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Article ; Online: Negative pressure ventilation, an umbrella against ventilator induced lung injury.

Roberts, James H M / Vanhoutte, Jane / Howard, David J / van Rijn, Clementina M / van Egmond, Jan

2024

Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Letter
ZDB-ID	80387-x
ISSN	1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0340-0964 ; 0342-4642 ; 0935-1701
DOI	10.1007/s00134-024-07416-5
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Zs.A 1089: Show issues

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Article ; Online: Perioperative Pulmonary Atelectasis: Comment.

van Egmond, Jan / Speight, Colin / Roberts, James H M / Patel, Anil / van Rijn, Clementina M / Coulthard, Malcolm

Anesthesiology

2022 Volume 137, Issue 1, Page(s) 125–126

MeSH term(s)	Humans ; Lung ; Pulmonary Atelectasis/diagnostic imaging ; Pulmonary Atelectasis/etiology
Language	English
Publishing date	2022-04-29
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	269-0
ISSN	1528-1175 ; 0003-3022
ISSN (online)	1528-1175
ISSN	0003-3022
DOI	10.1097/ALN.0000000000004231
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Uk I Zs.133: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 199: Show issues

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Book ; Thesis: Folic acid, epilepsy and the GABAA receptor complex

Rijn, Clementina M. van

complementary in vivo and in vitro studies concerning their interrelationships

1989

Author's details	door Clementina Maria van Rijn
Size	124 S. : Ill., graph. Darst.
Publishing country	Netherlands
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Nijmegen, Kath. Univ., Diss., 1989
Note	Zsfassung in niederländ. Sprache
HBZ-ID	HT001551345
ISBN	9090028285 ; 9789090028286
Database	Catalogue ZB MED Medicine, Health

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89 E 2000	order for loan	Magazin

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Article ; Online: Immediate versus late effects of vigabatrin on spike and wave discharges.

Perescis, Martin F J / van Luijtelaar, Gilles / van Rijn, Clementina M

Epilepsy research

2020 Volume 165, Page(s) 106379

Abstract: Vigabatrin increases GABA concentrations by inhibiting GABA transaminase. In previous studies, it was shown that vigabatrin increases the incidence of Spike and Wave Discharges (SWD) in the WAG/Rij rat model for absence epilepsy. Since following a single ...

Abstract	Vigabatrin increases GABA concentrations by inhibiting GABA transaminase. In previous studies, it was shown that vigabatrin increases the incidence of Spike and Wave Discharges (SWD) in the WAG/Rij rat model for absence epilepsy. Since following a single dose of vigabatrin GABA concentrations are known to be increased for several days, the present study sheds light on how the previously described changes in SWD characteristics develop over a longer time frame. To achieve this, we injected adult WAG/Rij rats with 500 mg/kg and recorded their EEG for 48 h. SWD were quantified, and their peak frequencies were calculated. Our results showed three rapid onset effects: a sharp increase in SWD incidence, from 12.5 /hour to 133/hour), this increase lasted only 4.4 h, an increase in mean SWD duration, from 4.6 s to 8.1 s and a drop in peak frequency, from 8 to 6 Hz. Since it takes several hours before GABA concentrations are sufficiently increased, we propose that these immediate effects are caused by direct stimulation of both GABA
MeSH term(s)	Animals ; Disease Models, Animal ; Electroencephalography/drug effects ; Epilepsy, Absence/drug therapy ; Frontal Lobe/drug effects ; Male ; Neural Pathways/drug effects ; Rats ; Thalamus/drug effects ; Vigabatrin/pharmacology
Chemical Substances	Vigabatrin (GR120KRT6K)
Language	English
Publishing date	2020-06-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632939-1
ISSN	1872-6844 ; 0920-1211
ISSN (online)	1872-6844
ISSN	0920-1211
DOI	10.1016/j.eplepsyres.2020.106379
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Zs.A 2193: Show issues

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Article ; Online: Network analysis reveals a role of the hippocampus in absence seizures: The effects of a cannabinoid agonist.

Sysoeva, Marina V / Kuznetsova, Galina D / Sysoev, Ilya V / Ngomba, Richard T / Vinogradova, Lyudmila V / Grishchenko, Anastasia A / van Rijn, Clementina M / van Luijtelaar, Gilles

Epilepsy research

2023 Volume 192, Page(s) 107135

Abstract: The role of the hippocampus (Hp) in absence epileptic networks and the effect of endocannabinoid system on this network remain enigmatic. Here, using adapted nonlinear Granger causality, we compared the differences in network strength in four intervals ( ... ...

