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  1. Article: An efficient LC-QTOF-mass spectrometry method for monitoring nal-trexone compliance in urine of opioid-dependent subjects.

    Jain, Raka / Mandal, Piyali / Rana, Sachin

    Journal of opioid management

    2024  Volume 20, Issue 1, Page(s) 5–9

    Abstract: Naltrexone (NTX) is an orally effective opiate antagonist used in maintenance treatment for opiate dependence. Its utility is limited by the patient's noncompliance. The study aimed to develop an efficient method for the detection of NTX in urine by LC- ... ...

    Abstract Naltrexone (NTX) is an orally effective opiate antagonist used in maintenance treatment for opiate dependence. Its utility is limited by the patient's noncompliance. The study aimed to develop an efficient method for the detection of NTX in urine by LC-QTOF-mass spectrometry (MS) and its application to NTX compliance in opioid-dependent subjects. Sample preparation included a dilution step and direct injection to LC-QTOF-MS. Chromatographic separation was achieved with a C-18 column using a mixture of mobile phase 0.1 percent formic acid in water and 0.1 percent formic acid in 95 percent methanol. The calibration curve was linear in the range 1-100 ng/mL with a correlation coefficient higher than 0.996. Precision and accuracy were acceptable, and the recovery efficiency range was 80-85 percent. The current LC-QTOF-MS method is simple, precise, sensitive, and can be used for monitoring NTX compliance among opioid-dependent subjects in a clinical setting.
    MeSH term(s) Humans ; Analgesics, Opioid ; Tandem Mass Spectrometry/methods ; Formates ; Naltrexone ; Reproducibility of Results
    Chemical Substances formic acid (0YIW783RG1) ; Analgesics, Opioid ; Formates ; Naltrexone (5S6W795CQM)
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397614-7
    ISSN 1551-7489
    ISSN 1551-7489
    DOI 10.5055/jom.0841
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6563: Show issues Location:
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  2. Article: Urine Drug Screens in Routine Clinical Care: Underutilized?

    Jain, Raka / Deep, Raman / Chadda, Rakesh K

    The Journal of the Association of Physicians of India

    2023  Volume 70, Issue 11, Page(s) 11–12

    MeSH term(s) Humans ; Mass Screening ; Substance-Related Disorders
    Language English
    Publishing date 2023-06-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Serum BDNF Levels Among Patients with Alcohol Dependence, Depression and Alcohol Dependence with Comorbid Depression - A Comparative Study.

    Brammanathan, Subathra / Jain, Raka / Sarkar, Siddharth / Raghav, Rahul / Sagar, Rajesh

    Journal of psychoactive drugs

    2023  , Page(s) 1–9

    Abstract: The study aimed to assess and compare the serum brain derived neurotrophic factor (BDNF) levels in patients with alcohol dependence, depression and alcohol dependence with comorbid depression. Three groups each of 30 alcohol-dependent, depressive and ... ...

    Abstract The study aimed to assess and compare the serum brain derived neurotrophic factor (BDNF) levels in patients with alcohol dependence, depression and alcohol dependence with comorbid depression. Three groups each of 30 alcohol-dependent, depressive and alcohol-dependent with comorbid depressive patients seeking treatment were included. BDNF levels were estimated, and scales were administered to assess severity of alcohol dependence (using severity of alcohol dependence questionnaire, SADQ) and depressive symptoms (using Hamilton depression rating scale, HDRS). The mean BDNF value in ADS, depression and ADS with comorbid depression group was 16.4 ng/mL, 14.4 ng/mL and 12.29 ng/mL respectively, and the differences were statistically significant. In ADS group and ADS with comorbid depression groups significant negative association existed between BDNF and SADQ scores (
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392405-1
    ISSN 2159-9777 ; 0279-1072
    ISSN (online) 2159-9777
    ISSN 0279-1072
    DOI 10.1080/02791072.2023.2192985
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  4. Article ; Online: Assessment of Cannabis use among alcohol and opioid dependent subjects based on urinalysis-A retrospective review.

    Jain, Raka / Ghosh, Shayani

    Asian journal of psychiatry

    2020  Volume 53, Page(s) 102388

    MeSH term(s) Analgesics, Opioid/therapeutic use ; Cannabis ; Humans ; Opioid-Related Disorders/drug therapy ; Opioid-Related Disorders/epidemiology ; Retrospective Studies ; Urinalysis
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2020-08-27
    Publishing country Netherlands
    Document type Letter ; Review
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2020.102388
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  5. Article: Impact of Chronic Alcohol and Opioid Dependence on Biochemical Parameters: A Retrospective Case Control Study from a Tertiary Care Treatment Center in North India.

