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Article ; Online: Hybrid cardiac imaging: complementary roles of CT angiography and PET in a patient with a history of radiation therapy.

Hong, Eric C T / Kimura-Hayama, Eric T / Di Carli, Marcelo F

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

2007 Volume 14, Issue 4, Page(s) 617–620

MeSH term(s)	Coronary Angiography/methods ; Echocardiography, Transesophageal/methods ; Hodgkin Disease/radiotherapy ; Humans ; Male ; Middle Aged ; Pericarditis/etiology ; Positron-Emission Tomography/methods ; Radiation Injuries ; Radiotherapy/adverse effects ; Radiotherapy/methods ; Risk Factors ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2007-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1212505-2
ISSN	1532-6551 ; 1071-3581
ISSN (online)	1532-6551
ISSN	1071-3581
DOI	10.1016/j.nuclcard.2007.05.002
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Article ; Online: Left ventricular noncompaction: a proposal of new diagnostic criteria by multidetector computed tomography.

Melendez-Ramirez, Gabriela / Castillo-Castellon, Francisco / Espinola-Zavaleta, Nilda / Meave, Aloha / Kimura-Hayama, Eric T

Journal of cardiovascular computed tomography

2012 Volume 6, Issue 5, Page(s) 346–354

Abstract: Background: Left ventricular noncompaction (LVNC) is a cardiomyopathy characterized by a noncompacted myocardial layer in the left ventricle, primarily diagnosed by echocardiographic and magnetic resonance criteria. Multidetector computed tomography ( ... ...

Abstract	Background: Left ventricular noncompaction (LVNC) is a cardiomyopathy characterized by a noncompacted myocardial layer in the left ventricle, primarily diagnosed by echocardiographic and magnetic resonance criteria. Multidetector computed tomography (MDCT) is an imaging method that has been increasingly used in cardiac evaluation. However, tomographic criteria to diagnose LVNC have not been determined. Objectives: We assessed the structural characteristics of LVNC with MDCT and proposed tomographic criteria that may differentiate LVNC from healthy subjects and patients with other cardiomyopathies that might be associated with increased myocardial trabeculation. Methods: Between March 2007 and June 2009 we studied 10 consecutive patients with LVNC diagnosed by echocardiogram and/or magnetic resonance imaging who underwent electrocardiogram-gated coronary CT angiography. We evaluated the ratio of noncompacted to compacted myocardium (NC/C ratio) in end diastole in each of the 17 segments established by the American Heart Association (excluding the apex). The results were compared with 9 healthy subjects, 14 patients with hypertrophic cardiomyopathy, and 17 patients with dilated cardiomyopathy to determine the cutoff that would distinguish patients with LVNC. Results: When considering involvement of more than 1 segment, the NC/C ratio of 2.2 distinguished pathologic noncompaction, with sensitivity and specificity of 100% and 95%, respectively. In addition, the involvement of ≥2 segments allows the distinction of all patients with LVNC from other cardiomyopathies and from healthy subjects. Conclusions: LVNC can be accurately diagnosed with MDCT when using a cutoff NC/C ratio of 2.2 at end diastole involving ≥2 segments.
MeSH term(s)	Adult ; Analysis of Variance ; Contrast Media ; Diagnosis, Differential ; Female ; Heart Ventricles/diagnostic imaging ; Humans ; Iopamidol ; Isolated Noncompaction of the Ventricular Myocardium/diagnostic imaging ; Male ; Middle Aged ; Multidetector Computed Tomography/methods ; Radiographic Image Enhancement/methods ; Radiographic Image Interpretation, Computer-Assisted/methods ; Sensitivity and Specificity ; Young Adult
Chemical Substances	Contrast Media ; Iopamidol (JR13W81H44)
Language	English
Publishing date	2012-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2394360-9
ISSN	1876-861X ; 1934-5925
ISSN (online)	1876-861X
ISSN	1934-5925
DOI	10.1016/j.jcct.2012.07.001
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Article: Hepatic steatosis as an independent risk factor for severe disease in patients with COVID-19: A computed tomography study

Palomar-Lever, Andres / Barraza, Gustavo / Galicia-Alba, Julieta / Echeverri-Bolaños, Melissa / Escarria-Panesso, Robert / Padua-Barrios, Jorge / Halabe-Cherem, Jose / Hernandez-Molina, Gabriela / Chargoy-Loustaunau, Talia Nila / Kimura-Hayama, Eric

Abstract: ... 967;2 and t student tests, logistic regression, and reported odds ratio (OR) with 95 ...

