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Article ; Conference proceedings: Severity, Distribution and Postoperative Therapy are not Predictors of Return to Work in Western Performance Horses with Stifle Chondromalacia

Esselman, A. M. / Johnson, S. A. / Hague, B. A. / Frisbie, D. D.

2024 Volume 07, Issue S 01

Event/congress	2024 American College of Veterinary Sports Medicine and Rehabilitation Symposium Scientific/Clinical Abstract Sessions, Arthrex Campus, Naples, Florida, United States, 2024-04-11
Language	English
Publishing date	2024-01-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2934191-7
ISSN	2625-2325 ; 2625-2325
ISSN (online)	2625-2325
ISSN	2625-2325
DOI	10.1055/s-0044-1786228
Database	Thieme publisher's database

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Article ; Online: What the COVID pandemic taught us about the management of pediatric minor trauma.

Plonczak, A M / Dole, H P / Pimblett, V / Conway, L / Hague, A / Falder, S

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2023 Volume 84, Page(s) 334–340

Abstract: The COVID-19 pandemic necessitated a change in our practice in the management of pediatric soft-tissue injuries. Patients were managed conservatively whenever possible. Our aim in this study was to see whether this more conservative approach adversely ... ...

Abstract	The COVID-19 pandemic necessitated a change in our practice in the management of pediatric soft-tissue injuries. Patients were managed conservatively whenever possible. Our aim in this study was to see whether this more conservative approach adversely affected clinical, and patient-reported outcomes, including scarring. A prospective record of children presenting to the plastic surgery "Early Bird" clinic for pediatric trauma between 01.04.2020 and 30.06.2020 was kept. Electronic patient records were reviewed. An outpatient telephone clinic was scheduled for all patients. Parents were asked about complications and what they thought about the scar and to rate it as either: "poor," "satisfactory," "good," or "excellent." There were 240 patients, including 136 (57%) males and 104 (43%) females. The most frequent type of injury was a facial laceration in 123 patients (51.3%), followed by hand lacerations in 43 (17.9%), fingertip injuries in 31 (12.9%), and others. Ninety out of 240 (37.5%) were offered surgery. Follow-up times ranged from 17 to 20 months. Most parents (86.2%) were happy with the scarring and reported it as "good" or "excellent." The proportion rating the scar "excellent" or "good" was similar in the non-operated cohort (i.e., 85.5%) versus the operated cohort (88.5%) (p-value 0.16). The overall complication rate of patients seen during this time was 5.9%; 7.4% in the conservatively managed and 4.9% of those who went to the theater. Despite managing more wounds, including some dog bites, conservatively, patients and parents reported low complication rates and high levels of satisfaction with the final scarring.
MeSH term(s)	Male ; Female ; Animals ; Dogs ; Humans ; Cicatrix ; Pandemics ; Prospective Studies ; COVID-19/epidemiology ; Lacerations/surgery ; Retrospective Studies
Language	English
Publishing date	2023-05-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2023.05.055
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Article ; Online: Gp120 Binds Cooperatively to Several Biologically Relevant Glycosphingolipids: Quantitative Measurements at Equilibrium by Total Internal Reflection Fluorescence Microscopy This research was supported by the NIH (AI40359-02), the NSF (CHE-9726132 and CHE-9623583), Eli Lilly (JGH), and the Alfred P. Sloan Foundation (J.G.H.). K.D.M. gratefully acknowledges receipt of the University of Arizona Dean's Fellowship and the Department of Chemistry Carl S. Marvel Fellowship. We thank Ying-Mei Gu for performing the streptavidin adsorption measurements.

Conboy / McReynolds / Gervay-Hague / Saavedra

Angewandte Chemie (International ed. in English)

2000 Volume 39, Issue 16, Page(s) 2882–2884

Language	English
Publishing date	2000-10-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/1521-3773(20000818)39:16<2882::aid-anie2882>3.0.co;2-m
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Article ; Online: How Perceptions of Aging Influence Physical Activity and Exercise in Older Age: Exploring the Behavior of People Aged 70+ Years Engaged in Fall Prevention Activities.

