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Article: Autophagy in spinal muscular atrophy: from pathogenic mechanisms to therapeutic approaches.

Rashid, Saman / Dimitriadi, Maria

2024 Volume 17, Page(s) 1307636

Abstract: Spinal muscular atrophy (SMA) is a devastating neuromuscular disorder caused by the depletion of the ubiquitously expressed survival motor neuron (SMN) protein. While the genetic cause of SMA has been well documented, the exact mechanism(s) by which SMN ... ...

Abstract	Spinal muscular atrophy (SMA) is a devastating neuromuscular disorder caused by the depletion of the ubiquitously expressed survival motor neuron (SMN) protein. While the genetic cause of SMA has been well documented, the exact mechanism(s) by which SMN depletion results in disease progression remain elusive. A wide body of evidence has highlighted the involvement and dysregulation of autophagy in SMA. Autophagy is a highly conserved lysosomal degradation process which is necessary for cellular homeostasis; defects in the autophagic machinery have been linked with a wide range of neurodegenerative disorders, including amyotrophic lateral sclerosis, Alzheimer's disease and Parkinson's disease. The pathway is particularly known to prevent neurodegeneration and has been suggested to act as a neuroprotective factor, thus presenting an attractive target for novel therapies for SMA patients. In this review, (a) we provide for the first time a comprehensive summary of the perturbations in the autophagic networks that characterize SMA development, (b) highlight the autophagic regulators which may play a key role in SMA pathogenesis and (c) propose decreased autophagic flux as the causative agent underlying the autophagic dysregulation observed in these patients.
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2023.1307636
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Article ; Online: In vitro evaluation of a silane containing self-adhesive resin luting agent.

Dimitriadi, Maria / Petropoulou, Aikaterini / Vakou, Dimitra / Zinelis, Spiros / Eliades, George

Dental materials : official publication of the Academy of Dental Materials

2023 Volume 39, Issue 2, Page(s) 181–191

Abstract: Objectives: To investigate the setting characteristics, wettability and bonding capacity with a lithium disilicate ceramic of a silane containing self-adhesive resin luting agent (Panavia SA Universal-PU).: Methods: The degree of conversion (DC %) ... ...

Abstract	Objectives: To investigate the setting characteristics, wettability and bonding capacity with a lithium disilicate ceramic of a silane containing self-adhesive resin luting agent (Panavia SA Universal-PU). Methods: The degree of conversion (DC %) and extent of acid neutralization (SY %) of PU were measured on dual- (DC) and self-cured (SC) specimens after 10, 30 and 60 min storage by ATR-FTIR spectroscopy, whereas the presence of silanols was traced by curve-fitting the 60 min spectra, using the silane-free analog (Panavia SA Plus-PS) as a control. The role of a dedicated adhesive (Clearfil Universal Bond Quick-CU) in assisting the early DC % in PU-SC was investigated on 10 min-stored specimens. The water contact angles on polished and HF acid-etched lithium disilicate surfaces (IPS e.max Press), were assessed before and after silanization by unset PU or a silane primer (Ultradent Silane-SL). Finally, the shear strength of PU-DC specimens bonded to the acid-etched ceramic surfaces was determined before and after SL treatment. Results: The DC % was higher in DC than SC (PU, PS; all time intervals), in PU-SC than PS-SC (30, 60 min) and in the CU assisted PU-SC group. The SY % was lower in DC than SC (PU, PS) and higher in PS-SC than PU-SC groups. Silanols were found only in unset PU and PU-DC groups. SL treatment provided higher water contact angles on polished and acid-etched ceramic surfaces and higher shear bond strength on acid-etched ceramic surfaces than PU (p < 0.05 for all comparisons). Significance: Although the degree of conversion of the silane containing luting agent was improved in the self-curing mode, especially in the adhesive assisted group, it was still inferior to light-curing. Acid-neutralization and presence of silanols were affected by the setting modes. The use of a silane primer enhanced the hydrophobicity and bond strength of the silane containing luting agent with the etched ceramic substrate.
MeSH term(s)	Resin Cements/chemistry ; Dental Cements ; Dental Bonding/methods ; Dental Porcelain ; Ceramics/chemistry ; Silanes/chemistry ; Water/chemistry ; Materials Testing ; Surface Properties ; Shear Strength
Chemical Substances	Resin Cements ; Dental Cements ; Dental Porcelain (12001-21-7) ; silanol (079V3J9O3X) ; Silanes ; Water (059QF0KO0R)
Language	English
Publishing date	2023-01-14
Publishing country	England
Document type	Journal Article
ZDB-ID	605995-8
ISSN	1879-0097 ; 0109-5641
ISSN (online)	1879-0097
ISSN	0109-5641
DOI	10.1016/j.dental.2022.12.007
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Article ; Online: The effect of cooling procedures on monomer elution from heat-cured polymethyl methacrylate denture base materials.

