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Article ; Online: Evidence That Metal Particles in Cannabis Vape Liquids Limit Measurement Reproducibility.

Gajdosechova, Zuzana / Marleau-Gillette, Joshua / Turnbull, Matthew J / Petts, Duane C / Jackson, Simon E / Cabecinha, Ashley / Abramovici, Hanan / Waye, Andrew / Melanson, Jeremy E

ACS omega

2022 Volume 7, Issue 47, Page(s) 42783–42792

Abstract: Cannabis vaping involves the vaporization of a cannabis vaping liquid or solid via a vaping accessory such as a vape pen constructed of various metals or other parts. An increasing number of reports advocate for expansion of the testing and regulation of ...

Abstract	Cannabis vaping involves the vaporization of a cannabis vaping liquid or solid via a vaping accessory such as a vape pen constructed of various metals or other parts. An increasing number of reports advocate for expansion of the testing and regulation of metal contaminants in cannabis vape liquids beyond the metals typically tested such as arsenic, cadmium, mercury, and lead to reflect the possibility of consumers' exposure to other metal contaminants. Metal contaminants may originate not only from the cannabis itself but also from the vape devices in which the cannabis vape liquid is packaged. However, metal analyses of cannabis vape liquids sampled from cannabis vaping devices are challenged by poor precision and reproducibility. Herein, we present data on the metal content of 12 metals in 20 legal and 21 illegal cannabis vape liquids. The lead mass fraction in several illegal samples reached up to 50 μg g
Language	English
Publishing date	2022-11-14
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c03797
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Article ; Online: Evidence That Metal Particles in Cannabis Vape Liquids Limit Measurement Reproducibility

Zuzana Gajdosechova / Joshua Marleau-Gillette / Matthew J. Turnbull / Duane C. Petts / Simon E. Jackson / Ashley Cabecinha / Hanan Abramovici / Andrew Waye / Jeremy E. Melanson

ACS Omega, Vol 7, Iss 47, Pp 42783-

2022 Volume 42792

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Neuroendocrine disruption: more than hormones are upset.

Waye, Andrew / Trudeau, Vance L

Journal of toxicology and environmental health. Part B, Critical reviews

2011 Volume 14, Issue 5-7, Page(s) 270–291

Abstract: Only a small proportion of the published research on endocrine-disrupting chemicals (EDC) directly examined effects on neuroendocrine processes. There is an expanding body of evidence that anthropogenic chemicals exert effects on neuroendocrine systems ... ...

Abstract	Only a small proportion of the published research on endocrine-disrupting chemicals (EDC) directly examined effects on neuroendocrine processes. There is an expanding body of evidence that anthropogenic chemicals exert effects on neuroendocrine systems and that these changes might impact peripheral organ systems and physiological processes. Neuroendocrine disruption extends the concept of endocrine disruption to include the full breadth of integrative physiology (i.e., more than hormones are upset). Pollutants may also disrupt numerous other neurochemical pathways to affect an animal's capacity to reproduce, develop and grow, or deal with stress and other challenges. Several examples are presented in this review, from both vertebrates and invertebrates, illustrating that diverse environmental pollutants including pharmaceuticals, organochlorine pesticides, and industrial contaminants have the potential to disrupt neuroendocrine control mechanisms. While most investigations on EDC are carried out with vertebrate models, an attempt is also made to highlight the importance of research on invertebrate neuroendocrine disruption. The neurophysiology of many invertebrates is well described and many of their neurotransmitters are similar or identical to those in vertebrates; therefore, lessons learned from one group of organisms may help us understand potential adverse effects in others. This review argues for the adoption of systems biology and integrative physiology to address the effects of EDC. Effects of pulp and paper mill effluents on fish reproduction are a good example of where relatively narrow hypothesis testing strategies (e.g., whether or not pollutants are sex steroid mimics) have only partially solved a major problem in environmental biology. It is clear that a global, integrative physiological approach, including improved understanding of neuroendocrine control mechanisms, is warranted to fully understand the impacts of pulp and paper mill effluents. Neuroendocrine disruptors are defined as pollutants in the environment that are capable of acting as agonists/antagonists or modulators of the synthesis and/or metabolism of neuropeptides, neurotransmitters, or neurohormones, which subsequently alter diverse physiological, behavioral, or hormonal processes to affect an animal's capacity to reproduce, develop and grow, or deal with stress and other challenges. By adopting a definition of neuroendocrine disruption that encompasses both direct physiological targets and their indirect downstream effects, from the level of the individual to the ecosystem, a more comprehensive picture of the consequences of environmentally relevant EDC exposure may emerge.
MeSH term(s)	Animals ; Endocrine Disruptors/toxicity ; Environmental Exposure/adverse effects ; Environmental Pollutants/toxicity ; Humans ; Invertebrates/drug effects ; Invertebrates/metabolism ; Invertebrates/physiology ; Models, Biological ; Neurosecretory Systems/drug effects ; Neurosecretory Systems/physiopathology ; Reproduction/drug effects
Chemical Substances	Endocrine Disruptors ; Environmental Pollutants
Language	English
Publishing date	2011-07-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1415246-0
ISSN	1521-6950 ; 1093-7404
ISSN (online)	1521-6950
ISSN	1093-7404
DOI	10.1080/10937404.2011.578273
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Article ; Online: An evaluation of genetic causes and environmental risks for bilateral optic atrophy.