Ambrens, Meghan / Macniven, Rona / Perram, Amy / Andrews, Sophie / Hawley-Hague, Helen / Razee, Husna / Todd, Chris / Valenzuela, Trinidad / Delbaere, Kim

Journal of applied gerontology : the official journal of the Southern Gerontological Society

2024 , Page(s) 7334648241238315

Abstract: For older people, physical inactivity increases fall risk as well as other preventable health conditions. Despite the well-documented benefits of physical activity, uptake and adherence continue to challenge efforts aimed at increasing physical activity ... ...

Abstract	For older people, physical inactivity increases fall risk as well as other preventable health conditions. Despite the well-documented benefits of physical activity, uptake and adherence continue to challenge efforts aimed at increasing physical activity and reducing falls. Nested within a randomized controlled trial, this study reports on the factors influencing the physical activity behavior of people, aged between 70 and 90 years, engaged in
Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	155897-3
ISSN	1552-4523 ; 0733-4648
ISSN (online)	1552-4523
ISSN	0733-4648
DOI	10.1177/07334648241238315
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Article ; Online: Congenital spongiform leukodystrophy in 2 female littermate German shepherd puppies.

De Miguel, Ricardo / Hague, Devon Wallis / Johnson, Jennifer L / Zilinger, Amber M / Kukekova, Anna / Lezmi, Stephane

Journal of veterinary internal medicine

2024

Abstract: Two 9-week-old female littermate German Shepherd puppies showed severe high-frequency low-amplitude trembling that worsened with movement. The white matter (WM) of the central nervous system (CNS) showed bilateral diffuse severe spongiosis in the ... ...

Abstract	Two 9-week-old female littermate German Shepherd puppies showed severe high-frequency low-amplitude trembling that worsened with movement. The white matter (WM) of the central nervous system (CNS) showed bilateral diffuse severe spongiosis in the cerebellum, brainstem, spinal cord, and the neuropil of the oculomotor and red nuclei. The cortical corona radiata was less severely affected. Rare necrotic or apoptotic glia-like cells also were identified in the WM. Luxol fast blue staining disclosed severe diffuse myelin loss in the entire CNS; peripheral nerves were spared. Glial fibrillary acidic protein immunohistochemistry showed diffuse astrogliosis and astrocytosis in the WM. Genetic analyses of the littermates excluded the aspartoacylase (ASPA) gene as a candidate for this condition in dogs. In conclusion, this description of a rare congenital spongiform leukodystrophy in the German Shepherd breed, closely resembling to Canavan disease in humans, is likely caused by a genetic alteration unrelated to the ASPA gene.
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	92798-3
ISSN	1939-1676 ; 0891-6640
ISSN (online)	1939-1676
ISSN	0891-6640
DOI	10.1111/jvim.17055
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Article ; Online: Pityriasis rubra pilaris-like eruption following administration of the BNT163b2 (Pfizer-BioNTech) mRNA COVID-19 vaccine.

Hunjan, M K / Roberts, C / Karim, S / Hague, J

Clinical and experimental dermatology

2021 Volume 47, Issue 1, Page(s) 188–190

Abstract: We describe a case of a pityriasis rubra pilaris (PRP)-like eruption occurring following administration of the Pfizer-Biontech mRNA COVID-19 vaccine, with worsening of the condition following the second dose. To our knowledge, this is the first reported ... ...

Abstract	We describe a case of a pityriasis rubra pilaris (PRP)-like eruption occurring following administration of the Pfizer-Biontech mRNA COVID-19 vaccine, with worsening of the condition following the second dose. To our knowledge, this is the first reported case of a PRP-like eruption as a cutaneous adverse event of the Pfizer-Biontech mRNA COVID-19 vaccine.
MeSH term(s)	BNT162 Vaccine/adverse effects ; COVID-19/prevention & control ; Drug Eruptions/etiology ; Drug Eruptions/pathology ; Humans ; Male ; Middle Aged ; Pityriasis Rubra Pilaris/chemically induced ; Pityriasis Rubra Pilaris/pathology ; SARS-CoV-2
Chemical Substances	BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2021-09-24
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1111/ced.14878
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Article ; Online: Three-dimensional simulations of embolic stroke and an equation for sizing emboli from imaging.