Abstract	The role of the hippocampus (Hp) in absence epileptic networks and the effect of endocannabinoid system on this network remain enigmatic. Here, using adapted nonlinear Granger causality, we compared the differences in network strength in four intervals (baseline or interictal, preictal, ictal and postictal) in two hours before (Epoch 1) and six hours (epochs 2, 3 and 4) after the administration of three different doses of the endocannabinoid agonist WIN55,212-2 (WIN) or solvent. Local field potentials were recorded for eight hours in 23 WAG/Rij rats in the Frontal (FC), Parietal PC), Occipital Cortex (OC) and in the hippocampus (Hp). The four intervals were visually marked by an expert neurophysiologist and the strength of couplings between electrode pairs were calculated in both directions. Ictally, a strong decrease in coupling strength was found between Hp and FC, as well as a large increase bidirectionally between PC and FC and unidirectionally from FC and PC to OC, and from FC to Hp over all epochs. The highest dose of WIN increased the couplings strength from FC to Hp and from OC to PC during 4 and 2 hr respectively in all intervals, and decreased the FC to PC coupling strength postictally in epoch 2. A single rat showed generalized convulsive seizures after the highest dose: this rat shared not only coupling changes with the other rats in the same condition, but showed many more. WIN reduced SWD number in epoch 2 and 3, their mean duration increased in epochs 3 and 4. Conclusions:during SWDs FC and PC are strongly coupled and drive OC, while at the same time the influence of Hp to FC is diminished. The first is in agreement with the cortical focus theory, the latter demonstrates an involvement of the hippocampus in SWD occurrence and that ictally the hippocampal control of the cortico-thalamo-cortical system is lost. WIN causes dramatic network changes which have major consequences for the decrease of SWDs, the occurrence of convulsive seizures, and the normal cortico-cortical and cortico-hippocampal interactions.
MeSH term(s)	Rats ; Animals ; Cannabinoid Receptor Agonists/pharmacology ; Electroencephalography ; Endocannabinoids ; Disease Models, Animal ; Epilepsy, Absence/drug therapy ; Seizures/chemically induced ; Seizures/drug therapy ; Hippocampus
Chemical Substances	Cannabinoid Receptor Agonists ; Endocannabinoids
Language	English
Publishing date	2023-04-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632939-1
ISSN	1872-6844 ; 0920-1211
ISSN (online)	1872-6844
ISSN	0920-1211
DOI	10.1016/j.eplepsyres.2023.107135
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Article ; Online: Neonatal exposure to AY-9944 increases typical spike and wave discharges in WAG/Rij and Wistar rats.

Perescis, Martin F J / van Luijtelaar, Gilles / van Rijn, Clementina M

Epilepsy research

2019 Volume 157, Page(s) 106184

Abstract: Absence-epileptic seizures appear in the EEG as Spike and Wave Discharges (SWDs). Typical SWDs develop spontaneously in WAG/Rij rats, an inbred Wistar strain. Atypical SWDs however were reported in studies in which the cholesterol synthesis inhibitor AY- ... ...

Abstract	Absence-epileptic seizures appear in the EEG as Spike and Wave Discharges (SWDs). Typical SWDs develop spontaneously in WAG/Rij rats, an inbred Wistar strain. Atypical SWDs however were reported in studies in which the cholesterol synthesis inhibitor AY-9944 was administered to neonatal Wistar rats, causing absence-like seizures later in life. Atypical SWDs seemed to differ from typical SWDs in 3 aspects: lower peak frequency, longer duration, and involvement of the hippocampus. The aim of the present study was to investigate the effect of AY-9944 on typical SWDs. Male Wistar and WAG/Rij rats were injected with 7.5 mg/kg AY-9944 or saline postnatally. After 6 months, EEGs were recorded from the cortex and the hippocampus. Incidence, duration and peak frequency of the SWDs were determined. The SWD stopping probability was estimated by hazard rate analysis. Hippocampal involvement was assessed by cross correlation analysis of the hippocampus and cortex channels. The Wistar rats unexpectedly showed a high incidence of spontaneous SWDs. The AY-treatment increased the total SWD duration in both Wistar and WAG/Rij rats: the incidence was 1.6 times higher and the mean SWD duration was 1.4 times longer than in the saline-treated rats. The peak frequency of the SWDs did not change. The hazard rates were lower in the AY-treated rats, so some very long SWDs were observed. Cross correlations of spiky activity in the hippocampus pointed to volume conduction rather than to genuine SWD activity in this area. In summary, we found no indication that SWDs in AY-treated animals differ from typical SWDs. However, since saline-treated rats had many spontaneous SWDs, other rat strains might respond differently. With respect to the mechanism, the appearance of long SWDs suggests that the SWD stopping mechanism is affected by the treatment. We speculate that this effect is due to changes in the distribution of GABA-ergic and glutamatergic receptors in lipid rafts.
MeSH term(s)	Animals ; Brain Waves/drug effects ; Brain Waves/physiology ; Cerebral Cortex/drug effects ; Cerebral Cortex/physiology ; Disease Models, Animal ; Electroencephalography ; Hippocampus/drug effects ; Hippocampus/physiology ; Male ; Rats ; Rats, Wistar ; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride/pharmacology
Chemical Substances	trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride (366-93-8)
Language	English
Publishing date	2019-08-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	632939-1
ISSN	1872-6844 ; 0920-1211
ISSN (online)	1872-6844
ISSN	0920-1211
DOI	10.1016/j.eplepsyres.2019.106184
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Article ; Online: Lateralized EEG mu power during action observation and motor imagery in typically developing children and children with unilateral Cerebral Palsy.

