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  1. Book ; Online ; E-Book: Opioids

    Koob, George F.

    (Neurobiology of Addiction Series ; v.Volume 4)

    2023  

    Abstract: A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Opioids, Volume 4 ... ...

    Author's details George F. Koob [and three others]
    Series title Neurobiology of Addiction Series ; v.Volume 4
    Abstract A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Opioids, Volume 4 in the series, explores the molecular, cellular and systems in the brain responsible for opioid addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation.
    Keywords Opioid abuse ; Opioids/Physiological effect
    Subject code 410.5
    Language English
    Size 1 online resource (426 pages)
    Publisher Academic Press
    Publishing place London, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 978-0-12-816989-6 ; 0-12-816989-3 ; 9780128169889 ; 0128169885
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Escaping Addiction

    Bordeaux, Patrick / Koob, George F.

    Resetting the Brain for Success

    2023  

    Author's details By Patrick Bordeaux and George F. Koob - Illustrated by Melanie Baillairge
    Keywords alcohol ; Cognitive Behavioral Therapy ; drugs ; gambling ; mindfulness ; Motivational Interviewing ; neurobiology ; neuroscience ; overcoming psychopharmacology ; recovery ; root; addiction; alcohol; Brain
    Language English
    Size 342 p.
    Publisher Rowman & Littlefield Publishers
    Document type Book
    Note PDA Manuell_24
    Format 145 x 222 x 24
    ISBN 9781538180747 ; 153818074X
    Database PDA

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  3. Book ; Online ; E-Book: Alcohol / Volume 3 /

    Koob, George F.

    (Neurobiology of Addiction ; Volume 3)

    2021  

    Abstract: This volume, Alcohol volume 3 in the series, explores the molecular, cellular, and neurocircuitry systems in the brain responsible for alcohol addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, ... ...

    Author's details edited by George F. Koob [and five others]
    Series title Neurobiology of Addiction ; Volume 3
    Abstract This volume, Alcohol volume 3 in the series, explores the molecular, cellular, and neurocircuitry systems in the brain responsible for alcohol addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. --Adapted from cover.
    Keywords Alcoholism
    Subject code 616.861
    Language English
    Size 1 online resource (402 pages)
    Publisher Academic Press is an imprint of Elsevier
    Publishing place London, United Kingdom
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-816794-7 ; 0-12-816793-9 ; 978-0-12-816794-6 ; 978-0-12-816793-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Alcohol Use Disorder Treatment: Problems and Solutions.

    Koob, George F

    Annual review of pharmacology and toxicology

    2024  Volume 64, Page(s) 255–275

    Abstract: Alcohol use disorder (AUD) afflicts over 29 million individuals and causes more than 140,000 deaths annually in the United States. A heuristic framework for AUD includes a three-stage cycle-binge/intoxication, withdrawal/negative affect, and ... ...

    Abstract Alcohol use disorder (AUD) afflicts over 29 million individuals and causes more than 140,000 deaths annually in the United States. A heuristic framework for AUD includes a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that provides a starting point for exploring the heterogeneity of AUD with regard to treatment. Effective behavioral health treatments and US Food and Drug Administration-approved medications are available but greatly underutilized, creating a major treatment gap. This review outlines challenges that face the alcohol field in closing this treatment gap and offers solutions, including broadening end points for the approval of medications for the treatment of AUD; increasing the uptake of screening, brief intervention, and referral to treatment; addressing stigma; implementing a heuristic definition of recovery; engaging early treatment; and educating health-care professionals and the public about challenges that are associated with alcohol misuse. Additionally, this review focuses on broadening potential targets for the development of medications for AUD by utilizing the three-stage heuristic model of addiction that outlines domains of dysfunction in AUD and the mediating neurobiology of AUD.
    MeSH term(s) United States ; Humans ; Alcoholism ; Behavior, Addictive ; Ethanol ; Biological Transport ; United States Food and Drug Administration
    Chemical Substances Ethanol (3K9958V90M)
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 196587-6
    ISSN 1545-4304 ; 0362-1642
    ISSN (online) 1545-4304
    ISSN 0362-1642
    DOI 10.1146/annurev-pharmtox-031323-115847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online ; E-Book: Psychostimulants

    Koob, George F. / Arends, Michael A. / McCracken, Mandy / Le Moal, Michel

    (Neurobiology of addiction series ; v. 2)

    2020  

    Author's details George F. Koob, PhD, National Institute on Alcoholism and National Institute on Drug Abuse at the National Institutes of Health, Bethesda, MD, USA, Michael A. Arends, Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA, Department of Psychiatry, University of California, San DIego, La Jolla, Ca, USA, Mandy L. McCracken, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA, Michel Le Moal, University of Bordeaux, Neurocentre Magendie, Inserm, Bordeaux, France
    Series title Neurobiology of addiction series ; v. 2
    MeSH term(s) Psychotropic Drugs
    Keywords Psychotropic drugs
    Language English
    Size 1 online resource
    Publisher Academic Press
    Publishing place London
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-816990-7 ; 978-0-12-816990-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article ; Online: NIAAA-Supported Research and the Public Discourse Around Alcohol: A Clarification Regarding Mitchell and McCambridge (2023).

