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  1. Article ; Online: Modeling neuro-immune interactions using human pluripotent stem cells.

    Garcia-Epelboim, Alan / Christian, Kimberly M

    Current opinion in neurobiology

    2023  Volume 79, Page(s) 102672

    Abstract: Human pluripotent stem cells can be differentiated into cell types that are representative of the central nervous system. Under specific culture conditions, these cells can be induced to self-organize into 3D organoids that are reminiscent of the ... ...

    Abstract Human pluripotent stem cells can be differentiated into cell types that are representative of the central nervous system. Under specific culture conditions, these cells can be induced to self-organize into 3D organoids that are reminiscent of the developing brain. Microglia are the resident immune cells of the brain but are derived from a different lineage than neural cells, which presents a challenge to modeling neuroimmune interactions. Although human microglia-like cells can be differentiated from pluripotent stem cells, important considerations include ensuring the identity of microglia, which can be influenced by both the lineage and the local environment, and developing culture methods that promote the integration and survival of diverse cell types in a physiologically relevant model. Recently, several strategies to generate neural organoids with integrated microglia have been demonstrated and provide new opportunities to interrogate interactions among microglia and neurons during development and in response to injury and disease.
    MeSH term(s) Humans ; Neuroimmunomodulation ; Induced Pluripotent Stem Cells/metabolism ; Pluripotent Stem Cells ; Brain ; Central Nervous System ; Cell Differentiation
    Language English
    Publishing date 2023-01-10
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1078046-4
    ISSN 1873-6882 ; 0959-4388
    ISSN (online) 1873-6882
    ISSN 0959-4388
    DOI 10.1016/j.conb.2022.102672
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Blended Suture-bridge Technique for Arthroscopic Rotator Cuff Repair.

    Chernchujit, Bancha / Mendoza, Christian Julius P / Samsuya, Katreese Kimberly M

    Arthroscopy techniques

    2023  Volume 12, Issue 4, Page(s) e569–e574

    Abstract: Techniques in rotator cuff repair are constantly evolving, with the main goal of a biologic, stable, and tension-free construct. Significant controversy exists between various methods, and there is no gold standard surgical protocol. We demonstrate an ... ...

    Abstract Techniques in rotator cuff repair are constantly evolving, with the main goal of a biologic, stable, and tension-free construct. Significant controversy exists between various methods, and there is no gold standard surgical protocol. We demonstrate an alternative arthroscopic rotator cuff repair technique with 2 key components. First, we performed a transosseous equivalent, suture bridge technique with a combination of triple-loaded medial anchors and knotless lateral anchors. Second, we incorporated 2-strand and 3-strand suture shuttling through the torn rotator cuff and selective medial knot-tying. A total of 6 passes through the tendon are made, comprising 1-2-3-3-2-1 strands each pass. This minimizes the number of passes through the tendon and the overall number of medial knots. Our technique retains the known biomechanical advantages akin to a double-row repair, including less gap formation and wider footprint coverage. In addition, using fewer medial knots with efficient suture passing may result to decreased cuff strangulation and favorable biologic environment for tendon healing. We theorize that this technique may yield lower retear rates while maintaining immediate stability, translating to improved clinical results.
    Language English
    Publishing date 2023-03-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2653101-X
    ISSN 2212-6287
    ISSN 2212-6287
    DOI 10.1016/j.eats.2022.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: "I wish I actually had known what the heck sex was:" What adolescent sexual minority males knew and wish they knew prior to sexual debut with a male partner.

    Stout, Claire D / Paredes, Christian D / Nelson, Kimberly M

    Sexuality research & social policy : journal of NSRC : SR & SP

    2022  Volume 20, Issue 1, Page(s) 84–93

    Abstract: Introduction: Understanding the sexual health needs of adolescent sexual minority males (ASMM) at the time of sexual debut will inform programs seeking to decrease sexual health inequities experienced by ASMM.: Methods: In 2020, sexually active, ... ...

    Abstract Introduction: Understanding the sexual health needs of adolescent sexual minority males (ASMM) at the time of sexual debut will inform programs seeking to decrease sexual health inequities experienced by ASMM.
    Methods: In 2020, sexually active, cisgender ASMM (
    Results: On average, participants were 14.5 years old (
    Conclusions: Results suggest sexual health programs for ASMM should occur prior to sexual debut, teach sexual communication skills, and teach media literacy skills to help youth deduce credible sexual health resources.
    Policy implications: Incorporating the sexual health needs and wants of ASMM into sexual health programs will likely improve acceptability and efficacy, and ultimately decrease sexual health inequities experienced by ASMM.
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2136442-4
    ISSN 1553-6610 ; 1868-9884
    ISSN (online) 1553-6610
    ISSN 1868-9884
    DOI 10.1007/s13178-021-00682-8
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  4. Article ; Online: Cascading indirect genetic effects in a clonal vertebrate.

