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Article ; Online: Very low-volume interval training improves nonalcoholic fatty liver disease fibrosis score and cardiometabolic health in adults with obesity and metabolic syndrome.

Reljic, D / Konturek, P C / Herrmann, H J / Siebler, J / Neurath, M F / Zopf, Y

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society

2022 Volume 72, Issue 6

Abstract: Non-alcoholic fatty liver disease (NAFLD) and cardiometabolic disorders are highly prevalent in obese individuals. Physical exercise is an important element in obesity and metabolic syndrome (MetS) treatment. However, the vast majority of individuals ... ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) and cardiometabolic disorders are highly prevalent in obese individuals. Physical exercise is an important element in obesity and metabolic syndrome (MetS) treatment. However, the vast majority of individuals with obesity do not meet the general physical activity recommendations (i.e. 150 min of moderate activity per week). The present study aimed to investigate the impact of a highly time-saving high-intensity interval training (HIIT) protocol (28 min time requirement per week) on NAFLD fibrosis (NFS) and cardiometabolic risk scores in obese patients with MetS and elevated NFS values. Twenty-nine patients performed HIIT on cycle ergometers (5 x 1 min at an intensity of 80 - 95% maximal heart rate) twice weekly for 12 weeks and were compared to a control group without exercise (CON, n = 17). Nutritional counseling for weight loss was provided to both groups. NFS, cardiometabolic risk indices, MetS z-score, cardiorespiratory fitness (VO
MeSH term(s)	Adult ; Cardiovascular Diseases ; Fibrosis ; Humans ; Metabolic Syndrome/therapy ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/therapy ; Obesity/complications ; Obesity/therapy ; Weight Loss
Language	English
Publishing date	2022-04-24
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1125221-2
ISSN	1899-1505 ; 0867-5910 ; 0044-6033
ISSN (online)	1899-1505
ISSN	0867-5910 ; 0044-6033
DOI	10.26402/jpp.2021.6.10
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Article ; Online: Therapeutische Modulation der Darmmikrobiota beim Reizdarmsyndrom : Von Probiotika bis zur fäkalen Mikrobiota-Therapie.

Konturek, P C / Zopf, Yurdagül

MMW Fortschritte der Medizin

2017 Volume 159, Issue Suppl 7, Page(s) 1–5

Abstract: Background: An abnormal intestinal microbiota (dysbiosis) plays a central role in the pathogenesis of the irritable bowel syndrome.: Method: An overview of four current options for the treatment of irritable bowel syndrome, which are characterized by ...

Title translation	Therapeutic modulation of intestinal microbiota in irritable bowel syndrome. From probiotics to fecal microbiota therapy.
Abstract	Background: An abnormal intestinal microbiota (dysbiosis) plays a central role in the pathogenesis of the irritable bowel syndrome. Method: An overview of four current options for the treatment of irritable bowel syndrome, which are characterized by modulation of intestinal microbiota, is given. Results and conclusions: Probiotics have very different effects on the individual symptoms of the irritable bowel. The choice of the appropriate preparation should therefore be based on the clinical symptomatology. The antibiotic rifaximin is effective in selected patients. Some patients also benefit from the repetition of this therapy. A FODMAP-reduced diet has shown significant alleviation of irritable bowel symptoms in studies. The fecal microbiota therapy (FMT) is a promising treatment option. At present, however, there are no such placebo-controlled studies to assess the effectiveness of this method.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Fecal Microbiota Transplantation ; Gastrointestinal Microbiome/drug effects ; Humans ; Irritable Bowel Syndrome/therapy ; Probiotics/therapeutic use
Chemical Substances	Anti-Bacterial Agents
Language	German
Publishing date	2017-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478211-x
ISSN	1613-3560 ; 1438-3276
ISSN (online)	1613-3560
ISSN	1438-3276
DOI	10.1007/s15006-017-0338-3
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Article: From Donor to Patient: Collection, Preparation and Cryopreservation of Fecal Samples for Fecal Microbiota Transplantation.

Nicco, Carole / Paule, Armelle / Konturek, Peter / Edeas, Marvin

Diseases (Basel, Switzerland)

2020 Volume 8, Issue 2

Abstract: Fecal Microbiota Transplantation (FMT) is suggested as an efficacious therapeutic strategy for restoring intestinal microbial balance, and thus for treating disease associated with alteration of gut microbiota. FMT consists of the administration of fresh ...

