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Article ; Online: Reply to A Drewnowski et al, O Devinsky, D A Booth and E L Gibson, and D J Millward.

Ludwig, David S / Aronne, Louis J / Astrup, Arne / de Cabo, Rafael / Cantley, Lewis C / Friedman, Mark I / Heymsfield, Steven B / Johnson, James D / King, Janet C / Krauss, Ronald M / Lieberman, Daniel E / Taubes, Gary / Volek, Jeff S / Westman, Eric C / Willett, Walter C / Yancy, William S / Ebbeling, Cara B

The American journal of clinical nutrition

2022 Volume 115, Issue 2, Page(s) 595–597

Language	English
Publishing date	2022-02-09
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	280048-2
ISSN	1938-3207 ; 0002-9165
ISSN (online)	1938-3207
ISSN	0002-9165
DOI	10.1093/ajcn/nqab385
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Ue I Zs.208: Show issues

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Article ; Online: The fundamental role of chromatin loop extrusion in physiological V(D)J recombination.

Zhang, Yu / Zhang, Xuefei / Ba, Zhaoqing / Liang, Zhuoyi / Dring, Edward W / Hu, Hongli / Lou, Jiangman / Kyritsis, Nia / Zurita, Jeffrey / Shamim, Muhammad S / Presser Aiden, Aviva / Lieberman Aiden, Erez / Alt, Frederick W

Nature

2019 Volume 573, Issue 7775, Page(s) 600–604

Abstract: The RAG endonuclease initiates Igh V(D)J assembly in B cell progenitors by joining D segments to J ...

Abstract	The RAG endonuclease initiates Igh V(D)J assembly in B cell progenitors by joining D segments to J
MeSH term(s)	Animals ; Cell Line ; Chromatin/metabolism ; Endonucleases/metabolism ; Mice, Inbred C57BL ; Precursor Cells, B-Lymphoid/metabolism ; V(D)J Recombination/physiology
Chemical Substances	Chromatin ; Endonucleases (EC 3.1.-)
Language	English
Publishing date	2019-09-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-019-1547-y
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Zs.MO 244: Show issues

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Article ; Online: Who is HOT and who is LOT? Detailed characterization of prescription opioid-induced changes in behavior between 129P3/J and 129S1/SvlmJ mouse substrains.

Szumlinski, Karen K / Coelho, Michal A / Tran, Tori / Stailey, Nicholas / Lieberman, Dylan / Gabriella, Ivette / Swauncy, Isaiah / Brewin, Lindsey W / Ferdousian, Sami

Genes, brain, and behavior

2019 Volume 19, Issue 5, Page(s) e12609

Abstract: ... identified the 129S1/SvlmJ (S1) and related 129P3/J (P3) mouse substrains, respectively, as low and high ...