Jongsma, Marijtje L A / Steenbergen, Bert / Baas, C Marjolein / Aarts, Pauline B / van Rijn, Clementina M

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

2020 Volume 131, Issue 12, Page(s) 2829–2840

Abstract: Objective: During motor execution (ME), mu power is diminished over the contralateral hemisphere and increased over the ipsilateral hemisphere, which has been associated with cortical activation of the contralateral motor areas and inhibition of the ... ...

Abstract	Objective: During motor execution (ME), mu power is diminished over the contralateral hemisphere and increased over the ipsilateral hemisphere, which has been associated with cortical activation of the contralateral motor areas and inhibition of the ipsilateral motor areas respectively. The influence of action observation (AO) and motor imagery (MI) on mu power is less clear, especially in children, and remains to be studied in children with unilateral cerebral palsy (uCP). Methods: We determined mu power during ME, AO, and MI of 45 typically developing (TD) children and 15 children with uCP over both hemispheres, for each hand. Results: In TD children, over the left hemisphere mu power was lowered during ME when the right hand was used. In line, over the right hemisphere mu power was lowered when the left hand was addressed. In addition, during AO and MI increased mu power was observed when the right hand was addressed. In children with uCP, over the spared hemisphere mu power was diminished during ME when the less-affected hand was used. However, over the lesioned hemisphere, no mu changes were observed. Conclusions: The results of TD children fit the activation/inhibition model of mu power. Significance: The results of children with uCP suggest that the lesioned hemisphere is unresponsive to the motor tasks.
MeSH term(s)	Adolescent ; Brain Waves/physiology ; Cerebral Palsy/physiopathology ; Cerebral Palsy/psychology ; Child ; Child Development/physiology ; Child, Preschool ; Electroencephalography/methods ; Female ; Humans ; Imagination/physiology ; Male ; Movement/physiology ; Photic Stimulation/methods ; Psychomotor Performance/physiology
Language	English
Publishing date	2020-10-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1463630-x
ISSN	1872-8952 ; 0921-884X ; 1388-2457
ISSN (online)	1872-8952
ISSN	0921-884X ; 1388-2457
DOI	10.1016/j.clinph.2020.08.022
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Article ; Online: Altered SWD stopping mechanism in WAG/Rij rats subchronically treated with the cannabinoid agonist R(+)WIN55,212-2.

Perescis, Martin F J / Flipsen, Nienke A R / van Luijtelaar, Gilles / van Rijn, Clementina M

Epilepsy & behavior : E&B

2019 Volume 102, Page(s) 106722

Abstract: A single injection of the cannabinoid agonist R(+)WIN55,212-2 (WIN) is known to cause an increase of the mean duration of spontaneously occurring spike-and-wave discharges (SWDs) in rats of the WAG/Rij strain, a genetic model for absence epilepsy. The ... ...

Abstract	A single injection of the cannabinoid agonist R(+)WIN55,212-2 (WIN) is known to cause an increase of the mean duration of spontaneously occurring spike-and-wave discharges (SWDs) in rats of the WAG/Rij strain, a genetic model for absence epilepsy. The aim of the present study was to establish whether repeated activation of CB
MeSH term(s)	Animals ; Cannabinoid Receptor Agonists/pharmacology ; Disease Models, Animal ; Electroencephalography/drug effects ; Epilepsy, Absence/drug therapy ; Epilepsy, Absence/physiopathology ; Male ; Rats ; Rats, Transgenic
Chemical Substances	Cannabinoid Receptor Agonists
Language	English
Publishing date	2019-12-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2010587-3
ISSN	1525-5069 ; 1525-5050
ISSN (online)	1525-5069
ISSN	1525-5050
DOI	10.1016/j.yebeh.2019.106722
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Zs.A 5289: Show issues

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Article ; Online: The interaction between pain and cognition: on the roles of task complexity and pain intensity.