Chen, Andrew T / Brady, Lauren / Bulman, Dennis E / Sundaram, Arun N E / Rodriguez, Amadeo R / Margolin, Edward / Waye, John S / Tarnopolsky, Mark A

PloS one

2019 Volume 14, Issue 11, Page(s) e0225656

Abstract: Purpose: To assess the clinical utility of next-generation sequencing (NGS) for the diagnosis of patients with optic atrophy (OA).: Design: Retrospective cohort study.: Methods: 97 patients were referred to the McMaster University Medical Center ( ... ...

Abstract	Purpose: To assess the clinical utility of next-generation sequencing (NGS) for the diagnosis of patients with optic atrophy (OA). Design: Retrospective cohort study. Methods: 97 patients were referred to the McMaster University Medical Center (Hamilton, Ontario) for evaluation of bilateral OA. All patients were sent for NGS including a 22 nuclear gene panel and/or complete mitochondrial DNA (mtDNA) sequencing. Positive genetic test results and abnormal vibration sensation were compared in patients +/- environmental exposures or a family history. Results: 19/94 (20.2%) had a positive nuclear variant, of which 15/19 (78.9%) were in the OPA1 gene. No positive mtDNA variants were identified. The detection of a positive genetic variant was significantly different in patients who reported excessive ethanol use, but not in patients who smoke (0/19 (0%) vs. 19/78 (24.4%), P = 0.0164 and 4/22 (18.2%) vs. 15/74 (20.3%), P = 0.829, respectively). Patients with a positive family history were more likely to have a positive genetic variant compared to patients with a negative family history (P = 0.0112). There were significantly more excessive drinkers with an abnormal vibration sensation (P = 0.026), and with a similar trend in smokers (P = 0.074). Conclusions: All positive genetic variants were identified in nuclear genes. We identified a potential independent pathophysiological link between a history of excessive ethanol consumption and bilateral OA. Further investigations should evaluate and identify potential environmental risk factors for OA.
MeSH term(s)	Aconitate Hydratase/genetics ; Alcohol Drinking ; DNA, Mitochondrial/chemistry ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; Environmental Exposure ; GTP Phosphohydrolases/genetics ; Genetic Variation ; High-Throughput Nucleotide Sequencing ; Humans ; Membrane Proteins/genetics ; Optic Atrophy/genetics ; Optic Atrophy/pathology ; Retrospective Studies ; Risk Factors ; Sequence Analysis, DNA ; Smoking
Chemical Substances	DNA, Mitochondrial ; Membrane Proteins ; wolframin protein ; GTP Phosphohydrolases (EC 3.6.1.-) ; OPA1 protein, human (EC 3.6.1.-) ; ACO2 protein, human (EC 4.2.1.3) ; Aconitate Hydratase (EC 4.2.1.3)
Language	English
Publishing date	2019-11-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0225656
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Article ; Online: Antibody-drug conjugates for the treatment of B-cell non-Hodgkin's lymphoma and leukemia.