Abstract	Genetic factors are theorized to contribute to the substantial inter-individual variability in opioid abuse/addiction. To advance the behavioral genetics of prescription opioid abuse, our prior work identified the 129S1/SvlmJ (S1) and related 129P3/J (P3) mouse substrains, respectively, as low and high opioid-taking. Herein, we related our prior results to measures of sucrose reward/reinforcement, basal anxiety, opioid-induced place-conditioning, locomotor activity and Straub tail reaction, as well as behavioral and physiological signs of withdrawal. Substrains were also re-examined for higher-dose oxycodone and fentanyl intake under limited-access drinking procedures. S1 mice failed to acquire sucrose self-administration under various operant-conditioning procedures and exhibited lower sucrose intake in the home-cage. However, sucrose intake under limited-access procedures escalated in both substrains with repeated sucrose experience. S1 mice exhibited less spontaneous locomotor activity, as well as less opioid-induced locomotor activity and Straub tail reaction, than P3 mice and failed to exhibit an oxycodone-induced place-preference. The lack of conditioned behavior by S1 mice was unrelated to behavioral signs of withdrawal-induced negative affect or dependence severity, but might reflect high levels of basal anxiety-like behavior. Intriguingly, S1 and P3 mice initially exhibited equivalent oxycodone and fentanyl consumption in the home-cage; however opioid intake escalated only in P3 mice with repeated opioid experience. No sex differences were observed for any of our measures. These data provide additional evidence for robust differences in opioid addiction-related behaviors between P3 and S1 substrains and suggest that anxiety, learning, and/or motivational impairments might confound interpretation of operant- and place-conditioning studies employing the S1 substrain.
MeSH term(s)	Analgesics, Opioid/toxicity ; Animals ; Anxiety/etiology ; Anxiety/genetics ; Anxiety/physiopathology ; Choice Behavior ; Conditioning, Operant ; Female ; Fentanyl/toxicity ; Genotype ; Locomotion ; Male ; Mice ; Mice, Inbred C57BL ; Motivation ; Opioid-Related Disorders/complications ; Opioid-Related Disorders/genetics ; Opioid-Related Disorders/physiopathology ; Oxycodone/toxicity ; Spatial Behavior
Chemical Substances	Analgesics, Opioid ; Oxycodone (CD35PMG570) ; Fentanyl (UF599785JZ)
Language	English
Publishing date	2019-10-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2075819-4
ISSN	1601-183X ; 1601-1848
ISSN (online)	1601-183X
ISSN	1601-1848
DOI	10.1111/gbb.12609
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Zs.A 5642: Show issues

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Book: Surgery of the hip

Berry, Daniel J. / Lieberman, Jay R.

(ExpertConsult)

2020

Author's details	Daniel J. Berry, MD, Jay R. Lieberman, MD
Series title	ExpertConsult
Language	English
Size	xxiii, 1343 Seiten, Illustrationen
Edition	Second edition
Publisher	Elsevier
Publishing place	Philadelphia
Publishing country	United States
Document type	Book
Note	Zugang zu Online-Ausgabe über Code
HBZ-ID	HT020399815
ISBN	978-0-323-55464-0 ; 9780323568418 ; 0-323-55464-4 ; 0323568416
Database	Catalogue ZB MED Medicine, Health

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2020 A 470	available for loan (reading room)	Lesesaal EG

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Article ; Online: How to diagnose IgE-mediated food allergy.

Lieberman, Jay / Muraro, Antonella / Blaiss, Michael

Archives of disease in childhood. Education and practice edition

2024

Abstract: Immunoglobulin E (IgE)-mediated food allergy is an immune response, typically to a food protein. Accurate diagnosis reduces unnecessary dietary restrictions and economic and psychological burden on patients and caregivers but relies on a rigorous ... ...

Abstract	Immunoglobulin E (IgE)-mediated food allergy is an immune response, typically to a food protein. Accurate diagnosis reduces unnecessary dietary restrictions and economic and psychological burden on patients and caregivers but relies on a rigorous clinical history, specific IgE diagnostic tests and, where needed, oral food challenge. Increased awareness is needed around which patients to test for IgE-mediated food allergy, as well as terms commonly associated with IgE-mediated food allergy testing, in order to optimise patient diagnosis and management. Herein, we describe approaches to diagnosis of IgE-mediated food allergy, appropriate interpretation of results and risks of overtesting.
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2148818-6
ISSN	1743-0593 ; 1743-0585
ISSN (online)	1743-0593
ISSN	1743-0585
DOI	10.1136/archdischild-2023-325938
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Article ; Online: Predicting overstriding with wearable IMUs during treadmill and overground running.

Baker, Lauren M / Yawar, Ali / Lieberman, Daniel E / Walsh, Conor J

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6347

Abstract: Running injuries are prevalent, but their exact mechanisms remain unknown largely due to limited real-world biomechanical analysis. Reducing overstriding, the horizontal distance that the foot lands ahead of the body, may be relevant to reducing injury ... ...