Abstract	Background and Aim: Hepatic steatosis (HS) is associated with diabetes, hypertension, and obesity, comorbidities recently related to COVID-19 severity. Here, we assessed if tomographic HS is also a risk factor for severe COVID-19 pneumonia. Methods: We included 213 patients with a positive real time polymerase chain reaction (RT-PCR) test and chest computed tomography (CT) from an out-hospital facility and a hospital. We obtained information on demographics; weight; height; smoking history; diabetes; hypertension; and cardiovascular, lung, and renal disease. Two radiologists scored the CO-RADs system (COVID-19 Reporting and Data System) (1 = normal, 2 = inconsistent, 3-4 = indeterminate, and 5 = typical findings) and the chest CT severity index (≥20 of 40 was considered severe disease). They evaluated the liver-to-spleen ratio (CTL/S) and defined tomographic steatosis as a CTL/S index ≤0.9. We used descriptive statistics, χ2 and t student tests, logistic regression, and reported odds ratio (OR) with 95% confidence interval (CI). Results: Of the patients, 61% were men, with a mean age of 51.2 years, 48.3% were CO-RADs 1 and 51.7% CO-RADs 2-5. Severe tomographic disease was present in 103 patients (48.4%), all CO-RADs 5. This group was older; mostly men; and with a higher prevalence of obesity, hypertension, diabetes, and HS (69.9 vs 29%). On multivariate analysis, age (OR 1.058, 95% CI 1.03-1.086, P < 0.0001), male gender (OR 1.9, 95% CI 1.03-3.8, P = 0.04), and HS (OR 4.9, 95% CI 2.4-9.7, P < 0.0001) remained associated. Conclusion: HS was independently associated with severe COVID pneumonia. The physiopathological explanation of this finding remains to be elucidated. CTL/S should be routinely measured in thoracic CT scans in patients with COVID-19 pneumonia.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #693238
Database	COVID19

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Article ; Online: Dental multisection CT for the placement of oral implants: technique and applications.

Saavedra-Abril, Jaime A / Balhen-Martin, Claudia / Zaragoza-Velasco, Kena / Kimura-Hayama, Eric T / Saavedra, Santiago / Stoopen, Miguel E

Radiographics : a review publication of the Radiological Society of North America, Inc

2010 Volume 30, Issue 7, Page(s) 1975–1991

Abstract: Dental computed tomography (CT) is a diagnostic examination for the preoperative evaluation of patients who will undergo placement of oral implants. It can be performed with multidetector CT or more recently with cone-beam CT. The growing older ... ...

Abstract	Dental computed tomography (CT) is a diagnostic examination for the preoperative evaluation of patients who will undergo placement of oral implants. It can be performed with multidetector CT or more recently with cone-beam CT. The growing older population and the consequent development of edentulism have increased the number of imaging studies performed for preoperative evaluation of dental implantation. Thus, radiologists are becoming more frequently involved in this type of testing. Dental CT is superior to conventional x-ray techniques because superimposition and distortion are eliminated; therefore, possible complications such as injury of the neurovascular bundle and perforation of the maxillary sinuses can be avoided. This noninvasive and fast method provides accurate information about the positions of important structures to allow one to determine the implant required. Dental CT enables analysis of the state, quality, and quantity of bone on two-dimensional and three-dimensional reformatted images, and its high spatial resolution allows exact measurements of the length and width of the alveolar ridge. Inclusion of all this information in the radiology report facilitates achievement of a successful implantation.
MeSH term(s)	Dental Implantation/methods ; Humans ; Radiography, Dental/methods ; Surgery, Computer-Assisted/methods ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2010-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.307105026
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Article ; Online: Uncommon congenital and acquired aortic diseases: role of multidetector CT angiography.