Polychronakis, Nick / Dimitriadi, Maria / Polyzois, Gregory / Eliades, George

Journal of applied oral science : revista FOB

2022 Volume 30, Page(s) e20220161

Abstract: Objective: To evaluate the amount of methyl methacrylate (MMA) released in water from heat-cured polymethyl methacrylate (PMMA) denture base materials subjected to different cooling procedures.: Methodology: Disk-shaped specimens (Ø:17 mm, h:2 mm) ... ...

Abstract	Objective: To evaluate the amount of methyl methacrylate (MMA) released in water from heat-cured polymethyl methacrylate (PMMA) denture base materials subjected to different cooling procedures. Methodology: Disk-shaped specimens (Ø:17 mm, h:2 mm) were fabricated from Paladon 65 (PA), ProBase Hot (PB), Stellon QC-20 (QC) and Vertex Rapid Simplified (VE) denture materials using five different cooling procedures (n=3/procedure): A) Bench-cooling for 10 min and then under running water for 15 min; B) Cooling in water-bath until room temperature; C) Cooling under running water for 15 min; D) Bench-cooling, and E) Bench-cooling for 30 min and under running water for 15 min. A, B, D, E procedures were proposed by the manufacturers, while the C was selected as the fastest one. Control specimens (n=3/material) were fabricated using a long polymerization cycle and bench-cooling. After deflasking, the specimens were ground, polished and stored in individual containers with 10 ml of distilled water for seven days (37oC). The amount of water-eluted MMA was measured per container using isocratic ultra-fast liquid chromatography (UFLC). Data were analyzed using Student's and Welch's t-test (α=0.05). Results: MMA values below the lower quantification limit (LoQ=5.9 ppm) were registered in B, C, E (PA); E (PB) and B, D, E (QC) procedures, whereas values below the detection limit (LoD=1.96 ppm) were registered in A, D (PA); A, B, C, D (PB); C, D, E (VE) and in all specimens of the control group. A, B (VE) and A, C (QC) procedures yielded values ranging from 6.4 to 13.2 ppm with insignificant differences in material and procedure factors (p>0.05). Conclusions: The cooling procedures may affect the monomer elution from denture base materials. The Ε procedure may be considered a universal cooling procedure compared to the ones proposed by the manufacturers, with the lowest residual monomer elution in water.
MeSH term(s)	Denture Bases ; Hot Temperature ; Humans ; Materials Testing ; Polymethyl Methacrylate/chemistry ; Water
Chemical Substances	Water (059QF0KO0R) ; Polymethyl Methacrylate (9011-14-7)
Language	English
Publishing date	2022-07-22
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2152066-5
ISSN	1678-7765 ; 1678-7765
ISSN (online)	1678-7765
ISSN	1678-7765
DOI	10.1590/1678-7757-2022-0161
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Article: Self-Etch Silane Primer: Reactivity and Bonding with a Lithium Disilicate Ceramic.

