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Article ; Online: Evidence That Skeletal Muscles Modulate HDL-Cholesterol in Metabolic Healthy Young Adults.

Lonardo, Maria Serena / Guida, Bruna / Cacciapuoti, Nunzia / Chiurazzi, Martina / Pacella, Daniela / Cataldi, Mauro

2024 Volume 16, Issue 8

Abstract: The aim of this study was to investigate whether skeletal muscle (SM) mass correlates with plasma lipids in metabolic healthy young adults. The study was designed as a retrospective observational monocentric study. Data on plasma lipids and SM mass of ... ...

Abstract	The aim of this study was to investigate whether skeletal muscle (SM) mass correlates with plasma lipids in metabolic healthy young adults. The study was designed as a retrospective observational monocentric study. Data on plasma lipids and SM mass of subjects attending our institution from 1999 to 2014 were analyzed. Inclusion criteria were being 18-45 years old and in apparently good health. SM mass was evaluated by bioelectrical impedance analysis (BIA) using the equation proposed by Janssen and normalized to height as skeletal muscle index (SMI: SM mass/height
MeSH term(s)	Humans ; Male ; Female ; Adult ; Cholesterol, HDL/blood ; Muscle, Skeletal/metabolism ; Retrospective Studies ; Young Adult ; Adolescent ; Middle Aged ; Obesity/blood ; Triglycerides/blood ; Body Mass Index ; Electric Impedance ; Overweight/blood ; Body Composition ; Cholesterol, LDL/blood
Chemical Substances	Cholesterol, HDL ; Triglycerides ; Cholesterol, LDL
Language	English
Publishing date	2024-04-10
Publishing country	Switzerland
Document type	Journal Article ; Observational Study
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16081110
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Article ; Online: Could Alcohol Abuse and Dependence on Junk Foods Inducing Obesity and/or Illicit Drug Use Represent Danger to Liver in Young People with Altered Psychological/Relational Spheres or Emotional Problems?

Tarantino, Giovanni / Cataldi, Mauro / Citro, Vincenzo

International journal of molecular sciences

2022 Volume 23, Issue 18

Abstract: Recent data show that young people, mainly due to the pressure of some risk factors or due to disrupted interpersonal relationships, utilise greater reward value and display greater sensitivity to the reinforcing properties of "pleasurable stimuli", ... ...

Abstract	Recent data show that young people, mainly due to the pressure of some risk factors or due to disrupted interpersonal relationships, utilise greater reward value and display greater sensitivity to the reinforcing properties of "pleasurable stimuli", specifically in those situations in which an enhanced dopamine release is present. Alcoholic beverages, foods rich in sugar and fat, and illicit drug use are pleasurable feelings associated with rewards. Research shows that there is a link between substance abuse and obesity in brain functioning. Still, alcohol excess is central in leading to obesity and obesity-related morbidities, such as hepatic steatosis, mainly when associated with illicit drug dependence and negative eating behaviours in young people. It is ascertained that long-term drinking causes mental damage, similarly to drug abuse, but also affects liver function. Indeed, beyond the pharmacokinetic interactions of alcohol with drugs, occurring in the liver due to the same metabolic enzymes, there are also pharmacodynamic interactions of both substances in the CNS. To complicate matters, an important noxious effect of junk foods consists of inducing obesity and obesity-related NAFLD. In this review, we focus on some key mechanisms underlying the impact of these addictions on the liver, as well as those on the CNS.
MeSH term(s)	Adolescent ; Alcoholism/complications ; Dopamine ; Humans ; Illicit Drugs ; Liver ; Obesity/complications ; Substance-Related Disorders/psychology ; Sugars
Chemical Substances	Illicit Drugs ; Sugars ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2022-09-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms231810406
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Article ; Online: Flavonoids and ω3-polyunsaturated fatty acid supplementation in renal transplant recipients: new arguments from COVID-19.

Guida, Bruna / Lonardo, Maria Serena / Cataldi, Mauro

Journal of nephrology

2021 Volume 35, Issue 1, Page(s) 95–97

MeSH term(s)	COVID-19 ; Dietary Supplements ; Fatty Acids, Omega-3 ; Flavonoids ; Humans ; Kidney Transplantation/adverse effects ; SARS-CoV-2
Chemical Substances	Fatty Acids, Omega-3 ; Flavonoids
Language	English
Publishing date	2021-11-13
Publishing country	Italy
Document type	Letter ; Comment
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-021-01194-9
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Article ; Online: Facilitators and barriers for the implementation of a telemedicine program in nutrition during the COVID-19 pandemic.

