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  1. Article ; Online: Obesity and the kidney: mechanistic links and therapeutic advances.

    Yau, Kevin / Kuah, Rachel / Cherney, David Z I / Lam, Tony K T

    Nature reviews. Endocrinology

    2024  

    Abstract: Obesity is strongly associated with the development of diabetes mellitus and chronic kidney disease (CKD), but there is evidence for a bidirectional relationship wherein the kidney also acts as a key regulator of body weight. In this Review, we highlight ...

    Abstract Obesity is strongly associated with the development of diabetes mellitus and chronic kidney disease (CKD), but there is evidence for a bidirectional relationship wherein the kidney also acts as a key regulator of body weight. In this Review, we highlight the mechanisms implicated in obesity-related CKD, and outline how the kidney might modulate feeding and body weight through a growth differentiation factor 15-dependent kidney-brain axis. The favourable effects of bariatric surgery on kidney function are discussed, and medical therapies designed for the treatment of diabetes mellitus that lower body weight and preserve kidney function independent of glycaemic lowering, including sodium-glucose cotransporter 2 inhibitors, incretin-based therapies and metformin, are also reviewed. In summary, we propose that kidney function and body weight are related in a bidirectional fashion, and that this interrelationship affects human health and disease.
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-024-00951-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6336: Show issues Location:
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  2. Article ; Online: A novel approach for designing hands-on training programs using Quick Reference code-linked videos.

    Manton, Jesse W / Nix, Ned L / Mashkoor, Fatima / Lam, David K

    Journal of dental education

    2024  

    Abstract: Providing training on the proper use of technology in the context of a large number of learners and limited faculty availability is a constant challenge to dental schools. We found the implementation of a QR-code-based autonomous program design to be ... ...

    Abstract Providing training on the proper use of technology in the context of a large number of learners and limited faculty availability is a constant challenge to dental schools. We found the implementation of a QR-code-based autonomous program design to be efficient and effective at providing trainees hands-on training with newly installed perioperative equipment.
    Language English
    Publishing date 2024-01-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410579-5
    ISSN 1930-7837 ; 0022-0337
    ISSN (online) 1930-7837
    ISSN 0022-0337
    DOI 10.1002/jdd.13448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 428: Show issues Location:
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  3. Article ; Online: Technique for Extraction and Revision of a Bent Intramedullary Nail for a Subtrochanteric Femur Fracture: A Case Report.

    Lam, Aaron W / Richardson, David / Kang, Kevin K

    JBJS case connector

    2023  Volume 13, Issue 1

    Abstract: Case: A 17-year-old adolescent boy presented 2 months after initial intramedullary nail (IMN) fixation of a comminuted subtrochanteric fracture with refracture at the previous site and approximately 20° varus angulation of the nail. The bent femoral ... ...

    Abstract Case: A 17-year-old adolescent boy presented 2 months after initial intramedullary nail (IMN) fixation of a comminuted subtrochanteric fracture with refracture at the previous site and approximately 20° varus angulation of the nail. The bent femoral nail was successfully extracted using an open technique using Lohman bone-holding clamps and a broad plate. At the 1-year follow-up, fracture union was achieved.
    Conclusions: Removal of a deformed IMN is rare. No standardized protocol exists in guiding orthopaedic surgeons. A thorough review of techniques is discussed on this unusual complication.
    MeSH term(s) Male ; Adolescent ; Humans ; Fracture Fixation, Intramedullary/methods ; Bone Nails ; Hip Fractures/surgery ; Femur/surgery ; Bone Plates
    Language English
    Publishing date 2023-02-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2160-3251
    ISSN (online) 2160-3251
    DOI e22.00453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Patient-Centered Approach to Writing Ambulatory Visit Notes in the Cures Act Era.

    Lam, Barbara D / Dupee, David / Gerard, Macda / Bell, Sigall K

    Applied clinical informatics

    2023  Volume 14, Issue 1, Page(s) 199–204

    MeSH term(s) Humans ; Electronic Health Records ; Patients ; Writing ; Patient-Centered Care
    Language English
    Publishing date 2023-03-08
    Publishing country Germany
    Document type Journal Article
    ISSN 1869-0327
    ISSN (online) 1869-0327
    DOI 10.1055/s-0043-1761436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Chronic balanitis: When should we be concerned?

    Lam, Kevin / Cook, David K

    Australian journal of general practice

    2020  Volume 49, Issue 12, Page(s) 839–841

    MeSH term(s) Aged ; Balanitis/complications ; Balanitis/diagnosis ; Diagnosis, Differential ; Exanthema/etiology ; Exanthema/physiopathology ; Humans ; Male ; Penis/abnormalities
    Language English
    Publishing date 2020-11-27
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 2924889-9
    ISSN 2208-7958 ; 2208-794X
    ISSN (online) 2208-7958
    ISSN 2208-794X
    DOI 10.31128/AJGP-03-20-5283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2235: Show issues Location:
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  6. Article ; Online: Soot-Embedded Extruded Talus Fracture After a 5-Story Fall: A Case Report.

    Varghese, Priscilla / Lam, Aaron / Richardson, David / Kang, Kevin K

    JBJS case connector

    2023  Volume 13, Issue 1

    Abstract: Case: A 17-year-old boy presented with an open talus fracture complicated by soot contamination after a chimney-related accident. Standard irrigation and debridement (I&D) methods were used, but complete removal of soot was not possible. At the latest ... ...