Abstract	Fecal Microbiota Transplantation (FMT) is suggested as an efficacious therapeutic strategy for restoring intestinal microbial balance, and thus for treating disease associated with alteration of gut microbiota. FMT consists of the administration of fresh or frozen fecal microorganisms from a healthy donor into the intestinal tract of diseased patients. At this time, in according to healthcare authorities, FMT is mainly used to treat recurrent
Keywords	covid19
Language	English
Publishing date	2020-04-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720869-2
ISSN	2079-9721
ISSN	2079-9721
DOI	10.3390/diseases8020009
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Article: Effect of substance P and its C-terminal hexapeptide on gastric and pancreatic secretion in the dog.

Konturek, S J / Jaworek, J / Tasler, J / Cieszkowski, M / Pawlik, W

The American journal of physiology

1981 Volume 241, Issue 1, Page(s) G74–81

Abstract: ... of substance P (SP) and its C-terminal hexapeptide (SP6-11) on gastric acid and pancreatic secretions were ... indicating that the C-terminal portion of SP exhibits a full spectrum of the biological action of the intact ...

Abstract	In five dogs with gastric fistulas, Heidenhain pouches, and pancreatic fistulas, the effects of substance P (SP) and its C-terminal hexapeptide (SP6-11) on gastric acid and pancreatic secretions were determined under basal conditions and in response to secretory stimulation. SP or SP6-11 infused alone in graded doses (0.25-2.0 nmol.kg-1.h-1) caused a slight but significant increase in pancreatic secretions in fasted dogs, but, when given during the secretory stimulation, they caused significant inhibition of these secretions. They reduced gastric acid response to pentagastrin and peptone meal without affecting the serum gastrin level. They caused dose-dependent inhibition of secretin-induced pancreatic bicarbonate secretion and suppressed the pancreatic protein response to caerulein, feeding, and duodenal acidification. SP6-11 was equipotent on a molar basis with SP in the inhibition of gastric or pancreatic secretion, indicating that the C-terminal portion of SP exhibits a full spectrum of the biological action of the intact molecule. The inhibitory effects of SP and SP6-11 on the stomach and pancreas were observed at a dose range that was without any significant influence on the blood pressure, indicating that they are not caused by the interference of the blood flow to the pancreas.
MeSH term(s)	Animals ; Bicarbonates/metabolism ; Blood Pressure/drug effects ; Dogs ; Dose-Response Relationship, Drug ; Duodenum/physiology ; Gastric Juice/drug effects ; Gastric Juice/secretion ; Heart Rate/drug effects ; Hydrogen-Ion Concentration ; Kinetics ; Pancreatic Juice/drug effects ; Pancreatic Juice/secretion ; Peptide Fragments/pharmacology ; Proteins/secretion ; Pyrrolidonecarboxylic Acid/analogs & derivatives ; Substance P/analogs & derivatives ; Substance P/pharmacology
Chemical Substances	Bicarbonates ; Peptide Fragments ; Proteins ; Substance P (33507-63-0) ; substance P (6-11) (51165-07-2) ; Pyrrolidonecarboxylic Acid (SZB83O1W42)
Language	English
Publishing date	1981-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2948-8
ISSN	0002-9513
ISSN	0002-9513
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Article ; Online: COVID-19 - more than respiratory disease: a gastroenterologist's perspective.

Konturek, P C / Harsch, I A / Neurath, M F / Zopf, Y

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society

2020 Volume 71, Issue 2

Abstract: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV2) outbreak is the most dramatic event since World War II. Originating as a cluster of unexplained cases of pneumonia, it turned out that this viral disease termed COVID-19 is not only a ... ...