Lier, Elisabeth J / van Rijn, Clementina M / de Vries, Marjan / van Goor, Harry / Oosterman, Joukje M

Scandinavian journal of pain

2021 Volume 22, Issue 2, Page(s) 385–395

Abstract: Objectives: The interaction between pain and cognition includes a concurrent negative effect of pain on cognitive performance and an analgesic effect of cognitive distraction on pain experience. The purpose of this exploratory study was to investigate ... ...

Abstract	Objectives: The interaction between pain and cognition includes a concurrent negative effect of pain on cognitive performance and an analgesic effect of cognitive distraction on pain experience. The purpose of this exploratory study was to investigate the role of pain intensity and task complexity on this interaction. Methods: Two experiments were conducted in healthy volunteers. In both experiments, participants completed 3 conditions: a pain only condition (consisting of the cold pressor test), a cognition only condition (consisting of the cognitive task) and a combined condition (concurrent administration of the cold pressor and cognitive task). In experiment I, participants performed one out of three possible tasks that differed in cognitive load (low, medium, high). In experiment II the parameters of the pain stimulus, induced by a cold pressor test, were adapted and only the high load cognitive task was employed. Pain scores, reaction times, and accuracy rates were recorded. Results: In experiment I, cognitive distraction significantly decreased pain scores, irrespective of the cognitive load of the task. Pain did not affect cognitive performance. In experiment II, pain diminished accuracy rates. No effect of cognitive distraction on pain was observed. Individual characteristics did not noticeably influence the interaction between pain and cognition. Conclusions: The results of this study suggest a two-way interaction, however no evidence for a simultaneous bidirectional relationship was found. Cognitive distraction successfully reduces pain, up until a certain point where this relationship is reversed, and pain starts to interfere with cognitive performance. This may imply that priorities shift at a certain pain-threshold, however further research should confirm this hypothesis. This study could contribute to further understanding of cognitive mechanisms related to pain perception.
MeSH term(s)	Attention ; Cognition ; Humans ; Pain/psychology ; Pain Measurement ; Pain Threshold/psychology
Language	English
Publishing date	2021-11-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2515451-5
ISSN	1877-8879 ; 1877-8860
ISSN (online)	1877-8879
ISSN	1877-8860
DOI	10.1515/sjpain-2021-0119
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Article ; Online: Pain catastrophizing is associated with altered EEG effective connectivity during pain‑related mental imagery.

Ferdek, Magdalena A / Adamczyk, Agnieszka K / van Rijn, Clementina M / Oosterman, Joukje M / Wyczesany, Miroslaw

Acta neurobiologiae experimentalis

2019 Volume 79, Issue 1, Page(s) 53–72

Abstract: Pain catastrophizing - defined as a tendency to exaggerate the threat value or seriousness of experienced pain ‑ has been shown to be a risk factor for pain chronification. However, the neural basis of pain catastrophizing remains unclear and requires ... ...

Abstract	Pain catastrophizing - defined as a tendency to exaggerate the threat value or seriousness of experienced pain ‑ has been shown to be a risk factor for pain chronification. However, the neural basis of pain catastrophizing remains unclear and requires thorough investigation. This study aimed to explore the relationship between pain catastrophizing and effective connectivity of the pain systems in healthy participants. EEG data were collected during an induced state of pain‑related negative, depressive, positive and neutral mental imagery conditions, and pain catastrophizing tendencies were measured by the Pain Catastrophizing Scale. The Directed Transfer Function, a method based on Granger causality principles, was used to assess the effective connectivity. Linear mixed effects analyses revealed a negative relationship between pain catastrophizing and beta information flow from the right temporal cortex to the frontal regions and a positive relationship between pain catastrophizing and increased beta information flow from the right somatosensory cortices to the right temporal cortices when thinking about pain. These patterns were not found in other imagery conditions. Taken together, this study suggests that individual differences in pain catastrophizing might be related to an altered frontotemporal regulatory loop and increased connectivity between pain and affective systems. Our study reveals connectivity patterns related to pain catastrophizing tendencies that are detectable even in pain‑free, healthy individuals.
MeSH term(s)	Affect/physiology ; Brain Mapping ; Catastrophization/physiopathology ; Cerebral Cortex/physiopathology ; Electroencephalography ; Female ; Functional Laterality ; Humans ; Imagination/physiology ; Male ; Models, Statistical ; Neural Pathways/physiology ; Pain/physiopathology ; Pain/psychology ; Pain Measurement ; Physical Stimulation ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2019-04-29
Publishing country	Poland
Document type	Journal Article
ZDB-ID	184409-x
ISSN	1689-0035 ; 0065-1400
ISSN (online)	1689-0035
ISSN	0065-1400
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