    Abstract Case: A 17-year-old boy presented with an open talus fracture complicated by soot contamination after a chimney-related accident. Standard irrigation and debridement (I&D) methods were used, but complete removal of soot was not possible. At the latest follow-up, there was no evidence of infection, hardware failure, or avascular necrosis.
    Conclusion: There is a lack of well-established guidelines regarding I&D of traumatic wounds contaminated with fine particulates. A review of potential debridement methods is discussed. Orthoapedic surgeons should be aware of hydrosurgical debridement as a potential treatment approach in these unique scenarios.
    MeSH term(s) Male ; Humans ; Adolescent ; Talus/diagnostic imaging ; Talus/surgery ; Ankle Injuries/surgery ; Ankle Fractures/diagnostic imaging ; Ankle Fractures/surgery ; Fracture Fixation ; Joint Dislocations/surgery ; Fractures, Open/diagnostic imaging ; Fractures, Open/surgery
    Language English
    Publishing date 2023-01-27
    Publishing country United States
    Document type Case Reports ; Review ; Journal Article
    ISSN 2160-3251
    ISSN (online) 2160-3251
    DOI e22.00517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Use of Tissue Microarray in Esophageal Squamous Cell Carcinoma.

    Lam, Alfred K / Lor, David K

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2129, Page(s) 119–135

    Abstract: Tissue microarray (TMA) is widely used for identifying the expression of markers in many tissues from patients with esophageal squamous cell carcinoma. The technology is mostly used in immunohistochemical studies to test the expression of markers and ... ...

    Abstract Tissue microarray (TMA) is widely used for identifying the expression of markers in many tissues from patients with esophageal squamous cell carcinoma. The technology is mostly used in immunohistochemical studies to test the expression of markers and oncoproteins in signalling pathway as well as targeting proteins involved in therapies for esophageal squamous cell carcinoma. Appropriate use of TMA sections needs consideration of labor, planning, and expertise involved. For the best performance, it is important to design the layout of the TMA as well as use whole-slide scanning for interpretation of the TMA sections.
    MeSH term(s) Biomarkers, Tumor/metabolism ; Carcinoma, Squamous Cell/pathology ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/classification ; Esophageal Squamous Cell Carcinoma/pathology ; Esophagus/pathology ; Female ; Humans ; Male ; Mouth Neoplasms/pathology ; Specimen Handling/methods ; Tissue Array Analysis/methods
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2020-02-13
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0377-2_10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A Patient-Centered Approach to Writing Ambulatory Visit Notes in the Cures Act Era

    Lam, Barbara D. / Dupee, David / Gerard, Macda / Bell, Sigall K.

    Applied Clinical Informatics

    2023  Volume 14, Issue 01, Page(s) 199–204

    Language English
    Publishing date 2023-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 1869-0327
    ISSN (online) 1869-0327
    DOI 10.1055/s-0043-1761436
    Database Thieme publisher's database

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  9. Article ; Online: Region-specific associations between gamma-aminobutyric acid A receptor binding and cortical thickness in high-functioning autistic adults.

    James, David / Lam, Vicky T / Jo, Booil / Fung, Lawrence K

    Autism research : official journal of the International Society for Autism Research

    2022  Volume 15, Issue 6, Page(s) 1068–1082

    Abstract: The neurobiology of autism has been shown to involve alterations in cortical morphology and gamma-aminobutyric acid A ( ... ...

    Abstract The neurobiology of autism has been shown to involve alterations in cortical morphology and gamma-aminobutyric acid A (GABA
    MeSH term(s) Adult ; Autism Spectrum Disorder ; Autistic Disorder/diagnostic imaging ; Autistic Disorder/pathology ; Brain/pathology ; Brain Mapping/methods ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; gamma-Aminobutyric Acid
    Chemical Substances gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2022-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2481338-2
    ISSN 1939-3806 ; 1939-3792
    ISSN (online) 1939-3806
    ISSN 1939-3792
    DOI 10.1002/aur.2703
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    Zs.A 6785: Show issues Location:
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  10. Article ; Online: Emerging factors in the progression of cancer-related pain.

    Lam, David K

    Pain management

    2016  Volume 6, Issue 5, Page(s) 487–496

    Abstract: Most cancer patients experience severe pain during their disease course, and the management of cancer pain is a major challenge for patients and the healthcare team. Many diverse translational models of cancer pain in recent years have improved our ... ...

    Abstract Most cancer patients experience severe pain during their disease course, and the management of cancer pain is a major challenge for patients and the healthcare team. Many diverse translational models of cancer pain in recent years have improved our understanding of cancer-related pain. Cancer and associated cells in the cancer microenvironment may release various peripheral mediators, including ATP, formaldehyde, protons, proteases, endothelin, bradykinin, TNF and NGF, that result in the activation and/or sensitization of peripheral and central neurons, that contribute to the clinical manifestations of cancer-related pain. Identification of these mediators and the peripheral and central mechanisms by which they contribute to cancer-related pain may provide novel therapeutic targets to alleviate cancer patient suffering.
    MeSH term(s) Animals ; Cancer Pain/etiology ; Cancer Pain/metabolism ; Cancer Pain/physiopathology ; Central Nervous System/metabolism ; Central Nervous System/physiopathology ; Central Nervous System Sensitization ; Disease Models, Animal ; Disease Progression ; Humans ; Neurons/metabolism ; Neurons/physiology ; Peripheral Nervous System/physiopathology
    Language English
    Publishing date 2016-10
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1758-1877
    ISSN (online) 1758-1877
    DOI 10.2217/pmt-2015-0003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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