Abstract	Running injuries are prevalent, but their exact mechanisms remain unknown largely due to limited real-world biomechanical analysis. Reducing overstriding, the horizontal distance that the foot lands ahead of the body, may be relevant to reducing injury risk. Here, we leverage the geometric relationship between overstriding and lower extremity sagittal segment angles to demonstrate that wearable inertial measurement units (IMUs) can predict overstriding during treadmill and overground running in the laboratory. Ten recreational runners matched their strides to a metronome to systematically vary overstriding during constant-speed treadmill running and showed similar overstriding variation during comfortable-speed overground running. Linear mixed models were used to analyze repeated measures of overstriding and sagittal segment angles measured with motion capture and IMUs. Sagittal segment angles measured with IMUs explained 95% and 98% of the variance in overstriding during treadmill and overground running, respectively. We also found that sagittal segment angles measured with IMUs correlated with peak braking force and explained 88% and 80% of the variance during treadmill and overground running, respectively. This study highlights the potential for IMUs to provide insights into landing and loading patterns over time in real-world running environments, and motivates future research on feedback to modify form and prevent injury.
MeSH term(s)	Biomechanical Phenomena ; Running ; Foot ; Exercise Test ; Wearable Electronic Devices
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56888-4
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Article ; Online: Longitudinal changes in adverse effects reporting in multiple dietary supplement classifications: The US military dietary supplement use study.

Knapik, Joseph J / Trone, Daniel W / Steelman, Ryan A / Lieberman, Harris R

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2024 Volume 188, Page(s) 114635

Abstract: Over 70% of United States military service members (SMs) regularly use dietary supplements (DSs) and about 18% have reported adverse effects (AEs) associated with use. This investigation examined longitudinal changes in AEs reporting among DS users. On ... ...

Abstract	Over 70% of United States military service members (SMs) regularly use dietary supplements (DSs) and about 18% have reported adverse effects (AEs) associated with use. This investigation examined longitudinal changes in AEs reporting among DS users. On two separate occasions 1.3 ± 0.2 years apart (mean ± standard deviation), 5778 SMs completed identical questionnaires on DS use and associated AEs. Among SMs reporting DS use ≥1 time/week, ≥1 AE was reported by 19% and 15% in the baseline and follow-up phases, respectively. The risk of reporting DS use at follow-up was similar among those reporting and not reporting AEs at baseline for most DS categories including prohormones, proteins/amino acids, individual vitamins and minerals, multivitamin/multiminerals, herbals, fish oils, joint health products, and other DSs. An exception was combination products where those reporting AEs at baseline had an increased risk of use at follow-up (risk ratio = 1.13, 95% confidence interval = 1.06-1.09). Those reporting AEs at baseline and continuing DS use in the follow-up were more likely to report AEs at follow-up compared to those not reporting baseline AEs. In conclusion, AEs reported at baseline did not deter many participants from using DSs in the follow-up period, and many SMs reporting AEs at baseline continued reporting them at follow-up.
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2024.114635
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Zs.A 529: Show issues

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Article: 5-HT1B receptors mediate dopaminergic inhibition of vesicular fusion and GABA release from striatonigral synapses.

Molinari, Maya / Lieberman, Ori J / Sulzer, David / Santini, Emanuela / Borgkvist, Anders

bioRxiv : the preprint server for biology

2024

Abstract: The substantia nigra pars reticulata (SNr), a crucial basal ganglia output nucleus, contains a dense expression of dopamine D1 receptors (D1Rs), along with dendrites belonging to dopaminergic neurons of substantia nigra pars compacta. These D1Rs are ... ...