Chu, Yu-Waye / Polson, Andrew

Future oncology (London, England)

2013 Volume 9, Issue 3, Page(s) 355–368

Abstract: Antibody-drug conjugates (ADCs) are a broad class of molecules comprising of a potent cytotoxic agent conjugated with a monoclonal antibody using a chemically stable linker. By selecting a monoclonal antibody directed against a tumor-specific or tumor- ... ...

Abstract	Antibody-drug conjugates (ADCs) are a broad class of molecules comprising of a potent cytotoxic agent conjugated with a monoclonal antibody using a chemically stable linker. By selecting a monoclonal antibody directed against a tumor-specific or tumor-associated antigen, ADCs allow the targeted delivery of highly potent cytotoxic agents that result in unacceptable toxicity when administered as free agents. ADCs are currently being developed for the treatment of a wide variety of tumors. In this review, the current clinical and preclinical status of ADCs for the treatment of B-cell non-Hodgkin's lymphoma and B-cell leukemia will be discussed. ADCs have the potential to alter treatment paradigms for these diseases by providing both increased efficacy and improved safety and tolerability over current chemotherapy-based regimens.
MeSH term(s)	Antibodies, Monoclonal, Humanized/pharmacokinetics ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antigens, CD/immunology ; Antigens, CD/metabolism ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/therapeutic use ; Clinical Trials as Topic ; Drug Carriers ; Humans ; Immunotoxins/pharmacokinetics ; Immunotoxins/therapeutic use ; Leukemia/drug therapy ; Leukemia/metabolism ; Lymphoma, B-Cell/drug therapy ; Lymphoma, B-Cell/metabolism ; Maytansine/analogs & derivatives ; Maytansine/therapeutic use
Chemical Substances	Antibodies, Monoclonal, Humanized ; Antigens, CD ; Antineoplastic Agents ; Drug Carriers ; Immunotoxins ; SAR 3419 ; Maytansine (14083FR882) ; Inotuzumab Ozogamicin (P93RUU11P7)
Language	English
Publishing date	2013-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2184533-5
ISSN	1744-8301 ; 1479-6694
ISSN (online)	1744-8301
ISSN	1479-6694
DOI	10.2217/fon.12.189
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Article ; Online: Cross talk between Leishmania donovani CpG DNA and Toll-like receptor 9: an immunoinformatics approach.

Gupta, Chhedi Lal / Akhtar, Salman / Waye, Andrew / Pandey, Nihar R / Pathak, Neelam / Bajpai, Preeti

Biochemical and biophysical research communications

2015 Volume 459, Issue 3, Page(s) 424–429

Abstract: The precise and potential contribution of Toll-like receptors (TLRs) signaling pathways in fighting parasitic infections of Leishmania spp., an intracellular protozoan parasite, has gained significant attention during the last decades. Although it is ... ...