    Makowicz, Amber M / Bierbach, David / Richardson, Christian / Hughes, Kimberly A

    Proceedings. Biological sciences

    2022  Volume 289, Issue 1978, Page(s) 20220731

    Abstract: Understanding how individual differences arise and how their effects propagate through groups are fundamental issues in biology. Individual differences can arise from indirect genetic effects (IGE): genetically based variation in the conspecifics with ... ...

    Abstract Understanding how individual differences arise and how their effects propagate through groups are fundamental issues in biology. Individual differences can arise from indirect genetic effects (IGE): genetically based variation in the conspecifics with which an individual interacts. Using a clonal species, the Amazon molly (
    MeSH term(s) Aggression ; Animals ; Biological Evolution ; Immunoglobulin E/genetics ; Poecilia/physiology
    Chemical Substances Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2022-07-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2022.0731
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1364: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Using 2D and 3D pluripotent stem cell models to study neurotropic viruses.

    LaNoce, Emma / Dumeng-Rodriguez, Jeriel / Christian, Kimberly M

    Frontiers in virology

    2022  Volume 2

    Abstract: Understanding the impact of viral pathogens on the human central nervous system (CNS) has been challenging due to the lack of viable human CNS models for controlled experiments to determine the causal factors underlying pathogenesis. Human embryonic stem ...

    Abstract Understanding the impact of viral pathogens on the human central nervous system (CNS) has been challenging due to the lack of viable human CNS models for controlled experiments to determine the causal factors underlying pathogenesis. Human embryonic stem cells (ESCs) and, more recently, cellular reprogramming of adult somatic cells to generate human induced pluripotent stem cells (iPSCs) provide opportunities for directed differentiation to neural cells that can be used to evaluate the impact of known and emerging viruses on neural cell types. Pluripotent stem cells (PSCs) can be induced to neural lineages in either two- (2D) or three-dimensional (3D) cultures, each bearing distinct advantages and limitations for modeling viral pathogenesis and evaluating effective therapeutics. Here we review the current state of technology in stem cell-based modeling of the CNS and how these models can be used to determine viral tropism and identify cellular phenotypes to investigate virus-host interactions and facilitate drug screening. We focus on several viruses (e.g., human immunodeficiency virus (HIV), herpes simplex virus (HSV), Zika virus (ZIKV), human cytomegalovirus (HCMV), SARS-CoV-2, West Nile virus (WNV)) to illustrate key advantages, as well as challenges, of PSC-based models. We also discuss how human PSC-based models can be used to evaluate the safety and efficacy of therapeutic drugs by generating data that are complementary to existing preclinical models. Ultimately, these efforts could facilitate the movement towards personalized medicine and provide patients and physicians with an additional source of information to consider when evaluating available treatment strategies.
    Language English
    Publishing date 2022-07-29
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-818X
    ISSN (online) 2673-818X
    DOI 10.3389/fviro.2022.869657
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  6. Article: Using Two- and Three-Dimensional Human iPSC Culture Systems to Model Psychiatric Disorders.

    Christian, Kimberly M / Song, Hongjun / Ming, Guo-Li

    Advances in neurobiology

    2020  Volume 25, Page(s) 237–257

    Abstract: Psychiatric disorders are among the most challenging human diseases to understand at a mechanistic level due to the heterogeneity of symptoms within established diagnostic categories, the general absence of focal pathology, and the genetic complexity ... ...

    Abstract Psychiatric disorders are among the most challenging human diseases to understand at a mechanistic level due to the heterogeneity of symptoms within established diagnostic categories, the general absence of focal pathology, and the genetic complexity inherent in these mostly polygenic disorders. Each of these features presents unique challenges to disease modeling for biological discovery, drug development, or improved diagnostics. In addition, live human neural tissue has been largely inaccessible to experimentation, leaving gaps in our knowledge derived from animal models that cannot fully recapitulate the features of the disease, indirect measures of brain function in human patients, and from analyses of postmortem tissue that can be confounded by comorbid conditions and medication history.
    MeSH term(s) Animals ; Humans ; Induced Pluripotent Stem Cells ; Mental Disorders
    Language English
    Publishing date 2020-06-23
    Publishing country United States
    Document type Journal Article
    ISSN 2190-5215
    ISSN 2190-5215
    DOI 10.1007/978-3-030-45493-7_9
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  7. Article ; Online: Global remapping in granule cells and mossy cells of the mouse dentate gyrus.

    Kim, Sang Hoon / GoodSmith, Douglas / Temme, Stephanie J / Moriya, Fumika / Ming, Guo-Li / Christian, Kimberly M / Song, Hongjun / Knierim, James J

    Cell reports

    2023  Volume 42, Issue 4, Page(s) 112334

    Abstract: Hippocampal place cells exhibit spatially modulated firing, or place fields, which can remap to encode changes in the environment or other variables. Unique among hippocampal subregions, the dentate gyrus (DG) has two excitatory populations of place ... ...