Dimitriadi, Maria / Zinelis, Spiros / Zafiropoulou, Maria / Silikas, Nikolaos / Eliades, George

Materials (Basel, Switzerland)

2020 Volume 13, Issue 3

Abstract: The aim of the study was to evaluate the stability, reactivity, and bond strength with a lithium disilicate ceramic of a self-etch silane primer (Monobond Etch and Prime/MEP). The stability was evaluated ... ...

Abstract	The aim of the study was to evaluate the stability, reactivity, and bond strength with a lithium disilicate ceramic of a self-etch silane primer (Monobond Etch and Prime/MEP). The stability was evaluated by
Language	English
Publishing date	2020-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma13030641
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Article ; Online: Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review.

Crawford, Hannah / Dimitriadi, Maria / Bassin, Jatinder / Cook, Michael T / Abelha, Thais Fedatto / Calvo-Castro, Jesus

Chemistry (Weinheim an der Bergstrasse, Germany)

2022 Volume 28, Issue 72, Page(s) e202202366

Abstract: The last decade has seen an increasingly large number of studies reporting on the development of novel small organic conjugated systems for mitochondrial imaging exploiting optical signal transduction pathways. Mitochondria are known to play a critical ... ...

Abstract	The last decade has seen an increasingly large number of studies reporting on the development of novel small organic conjugated systems for mitochondrial imaging exploiting optical signal transduction pathways. Mitochondria are known to play a critical role in a number of key biological processes, including cellular metabolism. Importantly, irregularities on their working function are nowadays understood to be intimately linked to a range of clinical conditions, highlighting the importance of targeting mitochondria for therapeutic benefits. In this work we carry out an in-depth evaluation on the progress to date in the field to pave the way for the realization of superior alternatives to those currently existing. The manuscript is structured by commonly used chemical scaffolds and comprehensively covers key aspects factored in design strategies such as synthetic approaches as well as photophysical and biological characterization, to foster collaborative work among organic and physical chemists as well as cell biologists.
MeSH term(s)	Mitochondria/metabolism ; Diagnostic Imaging ; Signal Transduction
Language	English
Publishing date	2022-10-26
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202202366
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Article: The Effect of Touch-Cure Polymerization on the Conversion and Hardness of Core Build-Up Resin Composites: A Laboratory Study.

Dimitriadi, Maria / Petropoulou, Aikaterini / Masouras, Konstantinos / Zafiropoulou, Maria / Zinelis, Spiros / Eliades, George

Materials (Basel, Switzerland)

2021 Volume 14, Issue 20

Abstract: To improve the self-curing capacity and interfacial strength with dentine of dual-cured composite materials, touch-cure activators have been introduced. The aim of the study was to evaluate the effect of these activators on the hardness and conversion of ...

Abstract	To improve the self-curing capacity and interfacial strength with dentine of dual-cured composite materials, touch-cure activators have been introduced. The aim of the study was to evaluate the effect of these activators on the hardness and conversion of dual-cured resin composite core build-up restoratives. The materials tested were Clearfil DC Core Plus (CF) and Gradia Core (GC) with the corresponding adhesives Clearfil S
Language	English
Publishing date	2021-10-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma14206025
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Article ; Online: Degree of Conversion and Mechanical Properties of Modern Self-Adhesive Luting Agents

Maria Dimitriadi / Aikaterini Petropoulou / Maria Zafiropoulou / Spiros Zinelis / George Eliades

Applied Sciences, Vol 11, Iss 12065, p

2021 Volume 12065

Abstract: New self-adhesive resin composite luting agents have currently been developed, claiming improved properties. The study aimed to evaluate the composition, degree of conversion, and mechanical properties of Panavia SA Plus (PSP), Panavia SA Universal (PSU), ...

