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  1. Article ; Online: Correction to: Featured lncRNA‑based signature for discriminating prognosis and progression of hepatocellular carcinoma.

    Qiu, Huiyuan / Jiang, Bo / Chen, Yinqi / Lin, Zhaoyi / Zheng, Wenjie / Cao, Xiaolei

    Journal of applied genetics

    2024  Volume 65, Issue 2, Page(s) 415

    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1235302-4
    ISSN 2190-3883 ; 1234-1983
    ISSN (online) 2190-3883
    ISSN 1234-1983
    DOI 10.1007/s13353-024-00845-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Aggregation-induced emission enhancement (AIEE) active bispyrene-based fluorescent probe: "turn-off" fluorescence for the detection of nitroaromatics.

    Cui, Fengjuan / Xie, Zhiyu / Yang, Rui / Zhang, Yu / Liu, Yue / Zheng, Huiyuan / Han, Xue

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

    2024  Volume 314, Page(s) 124222

    Abstract: The detection of nitroaromatic explosives in real samples is essential for environmental monitoring because of their strongly powerful nature and wide applications in industries. Aggregation-induced emission enhancement (AIEE) active fluorescent probe ... ...

    Abstract The detection of nitroaromatic explosives in real samples is essential for environmental monitoring because of their strongly powerful nature and wide applications in industries. Aggregation-induced emission enhancement (AIEE) active fluorescent probe has been widely employed to detect nitroaromatic explosives. Hereby, a simple V-shaped bispyrene-based fluorescent probe (called py-o) with AIEE properties was designed and synthesized, which was fully charactered by 1D NMR, ESI, FTIR, and 2D NOESY spectra. The py-o displayed bright blue-green fluorescence excimer emission at 480 nm in DMF/H
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 210413-1
    ISSN 1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
    ISSN (online) 1873-3557
    ISSN 0370-8322 ; 0584-8539 ; 1386-1425
    DOI 10.1016/j.saa.2024.124222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Deep Learning Modeling of Cardiac Arrhythmia Classification on Information Feature Fusion Image with Attention Mechanism

    Mingming Zhang / Huiyuan Jin / Bin Zheng / Wenbo Luo

    Entropy, Vol 25, Iss 1264, p

    2023  Volume 1264

    Abstract: The electrocardiogram (ECG) is a crucial tool for assessing cardiac health in humans. Aiming to enhance the accuracy of ECG signal classification, a novel approach is proposed based on relative position matrix and deep learning network information ... ...

    Abstract The electrocardiogram (ECG) is a crucial tool for assessing cardiac health in humans. Aiming to enhance the accuracy of ECG signal classification, a novel approach is proposed based on relative position matrix and deep learning network information features for the classification task in this paper. The approach improves the feature extraction capability and classification accuracy via techniques of image conversion and attention mechanism. In terms of the recognition strategy, this paper presents an image conversion using relative position matrix information. This information is utilized to describe the relative spatial relationships between different waveforms, and the image identification is successfully applied to the Gam-Resnet18 deep learning network model with a transfer learning concept for classification. Ultimately, this model achieved a total accuracy of 99.30%, an average positive prediction rate of 98.76%, a sensitivity of 98.90%, and a specificity of 99.84% with the relative position matrix approach. To evaluate the effectiveness of the proposed method, different image conversion techniques are compared on the test set. The experimental results demonstrate that the relative position matrix information can better reflect the differences between various types of arrhythmias, thereby improving the accuracy and stability of classification.
    Keywords ECG signal ; image conversion ; relative position matrix ; transfer learning ; deep learning ; Science ; Q ; Astrophysics ; QB460-466 ; Physics ; QC1-999
    Subject code 006
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Existing Barriers Faced by and Future Design Recommendations for Direct-to-Consumer Health Care Artificial Intelligence Apps

    Xin He / Xi Zheng / Huiyuan Ding

    Journal of Medical Internet Research, Vol 25, p e

    Scoping Review

    2023  Volume 50342

    Abstract: BackgroundDirect-to-consumer (DTC) health care artificial intelligence (AI) apps hold the potential to bridge the spatial and temporal disparities in health care resources, but they also come with individual and societal risks due to AI errors. ... ...

