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Book ; Online ; E-Book: Etiology-based dental and craniofacial diagnostics

Kjær, Inger

2017

Author's details	Inger Kjær
Keywords	Tooth Abnormalities / diagnosis ; Skull / embryology ; Skull / growth & development
Language	English
Size	1 Online-Ressource (v, 84 Seiten), Illustrationen
Publisher	Wiley Blackwell
Publishing place	Chichester
Publishing country	Great Britain
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019451301
ISBN	978-1-118-91210-2 ; 9781118912126 ; 9781118912119 ; 1-118-91210-1 ; 1118912128 ; 111891211X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Abnormal premolar eruption: classification, aetiology, and treatment based on a case series study.

Kjær, I

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

2021 Volume 22, Issue 6, Page(s) 1077–1086

Abstract: Aim: The aim of this case series study is to classify deviations in mandibular and maxillary premolar eruption according to aetiology, with a focus on the resorption pattern in the preceding primary molars. The purpose is also to give treatment guidance ...

Abstract	Aim: The aim of this case series study is to classify deviations in mandibular and maxillary premolar eruption according to aetiology, with a focus on the resorption pattern in the preceding primary molars. The purpose is also to give treatment guidance based on aetiology. Materials and methods: Radiographic material from 64 cases with abnormal premolar eruptions were grouped into three eruptions phases: Phase 1, from tooth bud to early root formation, sub-grouped according to "ankylosis" or "not ankylosis" of the primary molars; Phase 2, from start of eruption to the penetration of gingiva, sub-grouped according to normal or abnormal resorption of the primary molars and Phase 3, eruption after penetration of gingiva. Results: Phase 1: early ankylosis of primary molars, ectopic locations of the premolar crown, including occlusally displacement in relation to the primary molar, are demonstrated. Not ankylosed primary molar: different positions, even an upside-down position of the premolar, are demonstrated. The conditions are explained in relation to the early migration pattern of the premolar tooth bud. Regarding treatment, in cases with ankylosed primary molars these should be extracted as soon as diagnosed and in cases with not ankylosed primary molars these should be extracted when root formation of the premolars has started. The premolars should be observed and saved if possible. Phase 2: non-exfoliation of primary molar, aetiology and treatment of premolars depend on tissue types involved. In bone dysplasia, the eruption of premolars is delayed. In these cases, the primary molars should be extracted when eruptive movements of the premolars have started. In cases with ectoderm deviation, the crown follicle does not function normally during the resorption of the primary molars and the recommended treatment is extraction of primary molars before root closure of premolars. In cases in Phase 2 where the premolars were ankylosed these should be surgical removed. Phase 3: different aetiologies are highlighted, with focus on abnormal innervation and enzyme defects. The premolars are seemingly ankylosed, and surgery might be the only treatment. Conclusion: The case series presented demonstrate how ectopic and arrested premolars have different aetiologies and as a consequence, different treatments. The study highlights several aspects in pathological eruption, which still need to be elucidated.
MeSH term(s)	Bicuspid/diagnostic imaging ; Humans ; Mandible ; Molar/diagnostic imaging ; Tooth Eruption ; Tooth, Deciduous
Language	English
Publishing date	2021-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2472851-2
ISSN	1996-9805 ; 1818-6300
ISSN (online)	1996-9805
ISSN	1818-6300
DOI	10.1007/s40368-021-00658-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The ectopic mandibular canines can start tooth formation in three different locations: a case series study based on single orthopantomograms from 47 individuals.

Svanholt, P / Svanholt, M / Thomsen, J / Kjær, I

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

2024

Abstract: Introduction: A former study on orthopantomograms from young children with abnormal dental development (not canine ectopia) demonstrated that the tooth bud of the mandibular canine, compared to a stable longitudinal canine axis, could be located ... ...