Kimura-Hayama, Eric T / Meléndez, Gabriela / Mendizábal, Ana L / Meave-González, Aloha / Zambrana, Greby Fernando B / Corona-Villalobos, Celia P

Radiographics : a review publication of the Radiological Society of North America, Inc

2010 Volume 30, Issue 1, Page(s) 79–98

Abstract: State-of-the-art multidetector computed tomographic (CT) technology has replaced invasive angiography for evaluation of patients suspected to have aortic disease. Although most aortic disease is associated with atherosclerosis (ie, aneurysms and ... ...

Abstract	State-of-the-art multidetector computed tomographic (CT) technology has replaced invasive angiography for evaluation of patients suspected to have aortic disease. Although most aortic disease is associated with atherosclerosis (ie, aneurysms and dissection), the spectrum of aortic disease is vast and includes various congenital and acquired entities. Radiologists should also be familiar with uncommon aortic diseases, which are divided into those that are congenital in origin and acquired disorders, and with their findings at multidetector CT. The first group includes patent ductus arteriosus, aortic hypoplasia, aortic coarctation, interrupted aortic arch, aortopulmonary window, common arterial trunk, supravalvular aortic stenosis, and vascular rings. The acquired disorders include aortic dissection due to extension of a coronary artery dissection, Marfan syndrome, large-vessel vasculitis such as Takayasu arteritis, and mycotic aneurysms. Finally, specific conditions associated with therapeutic maneuvers--such as recoarctation, stent-graft rupture, and endoleaks--can also be assessed with multidetector CT. Multidetector CT is an alternative tool helpful in establishing the primary diagnosis, defining anatomic landmarks and their relationships, and identifying associated cardiovascular anomalies. It is also an adjunct in the evaluation of complications during follow-up.
MeSH term(s)	Adult ; Aged ; Angiography/methods ; Aortic Diseases/congenital ; Aortic Diseases/diagnostic imaging ; Aortography/methods ; Female ; Humans ; Infant, Newborn ; Male ; Middle Aged ; Rare Diseases/diagnostic imaging ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2010-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.301095061
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Article ; Online: Single nucleotide polymorphisms within LIPA (Lysosomal Acid Lipase A) gene are associated with susceptibility to premature coronary artery disease. a replication in the genetic of atherosclerotic disease (GEA) Mexican study.

Vargas-Alarcón, Gilberto / Posadas-Romero, Carlos / Villarreal-Molina, Teresa / Alvarez-León, Edith / Angeles, Javier / Vallejo, Maite / Posadas-Sánchez, Rosalinda / Cardoso, Guillermo / Medina-Urrutia, Aida / Kimura-Hayama, Eric

PloS one

2013 Volume 8, Issue 9, Page(s) e74703

Abstract: ... additive models, the rs1412444 T and rs2246833 T alleles were associated with an increased risk of premature CAD ... analyzed in premature CAD and controls (CAC score = 0). The T alleles in both polymorphisms after adjusting ...