Abstract	The substantia nigra pars reticulata (SNr), a crucial basal ganglia output nucleus, contains a dense expression of dopamine D1 receptors (D1Rs), along with dendrites belonging to dopaminergic neurons of substantia nigra pars compacta. These D1Rs are primarily located on the terminals of striatonigral medium spiny neurons, suggesting their involvement in the regulation of neurotransmitter release from the direct pathway in response to somatodendritic dopamine release. To explore the hypothesis that D1Rs modulate GABA release from striatonigral synapses, we conducted optical recordings of striatonigral activity and postsynaptic patch-clamp recordings from SNr neurons in the presence of dopamine and D1R agonists. We found that dopamine inhibits optogenetically triggered striatonigral GABA release by modulating vesicle fusion and Ca
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.14.584991
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Article ; Online: Effects of exercise training programs on motor skills of individuals with intellectual disabilities: a systematic review and meta-analysis.

Zarei, Hamed / Norasteh, Ali Asghar / Dehghani, Nastaran / Lieberman, Lauren J / Ertel, Michael W / Brian, Ali

Disability and rehabilitation

2024 , Page(s) 1–10

Abstract: Purpose: Motor skills are involved in many physical activities and are prerequisites for the performance of sport skills. The purpose of this systematic review was to examine the effects of exercise training programs (ETP) on the motor skills of ... ...

Abstract	Purpose: Motor skills are involved in many physical activities and are prerequisites for the performance of sport skills. The purpose of this systematic review was to examine the effects of exercise training programs (ETP) on the motor skills of individuals with intellectual disabilities (IwID). Methods: Primary sources were obtained from four databases including PubMed, SCOPUS, CENTRAL, and Web of Science. The search period covered years from inception to October 26 Results: A total of 14 studies involving 586 participants were included in the systematic review. The results of the present meta-analysis showed that ETP improved composite motor skills (1.28 95% CI: [0.86, 1.70], Conclusion: The results meta-analysis demonstrated that ETP improves the motor skills of IwID. Therefore, it is recommended to apply ETP to improve the motor skills of the IwID.
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1104775-6
ISSN	1464-5165 ; 0963-8288
ISSN (online)	1464-5165
ISSN	0963-8288
DOI	10.1080/09638288.2024.2318486
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Article: Parent American Sign Language skills correlate with child-but not toddler-ASL vocabulary size.

Berger, Lauren / Pyers, Jennie / Lieberman, Amy / Caselli, Naomi

Language acquisition

2023 Volume 31, Issue 2, Page(s) 85–99

Abstract: Most deaf children have hearing parents who do not know a sign language at birth, and are at risk of limited language input during early childhood. Studying these children as they learn a sign language has revealed that timing of first-language exposure ... ...

Abstract	Most deaf children have hearing parents who do not know a sign language at birth, and are at risk of limited language input during early childhood. Studying these children as they learn a sign language has revealed that timing of first-language exposure critically shapes language outcomes. But the input deaf children receive in their first language is not only delayed, it is much more variable than most first language learners, as many learn their first language from parents who are themselves new sign language learners. Much of the research on deaf children learning a sign language has considered the role of parent input using broad strokes, categorizing hearing parents as non-native, poor signers, and deaf parents as native, strong signers. In this study, we deconstruct these categories, and examine how variation in sign language skills among hearing parents might affect children's vocabulary acquisition. This study included 44 deaf children between 8- and 60-months-old who were learning ASL and had hearing parents who were also learning ASL. We observed an interactive effect of parent ASL proficiency and age, such that parent ASL proficiency was a significant predictor of child ASL vocabulary size, but not among the infants and toddlers. The proficiency of language models can affect acquisition above and beyond age of acquisition, particularly as children grow. At the same time, the most skilled parents in this sample were not as fluent as "native" deaf signers, and yet their children reliably had age-expected ASL vocabularies. Data and reproducible analyses are available at https://osf.io/9ya6h/.
Language	English
Publishing date	2023-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2017383-0
ISSN	1532-7817 ; 1048-9223
ISSN (online)	1532-7817
ISSN	1048-9223
DOI	10.1080/10489223.2023.2178312
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