Abstract	The precise and potential contribution of Toll-like receptors (TLRs) signaling pathways in fighting parasitic infections of Leishmania spp., an intracellular protozoan parasite, has gained significant attention during the last decades. Although it is well established that TLR9 recognizes CpG motifs in microbial genomes, the specificity of the CpG DNA pattern of Leishmania parasite interacting with endosomal TLR9 is still unknown. Hence in our study to identify the CpG DNA pattern of Leishmania donovani acting as ligand for TLR9, consecutive homology searches were performed using known CpG ODN 2216 as initial template until a consistent CpG pattern in L. donovani was found. A reliable model of TLR9 ectodomains (ECDs) as well as CpG DNA patterns was predicted to develop the 3D structural complexes of TLR9 ECD-CpG DNA utilizing molecular modeling and docking approaches. The results revealed the preferential specificity of L. donovani CpG DNA to TLR9 compared to control ODN and other CpG patterns. The interface between TLR9 and L. donovani CpG DNA was also found to be geometrically complementary with the LRR11 region of TLR9, acting as the critical region for ligand recognition. The L. donovani CpG pattern identified can be employed to derive a platform for development of an innate immunomodulatory agent for deadly disease.
MeSH term(s)	Animals ; Base Sequence ; Binding Sites ; Computational Biology ; CpG Islands ; DNA, Protozoan/chemistry ; DNA, Protozoan/genetics ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Leishmania donovani/genetics ; Leishmania donovani/immunology ; Leishmania donovani/pathogenicity ; Ligands ; Mice ; Models, Molecular ; Nucleic Acid Conformation ; Oligodeoxyribonucleotides/chemistry ; Oligodeoxyribonucleotides/genetics ; Protein Conformation ; Receptor Cross-Talk ; Signal Transduction ; Toll-Like Receptor 9/chemistry ; Toll-Like Receptor 9/metabolism
Chemical Substances	CpG ODN 2216 ; DNA, Protozoan ; Ligands ; Oligodeoxyribonucleotides ; TLR9 protein, human ; Tlr9 protein, mouse ; Toll-Like Receptor 9
Language	English
Publishing date	2015-04-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2015.02.121
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Zs.A 116: Show issues

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Article ; Online: Cannabis Inflorescence for Medical Purposes: USP Considerations for Quality Attributes.

Sarma, Nandakumara D / Waye, Andrew / ElSohly, Mahmoud A / Brown, Paula N / Elzinga, Sytze / Johnson, Holly E / Marles, Robin J / Melanson, Jeremy E / Russo, Ethan / Deyton, Lawrence / Hudalla, Christopher / Vrdoljak, Gordon A / Wurzer, Joshua H / Khan, Ikhlas A / Kim, Nam-Cheol / Giancaspro, Gabriel I

Journal of natural products

2020 Volume 83, Issue 4, Page(s) 1334–1351

Abstract: There is an active and growing interest in cannabis female inflorescence ( ...

Abstract	There is an active and growing interest in cannabis female inflorescence (
MeSH term(s)	Cannabidiol/chemistry ; Cannabinoids/analysis ; Cannabinoids/chemistry ; Cannabis/chemistry ; Dronabinol/chemistry ; Hallucinogens/chemistry ; Hallucinogens/metabolism ; Humans ; Inflorescence/chemistry
Chemical Substances	Cannabinoids ; Hallucinogens ; Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S)
Language	English
Publishing date	2020-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.9b01200
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Zs.A 1144: Show issues

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Article ; Online: The duplication mutation of Quebec platelet disorder dysregulates PLAU, but not C10orf55, selectively increasing production of normal PLAU transcripts by megakaryocytes but not granulocytes.

Hayward, Catherine P M / Liang, Minggao / Tasneem, Subia / Soomro, Asim / Waye, John S / Paterson, Andrew D / Rivard, Georges E / Wilson, Michael D

PloS one

2017 Volume 12, Issue 3, Page(s) e0173991

Abstract: Quebec Platelet disorder (QPD) is a unique bleeding disorder that markedly increases urokinase plasminogen activator (uPA) in megakaryocytes and platelets but not in plasma or urine. The cause is tandem duplication of a 78 kb region of chromosome 10 ... ...