    Abstract BackgroundDirect-to-consumer (DTC) health care artificial intelligence (AI) apps hold the potential to bridge the spatial and temporal disparities in health care resources, but they also come with individual and societal risks due to AI errors. Furthermore, the manner in which consumers interact directly with health care AI is reshaping traditional physician-patient relationships. However, the academic community lacks a systematic comprehension of the research overview for such apps. ObjectiveThis paper systematically delineated and analyzed the characteristics of included studies, identified existing barriers and design recommendations for DTC health care AI apps mentioned in the literature and also provided a reference for future design and development. MethodsThis scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines and was conducted according to Arksey and O’Malley’s 5-stage framework. Peer-reviewed papers on DTC health care AI apps published until March 27, 2023, in Web of Science, Scopus, the ACM Digital Library, IEEE Xplore, PubMed, and Google Scholar were included. The papers were analyzed using Braun and Clarke’s reflective thematic analysis approach. ResultsOf the 2898 papers retrieved, 32 (1.1%) covering this emerging field were included. The included papers were recently published (2018-2023), and most (23/32, 72%) were from developed countries. The medical field was mostly general practice (8/32, 25%). In terms of users and functionalities, some apps were designed solely for single-consumer groups (24/32, 75%), offering disease diagnosis (14/32, 44%), health self-management (8/32, 25%), and health care information inquiry (4/32, 13%). Other apps connected to physicians (5/32, 16%), family members (1/32, 3%), nursing staff (1/32, 3%), and health care departments (2/32, 6%), generally to alert these groups to abnormal conditions of consumer users. In addition, 8 barriers and 6 design recommendations related to DTC ...
    Keywords Computer applications to medicine. Medical informatics ; R858-859.7 ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher JMIR Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: ATX-LPA-Dependent Nuclear Translocation of Endonuclease G in Respiratory Epithelial Cells: A New Mode Action for DNA Damage Induced by Crystalline Silica Particles.

    Zheng, Huiyuan / Stenius, Ulla / Högberg, Johan

    Cancers

    2023  Volume 15, Issue 3

    Abstract: Crystalline silica particles (CSi) are an established human carcinogen, but it is not clear how these particles cause necessary mutations. A well-established scenario includes inflammation caused by retained particles in the bronchioles, activated ... ...

    Abstract Crystalline silica particles (CSi) are an established human carcinogen, but it is not clear how these particles cause necessary mutations. A well-established scenario includes inflammation caused by retained particles in the bronchioles, activated macrophages, and reactive oxygen species (ROS) that cause DNA damage. In previous studies, we showed that CSi in contact with the plasma membrane of human bronchial epithelium induced double strand breaks within minutes. A signaling pathway implicating the ATX-LPA axis, Rac1, NLRP3, and mitochondrial depolarization upstream of DSB formation was delineated. In this paper, we provide in vitro and in vivo evidence that this signaling pathway triggers endonuclease G (EndoG) translocation from the mitochondria to the nucleus. The DNA damage is documented as γH2AX and p53BP1 nuclear foci, strand breaks in the Comet assay, and as micronuclei. In addition, the DNA damage is induced by low doses of CSi that do not induce apoptosis. By inhibiting the ATX-LPA axis or by EndoG knockdown, we prevent EndoG translocation and DSB formation. Our data indicate that CSi in low doses induces DSBs by sub-apoptotic activation of EndoG, adding CSi to a list of carcinogens that may induce mutations via sub-apoptotic and "minority MOMP" effects. This is the first report linking the ATX-LPA axis to this type of carcinogenic effect.
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15030865
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Deep Learning Modeling of Cardiac Arrhythmia Classification on Information Feature Fusion Image with Attention Mechanism.

    Zhang, Mingming / Jin, Huiyuan / Zheng, Bin / Luo, Wenbo

    Entropy (Basel, Switzerland)

    2023  Volume 25, Issue 9

    Abstract: The electrocardiogram (ECG) is a crucial tool for assessing cardiac health in humans. Aiming to enhance the accuracy of ECG signal classification, a novel approach is proposed based on relative position matrix and deep learning network information ... ...

    Abstract The electrocardiogram (ECG) is a crucial tool for assessing cardiac health in humans. Aiming to enhance the accuracy of ECG signal classification, a novel approach is proposed based on relative position matrix and deep learning network information features for the classification task in this paper. The approach improves the feature extraction capability and classification accuracy via techniques of image conversion and attention mechanism. In terms of the recognition strategy, this paper presents an image conversion using relative position matrix information. This information is utilized to describe the relative spatial relationships between different waveforms, and the image identification is successfully applied to the Gam-Resnet18 deep learning network model with a transfer learning concept for classification. Ultimately, this model achieved a total accuracy of 99.30%, an average positive prediction rate of 98.76%, a sensitivity of 98.90%, and a specificity of 99.84% with the relative position matrix approach. To evaluate the effectiveness of the proposed method, different image conversion techniques are compared on the test set. The experimental results demonstrate that the relative position matrix information can better reflect the differences between various types of arrhythmias, thereby improving the accuracy and stability of classification.
    Language English
    Publishing date 2023-08-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e25091264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Existing Barriers Faced by and Future Design Recommendations for Direct-to-Consumer Health Care Artificial Intelligence Apps: Scoping Review.