    Quraishi, Rizwana / Sarkar, Siddharth / Jain, Raka

    Addiction & health

    2022  Volume 13, Issue 3, Page(s) 148–155

    Abstract: Background: Assessment of biochemical parameters can help in the comprehensive management of patients with substance use disorders (SUDs). The aim of this study was to analyse the biochemical parameters of patients with alcohol and opioid dependence at ... ...

    Abstract Background: Assessment of biochemical parameters can help in the comprehensive management of patients with substance use disorders (SUDs). The aim of this study was to analyse the biochemical parameters of patients with alcohol and opioid dependence at an addiction treatment facility.
    Methods: This retrospective study analysed the investigation reports of male patients (aged 18 to 70 years) who visited outpatient department (OPD) with primary diagnosis as opioid dependence syndrome (ODS) or alcohol dependence syndrome (ADS). The data included liver function tests (LFTs), kidney function tests (KFTs), and electrolyte tests conducted in the laboratory in a span of one year.
    Findings: The study included 713 ADS, 654 ODS, and 227 controls. The ADS group showed significant elevations in mean values of bilirubin, aspartate transaminase (AST), alanine transaminase (ALT), and gamma-glutamyl transferase (GGT) as compared to other groups. A significant decrease in albumin levels in ADS group and raised potassium levels in ODS group was observed. De Ritis ratio above threshold (AST/ALT > 2.0) alone and along with raised GGT levels was observed among 11.3% and 9.7% of patients with ADS, respectively (P < 0.001). Electrolyte abnormalities were present in about 20.0% of patients with ADS and ODS as compared to 8.4% among controls (P < 0.001).
    Conclusion: LFT and electrolyte abnormalities are frequently observed in patients with alcohol and opioid dependence. De Ritis ratio along with raised GGT levels significantly denotes ADS group. These results merit attention in the course of clinical care of alcohol and opioid-dependent patients.
    Language English
    Publishing date 2022-01-21
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2574430-6
    ISSN 2008-8469 ; 2008-4633
    ISSN (online) 2008-8469
    ISSN 2008-4633
    DOI 10.22122/ahj.v13i3.1215
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  6. Article ; Online: Assessment of codeine abuse among substance-abuse patients based on urinalysis: A retrospective study.

    Jain, Raka / Chatterjee, Biswadip / Gupta, Abhishek

    Asian journal of psychiatry

    2021  Volume 62, Page(s) 102719

    MeSH term(s) Codeine/adverse effects ; Humans ; Morphine ; Retrospective Studies ; Substance Abuse Detection ; Substance-Related Disorders/epidemiology ; Urinalysis
    Chemical Substances Morphine (76I7G6D29C) ; Codeine (UX6OWY2V7J)
    Language English
    Publishing date 2021-05-31
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2021.102719
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  7. Article ; Online: Urinalysis based assessment of compliance and drug use patterns in patients prescribed tramadol: A cross-sectional study from a tertiary care centre.

    Jain, Raka / Sarkar, Siddharth / Saifi, Nizamuddin / Ghosh, Shayani

    Asian journal of psychiatry

    2022  Volume 71, Page(s) 103080

    Abstract: Background: Strict adherence to pharmacological dosage regimens is a prerequisite to the success of most treatments, particularly for patients in drug abuse programs. The compliance of tramadol, an atypical non-scheduled narcotic analgesic, using ... ...

    Abstract Background: Strict adherence to pharmacological dosage regimens is a prerequisite to the success of most treatments, particularly for patients in drug abuse programs. The compliance of tramadol, an atypical non-scheduled narcotic analgesic, using objective method has not been adequately studied in an Indian setting.
    Aim: To evaluate the compliance and pattern of drug use among opioid-dependent subjects prescribed tramadol based on urinalysis.
    Method: Fifty male opioid-dependent patients (ICD 10), seeking treatment at a tertiary de-addiction treatment centre of North India on tramadol prescription for atleast past four weeks were included. Self-reported substance use was recorded using semi-structured proforma. Ten ml of urine was collected for the assessment of compliance of tramadol of other substance use (morphine, buprenorphine, dextropropoxyphene, pentazocine, cannabis, benzodiazepines, pheniramine). All these drugs were analyzed using the immunoassay-based Cassette test and Gas Chromatography in human urine.
    Result: Mean age of the participants was 42.8 years and the mean duration of opioid use was 15.9years. The urine specimen of all subjects tested positive for tramadol. Urinalysis revealed benzodiazepines, cannabis, and pheniramine to be the most common substances of use in this population. It was seen that agreement of self-reporting and urine test results was good for morphine (κ = 0.558) and cannabis (κ = 0.312) and was poor for buprenorphine, pentazocine, and pheniramine.
    Conclusion: The study demonstrates the continued use of several illicit or non-prescribed medications in a medication-assisted opioid treatment population. The results affirm the reliability of urinalysis as an adjunct for testing compliance in such a population.
    MeSH term(s) Adult ; Analgesics/therapeutic use ; Analgesics, Opioid/therapeutic use ; Benzodiazepines ; Buprenorphine/therapeutic use ; Cross-Sectional Studies ; Humans ; Male ; Morphine ; Opioid-Related Disorders/drug therapy ; Pentazocine ; Pheniramine ; Reproducibility of Results ; Tertiary Care Centers ; Tramadol/therapeutic use ; Urinalysis
    Chemical Substances Analgesics ; Analgesics, Opioid ; Benzodiazepines (12794-10-4) ; Pheniramine (134FM9ZZ6M) ; Tramadol (39J1LGJ30J) ; Buprenorphine (40D3SCR4GZ) ; Morphine (76I7G6D29C) ; Pentazocine (RP4A60D26L)
    Language English
    Publishing date 2022-03-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2022.103080
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  8. Article ; Online: WHO Expert Committee on Drug Dependence