Abstract	Introduction: A former study on orthopantomograms from young children with abnormal dental development (not canine ectopia) demonstrated that the tooth bud of the mandibular canine, compared to a stable longitudinal canine axis, could be located normally, anteriorly or posteriorly, with close relation to the first premolar. Aim: The aim of the present study is to analyse on orthopantomograms if the canine axis can demonstrate where the ectopic mandibular canine started tooth formation. Materials: The material consists of orthopantomograms with ectopic mandibular canines and presence of primary mandibular canines from 47 cases (29 cases 9-21 years old and 18 cases with unknown ages). The primary canines demonstrated from minor apical resorption to more severe apical resorption. Methods: Based on canine maturity, location of the canine axes and the interrelationships between the roots of the permanent canine and first premolar, the location from where the canine started tooth formation was determined. Canine maturity. Maturity stage below half root length and maturity stage above half root length revealed that 11 ectopic canines had less than half root length and 36 cases more than half root length. Canine axes. The canine axis, through the length of the primary canines Ax, is inserted on drawings of the orthopantomograms using the tracing programme Inkscape®. Interrelationship between roots. By visual inspection, the distance between the canine and first premolar was designated close distance, normal distance and extended distance. Results: The results are divided into 3 groups. Group 1: The initial site of the permanent ectopic canine is located within the canine axis (6 cases). Group 2: The initial site of the permanent ectopic canine is located posterior to the canine axis (36 cases). Group 3: The initial site of the permanent ectopic canine is located anterior to the canine axis (5 cases). Conclusion: The study explained that the canine axis could divide cases of ectopic canines into three groups according to the location from where tooth formation starts. For getting closer to the pattern of the ectopic canine eruption, it is necessary to analyse series of orthopantomograms taken from the same individual over several years.
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2472851-2
ISSN	1996-9805 ; 1818-6300
ISSN (online)	1996-9805
ISSN	1818-6300
DOI	10.1007/s40368-024-00865-y
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Article ; Online: The location of the permanent mandibular canine as identified in orthopantomograms from children younger than 5 years of age: a case series study.

Kjær, I / Svanholt, M / Svanholt, P

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

2023 Volume 24, Issue 5, Page(s) 613–619

Abstract: Aim: The aim of this case series study is to describe where the crowns of the permanent mandibular canines are located in early childhood in relation to the preceding primary canines.: Materials and methods: From a sample of 31 orthopantomograms from ...

Abstract	Aim: The aim of this case series study is to describe where the crowns of the permanent mandibular canines are located in early childhood in relation to the preceding primary canines. Materials and methods: From a sample of 31 orthopantomograms from children, younger than 5 years of age, the location of the mandibular canines was analysed by visual inspection. The radiographs were taken due to different deviations in the dentition and forwarded during a period of 28 years for elucidating different diagnostic questions. From an embryological point of view, the primary canine was considered as a stable structure in the jawbone. A longitudinal axis through the primary canine was named the canine axis. The initial site of the permanent crown was the site, where the permanent lamina "placed" the tooth bud for final development. A normal site was determined when the canine axis passed though the permanent crown and a pathological site was determined when this did not happen. Results: Normal sites for the permanent crowns were observed in 19 cases and abnormal sites in 8 cases. In four cases, the interrelationship between the canine axis and the permanent crown could not be decided. The study demonstrated that the tooth germ for the permanent canine can start initial formation misplaced distally or mesially to the preceding primary tooth. Conclusion: The study demonstrates different malpositions of the initial crowns of the permanent mandibular canines in children younger than 5 years of age. The results are considered of importance for future understanding of the aetiology behind ectopic mandibular canines.
MeSH term(s)	Humans ; Child ; Child, Preschool ; Maxilla/pathology ; Radiography, Panoramic ; Cuspid/diagnostic imaging ; Mandible/diagnostic imaging ; Tooth Crown/diagnostic imaging
Language	English
Publishing date	2023-08-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2472851-2
ISSN	1996-9805 ; 1818-6300
ISSN (online)	1996-9805
ISSN	1818-6300
DOI	10.1007/s40368-023-00825-y
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Article: L’ectoderme, le mésoderme et le neurectoderme sont des types tissulaires importants pour la compréhension et la prévention des résorptions radiculaires. Recommandations cliniques.

Kjær, Inger

L' Orthodontie francaise

2016 Volume 87, Issue 3, Page(s) 309–319

Abstract: Introduction: This three-part article summarizes ideas already described elsewhere by the author. Part 1. New way of diagnosing the dentition. For diagnostic purposes origin and appearance of the three tissue types - ectoderm, mesoderm (ectomesenchyme) ... ...