Hague, James P / Keelan, Jonathan / Beishon, Lucy / Swienton, David / Robinson, Thompson G / Chung, Emma M L

Scientific reports

2023 Volume 13, Issue 1, Page(s) 3021

Abstract: ... were released into an in silico vasculature to simulate 1000 s of strokes. Infarct volume distributions ...

Abstract	Stroke simulations are needed to run in-silico trials, develop hypotheses for clinical studies and to interpret ultrasound monitoring and radiological imaging. We describe proof-of-concept three-dimensional stroke simulations, carrying out in silico trials to relate lesion volume to embolus diameter and calculate probabilistic lesion overlap maps, building on our previous Monte Carlo method. Simulated emboli were released into an in silico vasculature to simulate 1000 s of strokes. Infarct volume distributions and probabilistic lesion overlap maps were determined. Computer-generated lesions were assessed by clinicians and compared with radiological images. The key result of this study is development of a three-dimensional simulation for embolic stroke and its application to an in silico clinical trial. Probabilistic lesion overlap maps showed that the lesions from small emboli are homogeneously distributed throughout the cerebral vasculature. Mid-sized emboli were preferentially found in posterior cerebral artery (PCA) and posterior region of the middle cerebral artery (MCA) territories. For large emboli, MCA, PCA and anterior cerebral artery (ACA) lesions were comparable to clinical observations, with MCA, PCA then ACA territories identified as the most to least probable regions for lesions to occur. A power law relationship between lesion volume and embolus diameter was found. In conclusion, this article showed proof-of-concept for large in silico trials of embolic stroke including 3D information, identifying that embolus diameter could be determined from infarct volume and that embolus size is critically important to the resting place of emboli. We anticipate this work will form the basis of clinical applications including intraoperative monitoring, determining stroke origins, and in silico trials for complex situations such as multiple embolisation.
MeSH term(s)	Humans ; Embolic Stroke ; Stroke/pathology ; Embolism ; Ultrasonography ; Infarction
Language	English
Publishing date	2023-02-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-29974-2
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Article ; Online: Novel genetic variant associated with globoid cell leukodystrophy in a family of mixed breed dogs.

Hammack, Samantha / Hague, Devon Wallis / Vieson, Miranda D / Esdaile, Elizabeth / Hughes, Shayne S / Bellone, Rebecca R / McCoy, Annette M

Journal of veterinary internal medicine

2023 Volume 37, Issue 5, Page(s) 1710–1715

Abstract: Background: Globoid cell leukodystrophy (GCL) is a fatal autosomal recessive disease caused by variants in the galactosylceramidase (GALC) gene. Two dog breed-specific variants are reported.: Objectives: Characterize the putatively causative GALC ... ...