Abstract	Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV2) outbreak is the most dramatic event since World War II. Originating as a cluster of unexplained cases of pneumonia, it turned out that this viral disease termed COVID-19 is not only a respiratory infection, but a systemic disease associated with a number of extrapulmonary complications. One of the medical disciplines that is strongly affected by this viral infection is gastroenterology. COVID-19 causes in some patients typical symptoms of enteritis such as diarrhea or abdominal pain. There is also evidence that this infection may lead to liver and pancreatic injury. Since the SARS-CoV2 virus was detected in stool, a fecal-oral route of transmission is possible. Moreover, viral receptor angiotensin converting enzyme 2 (ACE2) is highly expressed in the gastrointestinal tract and enables the invasion of the gastrointestinal epithelium as demonstrated in vitro and in vivo. COVID-19 pandemic has an impact on the daily practice and the workflows in endoscopy leading to a dramatic decrease of screening and surveillance procedures. COVID-19 impacts the therapy of patients with inflammatory bowel disease (IBD), particularly those using high doses of corticosteroids, immunosuppressive agents and biologics. Patients with preexisting liver disease, especially metabolic associated liver fatty disease (MALFD) with fibrosis or liver cirrhosis, are at high risk for severe COVID-19. As long as no active vaccine against SARS-CoV2 is available, gastroenterologists have to be aware of these problems that affect their daily routine practice.
MeSH term(s)	Animals ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/physiopathology ; Coronavirus Infections/therapy ; Disease Outbreaks ; Gastroenterologists ; Gastrointestinal Diseases/physiopathology ; Gastrointestinal Diseases/therapy ; Gastrointestinal Diseases/virology ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/therapy ; Risk Factors ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-07-02
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	1125221-2
ISSN	1899-1505 ; 0867-5910 ; 0044-6033
ISSN (online)	1899-1505
ISSN	0867-5910 ; 0044-6033
DOI	10.26402/jpp.2020.2.02
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Article: CME Zertifizierte Fortbildung. Reizdarmsyndrom. Diagnostik und therapeutische Optionen. Irritable bowel syndrome. Diagnosis and therapeutic options / Testfragen

Konturek, P. C.

Tägliche Praxis

2014 Volume 55, Issue 2, Page(s) 249/259

Language	German
Document type	Article
ZDB-ID	506157-x
ISSN	0494-464X
Database	Current Contents Medicine

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Article: CME Zertifizierte Fortbildung. Teilnahmebedingungen und Testbogen / Reizdarmsyndrom. Diagnostik und therapeutische Optionen. Irritable bowel syndrome. Diagnosis and therapeutic options / Testfragen / Auflösung aus Band 54, Heft 1

Konturek, P. C.

Internistische Praxis

2014 Volume 54, Issue 2, Page(s) 267/269/279/281

Language	German
Document type	Article
ZDB-ID	209039-9
ISSN	0020-9570
Database	Current Contents Medicine

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Article ; Online: Hypoglycemic side effects of sulfonylureas and repaglinide in ageing patients - knowledge and self-management.

Harsch, I A / Kaestner, R H / Konturek, P C

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society

2018 Volume 69, Issue 4

Abstract: Insulinotropic oral antidiabetics (OAD) such as sulfonylureas and (SU) glinides are among the frequently prescribed OAD. Side effects are the potential to induce hypoglycemias and weight gain. The aim was to assess the self-managing skills in case of a ... ...

Abstract	Insulinotropic oral antidiabetics (OAD) such as sulfonylureas and (SU) glinides are among the frequently prescribed OAD. Side effects are the potential to induce hypoglycemias and weight gain. The aim was to assess the self-managing skills in case of a hypoglycemic event in an elderly type 2 diabetic patient population. In a 2-year period, 160 hospitalized patients (mean age 77.4 years) under insulinotrophic OAD were interviewed using a standardized questionnaire. Additionally, possible dementia was evaluated by using the Mini-Mental State Examination (MMSE) and the Clock-Drawing Test (CDT). The mean HbA1c was 7.6%. MMSE and CDT did intraindividually correlate well and 23.8% of the patients had moderate dementia (10 - 20 points MMSE), 13.1% had severe dementia (0 - 10 points MMSE) at the time of the survey. When under treatment with a sulfonylurea, only 16.0% of patients were aware of the potential hypoglycemia-inducing side effect. Moreover, only 11.8% of patients treated with a combination of a sulfonylurea and insulin knew this side effect of the OAD. The awareness of the side effects of repaglinide was 21.6% (without insulin therapy) versus 21.4% in the insulin-comedicated group. Only 42.6% of patients treated with sulfonylureas or repaglinide knew how to act in the case of hypoglycemia. Even under comedication with insulin, only in 41.2% of the respondents in the comedicated group knew how to take action if they were to experience hypoglycemia. Our findings raise concerns and demonstrate, that the self-managing skills in an elderly patient group are not good, which may become an increasing problem in an ageing population. The prescription or the re-prescription of insulinotropic OAD needs to be adapted to the current cognitive situation and re-evaluated regularly.
MeSH term(s)	Aged ; Aged, 80 and over ; Aging ; Carbamates/adverse effects ; Diabetes Mellitus, Type 2/drug therapy ; Drug Therapy, Combination ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Hypoglycemia/chemically induced ; Hypoglycemic Agents/adverse effects ; Male ; Middle Aged ; Piperidines/adverse effects ; Self-Management ; Sulfonylurea Compounds/adverse effects
Chemical Substances	Carbamates ; Hypoglycemic Agents ; Piperidines ; Sulfonylurea Compounds ; repaglinide (668Z8C33LU)
Language	English
Publishing date	2018-12-09
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1125221-2
ISSN	1899-1505 ; 0867-5910 ; 0044-6033
ISSN (online)	1899-1505
ISSN	0867-5910 ; 0044-6033
DOI	10.26402/jpp.2018.4.15
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Article ; Online: Impact of autofluorescence for detection of parathyroid glands during thyroidectomy on postoperative parathyroid hormone levels: parallel multicentre randomized clinical trial.