Cataldi, Mauro / Lonardo, Serena M / Cacciapuoti, Nunzia / Guida, Bruna

Nutrition, metabolism, and cardiovascular diseases : NMCD

2021 Volume 31, Issue 10, Page(s) 2987–2988

Language	English
Publishing date	2021-07-24
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1067704-5
ISSN	1590-3729 ; 0939-4753
ISSN (online)	1590-3729
ISSN	0939-4753
DOI	10.1016/j.numecd.2021.07.012
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Zs.A 3149: Show issues

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Article ; Online: Steatosis, Steatohepatitis and Cancer Immunotherapy: An Intricate Story.

Cataldi, Mauro / Manco, Federica / Tarantino, Giovanni

International journal of molecular sciences

2021 Volume 22, Issue 23

Abstract: Immune checkpoint inhibitors represent one of the most significant recent advances in clinical oncology, since they dramatically improved the prognosis of deadly cancers such as melanomas and lung cancer. Treatment with these drugs may be complicated by ... ...

Abstract	Immune checkpoint inhibitors represent one of the most significant recent advances in clinical oncology, since they dramatically improved the prognosis of deadly cancers such as melanomas and lung cancer. Treatment with these drugs may be complicated by the occurrence of clinically-relevant adverse drug reactions, most of which are immune-mediated, such as pneumonitis, colitis, endocrinopathies, nephritis, Stevens Johnson syndrome and toxic epidermal necrolysis. Drug-induced steatosis and steatohepatitis are not included among the typical forms of cancer immunotherapy-induced liver toxicity, which, instead, usually occurs as a panlobular hepatitis with prominent lymphocytic infiltrates. Nonetheless, non-alcoholic fatty liver disease is a risk factor for immunotherapy-induced hepatitis, and steatosis and steatohepatitis are frequently observed in this condition. In the present review we discuss how these pathology findings could be explained in the context of current models suggesting immune-mediated pathogenesis for steatohepatitis. We also review evidence suggesting that in patients with hepatocellular carcinoma, the presence of steatosis or steatohepatitis could predict a poor therapeutic response to these agents. How these findings could fit with immune-mediated mechanisms of these liver diseases will also be discussed.
MeSH term(s)	Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/immunology ; Carcinoma, Hepatocellular/therapy ; Fatty Liver/etiology ; Fatty Liver/immunology ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Immunotherapy/adverse effects ; Liver/drug effects ; Liver/pathology ; Liver Neoplasms/complications ; Liver Neoplasms/immunology ; Liver Neoplasms/therapy ; Models, Biological ; Neoplasms/immunology ; Neoplasms/therapy ; Non-alcoholic Fatty Liver Disease/complications ; Prognosis ; Risk Factors
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2021-11-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222312947
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Article ; Online: Neurological risks and benefits of cytokine-based treatments in coronavirus disease 2019: from preclinical to clinical evidence.

Pignataro, Giuseppe / Cataldi, Mauro / Taglialatela, Maurizio

British journal of pharmacology

2021 Volume 179, Issue 10, Page(s) 2149–2174

Abstract: Immunodeficiency and hyperinflammation are responsible for the most frequent and life-threatening forms of coronavirus disease 2019 (COVID-19). Therefore, cytokine-based treatments targeting immuno-inflammatory mechanisms are currently undergoing ... ...

