint existing insights into the lifelong concept of LUTS, particularly at the pelvic level. The experts reviewed the existing literature and held a webinar to discuss their findings. Results: Childhood LUTS can persist, resolve, or progress into bladder underactivity, dysfunctional voiding, or pain syndromes. The Lifelong character can be explained by pelvic organ cross-talk facilitated through complex neurological and nonneurological interactions. At the molecular level, the role of vasopressin receptors in the bladder's modulation and their potential relevance to therapeutic strategies for LUTS are explored. Frailty emerges as a parallel concept to lifelong LUTS, with a complex and synergistic relationship. Frailty, not solely an age-related condition, accentuates LUTS severity with insufficient evidence regarding the effectiveness and safety profile of the available therapeutic modalities. Conclusion: Understanding lifelong LUTSs offers insights into genetic, anatomical, neurological, and molecular mechanisms. Further research could identify predictive biomarkers, elucidate the role of clinically translatable elements in pelvic cross-talk, and uncover molecular signatures for personalized management.
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604904-7
ISSN	1520-6777 ; 0733-2467
ISSN (online)	1520-6777
ISSN	0733-2467
DOI	10.1002/nau.25304
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Article ; Online: Editorial comment.

Birder, Lori

Neurourology and urodynamics

2009 Volume 28, Issue 5, Page(s) 470

MeSH term(s)	Animals ; Mice ; Mice, Knockout ; Mucoproteins/deficiency ; Mucoproteins/genetics ; Urinary Bladder/metabolism ; Urinary Bladder/pathology ; Urinary Incontinence, Stress/metabolism ; Urinary Incontinence, Stress/pathology ; Urinary Incontinence, Stress/physiopathology ; Urination ; Uromodulin
Chemical Substances	Mucoproteins ; Umod protein, mouse ; Uromodulin
Language	English
Publishing date	2009
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	604904-7
ISSN	1520-6777 ; 0733-2467
ISSN (online)	1520-6777
ISSN	0733-2467
DOI	10.1002/nau.20696
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Article ; Online: Effects of vasopressin receptor agonists on detrusor smooth muscle tone in young and aged bladders: Implications for nocturia treatment.

Ikeda, Youko / Zabbarova, Irina / de Rijk, Mathijs / Kanai, Anthony / Wolf-Johnston, Amanda / Weiss, Jeffrey P / Jackson, Edwin / Birder, Lori

Continence (Amsterdam, Netherlands)

2022 Volume 2

Abstract: Purpose: The main goal of this study was to determine the effects of arginine vasopressin (AVP) and desmopressin on bladder contractility and to examine whether the effects of these vasopressin receptor (VR) agonists differ in young versus aged animals. ...

Abstract	Purpose: The main goal of this study was to determine the effects of arginine vasopressin (AVP) and desmopressin on bladder contractility and to examine whether the effects of these vasopressin receptor (VR) agonists differ in young versus aged animals. These aims were addressed using urinary bladders from young (3 months) and aged (24 month) female Fischer 344 rats that were isolated and dissected into strips for isometric tension recordings. Bladder strips were exposed to AVP and desmopressin through the perfusate, and tension changes recorded. Results: In young rat bladders, AVP, an agonist at both vasopressin-1 receptors (V Conclusion: These findings support a direct role for VRs in regulating detrusor tone with V
Language	English
Publishing date	2022-05-25
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-9737
ISSN (online)	2772-9737
DOI	10.1016/j.cont.2022.100032
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Article ; Online: A constrained mixture-micturition-growth (CMMG) model of the urinary bladder: Application to partial bladder outlet obstruction (BOO).

Cheng, Fangzhou / Watton, Paul N / Pederzani, Giulia / Kurobe, Masahiro / Takaoka, Ei-Ichiro / Chapple, Chris / Birder, Lori / Yoshimura, Naoki / Robertson, Anne M

Journal of the mechanical behavior of biomedical materials

2022 Volume 134, Page(s) 105337

Abstract: We present a constrained mixture-micturition-growth (CMMG) model for the bladder. It simulates bladder mechanics, voiding function (micturition) and tissue adaptations in response to altered biomechanical conditions. The CMMG model is calibrated with ... ...

Abstract	We present a constrained mixture-micturition-growth (CMMG) model for the bladder. It simulates bladder mechanics, voiding function (micturition) and tissue adaptations in response to altered biomechanical conditions. The CMMG model is calibrated with both in vivo and in vitro data from healthy male rat urinary bladders (cystometry, bioimaging of wall structure, mechanical testing) and applied to simulate the growth and remodeling (G&R) response to partial bladder outlet obstruction (BOO). The bladder wall is represented as a multi-layered, anisotropic, nonlinear constrained mixture. A short time scale micturition component of the CMMG model accounts for the active and passive mechanics of voiding. Over a second, longer time scale, G&R algorithms for the evolution of both cellular and extracellular constituents act to maintain/restore bladder (homeostatic) functionality. The CMMG model is applied to a spherical membrane model of the BOO bladder utilizing temporal data from an experimental male rodent model to parameterize and then verify the model. Consistent with the experimental studies of BOO, the model predicts: an initial loss of voiding capacity followed by hypertrophy of SMC to restore voiding function; bladder enlargement; collagen remodeling to maintain its role as a protective sheath; and increased voiding duration with lower average flow rate. This CMMG model enables a mechanistic approach for investigating the bladder's structure-function relationship and its adaption in pathological conditions. While the approach is illustrated with a conceptual spherical bladder model, it provides the basis for application of the CMMG model to anatomical geometries. Such a mechanistic approach has promise as an in silico tool for the rational development of new surgical and pharmacological treatments for bladder diseases such as BOO.
MeSH term(s)	Animals ; Disease Models, Animal ; Guanine/analogs & derivatives ; Male ; Rats ; Urinary Bladder ; Urinary Bladder Neck Obstruction/pathology ; Urination/physiology ; Urodynamics
Chemical Substances	Guanine (5Z93L87A1R) ; 9-carboxymethoxymethylguanine (N28227W35C)
Language	English
Publishing date	2022-06-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2378381-3
ISSN	1878-0180 ; 1751-6161
ISSN (online)	1878-0180
ISSN	1751-6161
DOI	10.1016/j.jmbbm.2022.105337
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