Abstract	Quebec Platelet disorder (QPD) is a unique bleeding disorder that markedly increases urokinase plasminogen activator (uPA) in megakaryocytes and platelets but not in plasma or urine. The cause is tandem duplication of a 78 kb region of chromosome 10 containing PLAU (the uPA gene) and C10orf55, a gene of unknown function. QPD increases uPA in platelets and megakaryocytes >100 fold, far more than expected for a gene duplication. To investigate the tissue-specific effect that PLAU duplication has on gene expression and transcript structure in QPD, we tested if QPD leads to: 1) overexpression of normal or unique PLAU transcripts; 2) increased uPA in leukocytes; 3) altered levels of C10orf55 mRNA and/or protein in megakaryocytes and leukocytes; and 4) global changes in megakaryocyte gene expression. Primary cells and cultured megakaryocytes from donors were prepared for quantitative reverse polymerase chain reaction analyses, RNA-seq and protein expression analyses. Rapidly isolated blood leukocytes from QPD subjects showed only a 3.9 fold increase in PLAU transcript levels, in keeping with the normal to minimally increased uPA in affinity purified, QPD leukocytes. All subjects had more uPA in granulocytes than monocytes and minimal uPA in lymphocytes. QPD leukocytes expressed PLAU alleles in proportions consistent with an extra copy of PLAU on the disease chromosome, unlike QPD megakaryocytes. QPD PLAU transcripts were consistent with reference gene models, with a much higher proportion of reads originating from the disease chromosome in megakaryocytes than granulocytes. QPD and control megakaryocytes contained minimal reads for C10orf55, and C10orf55 protein was not increased in QPD megakaryocytes or platelets. Finally, our QPD megakaryocyte transcriptome analysis revealed a global down regulation of the interferon type 1 pathway. We suggest that the low endogenous levels of uPA in blood are actively regulated, and that the regulatory mechanisms are disrupted in QPD in a megakaryocyte-specific manner.
MeSH term(s)	Factor V Deficiency/genetics ; Gene Duplication ; Granulocytes/metabolism ; Humans ; Megakaryocytes/metabolism ; Mutation ; Open Reading Frames ; RNA, Messenger/biosynthesis ; Reverse Transcriptase Polymerase Chain Reaction ; Urokinase-Type Plasminogen Activator/genetics
Chemical Substances	RNA, Messenger ; Urokinase-Type Plasminogen Activator (EC 3.4.21.73)
Language	English
Publishing date	2017-03-16
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0173991
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Article ; Online: Extracts from hardwood trees used in commercial paper mills contain biologically active neurochemical disruptors.

Basu, Niladri / Waye, Andrew / Trudeau, Vance L / Arnason, John T

The Science of the total environment

2012 Volume 414, Page(s) 205–209

Abstract: Following on our discovery that pulp and paper mill effluents can interact with, and disrupt, various neurotransmitter receptors and enzymes important to fish reproduction, we tested wood and bark extracts of 14 Eastern North American hardwood trees used ...

Abstract	Following on our discovery that pulp and paper mill effluents can interact with, and disrupt, various neurotransmitter receptors and enzymes important to fish reproduction, we tested wood and bark extracts of 14 Eastern North American hardwood trees used in pulp and paper production. Radioligand binding to neurotransmitter receptors, including the dopamine-2 receptor (D2), the gamma aminobutyric acid receptor A (GABA(A)), N-methyl-D-aspartic acid (NMDA) receptor, and muscarinic cholinergic receptor (mACh-R), were significantly changed following in vitro incubations with many but not all extracts. Activities of neurotransmitter-related enzymes monoamine oxidase (MAO), GABA-transaminase (GABA-T), acetylcholinesterase (AChE) and glutamic acid decarboxylase (GAD) were also significantly altered. Butternut wood extracts and the isolated compound juglone significantly inhibited the enzymatic activities of MAO and GAD which we suggest may be part of a mechanism that may negatively affect fish reproduction. Besides giving credence to the hypothesis that neuroactive compounds in pulp and paper effluent may originate in the trees used by mills, the results reported here also indicate important neuropharmacological activities in hardwoods which may help identify new sources of biologically active natural products.
MeSH term(s)	Acetylcholinesterase/metabolism ; Analysis of Variance ; Animals ; Brain/drug effects ; Brain/metabolism ; Glutamate Decarboxylase/metabolism ; Goldfish ; Monoamine Oxidase/metabolism ; Naphthoquinones/analysis ; Naphthoquinones/pharmacology ; North America ; Paper ; Plant Bark/chemistry ; Plant Extracts/pharmacology ; Radioligand Assay ; Receptors, Dopamine D2/metabolism ; Receptors, GABA-A/metabolism ; Receptors, Muscarinic/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Receptors, Neurotransmitter/metabolism ; Transaminases/metabolism ; Trees/chemistry ; Wood/chemistry
Chemical Substances	Naphthoquinones ; Plant Extracts ; Receptors, Dopamine D2 ; Receptors, GABA-A ; Receptors, Muscarinic ; Receptors, N-Methyl-D-Aspartate ; Receptors, Neurotransmitter ; Monoamine Oxidase (EC 1.4.3.4) ; Transaminases (EC 2.6.1.-) ; Acetylcholinesterase (EC 3.1.1.7) ; Glutamate Decarboxylase (EC 4.1.1.15) ; juglone (W6Q80SK9L6)
Language	English
Publishing date	2012-01-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2011.10.061
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Article ; Online: Ovulation but not milt production is inhibited in fathead minnows (Pimephales promelas) exposed to a reproductively inhibitory pulp mill effluent.

