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  1. Book ; Thesis: Progression of autonomic small fiber dysfunction in early Parkinson´s disease

    Arndt, Martin / Siepmann, Timo / El-Armouche, Ali

    a prospective observational study

    2022  

    Institution Klinik und Poliklinik für Neurologie
    Author's details von Martin Arndt aus Berlin ; Klinik und Poliklinik für Neurologie [Dresden]
    Language English
    Size ii, 124 Seiten, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2023
    HBZ-ID HT030333921
    Database Catalogue ZB MED Medicine, Health

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  2. Book ; Thesis: Der retinale Venendruck gemessen mit der Kontaktglasdynamometrie und einem neuen Verfahren

    Wetzk, Emilie / Terai, Naim / Siepmann, Timo

    2020  

    Institution Klinik und Poliklinik für Augenheilkunde
    Author's details von Emilie Wetzk
    Language German
    Size IV, 109 Blätter, Illustrationen, Diagramme, 31 cm
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, 2021
    HBZ-ID HT021707173
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Online: Integrity of the Autonomic Nervous System in Psychiatric and Neurological Disorders

    Siepmann, Timo / Barlinn, Kristian / Min-Woo Illigens, Ben

    2020  

    Keywords Medicine ; Neurology & clinical neurophysiology ; autonomic ; psychiatry ; neurology ; assessment ; treatment
    Size 1 electronic resource (96 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229974
    ISBN 9782889636273 ; 2889636275
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Thesis: Untersuchung der Wirkung von Venlafaxin auf autonome und kognitive Funktionen

    Siepmann, Timo

    2008  

    Author's details vorgelegt von Timo Siepmann
    Language German
    Size 5, 16 Bl., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dresden, Techn. Univ., Diss., 2008
    Note Enth. Sonderabdr. aus: Journal of Clinical Psychopharmacology ; Vol. 27.2007
    HBZ-ID HT015789873
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Heart Rate Variability: A Measure of Cardiovascular Health and Possible Therapeutic Target in Dysautonomic Mental and Neurological Disorders.

    Siepmann, Martin / Weidner, Kerstin / Petrowski, Katja / Siepmann, Timo

    Applied psychophysiology and biofeedback

    2022  Volume 47, Issue 4, Page(s) 273–287

    Abstract: Mental illness such as depression and anxiety as well as cerebrovascular disease are linked to impairment of neurocardiac function mediated by changes to the autonomic nervous system with increased sympathetic and decreased parasympathetic activity. ... ...

    Abstract Mental illness such as depression and anxiety as well as cerebrovascular disease are linked to impairment of neurocardiac function mediated by changes to the autonomic nervous system with increased sympathetic and decreased parasympathetic activity. Autonomic neurocardiac function can be evaluated by computing heart rate variability (HRV). Over the past decades, research has demonstrated the diagnostic value of HRV as independent predictor of cardiovascular mortality and as disease marker in progressive autonomic nervous system disorders such as Parkinson's disease. Here we summarize our studies on HRV and its therapeutic modulation in the context of psychopharmacology as well as psychiatric and neurological disorders to honor the life of Professor Evgeny Vaschillo, the true pioneer of HRV research who sadly passed away on November 21st, 2020.
    MeSH term(s) Humans ; Heart Rate ; Nervous System Diseases ; Autonomic Nervous System ; Autonomic Nervous System Diseases ; Anxiety
    Language English
    Publishing date 2022-11-22
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1390949-6
    ISSN 1573-3270 ; 1090-0586
    ISSN (online) 1573-3270
    ISSN 1090-0586
    DOI 10.1007/s10484-022-09572-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Prävention der Post-Stroke-Depression.

    Simon, Erik / Barlinn, Kristian / Siepmann, Timo

    Fortschritte der Neurologie-Psychiatrie

    2023  Volume 91, Issue 12, Page(s) 510–515

    Abstract: Post-stroke depression (PSD) is a clinically relevant complication of ischemic and hemorrhagic cerebral infarction that affects about 30% of all stroke survivors. It is associated with reduced quality of life as well as delayed recovery from neurological ...