    Abstract Hippocampal place cells exhibit spatially modulated firing, or place fields, which can remap to encode changes in the environment or other variables. Unique among hippocampal subregions, the dentate gyrus (DG) has two excitatory populations of place cells, granule cells and mossy cells, which are among the least and most active spatially modulated cells in the hippocampus, respectively. Previous studies of remapping in the DG have drawn different conclusions about whether granule cells exhibit global remapping and contribute to the encoding of context specificity. By recording granule cells and mossy cells as mice foraged in different environments, we found that by most measures, both granule cells and mossy cells remapped robustly but through different mechanisms that are consistent with firing properties of each cell type. Our results resolve the ambiguity surrounding remapping in the DG and suggest that most spatially modulated granule cells contribute to orthogonal representations of distinct spatial contexts.
    MeSH term(s) Mice ; Animals ; Mossy Fibers, Hippocampal ; Dentate Gyrus/metabolism ; Hippocampus ; Place Cells
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112334
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  8. Article ; Online: Applications of Brain Organoids for Infectious Diseases.

    Fan, Wenqiang / Christian, Kimberly M / Song, Hongjun / Ming, Guo-Li

    Journal of molecular biology

    2021  Volume 434, Issue 3, Page(s) 167243

    Abstract: Brain organoids are self-organized three-dimensional aggregates generated from pluripotent stem cells. They exhibit complex cell diversities and organized architectures that resemble human brain development ranging from neural tube formation, ... ...

    Abstract Brain organoids are self-organized three-dimensional aggregates generated from pluripotent stem cells. They exhibit complex cell diversities and organized architectures that resemble human brain development ranging from neural tube formation, neuroepithelium differentiation, neurogenesis and gliogenesis, to neural circuit formation. Rapid advancements in brain organoid culture technologies have allowed researchers to generate more accurate models of human brain development and neurological diseases. These models also allow for direct investigation of pathological processes associated with infectious diseases affecting the nervous system. In this review, we first briefly summarize recent advancements in brain organoid methodologies and neurodevelopmental processes that can be effectively modeled by brain organoids. We then focus on applications of brain organoids to investigate the pathogenesis of neurotropic viral infection. Finally, we discuss limitations of the current brain organoid methodologies as well as applications of other organ specific organoids in the infectious disease research.
    MeSH term(s) Brain/growth & development ; Brain/virology ; Central Nervous System Viral Diseases/virology ; Humans ; Neurogenesis ; Organoids/virology
    Language English
    Publishing date 2021-09-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1016/j.jmb.2021.167243
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 867: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Applications of Brain Organoids for Infectious Diseases

    Fan, Wenqiang / Christian, Kimberly M. / Song, Hongjun / Ming, Guo-li

    Journal of molecular biology. 2022 Feb. 15, v. 434, no. 3

    2022  

    Abstract: Brain organoids are self-organized three-dimensional aggregates generated from pluripotent stem cells. They exhibit complex cell diversities and organized architectures that resemble human brain development ranging from neural tube formation, ... ...

    Abstract Brain organoids are self-organized three-dimensional aggregates generated from pluripotent stem cells. They exhibit complex cell diversities and organized architectures that resemble human brain development ranging from neural tube formation, neuroepithelium differentiation, neurogenesis and gliogenesis, to neural circuit formation. Rapid advancements in brain organoid culture technologies have allowed researchers to generate more accurate models of human brain development and neurological diseases. These models also allow for direct investigation of pathological processes associated with infectious diseases affecting the nervous system. In this review, we first briefly summarize recent advancements in brain organoid methodologies and neurodevelopmental processes that can be effectively modeled by brain organoids. We then focus on applications of brain organoids to investigate the pathogenesis of neurotropic viral infection. Finally, we discuss limitations of the current brain organoid methodologies as well as applications of other organ specific organoids in the infectious disease research.
    Keywords brain ; humans ; infectious diseases ; molecular biology ; neural networks ; neurogenesis ; organoids ; pathogenesis
    Language English
    Dates of publication 2022-0215
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1016/j.jmb.2021.167243
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4' 63/108: Show issues

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  10. Article ; Online: A previously undetected pathology of Zika virus infection.

    Christian, Kimberly M / Song, Hongjun / Ming, Guo-Li

    Nature medicine

    2018  Volume 24, Issue 3, Page(s) 258–259

    MeSH term(s) Brain ; Humans ; Neurogenesis ; Pregnancy Complications, Infectious ; Zika Virus ; Zika Virus Infection/congenital
    Language English
    Publishing date 2018-03-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/nm.4510
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4212: Show issues Location:
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    Zs.MG 39: Show issues

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