    He, Xin / Zheng, Xi / Ding, Huiyuan

    Journal of medical Internet research

    2023  Volume 25, Page(s) e50342

    Abstract: Background: Direct-to-consumer (DTC) health care artificial intelligence (AI) apps hold the potential to bridge the spatial and temporal disparities in health care resources, but they also come with individual and societal risks due to AI errors. ... ...

    Abstract Background: Direct-to-consumer (DTC) health care artificial intelligence (AI) apps hold the potential to bridge the spatial and temporal disparities in health care resources, but they also come with individual and societal risks due to AI errors. Furthermore, the manner in which consumers interact directly with health care AI is reshaping traditional physician-patient relationships. However, the academic community lacks a systematic comprehension of the research overview for such apps.
    Objective: This paper systematically delineated and analyzed the characteristics of included studies, identified existing barriers and design recommendations for DTC health care AI apps mentioned in the literature and also provided a reference for future design and development.
    Methods: This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines and was conducted according to Arksey and O'Malley's 5-stage framework. Peer-reviewed papers on DTC health care AI apps published until March 27, 2023, in Web of Science, Scopus, the ACM Digital Library, IEEE Xplore, PubMed, and Google Scholar were included. The papers were analyzed using Braun and Clarke's reflective thematic analysis approach.
    Results: Of the 2898 papers retrieved, 32 (1.1%) covering this emerging field were included. The included papers were recently published (2018-2023), and most (23/32, 72%) were from developed countries. The medical field was mostly general practice (8/32, 25%). In terms of users and functionalities, some apps were designed solely for single-consumer groups (24/32, 75%), offering disease diagnosis (14/32, 44%), health self-management (8/32, 25%), and health care information inquiry (4/32, 13%). Other apps connected to physicians (5/32, 16%), family members (1/32, 3%), nursing staff (1/32, 3%), and health care departments (2/32, 6%), generally to alert these groups to abnormal conditions of consumer users. In addition, 8 barriers and 6 design recommendations related to DTC health care AI apps were identified. Some more subtle obstacles that are particularly worth noting and corresponding design recommendations in consumer-facing health care AI systems, including enhancing human-centered explainability, establishing calibrated trust and addressing overtrust, demonstrating empathy in AI, improving the specialization of consumer-grade products, and expanding the diversity of the test population, were further discussed.
    Conclusions: The booming DTC health care AI apps present both risks and opportunities, which highlights the need to explore their current status. This paper systematically summarized and sorted the characteristics of the included studies, identified existing barriers faced by, and made future design recommendations for such apps. To the best of our knowledge, this is the first study to systematically summarize and categorize academic research on these apps. Future studies conducting the design and development of such systems could refer to the results of this study, which is crucial to improve the health care services provided by DTC health care AI apps.
    MeSH term(s) Humans ; Artificial Intelligence ; Empathy ; Family ; General Practice ; Physician-Patient Relations
    Language English
    Publishing date 2023-12-18
    Publishing country Canada
    Document type Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2028830-X
    ISSN 1438-8871 ; 1438-8871
    ISSN (online) 1438-8871
    ISSN 1438-8871
    DOI 10.2196/50342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Immune Remodeling during Aging and the Clinical Significance of Immunonutrition in Healthy Aging.

    Dou, Lei / Peng, Yang / Zhang, Bin / Yang, Huiyuan / Zheng, Kai

    Aging and disease

    2023  

    Abstract: Aging is associated with changes in the immune system and the gut microbiota. Immunosenescence may lead to a low-grade, sterile chronic inflammation in a multifactorial and dynamic way, which plays a critical role in most age-related diseases. Age- ... ...