    Koob, George F

    Journal of studies on alcohol and drugs

    2023  Volume 84, Issue 2, Page(s) 346–347

    MeSH term(s) United States ; Humans ; National Institute on Alcohol Abuse and Alcoholism (U.S.) ; Alcohol Drinking/epidemiology ; Alcoholism ; Ethanol
    Chemical Substances Ethanol (3K9958V90M)
    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2266450-6
    ISSN 1938-4114 ; 1934-2683 ; 1937-1888 ; 0096-882X
    ISSN (online) 1938-4114 ; 1934-2683
    ISSN 1937-1888 ; 0096-882X
    DOI 10.15288/jsad.23-00073
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  7. Book ; Online ; E-Book: Compulsive eating behavior and food addiction

    Cottone, Pietro / Sabino, Valentina / Moore, Catherine F. / Koob, George F.

    emerging pathological constructs

    2019  

    Author's details edited by Pietro Cottone, Valentina Sabino, Catherine F. Moore, George F. Koob
    Keywords Compulsive eating ; Compulsive eaters
    Subject code 616.8526
    Language English
    Size 1 Online-Ressource (xx, 475 Seiten)
    Publisher Elsevier AP Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020231861
    ISBN 978-0-12-816383-2 ; 9780128162071 ; 0-12-816383-6 ; 0128162074
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: NIAAA 50th Anniversary Festschrift: From the Editor.

    Koob, George F

    Alcohol research : current reviews

    2022  Volume 42, Issue 1, Page(s) 14

    MeSH term(s) United States ; Humans ; Anniversaries and Special Events ; National Institute on Alcohol Abuse and Alcoholism (U.S.)
    Language English
    Publishing date 2022-11-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2677485-9
    ISSN 2169-4796 ; 1930-0573 ; 2168-3492 ; 0090-838X
    ISSN (online) 2169-4796 ; 1930-0573
    ISSN 2168-3492 ; 0090-838X
    DOI 10.35946/arcr.v42.1.14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2180: Show issues Location:
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  9. Article: Anhedonia, Hyperkatifeia, and Negative Reinforcement in Substance Use Disorders.

    Koob, George F

    Current topics in behavioral neurosciences

    2022  Volume 58, Page(s) 147–165

    Abstract: Drug addiction has been defined as a chronically relapsing disorder that is characterized by a compulsion to seek and take a drug or stimulus, the loss of control in limiting intake, and the emergence of a negative emotional state when access to the drug ...

    Abstract Drug addiction has been defined as a chronically relapsing disorder that is characterized by a compulsion to seek and take a drug or stimulus, the loss of control in limiting intake, and the emergence of a negative emotional state when access to the drug or stimulus is prevented, a component of which is anhedonia. The present review explores a heuristic framework for understanding the role of anhedonia in addiction, in which anhedonia is a key component of hyperkatifeia (conceptualized as the potentiated intensity of negative emotional/motivational symptoms during drug withdrawal) and negative reinforcement in addiction. The neural substrates that mediate such anhedonia and crosstalk between elements of hyperkatifeia that contribute to anhedonia are then explored, including crosstalk between physical pain and emotional pain systems. The present review explores current knowledge of neurochemical neurocircuitry changes that are associated with conditioned hyperkatifeia/anhedonia. The overall hypothesis is that the shift in motivation toward negative reinforcement in addiction reflects the allostatic misregulation of hedonic tone, such that drug taking makes anhedonia worse during the process of seeking temporary relief by compulsive drug taking, thereby perpetuating the addiction cycle and hedonic comorbidities that are associated with addiction.
    MeSH term(s) Anhedonia ; Brain ; Humans ; Pain ; Reinforcement, Psychology ; Substance-Related Disorders/psychology
    Language English
    Publishing date 2022-02-09
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 1866-3370
    ISSN 1866-3370
    DOI 10.1007/7854_2021_288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A Basolateral Amygdala Microcircuit for Drug Craving: Is There a Craving Engram?

    Koob, George F

    Biological psychiatry

    2021  Volume 89, Issue 4, Page(s) 323–325

    MeSH term(s) Basolateral Nuclear Complex ; Cocaine ; Craving ; Cues ; Nucleus Accumbens ; Pharmaceutical Preparations
    Chemical Substances Pharmaceutical Preparations ; Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2021-01-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2020.11.008
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