Abstract	Immunodeficiency and hyperinflammation are responsible for the most frequent and life-threatening forms of coronavirus disease 2019 (COVID-19). Therefore, cytokine-based treatments targeting immuno-inflammatory mechanisms are currently undergoing clinical scrutiny in COVID-19-affected patients. In addition, COVID-19 patients also exhibit a wide range of neurological manifestations (neuro-COVID), which may also benefit from cytokine-based treatments. In fact, such drugs have shown some clinical efficacy also in neuroinflammatory diseases. On the other hand, anti-cytokine drugs are endowed with significant neurological risks, mainly attributable to their immunodepressant effects. Therefore, the aim of the present manuscript is to briefly describe the role of specific cytokines in neuroinflammation, to summarize the efficacy in preclinical models of neuroinflammatory diseases of drugs targeting these cytokines and to review the clinical data regarding the neurological effects of these drugs currently being investigated against COVID-19, in order to raise awareness about their potentially beneficial and/or detrimental neurological consequences. LINKED ARTICLES: This article is part of a themed issue on The second wave: are we any closer to efficacious pharmacotherapy for COVID 19? (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.10/issuetoc.
MeSH term(s)	COVID-19/drug therapy ; Cytokines ; Humans ; Risk Assessment ; SARS-CoV-2
Chemical Substances	Cytokines
Language	English
Publishing date	2021-03-12
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.15397
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Article ; Online: Findings from Studies Are Congruent with Obesity Having a Viral Origin, but What about Obesity-Related NAFLD?

Tarantino, Giovanni / Citro, Vincenzo / Cataldi, Mauro

Viruses

2021 Volume 13, Issue 7

Abstract: Infection has recently started receiving greater attention as an unusual causative/inducing factor of obesity. Indeed, the biological plausibility of infectobesity includes direct roles of some viruses to reprogram host metabolism toward a more lipogenic ...

Abstract	Infection has recently started receiving greater attention as an unusual causative/inducing factor of obesity. Indeed, the biological plausibility of infectobesity includes direct roles of some viruses to reprogram host metabolism toward a more lipogenic and adipogenic status. Furthermore, the probability that humans may exchange microbiota components (virome/virobiota) points out that the altered response of IFN and other cytokines, which surfaces as a central mechanism for adipogenesis and obesity-associated immune suppression, is due to the fact that gut microbiota uphold intrinsic IFN signaling. Last but not least, the adaptation of both host immune and metabolic system under persistent viral infections play a central role in these phenomena. We hereby discuss the possible link between adenovirus and obesity-related nonalcoholic fatty liver disease (NAFLD). The mechanisms of adenovirus-36 (Ad-36) involvement in hepatic steatosis/NAFLD consist in reducing leptin gene expression and insulin sensitivity, augmenting glucose uptake, activating the lipogenic and pro-inflammatory pathways in adipose tissue, and increasing the level of macrophage chemoattractant protein-1, all of these ultimately leading to chronic inflammation and altered lipid metabolism. Moreover, by reducing leptin expression and secretion Ad-36 may have in turn an obesogenic effect through increased food intake or decreased energy expenditure via altered fat metabolism. Finally, Ad-36 is involved in upregulation of cAMP, phosphatidylinositol 3-kinase, and p38 signaling pathways, downregulation of Wnt10b expression, increased expression of CCAAT/enhancer binding protein-beta, and peroxisome proliferator-activated receptor gamma 2 with consequential lipid accumulation.
MeSH term(s)	Adenoviridae/immunology ; Adenoviridae Infections/complications ; Adenoviridae Infections/immunology ; Animals ; Diet, High-Fat ; Glucose/metabolism ; Humans ; Inflammation ; Lipid Metabolism ; Lipogenesis ; Mice ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/virology ; Obesity/complications ; Obesity/etiology ; Obesity/immunology ; Obesity/virology ; Signal Transduction
Chemical Substances	Glucose (IY9XDZ35W2)
Language	English
Publishing date	2021-07-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13071285
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Article ; Online: Effects of Nordic Walking Training on Anthropometric, Body Composition and Functional Parameters in the Middle-Aged Population.

Grigoletto, Alessia / Mauro, Mario / Oppio, Alberto / Greco, Gianpiero / Fischetti, Francesco / Cataldi, Stefania / Toselli, Stefania

International journal of environmental research and public health

2022 Volume 19, Issue 12

Abstract: Nordic walking (NW) is an easy physical exercise that is usually proposed for clinical populations and for the elderly. The aim of the present study was to examine the effects of a period of NW training in a non-clinical middle-aged population on ... ...