Title translation	Ectoderm, mesoderm and neuroectoderm are tissue types of importance for understanding and preventing root resorption. Clinical guidelines.
Abstract	Introduction: This three-part article summarizes ideas already described elsewhere by the author. Part 1. New way of diagnosing the dentition. For diagnostic purposes origin and appearance of the three tissue types - ectoderm, mesoderm (ectomesenchyme) and peripheral nerves - are depicted on orthopantomograms. Same tissue types are marked on the root surface (peri-root sheet). Part 2. Factors provoking root resorption. Resorption can be explained from the composition of the peri-root sheet. Deviations (inborn or acquired) in each of the three tissue layers can provoke inflammation, resulting in resorption. Orthodontic forces resulting in resorption can occur in normal peri-root sheets, but also in peri-root sheets with inborn deviations, important to diagnose. Part 3. How to prevent root resorption - Clinical guidelines. General diseases and different dental morphologies are signs predisposing for root resorption (ectoderm and mesoderm), so are local or general virus attacks (neuroectoderm). Resorption often occurs in dentitions never treated orthodontically. Material and method: The author performed a review of the literature in order to present a new diagnostic approach incorporating histological and embryological concepts. Results: The review revealed different etiologies and sites involved in root resorption. Patients presenting variations of the peri-root sheet are most exposed to root resorption. Discussion: At this stage, it is difficult to diagnose these variations. The author offers diagnostic recommendations to be followed prior to orthodontic treatment. Even when no orthodontic treatment is given, root resorption can occur unexpectedly. In these cases, resorption prevention is currently impossible.
MeSH term(s)	Ectoderm/anatomy & histology ; Humans ; Mesoderm/anatomy & histology ; Neural Plate/anatomy & histology ; Practice Guidelines as Topic ; Root Resorption/prevention & control
Language	French
Publishing date	2016-09
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	417383-1
ISSN	0078-6608 ; 1966-5202
ISSN	0078-6608 ; 1966-5202
DOI	10.1051/orthodfr/2016028
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Article: Co-occurring orchid species associated with different low-abundance mycorrhizal fungi from the soil in a high-diversity conservation area in Denmark.

Hartvig, Ida / Kosawang, Chatchai / Rasmussen, Hanne / Kjær, Erik Dahl / Nielsen, Lene Rostgaard

Ecology and evolution

2024 Volume 14, Issue 2, Page(s) e10863

Abstract: Plant-fungal interactions are ubiquitous across ecosystems and contribute significantly to plant ecology and evolution. All orchids form obligate symbiotic relationships with specific fungi for germination and early growth, and the distribution of ... ...

Abstract	Plant-fungal interactions are ubiquitous across ecosystems and contribute significantly to plant ecology and evolution. All orchids form obligate symbiotic relationships with specific fungi for germination and early growth, and the distribution of terrestrial orchid species has been linked to occurrence and abundance of specific orchid mycorrhizal fungi (OMF) in the soil. The availability of OMF can therefore be a habitat requirement that is relevant to consider when establishing management and conservation strategies for threatened orchid species, but knowledge on the spatial distribution of OMF in soil is limited. We here studied the mycorrhizal associations of three terrestrial orchid species (
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.10863
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Article ; Online: Sella turcica morphology and the pituitary gland-a new contribution to craniofacial diagnostics based on histology and neuroradiology.

Kjær, Inger

European journal of orthodontics

2015 Volume 37, Issue 1, Page(s) 28–36

Abstract: The present review summarizes two decades of published and unpublished studies on normal and pathological development of sella turcica and pituitary gland in humans. The pathological conditions are studied in known genotype deviations, syndromes, and ... ...

Abstract	The present review summarizes two decades of published and unpublished studies on normal and pathological development of sella turcica and pituitary gland in humans. The pathological conditions are studied in known genotype deviations, syndromes, and other malformations. The studies include histological analyses of human prenatal material and profile radiographic analyses of human postnatal material, supplemented in a few cases with neuroradiology. Prenatal and postnatal results are compared. Similarities between prenatal and postnatal deviations in sella turcica morphology were demonstrated. Malformations in the pituitary gland were observed in several cases. For diagnostic purposes, the review distinguishes between deviations in the anterior wall and in the posterior wall of the sella turcica. Deviations in the anterior wall seem to be associated with deviations specifically in the frontonasal developmental field, while deviations in the posterior wall are often connected with malformations in the posterior structures, e.g. the cerebellum. In normal cases, minor variations in morphology are observed. In each pathological case, a specific malformation pattern was observed in sella turcica morphology, varying from mild to severe phenotype. The malformation in the sella turcica/pituitary gland can be associated with a malformation within a developmental field that forms the craniofacial region (frontonasal, maxillary, palatal, and mandibular fields), sometimes also involving the brain stem, thymus, thyroid, and heart (velocardiofacial syndrome). Pathological sella turcica morphology can also be associated with malformations in the cerebellum and larynx (Cri-du-Chat syndrome). This review demonstrates the value of combining profile radiographic diagnostics with neuroradiological diagnostics in cases with malformed sella turcicae.
MeSH term(s)	Abnormalities, Multiple/diagnostic imaging ; Abnormalities, Multiple/pathology ; Craniofacial Abnormalities/diagnostic imaging ; Craniofacial Abnormalities/pathology ; Humans ; Pituitary Gland/abnormalities ; Pituitary Gland/diagnostic imaging ; Pituitary Gland/pathology ; Radiography ; Sella Turcica/abnormalities ; Sella Turcica/diagnostic imaging ; Sella Turcica/pathology ; Syndrome
Language	English
Publishing date	2015-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	423731-6
ISSN	1460-2210 ; 0141-5387
ISSN (online)	1460-2210
ISSN	0141-5387
DOI	10.1093/ejo/cjs091
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Article: Mechanism of human tooth eruption: review article including a new theory for future studies on the eruption process.