Abstract	Aim: The rs1412444 and rs2246833 polymorphisms within the LIPA gene were recently found to be significantly associated with coronary artery disease (CAD) in genome-wide association studies in Caucasian and Asian populations. The aim of the present study was to replicate this association in an independent population with a different genetic background. Methods: The rs1412444 and rs2246833 polymorphisms of the LIPA gene were genotyped by 5' exonuclease TaqMan genotyping assays in a sample of 899 Mexican patients with premature CAD, 270 individuals with subclinical atherosclerosis, and 677 healthy unrelated controls. Haplotypes were constructed after linkage disequilibrium analysis. Results: Under recessive and additive models, the rs1412444 T and rs2246833 T alleles were associated with an increased risk of premature CAD when compared to controls adjusting for age, gender, BMI, and total cholesterol (OR = 1.53, PRec = 0.0013 and OR = 1.34, PAdd = 5 × 10(-4) for rs1412444 and OR = 1.45, PRec = 0.0039 and OR = 1.28, PAdd = 0.0023 for rs2246833). The effect of the two polymorphisms on various metabolic cardiovascular risk factors was analyzed in premature CAD and controls (CAC score = 0). The T alleles in both polymorphisms after adjusting for age, gender, BMI, and medication were associated with hypo-α-lipoproteinemia, hypercholesterolemia, hypertriglyceridemia, metabolic syndrome, and type 2 diabetes mellitus using recessive and additive models. The polymorphisms were in strong linkage disequilibrium and, based on SNP functional prediction software, only the rs1412444 polymorphism seemed to be functional. Conclusions: These results indicate that the rs1412444 and rs2246833 of the LIPA gene are shared susceptibility polymorphisms for CAD among different ethnicities.
MeSH term(s)	Adult ; Aged ; Alleles ; Coronary Artery Disease/genetics ; Coronary Artery Disease/metabolism ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Mexico/ethnology ; Middle Aged ; Odds Ratio ; Polymorphism, Single Nucleotide ; Risk Factors ; Sterol Esterase/genetics
Chemical Substances	LIPA protein, human (EC 3.1.1.13) ; Sterol Esterase (EC 3.1.1.13)
Language	English
Publishing date	2013-09-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0074703
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Article ; Online: TIMP2 gene polymorphisms are associated with hypertension in patients with myocardial infarction.

Rodríguez-Pérez, José Manuel / Martínez-Rodríguez, Nancy / Vargas-Alarcón, Gilberto / Vallejo, Maite / Monroy-Muñoz, Irma Eloisa / Posadas-Romero, Carlos / Kimura-Hayama, Eric / Juárez-Cedillo, Teresa / Fragoso, José Manuel / Pérez-Hernández, Nonanzit

Journal of genetics

2014 Volume 93, Issue 2, Page(s) 517–522

MeSH term(s)	Aged ; Case-Control Studies ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Hypertension/genetics ; Male ; Middle Aged ; Myocardial Infarction/genetics ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Tissue Inhibitor of Metalloproteinase-2/genetics
Chemical Substances	TIMP2 protein, human ; Tissue Inhibitor of Metalloproteinase-2 (127497-59-0)
Language	English
Publishing date	2014-09-04
Publishing country	India
Document type	Journal Article
ZDB-ID	3039-9
ISSN	0973-7731 ; 0958-8361 ; 0022-1333
ISSN (online)	0973-7731
ISSN	0958-8361 ; 0022-1333
DOI	10.1007/s12041-014-0388-6
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Article: Valor predictivo de la tomografía multicorte para evaluar lesiones obstructivas coronarias, en el preoperatorio de cirugía cardiaca no coronaria.

Trevethan-Cravioto, Sergio / Cossío-Aranda, Jorge / Martínez-Ríos, Marco A / Arias-González, José A / Vallejo, Enrique / Meave, Aloha / Kimura-Hayama, Eric

Archivos de cardiologia de Mexico

2011 Volume 81, Issue 2, Page(s) 75–81

Abstract: ... Analysis showed than CAC>400 UA (Coef β 0,351, t = 4.402 p = 0.000) and male gender (Coef β 0,179, t = 2 ...