    Title translation Prevention of Post-Stroke Depression.
    Abstract Post-stroke depression (PSD) is a clinically relevant complication of ischemic and hemorrhagic cerebral infarction that affects about 30% of all stroke survivors. It is associated with reduced quality of life as well as delayed recovery from neurological deficits and functional impairment, frequently leading to impeded rehabilitation. Suitable screening methods allow early detection of PSD. Timely initiation of treatment in patients with manifest PSD as well as implantation of effective prevention strategies can help reduce medical and socioeconomic burden associated with the disease. We reviewed the current literature on pharmacological and non-pharmacological prevention of PSD.
    MeSH term(s) Humans ; Depression/etiology ; Depression/prevention & control ; Quality of Life ; Risk Factors ; Stroke/complications
    Language German
    Publishing date 2023-12-11
    Publishing country Germany
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 625328-3
    ISSN 1439-3522 ; 0720-4299
    ISSN (online) 1439-3522
    ISSN 0720-4299
    DOI 10.1055/a-2190-9141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Der Zusammenhang zwischen COVID-19 und Schlaganfall: Pathophysiologie und klinische Bedeutung.

    Siepmann, Timo / Barlinn, Kristian

    Fortschritte der Neurologie-Psychiatrie

    2021  Volume 89, Issue 6, Page(s) 289–295

    Title translation Association of COVID-19 and Stroke: Pathophysiology and Clinical Relevance.
    MeSH term(s) COVID-19 ; Humans ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Stroke
    Language German
    Publishing date 2021-05-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 625328-3
    ISSN 1439-3522 ; 0720-4299
    ISSN (online) 1439-3522
    ISSN 0720-4299
    DOI 10.1055/a-1484-0224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Regulation of Blood Flow in the Cerebral Posterior Circulation by Parasympathetic Nerve Fibers: Physiological Background and Possible Clinical Implications in Patients With Vertebrobasilar Stroke.

    Tamayo, Arturo / Siepmann, Timo

    Frontiers in neurology

    2021  Volume 12, Page(s) 660373

    Abstract: Posterior circulation involves the vertebrobasilar arteries, which supply oxygen and glucose to vital human brainstem structures and other areas. This complex circulatory- perfusion system is not homogenous throughout the day; rather, its hemodynamic ... ...

    Abstract Posterior circulation involves the vertebrobasilar arteries, which supply oxygen and glucose to vital human brainstem structures and other areas. This complex circulatory- perfusion system is not homogenous throughout the day; rather, its hemodynamic changes rely on physiological demands, ensuring brainstem perfusion. This dynamic autoregulatory pattern maintains cerebral perfusion during blood pressure changes. Accumulative evidence suggests that activity within the autonomic nervous system is involved in the regulation of cerebral blood flow. Neither the sympathetic nor parasympathetic nervous systems work independently. Functional studies have shown a tight and complicated cross talk between these systems. In pathological processes where sympathetic stimulation is present, systemic vasoconstriction is followed, representing the most important CNS parasympathetic trigger that will promote local vasodilation. Stroke is a clear example of this process. The posterior circulation is affected in 30% of strokes, causing high morbidity and mortality outcomes. Currently, the management of ischemic stroke is focused on thrombolytic treatment and endovascular thrombectomy within an overall tight 4.5 to 6 h ischemic time window. Therefore, the autonomic nervous system could represent a potential therapeutic target to modulate reperfusion after cerebral ischemia through vasodilation, which could potentially decrease infarct size and increase the thrombolytic therapeutic ischemic window. In addition, shifting the autonomic nervous system balance toward its parasympathetic branch has shown to enhance neurogenesis and decrease local inflammation. Regretfully, the vast majority of animal models and human research on neuromodulation during brain ischemia have been focused on anterior circulation with disappointing results. In addition, the source of parasympathetic inputs in the vertebrobasilar system in humans is poorly understood, substantiating a gap and controversy in this area. Here, we reviewed current available literature regarding the parasympathetic vascular function and challenges of its stimulation in the vertebrobasilar system.
    Language English
    Publishing date 2021-10-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.660373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Intravenous thrombolysis and endovascular therapy for acute ischemic stroke in COVID-19: a systematic review and meta-analysis.