Abstract	New self-adhesive resin composite luting agents have currently been developed, claiming improved properties. The study aimed to evaluate the composition, degree of conversion, and mechanical properties of Panavia SA Plus (PSP), Panavia SA Universal (PSU), SpeedCem Plus (SPC) and TheraCem Ca (THC), with the resin luting agent Panavia V5 (PV5) serving as a control. The structure of the materials was studied by FTIR spectroscopy and SEM/EDX spectrometry. Disk-shaped specimens were prepared from each material under dual- and self-curing modes (n = 5/mode and material). After a 3-week storage period (dark/37 °C/80%RH) the Martens hardness, indentation modulus, elastic index, and creep were determined by instrumented indentation testing (IIT), while the degree of conversion was assessed by FTIR spectroscopy. Statistical analysis was performed by 2-way ANOVA and post-hoc testing (α = 0.05). All materials were based on aromatic monomers, except for SPC. Fillers with potentially bioactive Ca-glasses were identified in SPC and THC, which showed the highest P/Si ratio. The dual-curing mode demonstrated superior performance in all properties. Differences between materials within each curing mode were limited to SPC, THC (highest conversion) and PSA, PSU, SPC (highest elastic index) for dual-curing, and THC (lowest hardness and elastic index). The results confirmed a lower self-curing conversion in these materials, which may affect some of the mechanical properties tested.
Keywords	self-adhesive luting agents ; composition ; degree of cure ; mechanical properties ; X-ray microanalysis ; infrared spectroscopy ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	620
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: The effect of different cooling procedures on mechanical properties of denture base materials measured by instrumented indentation testing.

Polychronakis, Nick / Dimitriadi, Maria / Ioannidis, Alexis / Papadopoulos, Triantafyllos

Journal of prosthodontic research

2019 Volume 64, Issue 3, Page(s) 326–331

Abstract: Purpose: To evaluate the different cooling procedures on the mechanical properties of five heat-cured polymethyl methacrylate (PMMA) denture materials.: Methods: 250 specimens were made equally from Meliodent (ME), Paladon 65 (PA), Probase Hot (PB), ... ...

Abstract	Purpose: To evaluate the different cooling procedures on the mechanical properties of five heat-cured polymethyl methacrylate (PMMA) denture materials. Methods: 250 specimens were made equally from Meliodent (ME), Paladon 65 (PA), Probase Hot (PB), Stellon QC-20 (QC) and Vertex Rapid Simplified (VE) implementing five different cooling procedures (n=10/procedure): A) removal from water bath, bench-cooling (10min) and cooling under water (15min), B) remain in water bath till room temperature, C) removal from water bath and cooling in water for 15min, D) removal from water bath and bench cooling till room temperature and E) removal from water bath, bench cooling for 30min and cooling under water for 15min. The specimens were immersed in distilled water (15 days/37ºC) and then subjected to Instrumented Indentation Testing for Martens Hardness (HM), indentation modulus (E Results: The highest values for HM were recorded for QC, PA, VE with B cooling procedure, PB with A and ME with E, for E Conclusions: The cooling procedures recommended for PB resulted in the lowest mechanical properties. A and B may be considered as universal short- and long-cooling procedures respectively providing the highest mechanical properties for the materials tested.
MeSH term(s)	Dental Materials ; Denture Bases ; Hardness ; Materials Testing ; Phase Transition ; Polymethyl Methacrylate ; Surface Properties
Chemical Substances	Dental Materials ; Polymethyl Methacrylate (9011-14-7)
Language	English
Publishing date	2019-09-30
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2470657-7
ISSN	2212-4632 ; 1883-1958
ISSN (online)	2212-4632
ISSN	1883-1958
DOI	10.1016/j.jpor.2019.09.005
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Article: Surface Characteristics and Color Stability of Gingiva-Colored Resin Composites.

Petropoulou, Aikaterini / Dimitriadi, Maria / Zinelis, Spiros / Sarafianou, Aspasia / Eliades, George

Materials (Basel, Switzerland)

2020 Volume 13, Issue 11

Abstract: The purpose of this study was to investigate the surface characteristics and color stability of gingiva-colored composite restorative materials (Anaxgum-ANG, Ceramage-CMG and Gradia Gum-GRG). The microstructure, composition, degree of conversion (DC %) ... ...