Title translation	Predictive value of multi-sliced computed tomography to evaluate obstructive coronary vessel, in the preoperative assessment of non-coronary cardiac surgery.
Abstract	Introduction: Significant Coronary Artery Disease (CAD>50%) it can easily detected with Multislice Computed Tomography (MSCT), nevertheless if MSCT may replace Invasive Coronary Angiography (ICA) in the preoperative assessment of the patient undergoing to non-coronary cardiac surgery is not well defined. The objective of this study was to know if the MSCT can replace ICA in the preoperative valuation of patients who go to cardiac surgery Method: 64 consecutive patients in Class I recommendation of American College of Cardiology / American Heart Association (ACC/AHA) guidelines for preoperative ICA were evaluated. Patients with angina, contrast medium allergy, serum creatinine up to 2.0 mg/dL, previous coronary cardiac surgery or coronary angioplasty and supraventricular arrhythmias were excluded. Both, Coronary artery calcium (CAC) and coronary angiography were evaluated. Results: The prevalence of significant (>50%) CAD was 12.5%. The Sensitivity of MSCT to detect significant CAD was 87.5%, its Specificity of 92.8%, Predictive Negative Value was 98.1% and Area Under the Curve (ROC analysis) = 0.90. Anyone with Rheumatic Valvular Disease had significant CAD or CAC>400 UA (RR = 0.80, IC95% 0.69-0.94). Degenerative Aortic Valve Stenosis had a major probability of significant CAD (RR of 9.0; IC 95% 1.64-49.80). Logistic Regression Analysis showed than CAC>400 UA (Coef β 0,351, t = 4.402 p = 0.000) and male gender (Coef β 0,179, t = 2.445, p = 0.017), were the best predicting variables of CAD. This study shows different populations in patients undergoing to non-coronary cardiac surgery. Conclusions: Gender, CAC> 400 UA and type of cardiac disease previously surgery may be useful for triage to MSCT or ICA in the preoperative assessment. This study shows that ICA may be necessarily indicated in some patients in assessment of non-coronary cardiac surgery but not absolutely indicated in all patients that Guidelines of ACC/AHA have recommended.
MeSH term(s)	Cardiac Surgical Procedures ; Coronary Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Female ; Humans ; Male ; Middle Aged ; Multidetector Computed Tomography ; Predictive Value of Tests ; Preoperative Care
Language	Spanish
Publishing date	2011-04
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	2047800-8
ISSN	1405-9940
ISSN	1405-9940
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Article ; Online: Neurocysticercosis: radiologic-pathologic correlation.

Kimura-Hayama, Eric T / Higuera, Jesús A / Corona-Cedillo, Roberto / Chávez-Macías, Laura / Perochena, Anamari / Quiroz-Rojas, Laura Yadira / Rodríguez-Carbajal, Jesús / Criales, José L

Radiographics : a review publication of the Radiological Society of North America, Inc

2010 Volume 30, Issue 6, Page(s) 1705–1719

Abstract: ... the differential diagnosis. Imaging findings depend on several factors, including the stage of the life cycle of T solium ...

Abstract	Neurocysticercosis is a neurologic parasitic disease caused by the encysted larva of the tapeworm Taenia solium and is the most important parasitic disease of the human central nervous system. It is the most common cause of acquired epilepsy in endemic settings and constitutes a public health challenge for most of the developing world. Nowadays, however, as a result of globalization, neurocysticercosis is being seen more frequently in developed countries as well. Neurocysticercosis is acquired through fecal-oral contamination, and the disease course is complex, with two intermediate hosts (ie, pigs and humans) and a definitive host (humans). Traditionally, it has been classified into active and nonactive forms according to disease location. Radiologists must be aware of its imaging appearance, which is quite variable, as is the differential diagnosis. Imaging findings depend on several factors, including the stage of the life cycle of T solium at presentation; the number and location (ie, subarachnoid, cisternal, or intraventricular) of parasites; and associated complications such as vascular involvement (ie, arteritis with or without infarction), inflammatory response (ie, edema, gliosis, or arachnoiditis), and, in ventricular forms, degree of obstruction. Thus, the diagnostic approach, management, and prognosis for neurocysticercosis differ widely depending on the type of infection.
MeSH term(s)	Animals ; Anthelmintics/therapeutic use ; Diagnosis, Differential ; Diagnostic Imaging ; Humans ; Life Cycle Stages ; Neurocysticercosis/diagnosis ; Neurocysticercosis/drug therapy ; Neurocysticercosis/epidemiology ; Neurocysticercosis/physiopathology ; Taenia solium/growth & development ; Taenia solium/physiology
Chemical Substances	Anthelmintics
Language	English
Publishing date	2010-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.306105522
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Article ; Online: IL-24 gene polymorphisms are associated with cardiometabolic parameters and cardiovascular risk factors but not with premature coronary artery disease: the genetics of atherosclerotic disease Mexican study.