Abstract	Background: Globoid cell leukodystrophy (GCL) is a fatal autosomal recessive disease caused by variants in the galactosylceramidase (GALC) gene. Two dog breed-specific variants are reported. Objectives: Characterize the putatively causative GALC variant for GCL in a family of dogs and determine population allele frequency. Animals: Four related mixed-breed puppies with signs of neurologic disease were evaluated. Subsequently, 33 related dogs were tested for genetic markers for parentage and the identified GALC variant. Additional GALC genotyping was performed on 278 banked samples from various breeds. Methods: The 4 affected puppies had neurological exams and necropsies. DNA was isolated from blood samples. Variants in GALC were identified via Sanger sequencing. Parentage testing was performed using short tandem repeat markers. Prevalence of the GALC variant of interest was investigated in other breeds. Results: GCL was confirmed histopathologically. A novel missense variant in GALC (NC_006590.4:g.58893972G>A) was homozygous in all affected animals (n = 4). A recessive mode of inheritance was confirmed by parentage testing as was variant linkage with the phenotype (LOD = 3.36). Among the related dogs (n = 33), 3 dogs were homozygous and 7 heterozygous. The variant allele was not detected in screening 278 dogs from 5 breeds. The novel variant is either unique to this family or has an extremely low allele frequency in the general population. Conclusions and clinical importance: A novel GALC variant was identified that likely explains GCL in this cohort. The identification of multiple causal variants for GCL in dogs is consistent with findings in humans.
MeSH term(s)	Humans ; Dogs ; Animals ; Leukodystrophy, Globoid Cell/genetics ; Leukodystrophy, Globoid Cell/veterinary ; Galactosylceramidase/genetics ; DNA ; Gene Frequency ; Homozygote ; Dog Diseases/genetics
Chemical Substances	Galactosylceramidase (EC 3.2.1.46) ; DNA (9007-49-2)
Language	English
Publishing date	2023-08-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	92798-3
ISSN	1939-1676 ; 0891-6640
ISSN (online)	1939-1676
ISSN	0891-6640
DOI	10.1111/jvim.16822
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Article ; Online: USP7/Maged1-mediated H2A monoubiquitination in the paraventricular thalamus: an epigenetic mechanism involved in cocaine use disorder.

Cheron, Julian / Beccari, Leonardo / Hagué, Perrine / Icick, Romain / Despontin, Chloé / Carusone, Teresa / Defrance, Matthieu / Bhogaraju, Sagar / Martin-Garcia, Elena / Capellan, Roberto / Maldonado, Rafael / Vorspan, Florence / Bonnefont, Jérôme / de Kerchove d'Exaerde, Alban

Nature communications

2023 Volume 14, Issue 1, Page(s) 8481

Abstract: The risk of developing drug addiction is strongly influenced by the epigenetic landscape and chromatin remodeling. While histone modifications such as methylation and acetylation have been studied in the ventral tegmental area and nucleus accumbens (NAc), ...

Abstract	The risk of developing drug addiction is strongly influenced by the epigenetic landscape and chromatin remodeling. While histone modifications such as methylation and acetylation have been studied in the ventral tegmental area and nucleus accumbens (NAc), the role of H2A monoubiquitination remains unknown. Our investigations, initially focused on the scaffold protein melanoma-associated antigen D1 (Maged1), reveal that H2A monoubiquitination in the paraventricular thalamus (PVT) significantly contributes to cocaine-adaptive behaviors and transcriptional repression induced by cocaine. Chronic cocaine use increases H2A monoubiquitination, regulated by Maged1 and its partner USP7. Accordingly, Maged1 specific inactivation in thalamic Vglut2 neurons, or USP7 inhibition, blocks cocaine-evoked H2A monoubiquitination and cocaine locomotor sensitization. Additionally, genetic variations in MAGED1 and USP7 are linked to altered susceptibility to cocaine addiction and cocaine-associated symptoms in humans. These findings unveil an epigenetic modification in a non-canonical reward pathway of the brain and a potent marker of epigenetic risk factors for drug addiction in humans.
MeSH term(s)	Humans ; Ubiquitin-Specific Peptidase 7/metabolism ; Cocaine/pharmacology ; Cocaine/metabolism ; Cocaine-Related Disorders/genetics ; Cocaine-Related Disorders/metabolism ; Substance-Related Disorders/genetics ; Epigenesis, Genetic ; Nucleus Accumbens/metabolism ; Thalamus/metabolism
Chemical Substances	Ubiquitin-Specific Peptidase 7 (EC 3.4.19.12) ; Cocaine (I5Y540LHVR) ; USP7 protein, human (EC 3.4.19.12)
Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-44120-2
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Article: Facial Cartilaginous Reconstruction-A Historical Perspective, State-of-the-Art, and Future Directions.

Jessop, Zita M / Hague, Adam / Dobbs, Thomas D / Stewart, Kenneth J / Whitaker, Iain S

Frontiers in surgery

2021 Volume 8, Page(s) 680186

Abstract: Importance: ...

Abstract	Importance:
Language	English
Publishing date	2021-08-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2021.680186
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