Waye, Andrew / Lado, Wudu E / Martel, Pierre H / Arnason, John T / Trudeau, Vance L

Reproductive biology and endocrinology : RB&E

2014 Volume 12, Page(s) 43

Abstract: Background: A 5-day fathead minnow (FHM) spawning assay is used by industry to monitor pulp mill effluent quality, with some mill effluents capable of completely inhibiting spawning. The purpose of this report is to characterize the effect of an ... ...

Abstract	Background: A 5-day fathead minnow (FHM) spawning assay is used by industry to monitor pulp mill effluent quality, with some mill effluents capable of completely inhibiting spawning. The purpose of this report is to characterize the effect of an inhibitory effluent on egg and milt production in FHM. Methods: Eight tanks were treated with an inhibitory effluent while eight were kept with clean water. Each tank contained two males and four females as per the 5-day FHM spawning assay used by industry. Females were stripped of ovulated eggs and males of milt in four effluent-exposed and four control tanks. Eggs oviposited in every tank were also counted and checked for fertilization and data analyzed with 2-way ANOVA. Results: We show that female, but not male, fathead minnow reproductive function is impaired in the 5-day fathead minnow spawning assay used by industry to evaluate pulp mill effluent quality in Canada. Milt production was not changed in the control or exposed males mid-way and at the end of the five day exposure (p > 0.05; n = 8). Total egg production (stripped + oviposited) was impaired (p < 0.05) in fathead minnows exposed to effluent (288 eggs/tank, n = 4 tanks) compared to those in control tanks (753 eggs/tank, n = 4 tanks). Conclusions: Our results indicate that males are able to detect female signals and prepare appropriately for spawning while in females inhibition of ovulation is occurring somewhere along the hypothalamus-pituitary-gonad reproductive axis. These results suggest female-specific neuroendocrine disruption and provide mechanistic insight into an assay used by industry to assess pulp mill effluent quality.
MeSH term(s)	Animals ; Aquaculture ; Biological Assay ; Canada ; Cyprinidae/physiology ; Drug Resistance ; Endocrine Disruptors/analysis ; Endocrine Disruptors/toxicity ; Female ; Fertilization/drug effects ; Infertility, Female/chemically induced ; Infertility, Male/chemically induced ; Male ; Oviposition/drug effects ; Ovulation/drug effects ; Ovum/drug effects ; Sex Characteristics ; Waste Water/chemistry ; Waste Water/toxicity ; Water Pollutants, Chemical/analysis ; Water Pollutants, Chemical/toxicity ; Water Quality ; Wood
Chemical Substances	Endocrine Disruptors ; Waste Water ; Water Pollutants, Chemical
Language	English
Publishing date	2014-05-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1477-7827
ISSN (online)	1477-7827
DOI	10.1186/1477-7827-12-43
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