Abstract	The purpose of this study was to investigate the surface characteristics and color stability of gingiva-colored composite restorative materials (Anaxgum-ANG, Ceramage-CMG and Gradia Gum-GRG). The microstructure, composition, degree of conversion (DC %) and 3D roughness (Sa, Sz, Sdr, Sc) were examined by LV-SEM/EDS, ATR-FTIR and optical profilometry, respectively. For the color stability (CIE L, a, b* system) and hardness (HV), measurements were performed at baseline and after 30 days storage in distilled water, coffee and red wine. The ANG and GRG contain prepolymerized particles in aromatic and aliphatic resin matrices, respectively, whereas CMG contains inorganic zirconia silicate/silica particles, in an aromatic resin matrix, with a smaller particle size and a higher surface area fraction. Urethane monomers were mainly identified in CMG and GRG. The DC% showed statistically insignificant differences between the materials. The same applied for the roughness parameters, except for the greatest Sdr in CMG. ANG showed a color difference (ΔE) of > 3.3 after immersion in all media, CMG in coffee and wine and GRG only in coffee. Sc was the only roughness parameter demonstrating correlations with the ΔL, Δb and ΔE*. The HV values showed insignificant differences between the storage conditions per material. There are important differences in the color stability of the materials tested, which were mostly affected by the roughness parameters due to variations in their microstructure.
Language	English
Publishing date	2020-06-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma13112540
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Article ; Online: Silane reactivity and resin bond strength to lithium disilicate ceramic surfaces.

Dimitriadi, Maria / Zafiropoulou, Maria / Zinelis, Spiros / Silikas, Nick / Eliades, George

Dental materials : official publication of the Academy of Dental Materials

2019 Volume 35, Issue 8, Page(s) 1082–1094

Abstract: Objective: To evaluate the silane status in commercially available products and their bonding capacity with polished glass-ceramic surfaces before and after hydrofluoric (HF) acid-etching.: Methods: The products tested were Calibra Silane Coupling ... ...

Abstract	Objective: To evaluate the silane status in commercially available products and their bonding capacity with polished glass-ceramic surfaces before and after hydrofluoric (HF) acid-etching. Methods: The products tested were Calibra Silane Coupling Agent/CS, G-Multi Primer/GM, Kerr Silane Primer/KS, Monobond Plus/MB and Scotchbond Universal Adhesive/SB. The silane status was studied by Results: The NMR analysis showed the presence of silanol monomers only in CS. Methoxylated-siloxane adducts were found in GM, silanol-siloxane adducts in MB, SB, and siloxane polymers in KS. Acid-etching greatly increased Sa, Sz, Sdr, Sc and Sv parameters (p < 0.001) and ATR-FTIR analysis demonstrated evidence of bonding with the substrate in CS. Weibull analysis of SBS revealed the following rankings in characteristic life (p < 0.05): CS > SB,KS,MB > GM > NS (group A) and CS > GM > SB,KS,MB,NS (group B). The most reliable treatment in both groups was CS. For the same silane treatment, the SBS of group B were significantly higher from group A. Failures were mainly of adhesive type, except of several partial resin cohesive failures found in group B. Significance: The chemical bonding capacity of the silanes was highest in products with silanol monomers. Acid-etching increased bond strength to a level that neutralized the silane contribution in products with silanol-siloxane adducts and siloxane polymers, providing thus bond strength values similar to silane-free treatments.
MeSH term(s)	Ceramics ; Dental Bonding ; Dental Porcelain ; Hydrofluoric Acid ; Materials Testing ; Resin Cements ; Shear Strength ; Silanes ; Surface Properties
Chemical Substances	Resin Cements ; Silanes ; lithia disilicate ; Dental Porcelain (12001-21-7) ; Hydrofluoric Acid (RGL5YE86CZ)
Language	English
Publishing date	2019-06-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605995-8
ISSN	1879-0097 ; 0109-5641
ISSN (online)	1879-0097
ISSN	0109-5641
DOI	10.1016/j.dental.2019.05.002
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