Kjær, Inger

Scientifica

2014 Volume 2014, Page(s) 341905

Abstract: Human eruption is a unique developmental process in the organism. The aetiology or the mechanism behind eruption has never been fully understood and the scientific literature in the field is extremely sparse. Human and animal tissues provide different ... ...

Abstract	Human eruption is a unique developmental process in the organism. The aetiology or the mechanism behind eruption has never been fully understood and the scientific literature in the field is extremely sparse. Human and animal tissues provide different possibilities for eruption analyses, briefly discussed in the introduction. Human studies, mainly clinical and radiological, have focused on normal eruption and gender differences. Why a tooth begins eruption and what enables it to move eruptively and later to end these eruptive movements is not known. Pathological eruption courses contribute to insight into the aetiology behind eruption. A new theory on the eruption mechanism is presented. Accordingly, the mechanism of eruption depends on the correlation between space in the eruption course, created by the crown follicle, eruption pressure triggered by innervation in the apical root membrane, and the ability of the periodontal ligament to adapt to eruptive movements. Animal studies and studies on normal and pathological eruption in humans can support and explain different aspects in the new theory. The eruption mechanism still needs elucidation and the paper recommends that future research on eruption keeps this new theory in mind. Understanding the aetiology of the eruption process is necessary for treating deviant eruption courses.
Language	English
Publishing date	2014-02-12
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	2672321-9
ISSN	2090-908X
ISSN	2090-908X
DOI	10.1155/2014/341905
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Book: Etiology-based dental and craniofacial diagnostics

Kjær, Inger

2017

Author's details	Inger Kjær
MeSH term(s)	Tooth Abnormalities/diagnosis ; Skull/embryology ; Skull/growth & development
Language	English
Size	xii, 244 pages, illustrations
Document type	Book
ISBN	9781118912126 ; 9781118912102 ; 9781118912119 ; 1118912128 ; 1118912101 ; 111891211X
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: The prognostic value of tumor budding in a thoroughly characterized stage II colon cancer population in the context of a national screening program.

Pihlmann Kristensen, Maria / Korsgaard, Ulrik / Timm, Signe / Hansen, Torben Frøstrup / Zlobec, Inti / Hager, Henrik / Kjær-Frifeldt, Sanne

Human pathology

2024 Volume 146, Page(s) 15–22

Abstract: Tumor budding as a prognostic marker in colorectal cancer has not previously been investigated in a cohort of screened stage II colon cancer patients. We assessed the prognostic significance of tumor budding in a thoroughly characterized stage II colon ... ...

Abstract	Tumor budding as a prognostic marker in colorectal cancer has not previously been investigated in a cohort of screened stage II colon cancer patients. We assessed the prognostic significance of tumor budding in a thoroughly characterized stage II colon cancer population comprising surgically resected patients in the Region of Southern Denmark from 2014 to 2016. Tumors were re-staged according to the 8th edition of UICC TNM Classification, undergoing detailed histopathological evaluation and tumor budding assessment following guidelines from the International Tumor Budding Consensus Conference. Prognostic evaluation utilized Kaplan-Meier curves, log-rank tests, and Cox proportional hazard models for time to recurrence (TTR), recurrence-free survival (RFS), and overall survival (OS). Out of 497 patients, 20% were diagnosed through the national colorectal cancer screening program. High-grade tumor budding (Bd3) was found in 19% of tumors and was associated with glandular subtype, perineural invasion, mismatch repair proficient tumors, and tumor recurrence (p < 0.001, p < 0.001, p = 0.045, and p = 0.007 respectively). In multivariable Cox regression, high-grade budding was a significant prognostic factor for TTR compared to low-grade (Bd3 HR 2.617; p = 0.007). An association between tumor budding groups and RFS was observed, and the difference was significant in univariable analysis for high-grade compared to low-grade tumor budding (Bd3 HR 1.461; p = 0.041). No significant differences were observed between tumor budding groups and OS. High-grade tumor budding is a predictor of recurrence in a screened population of patients with stage II colon cancer and should be considered a high-risk factor in a shared decision-making process when stratifying patients to adjuvant chemotherapy.
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	207657-3
ISSN	1532-8392 ; 0046-8177
ISSN (online)	1532-8392
ISSN	0046-8177
DOI	10.1016/j.humpath.2024.02.010
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