    Stuckart, Isabella / Kabsha, Ahmed / Siepmann, Timo / Barlinn, Kristian / Barlinn, Jessica

    Frontiers in neurology

    2023  Volume 14, Page(s) 1239953

    Abstract: Background: The impact of COVID-19 on clinical outcomes in acute ischemic stroke patients receiving reperfusion therapy remains unclear. We therefore aimed to synthesize the available evidence to investigate the safety and short-term efficacy of ... ...

    Abstract Background: The impact of COVID-19 on clinical outcomes in acute ischemic stroke patients receiving reperfusion therapy remains unclear. We therefore aimed to synthesize the available evidence to investigate the safety and short-term efficacy of reperfusion therapy in this patient population.
    Methods: We searched the electronic databases MEDLINE, Embase and Cochrane Library Reviews for randomized controlled trials and observational studies that investigated the use of intravenous thrombolysis, endovascular therapy, or a combination of both in acute ischemic stroke patients with laboratory-confirmed COVID-19, compared to controls. Our primary safety outcomes included any intracerebral hemorrhage (ICH), symptomatic ICH and all-cause in-hospital mortality. Short-term favorable functional outcomes were assessed at discharge and at 3 months. We calculated pooled risk ratios (RR) and 95% confidence intervals (CI) using DerSimonian and Laird random-effects model. Heterogeneity was evaluated using Cochran's Q test and
    Results: We included 11 studies with a total of 477 COVID-19 positive and 8,092 COVID-19 negative ischemic stroke patients who underwent reperfusion therapy. COVID-19 positive patients exhibited a significantly higher risk of experiencing any ICH (RR 1.54, 95% CI 1.16-2.05,
    Conclusion: COVID-19 appears to have an adverse impact on acute ischemic stroke patients who undergo reperfusion therapy, leading to an elevated risk of any ICH, higher mortality and lower likelihood of favorable functional outcome.
    Systematic review registration: PROSPERO, identifier CRD42022309785.
    Language English
    Publishing date 2023-08-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1239953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Acute Ischemic Stroke in the Context of SARS-CoV-2 Vaccination: A Systematic Review.

    Rahmig, Jan / Altarsha, Eyad / Siepmann, Timo / Barlinn, Kristian

    Neuropsychiatric disease and treatment

    2022  Volume 18, Page(s) 1907–1916

    Abstract: Background: There have been reports suggesting an increased incidence of acute ischemic stroke among anti-SARS-CoV-2 vaccinees. We aimed to systematically review the literature to summarize the available evidence on the association between SARS-CoV-2 ... ...

    Abstract Background: There have been reports suggesting an increased incidence of acute ischemic stroke among anti-SARS-CoV-2 vaccinees. We aimed to systematically review the literature to summarize the available evidence on the association between SARS-CoV-2 vaccination and acute ischemic stroke.
    Methods: A systematic literature search on MEDLINE, LitCovid and LIVIVO databases was performed for eligible randomized controlled trials, observational studies, registries and case reports that reported on imaging-confirmed acute ischemic stroke in the context of any SARS-CoV-2 vaccination with BNT162b2, mRNA-1273, Ad26.COV2.S, ChAdOx1 or Gam-COVID-Vac. Literature search was limited to English and German languages and publication date before October 19, 2021.
    Results: We identified a total of 395,105,670 individuals who underwent vaccination. We found 21 sources, including 2 cohort studies, 4 registry studies, 3 randomized clinical trials, and 12 case reports. Individuals included in these studies were at least 16 years old. Cari et al observed a higher likelihood of acute ischemic stroke in vaccinees aged 18-64 years, compared to Whiteley et al observing vaccinees older than 70 years when vaccinated. In addition, differences in the likelihood of acute ischemic stroke were found among the vaccines studied, although no overall increased stroke incidence was demonstrated with vaccination.
    Conclusion: In this systematic review of the available literature, we found that the risk of acute ischemic stroke does not appear to be increased in vaccinated individuals who have received any of the currently licensed SARS-CoV-2 vaccines compared with the baseline incidence of stroke.
    Language English
    Publishing date 2022-08-30
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/NDT.S374549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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