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  1. Book: Oncologic critical care / Volume 1

    Nates, Joseph L. / Price, Kristen J.

    2020  

    Institution ONCCC-R-NET
    Author's details Joseph L. Nates, Kristen J. Price
    Collection Oncologic critical care
    Language English
    Size xlv, 707 Seiten, Illustrationen
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT020366517
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 222 available for loan (reading room) Lesesaal EG

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  2. Book: Oncologic critical care / Volume 2

    Nates, Joseph L. / Price, Kristen J.

    2020  

    Institution ONCCC-R-NET
    Author's details Joseph L. Nates, Kristen J. Price
    Collection Oncologic critical care
    Language English
    Size xlv Seiten, Seite 711 - 1476, Illustrationen
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT020366518
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 223 available for loan (reading room) Lesesaal EG

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  3. Book: Oncologic critical care / Volume 3

    Nates, Joseph L. / Price, Kristen J.

    2020  

    Institution ONCCC-R-NET
    Author's details Joseph L. Nates, Kristen J. Price
    Collection Oncologic critical care
    Language English
    Size xlv Seiten, Seite 1479 - 2099, Illustrationen
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT020366523
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 224 available for loan (reading room) Lesesaal EG

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  4. Book ; Collection: Oncologic critical care

    Nates, Joseph L. / Price, Kristen J.

    2020  

    Institution ONCCC-R-NET
    Author's details Joseph L. Nates, Kristen J. Price
    Keywords ICU ; infectious diseases ; neurologic diseases ; respiratory diseases ; cardiovascular diseases ; pain management
    Subject code 610
    Language English
    Size 3 Bände
    Edition First edition
    Publisher Springer Nature
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Collection (display volumes)
    HBZ-ID HT020354362
    ISBN 978-3-319-74587-9 ; 3-319-74587-5 ; 9783319745886 ; 9783319745893 ; 3319745883 ; 3319745891
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Epigenetic regulation of drug metabolism in aging: utilizing epigenetics to optimize geriatric pharmacotherapy.

    Abudahab, Sara / Slattum, Patricia W / Price, Elvin T / McClay, Joseph L

    Pharmacogenomics

    2023  Volume 25, Issue 1, Page(s) 41–54

    Abstract: We explore the relationship between epigenetic aging and drug metabolism. We review current evidence for changes in drug metabolism in normal aging, followed by a description of how epigenetic modifications associated with age can regulate the expression ...

    Abstract We explore the relationship between epigenetic aging and drug metabolism. We review current evidence for changes in drug metabolism in normal aging, followed by a description of how epigenetic modifications associated with age can regulate the expression and functionality of genes. In particular, we focus on the role of epigenome-wide studies of human and mouse liver in understanding these age-related processes with respect to xenobiotic processing. We highlight genes encoding drug metabolizing enzymes and transporters revealed to be affected by epigenetic aging in these studies. We conclude that substantial evidence exists for epigenetic aging impacting drug metabolism and transport genes, but more work is needed. We further highlight the promise of pharmacoepigenetics applied to enhancing drug safety in older adults.
    MeSH term(s) Animals ; Mice ; Humans ; Aged ; Epigenesis, Genetic/genetics ; DNA Methylation ; Aging/genetics ; Membrane Transport Proteins/genetics
    Chemical Substances Membrane Transport Proteins
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2023-0199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: The Efficacy of Cannabis in Reducing Back Pain: A Systematic Review.

    Price, Richard L / Charlot, Kaarina V / Frieler, Sven / Dettori, Joseph R / Oskouian, Rod / Chapman, Jens R

    Global spine journal

    2022  Volume 12, Issue 2, Page(s) 343–352

    Abstract: Objective: To critically analyze the evidence and efficacy of cannabis to treat surgical and nonsurgical back pain via a Systematic Review.: Methods: We conducted a systematic review to investigate the efficacy of cannabis to treat non-surgical and ... ...