Bergenfelz, Anders / Barczynski, Marcin / Heie, Anette / Muth, Andreas / Passler, Christian / Schneider, Max / Wierzbicka, Paulina / Konturek, Alexander / Brauckhoff, Katrin / Elf, Anna-Karin / Dahlberg, Jakob / Hermann, Michael

The British journal of surgery

2023 Volume 110, Issue 12, Page(s) 1824–1833

Abstract: ... and 77 (32.1 per cent) in the control group had low levels of PTH after thyroidectomy (P = 0.141 ... relative risk (RR) 0.81, 95 per cent c.i. 0.61 to 1.07). Subanalysis of 174 patients undergoing central ... in the control group had low levels of PTH on postoperative day 1 (P = 0.021; RR 0.54, 0.31 to 0.93). More ...

Abstract	Background: Techniques for autofluorescence have been introduced to visualize the parathyroid glands during surgery and to reduce hypoparathyroidism after thyroidectomy. Methods: This parallel multicentre RCT investigated the use of Fluobeam® LX to visualize the parathyroid glands by autofluorescence during total thyroidectomy compared with no use. There was no restriction on the indication for surgery. Patients were randomized 1 : 1 and were blinded to the group allocation. The hypothesis was that autofluorescence enables identification and protection of the parathyroid glands during thyroidectomy. The primary endpoint was the rate of low parathyroid hormone (PTH) levels the day after surgery. Results: Some 535 patients were randomized, and 486 patients received an intervention according to the study protocol, 246 in the Fluobeam® LX group and 240 in the control group. Some 64 patients (26.0 per cent) in the Fluobeam® LX group and 77 (32.1 per cent) in the control group had low levels of PTH after thyroidectomy (P = 0.141; relative risk (RR) 0.81, 95 per cent c.i. 0.61 to 1.07). Subanalysis of 174 patients undergoing central lymph node clearance showed that 15 of 82 (18 per cent) in the Fluobeam® LX group and 31 of 92 (33 per cent) in the control group had low levels of PTH on postoperative day 1 (P = 0.021; RR 0.54, 0.31 to 0.93). More parathyroid glands were identified during operation in patients who had surgery with Fluobeam® LX, and fewer parathyroid glands in the surgical specimen on definitive histopathology. No specific harm related to the use of Fluobeam® LX was reported. Conclusion: The use of autofluorescence during thyroidectomy did not reduce the rate of low PTH levels on postoperative day 1 in the whole group of patients. It did, however, reduce the rate in a subgroup of patients. Registration number: NCT04509011 (http://www.clinicaltrials.gov).
MeSH term(s)	Humans ; Parathyroid Glands/surgery ; Thyroidectomy/adverse effects ; Thyroidectomy/methods ; Parathyroid Hormone ; Hypoparathyroidism/etiology ; Hypoparathyroidism/prevention & control ; Lymph Nodes ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control ; Postoperative Complications/surgery ; Hypocalcemia/etiology
Chemical Substances	Parathyroid Hormone
Language	English
Publishing date	2023-09-27
Publishing country	England
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1093/bjs/znad278
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Article: Therapeutische Modulation der Darmmikrobiota beim Reizdarmsyndrom. Von Probiotika bis zur fäkalen Mikrobiota-Therapie

Konturek, P. C. / Zopf, Y.

MMW - Fortschritte der Medizin : Originalien

2017 Volume -, Issue 4 = Suppl.7, Page(s) 1

Language	German
Document type	Article
ZDB-ID	2126515-X
ISSN	1438-3276
Database	Current Contents Medicine

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