    Raka Jain

    Indian Journal of Medical Research, Vol 139, Iss 6, Pp 967-

    2014  Volume 968

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Publishing date 2014-01-01T00:00:00Z
    Publisher Indian Council of Medical Research
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Disability and quality of life in patients with treatment-resistant schizophrenia on long- term clozapine therapy.

    Nandakumar, Dhandapani / Ganesh, Ragul / Deb, Koushik S / Jain, Raka / Sood, Mamta

    Indian journal of psychiatry

    2023  Volume 65, Issue 6, Page(s) 694–697

    Abstract: Objectives: To assess disability and quality of life (QOL) in treatment resistant schizophrenia (TRS) on long term clozapine therapy and assess their correlation with positive, negative and cognitive symptoms.: Methodology: Disability and QOL in ... ...

    Abstract Objectives: To assess disability and quality of life (QOL) in treatment resistant schizophrenia (TRS) on long term clozapine therapy and assess their correlation with positive, negative and cognitive symptoms.
    Methodology: Disability and QOL in forty patients with TRS (as per modified Kane's criteria) were assessed using World Health Organization Disability Assessment Schedule 2.0 and World Health Organization Quality of Life-BREF. Scale for assessment of positive symptoms, scale for assessment of negative symptoms and Addenbrooke's cognitive examination-III were used to assess positive, negative and cognitive symptoms. Medication adherence rating scale assessed medication adherence.
    Results: Disability and QOL correlated significantly with medication adherence, negative and cognitive symptoms but not with positive symptoms. Subgroup analysis revealed significant difference between medication adherence (good vs poor) and cognitive (impairment vs non-impairment) groups.
    Conclusion: Negative and cognitive symptoms, and medication adherence correlated with disability and QOL.
    Language English
    Publishing date 2023-06-19
    Publishing country India
    Document type Journal Article
    ZDB-ID 221523-8
    ISSN 0019-5545
    ISSN 0019-5545
    DOI 10.4103/indianjpsychiatry.indianjpsychiatry_320_22
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  10. Article ; Online: Serum Corticotrophin Releasing Factor (CRF) and its correlation with stress and craving in detoxified opioid-dependent subjects.

    Chatterjee, Biswadip / Jain, Raka / Chawla, Nishtha / Raghav, Rahul

    Asian journal of psychiatry

    2021  Volume 68, Page(s) 102964

    Abstract: Corticotrophin Releasing Factor (CRF) might be suitable as biological measure of stress as it is implicated directly in both central neurological and endocrine stress-response. The study aims to compare serum CRF levels and perceived stress in opioid- ... ...

    Abstract Corticotrophin Releasing Factor (CRF) might be suitable as biological measure of stress as it is implicated directly in both central neurological and endocrine stress-response. The study aims to compare serum CRF levels and perceived stress in opioid-dependent subjects (n = 53) with non-using controls (n = 47) and to correlate them with general and instantaneous craving (in cases only). Perceived stress score and serum CRF levels were significantly higher among the users. No significant correlation with craving was found. The significant difference in serum CRF levels indicate feasibility of measuring CRF levels in peripheral fluids and asserts its role as biochemical measure of stress.
    MeSH term(s) Adrenocorticotropic Hormone ; Analgesics, Opioid ; Corticotropin-Releasing Hormone ; Craving ; Humans
    Chemical Substances Analgesics, Opioid ; Adrenocorticotropic Hormone (9002-60-2) ; Corticotropin-Releasing Hormone (9015-71-8)
    Language English
    Publishing date 2021-12-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2021.102964
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