    Abstract Objective: To critically analyze the evidence and efficacy of cannabis to treat surgical and nonsurgical back pain via a Systematic Review.
    Methods: We conducted a systematic review to investigate the efficacy of cannabis to treat non-surgical and surgical back pain. A literature search was performed with MEDLINE and Embase databases. Only RCTs and prospective cohort studies with concurrent control were included in this study. Risk of bias and quality grading was assessed for each included study.
    Results: Database searches returned 1738 non-duplicated results. An initial screening excluded 1716 results. Twenty-two full text articles were assessed for eligibility. Four articles ultimately met pre-determined eligibility and were included in the study. Two studies addressed post-SCI pain while other two studies addressed low back pain. No studies specifically examined the use of cannabis for surgical back pain. The type of cannabis varied between study and included THC, dronabinol, and Nabilone. A total of 110 patients were included in the four studies reviewed. In each study, there was a quantifiable advantage of cannabis therapy for alleviating back pain. There were no serious adverse effects reported.
    Conclusions: In all articles, cannabis was shown to be effective to treat back pain with an acceptable side effect profile. However, long-term follow up is lacking. As medicinal cannabis is being used more commonly for analgesic effect and patients are "self-prescribing" cannabis for back pain, additional studies are needed for healthcare providers to confidently recommend cannabis therapy for back pain.
    Study design: Systematic review.
    Language English
    Publishing date 2022-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2648287-3
    ISSN 2192-5690 ; 2192-5682
    ISSN (online) 2192-5690
    ISSN 2192-5682
    DOI 10.1177/21925682211065411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Efficacy of Control-IQ Technology in a General Endocrine Clinic.

    Usoh, Chinenye O / Price, Catherine / Johnson, Crystal Paige / Speiser, Jaime L / Aloi, Joseph A

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2022  

    Abstract: Objective: Recent advances in technology have allowed for the expanded use of hybrid closed-loop insulin pump therapy and automated insulin delivery systems for the management of diabetes mellitus. We assessed the outcomes of introducing Tandem t:slim ... ...

    Abstract Objective: Recent advances in technology have allowed for the expanded use of hybrid closed-loop insulin pump therapy and automated insulin delivery systems for the management of diabetes mellitus. We assessed the outcomes of introducing Tandem t:slim X2 with the Control-IQ technology in a general endocrine clinic.
    Methods: Data from 66 adults with type 1 (n = 61) and type 2 (n = 5) diabetes mellitus were aggregated for analysis. Patients were either transitioned from traditional insulin pump therapy or multiple daily injection therapy to Tandem t:slim X2 with the Control-IQ technology from January 2020 to June 2021. The assessed clinical end points included changes in time below range, time above range, and time in target range. Changes in hemoglobin A1C before and after Control-IQ technology implementation were noted. The primary outcome was a change in time in target range with the Control-IQ technology.
    Results: There was a significant increase in time in target range when comparing pre- and post-Control-IQ technology (49.5% vs 63.3%, P < .0003) values. There was a reduction in time above range (46.8% vs 34.9%, P < .0013), a decrease in time below range (4.0% vs 1.7%, P = .017), and a decrease in hemoglobin A1C after transitioning to the Control-IQ technology (7.7% [61 mmol/mol] vs 7.1% [54 mmol/mol], P < .017). The patient dropout rate was low (7%).
    Conclusion: The Control-IQ technology system was effective in reducing hyperglycemia while increasing time in target range and decreasing hypoglycemia. This technology is a useful and effective addition to the growing number of automated insulin delivery systems. The clinical outcomes mirror the results found in the key adult pivotal trials.
    Language English
    Publishing date 2022-10-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.1016/j.eprac.2022.10.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5034: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 508: Show issues

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  8. Article ; Online: Case study of invalid to valid shift in cognitive performance following successful treatment of psychogenic nonepileptic seizure events.

    Drane, Daniel L / Hewitt, Kelsey C / Price, Michele E / Rush, Beth K / Blackmon, Karen / Okada, Noah / Shade, Taylor / Valentin, Edward / Vinson, Joseph / Rosen, Phyllis / Loring, David W

    Journal of clinical and experimental neuropsychology

    2024  Volume 45, Issue 10, Page(s) 1024–1038

    Abstract: Patients with psychogenic nonepileptic seizure (PNES) who fail performance validity testing (PVT) may appear to produce non-valid cognitive profiles. Consequently, they may not get referred to treatment and events persist, with worsening disability and ... ...

    Abstract Patients with psychogenic nonepileptic seizure (PNES) who fail performance validity testing (PVT) may appear to produce non-valid cognitive profiles. Consequently, they may not get referred to treatment and events persist, with worsening disability and high resource utilization. As a result, we report pre- and post-treatment neuropsychological evaluation findings in a 59-year-old woman with a confirmed diagnosis of PNES established using video-EEG monitoring. At pre-treatment baseline neuropsychological evaluation, PNES events occurred weekly to daily. Performance was impaired across PVTs and across multiple cognitive domains. After behavioral intervention specific to PNES, these events substantially reduced in frequency to rare stress-induced flares. Post-treatment neuropsychological evaluation revealed marked improvement of most cognitive and behavioral scores from baseline, and valid PVT scores. We review predisposing, precipitating, and perpetuating factors for PNES and cognitive impairment in this case and discuss the patient's outcome from treatment. Effectively managing PNES events and dissociative tendencies while reducing unnecessary pharmacological interventions appears to have allowed this patient to function closer to her optimal state. This case illustrates the complexity of Functional Neurologic Disorder (FND) clinical presentation and challenges the assumption that suboptimal neuropsychological performance predicts poor treatment engagement and outcome. We showcase the reversibility of PNES and cognitive manifestations of FND using targeted psychotherapeutic interventions, which resulted in reduced disability and associated healthcare costs, as well as re-engagement in life.
    MeSH term(s) Humans ; Female ; Middle Aged ; Seizures/therapy ; Neuropsychological Tests/standards ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/therapy ; Cognitive Dysfunction/physiopathology ; Psychophysiologic Disorders/therapy ; Electroencephalography
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Case Reports ; Review ; Journal Article
    ZDB-ID 605982-x
    ISSN 1744-411X ; 0168-8634 ; 1380-3395
    ISSN (online) 1744-411X
    ISSN 0168-8634 ; 1380-3395
    DOI 10.1080/13803395.2024.2335600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2393: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: SNP-to-gene linking strategies reveal contributions of enhancer-related and candidate master-regulator genes to autoimmune disease.