    Abstract Aging is associated with changes in the immune system and the gut microbiota. Immunosenescence may lead to a low-grade, sterile chronic inflammation in a multifactorial and dynamic way, which plays a critical role in most age-related diseases. Age-related changes in the gut microbiota also shape the immune and inflammatory responses. Nutrition is a determinant of immune function and of the gut microbiota. Immunonutrion has been regarded as a new strategy for disease prevention and management, including many age-related diseases. However, the understanding of the cause-effect relationship is required to be more certain about the role of immunonutrition in supporting the immune homeostasis and its clinical relevance in elderly individuals. Herein, we review the remarkable quantitative and qualitative changes during aging that contribute to immunosenescence, inflammaging and microbial dysbiosis, and the effects on late-life health conditions. Furthermore, we discuss the clinical significance of immunonutrition in the treatment of age-related diseases by systematically reviewing its modulation of the immune system and the gut microbiota to clarify the effect of immunonutrition-based interventions on the healthy aging.
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2625789-0
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2023.0923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Featured lncRNA-based signature for discriminating prognosis and progression of hepatocellular carcinoma.

    Qiu, Huiyuan / Jiang, Bo / Chen, Yinqi / Lin, Zhaoyi / Zheng, Wenjie / Cao, Xiaolei

    Journal of applied genetics

    2024  Volume 65, Issue 2, Page(s) 355–366

    Abstract: Long non-coding RNAs (lncRNAs) have been implicated in carcinogenesis and progression of hepatocellular carcinoma (HCC). This study aimed to identify a robust lncRNA signature for predicting the survival of HCC patients. We performed an integrated ... ...

    Abstract Long non-coding RNAs (lncRNAs) have been implicated in carcinogenesis and progression of hepatocellular carcinoma (HCC). This study aimed to identify a robust lncRNA signature for predicting the survival of HCC patients. We performed an integrated analysis of the lncRNA expression profiling in The Cancer Genome Atlas (TCGA)-liver hepatocellular carcinoma database to identify the prognosis-related lncRNA for the HCC. The HCC cohort was randomly divided into a training set (n = 250) and a testing set (n = 113). Following a two-step screening, we identified an 18-lncRNA signature risk score. The high-risk subgroups had significantly shorter survival time than the low-risk group in both the training set (P < 0.0001) and the testing set (P = 0.005). Stratification analysis revealed that the prognostic value of the lncRNA-based signature was independent of the tumor stage and pathologic stage. The area under the receiver operating characteristic curve (AUROC) of the 18-lncRNA signature risk score was 0.826 (95%CI, 0.764-0.888), 0.817 (95%CI, 0.759-0.876), and 0.799 (95%CI, 0.731-0.867) for 1-year, 3-year, and 5-year follow-up, respectively. Bioinformatics analyses indicated that the 18 lncRNA might mediate cell cycle, DNA replication processes, and canonical cancer-related pathways, in which MCM3AP-AS1 was a potential target for HCC. In conclusion, the 18-lncRNA signature was a robust predictive biomarker for the prognosis and progression of HCC.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Biomarkers, Tumor/genetics ; Gene Expression Regulation, Neoplastic ; Prognosis ; Acetyltransferases/genetics ; Acetyltransferases/metabolism ; Intracellular Signaling Peptides and Proteins/genetics
    Chemical Substances RNA, Long Noncoding ; Biomarkers, Tumor ; MCM3AP protein, human (EC 2.3.1.-) ; Acetyltransferases (EC 2.3.1.-) ; Intracellular Signaling Peptides and Proteins
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1235302-4
    ISSN 2190-3883 ; 1234-1983
    ISSN (online) 2190-3883
    ISSN 1234-1983
    DOI 10.1007/s13353-024-00836-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Anomalous Magneto-Optical Response and Chiral Interface of Dipolar Excitons at Twisted Valleys.

    Zheng, Huiyuan / Zhai, Dawei / Yao, Wang

    Nano letters

    2022  Volume 22, Issue 13, Page(s) 5466–5472

    Abstract: An anomalous magneto-optical spectrum is discovered for dipolar valley excitons in twisted double-layer transition metal dichalcogenides, where the in-plane magnetic field induces a sizable multiplet splitting of exciton states inside the light cone. ... ...

    Abstract An anomalous magneto-optical spectrum is discovered for dipolar valley excitons in twisted double-layer transition metal dichalcogenides, where the in-plane magnetic field induces a sizable multiplet splitting of exciton states inside the light cone. Chiral dispersions of the split branches make possible an efficient optical injection of the unidirectional exciton current. We also find an analog effect with a modest heterostrain replacing the magnetic field for introducing large splitting and chiral dispersions in the light cone. Angular orientation of the photoinjected exciton flow can be controlled by strain, with left-right unidirectionality selected by circular polarization.
    Language English
    Publishing date 2022-06-17
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.2c01508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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