Vargas-Alarcón, Gilberto / Posadas-Romero, Carlos / Villarreal-Molina, Teresa / Alvarez-León, Edith / Angeles-Martinez, Javier / Posadas-Sanchez, Rosalinda / Monroy-Muñoz, Irma / Luna-Fuentes, Sergio / González-Salazar, Carmen / Ramirez-Bello, Julian / Cardoso-Saldaña, Guillermo / Medina-Urrutia, Aida / Kimura-Hayama, Eric

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

2014 Volume 34, Issue 9, Page(s) 659–666

Abstract: Coronary artery disease (CAD) is a multifactorial and polygenic disorder that results from an excessive inflammatory response. We analyzed whether interleukin-24 (IL-24) gene polymorphisms are associated with premature CAD in a case-control association ... ...

Abstract	Coronary artery disease (CAD) is a multifactorial and polygenic disorder that results from an excessive inflammatory response. We analyzed whether interleukin-24 (IL-24) gene polymorphisms are associated with premature CAD in a case-control association study. Four polymorphisms (rs1150253, rs1150256, rs1150258, and rs3762344) of the IL-24 gene were analyzed by 5' exonuclease TaqMan genotyping assays in a group of 952 patients with premature CAD, 284 individuals with subclinical atherosclerosis (SA), and 912 controls. The studied polymorphisms were not associated with the risk of premature CAD or SA (P>0.05). Under dominant models adjusted for age, sex, body mass index, and medication, the polymorphisms were associated with cardiometabolic parameters and cardiovascular risk factors. Three polymorphisms (rs1150253, rs1150256, and rs3762344) were associated with hypertension and increased levels of systolic blood pressure in controls. In SA, 2 polymorphisms (rs1150256 and rs3762344) were associated with type 2 diabetes mellitus, gamma-glutamyl transpeptidase (GGT), and alkaline phosphatase, whereas rs1150253 was associated with GGT and type 2 diabetes mellitus and rs1150258 with GGT and alkaline phosphatase. In premature CAD, the 4 polymorphisms were associated with total cholesterol >200 mg/dL, low-density lipoprotein cholesterol (LDL-C), and GGT, whereas rs1150256 was associated also with ApoA. On the other hand, rs1150258 was associated with ApoA, LDL-C >100 mg/dL, and apoB/apoA ratio, and rs3762344 with ApoA, apoB/apoA ratio, LDL-C >100 mg/dL, and total cholesterol. On the basis of single-nucleotide polymorphism functional prediction software, rs1150253 and rs1150258 polymorphisms seem to be functional. The 4 studied polymorphisms were in linkage disequilibrium and had a similar haplotype distribution in patients and controls. Our study demonstrates the association of IL-24 polymorphisms with metabolic and cardiovascular risk factors in individuals with premature CAD, SA, and controls.
MeSH term(s)	Atherosclerosis/genetics ; Case-Control Studies ; Coronary Artery Disease/genetics ; Diabetes Mellitus, Type 2/genetics ; Female ; Genetic Predisposition to Disease ; Genotype ; Haplotypes ; Humans ; Interleukins/genetics ; Linkage Disequilibrium ; Male ; Mexico ; Middle Aged ; Polymorphism, Single Nucleotide ; Risk ; Risk Factors
Chemical Substances	Interleukins ; interleukin-24
Language	English
Publishing date	2014-02-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1226675-9
ISSN	1557-7465 ; 1079-9907
ISSN (online)	1557-7465
ISSN	1079-9907
DOI	10.1089/jir.2013.0081
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