    Dey, Kushal K / Gazal, Steven / van de Geijn, Bryce / Kim, Samuel Sungil / Nasser, Joseph / Engreitz, Jesse M / Price, Alkes L

    Cell genomics

    2022  Volume 2, Issue 7

    Abstract: We assess contributions to autoimmune disease of genes whose regulation is driven by enhancer regions (enhancer-related) and genes that regulate other genes ... ...

    Abstract We assess contributions to autoimmune disease of genes whose regulation is driven by enhancer regions (enhancer-related) and genes that regulate other genes in
    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Journal Article
    ISSN 2666-979X
    ISSN (online) 2666-979X
    DOI 10.1016/j.xgen.2022.100145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cardiovascular health assessment in routine cancer follow-up in community settings: survivor risk awareness and perspectives.

    Weaver, Kathryn E / Dressler, Emily V / Smith, Sydney / Nightingale, Chandylen L / Klepin, Heidi D / Lee, Simon Craddock / Wells, Brian J / Hundley, W Gregory / DeMari, Joseph A / Price, Sarah N / Foraker, Randi E

    BMC cancer

    2024  Volume 24, Issue 1, Page(s) 158

    Abstract: Background: Guidelines recommend cardiovascular risk assessment and counseling for cancer survivors. For effective implementation, it is critical to understand survivor cardiovascular health (CVH) profiles and perspectives in community settings. We ... ...

    Abstract Background: Guidelines recommend cardiovascular risk assessment and counseling for cancer survivors. For effective implementation, it is critical to understand survivor cardiovascular health (CVH) profiles and perspectives in community settings. We aimed to (1) Assess survivor CVH profiles, (2) compare self-reported and EHR-based categorization of CVH factors, and (3) describe perceptions regarding addressing CVH during oncology encounters.
    Methods: This cross-sectional analysis utilized data from an ongoing NCI Community Oncology Research Program trial of an EHR heart health tool for cancer survivors (WF-1804CD). Survivors presenting for routine care after potentially curative treatment recruited from 8 oncology practices completed a pre-visit survey, including American Heart Association Simple 7 CVH factors (classified as ideal, intermediate, or poor). Medical record abstraction ascertained CVD risk factors and cancer characteristics. Likert-type questions assessed desired discussion during oncology care.
    Results: Of 502 enrolled survivors (95.6% female; mean time since diagnosis = 4.2 years), most had breast cancer (79.7%). Many survivors had common cardiovascular comorbidities, including high cholesterol (48.3%), hypertension or high BP (47.8%) obesity (33.1%), and diabetes (20.5%); 30.5% of survivors received high cardiotoxicity potential cancer treatment. Less than half had ideal/non-missing levels for physical activity (48.0%), BMI (18.9%), cholesterol (17.9%), blood pressure (14.1%), healthy diet (11.0%), and glucose/ HbA1c (6.0%). While > 50% of survivors had concordant EHR-self-report categorization for smoking, BMI, and blood pressure; cholesterol, glucose, and A1C were unknown by survivors and/or missing in the EHR for most. Most survivors agreed oncology providers should talk about heart health (78.9%).
    Conclusions: Tools to promote CVH discussion can fill gaps in CVH knowledge and are likely to be well-received by survivors in community settings.
    Trial registration: NCT03935282, Registered 10/01/2020.
    MeSH term(s) Female ; Humans ; Male ; Blood Pressure ; Breast Neoplasms ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cholesterol ; Cross-Sectional Studies ; Follow-Up Studies ; Glucose ; Health Status ; Risk Assessment ; Risk Factors ; Survivors ; United States ; Clinical Trials as Topic
    Chemical Substances Cholesterol (97C5T2UQ7J) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-024-11912-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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