Abstract	Nordic walking (NW) is an easy physical exercise that is usually proposed for clinical populations and for the elderly. The aim of the present study was to examine the effects of a period of NW training in a non-clinical middle-aged population on anthropometric, body composition and functional parameters. A pre-test/post-test study design was conducted on 77 participants: 56 women (72.7%, age 55.53 ± 9.73 years) and 21 men (27.3%, age 60.51 ± 8.15 years). The measurements were carried out with physical tests at the baseline and at the follow up. Participants did two weekly NW training sessions of about 60 min each. A questionnaire was administered to evaluate their feelings after the training period. Paired Students' test was carried out to evaluate the pre-post differences, and the analysis of variance was performed to evaluate the questionnaire. Participants had significantly less stress and anxiety after the NW training. Body fat parameters showed a significant decrease, especially for women. Phase angle and strength of lower body presented a significant increase in both sexes after the training period. In conclusion, NW shows many potential benefits also for the nonclinical population and could be an important exercise to remain active and to maintain a good health condition.
MeSH term(s)	Aged ; Anthropometry ; Body Composition ; Exercise ; Exercise Therapy ; Female ; Humans ; Male ; Middle Aged ; Nordic Walking ; Walking
Language	English
Publishing date	2022-06-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19127433
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Article ; Online: Short-term effectiveness of guselkumab in psoriatic arthritis patients and suggestive features of axial involvement: results from a real-life multicentre cohort.

Ruscitti, Piero / Pantano, Ilenia / Cataldi, Giulia / Gentile, Martina / Arrigoni, Francesco / Riccio, Luca / Marrone, Sabrina / Mauro, Daniele / Ursini, Francesco / Esposito, Maria / Barile, Antonio / Fargnoli, Maria Concetta / Giacomelli, Roberto / Ciccia, Francesco / Cipriani, Paola

Rheumatology (Oxford, England)

2024

Abstract: Objective: To evaluate the short-term effectiveness of guselkumab in patients with psoriatic arthritis (PsA) and suggestive features of axial involvement in a prospective "real-life" multicentre cohort.: Methods: Between June 2022 and June 2023, PsA ... ...

Abstract	Objective: To evaluate the short-term effectiveness of guselkumab in patients with psoriatic arthritis (PsA) and suggestive features of axial involvement in a prospective "real-life" multicentre cohort. Methods: Between June 2022 and June 2023, PsA patients with axial involvement were evaluated if treated at least for 4 months with guselkumab. The effectiveness was evaluated by BASDAI, ASDAS, DAPSA, and achievement of BASDAI ≤ 4, also exploiting predictive factors. In a group of patients, MRI findings on sacroiliac joints were assessed before and after guselkumab administration. Results: Sixty-seven patients with PsA and suggestive features of axial involvement (age 53.4 ± 11.2 years, male sex 26.9%) were treated with guselkumab. After 4 months, a significant reduction of BASDAI, ASDAS, and DAPSA was observed. A ΔBASDAI of -2.11 ± 0.43 was estimated assessing the mean difference values before and after guselkumab administration and 52.2% of patients reached a BASDAI ≤ 4. In 27 patients, MRI findings on sacroiliac joints were assessed before and after guselkumab administration. A reduction of 0.80 or larger of the sacroiliac joint lesion score was observed in the majority of patients (70.3%) based on MRI improvements, paralleling with the clinical response.No life-threatening side effects were recorded; 17.9% of patients reported minor adverse events mainly injection site reactions. Conclusions: The short-term effectiveness of guselkumab in patients with PsA and suggestive features of axial involvement was shown. Although further studies are needed, our multicentre "real-life" study may suggest the clinical usability of guselkumab in this context.
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keae220
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Zs.B 240: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 497: Show issues

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Article ; Online: The evolving concept of the intrinsic hippocampal theta/gamma oscillator.

Cataldi, Mauro / Vigliotti, Chiara

Frontiers in bioscience (Scholar edition)

2018 Volume 10, Issue 1, Page(s) 143–165

Abstract: Three main types of electrical oscillations are recorded from the ... ...

Abstract	Three main types of electrical oscillations are recorded from the hippocampus
MeSH term(s)	Animals ; Biological Clocks/physiology ; Gamma Rhythm/physiology ; Hippocampus/physiology ; Humans ; Neurons/physiology ; Theta Rhythm/physiology
Language	English
Publishing date	2018-01-01
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	2565100-6
ISSN	1945-0524 ; 1945-0516
ISSN (online)	1945-0524
ISSN	1945-0516
DOI	10.2741/s505
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