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Article: Systematic Review of the Apomorphine Challenge Test in the Assessment of Dopaminergic Activity in Schizophrenia.

Duval, Fabrice

2023 Volume 11, Issue 10

Abstract: So far, neuroendocrine studies conducted in schizophrenic patients have yielded conflicting results. Many of these discrepancies may be explained by the diversity of factors that influence the hormonal levels (at baseline and in response to ... ...

Abstract	So far, neuroendocrine studies conducted in schizophrenic patients have yielded conflicting results. Many of these discrepancies may be explained by the diversity of factors that influence the hormonal levels (at baseline and in response to pharmacological stimuli), the heterogeneity of the populations studied, the absence of standardization of test challenges and the confounding and long-lasting effects of previous treatments. Numerous studies have used apomorphine (APO) in the evaluation of dopaminergic (DA) function in schizophrenic patients. APO, a direct acting DA receptor agonist, decreases prolactin (PRL) and stimulates growth hormone (GH), adrenocorticotropic hormone (ACTH) and cortisol secretion. Therefore, the magnitude of hormonal responses to APO is an indirect assessment of the functionality of DA receptors at the hypothalamic-pituitary level. This review provides an update on the applications of the APO test in schizophrenia in clinical, pathophysiological and therapeutic fields.
Language	English
Publishing date	2023-05-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11101487
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Article ; Online: Hypothalamic-pituitary-adrenal axis hyperactivity is normalized after successful intermittent theta-burst stimulation in resistant depressed patients.

Duval, Fabrice / Mokrani, Marie-Claude / Danila, Vlad / Weiss, Thomas / Lopera, Felix Gonzalez / Tomsa, Mihaela

Psychoneuroendocrinology

2024 Volume 165, Page(s) 107037

Abstract: The present pilot study assessed the effects of multi-session intermittent theta-burst stimulation (iTBS) applied to the left dorsolateral prefrontal cortex in 17 treatment resistant depressed inpatients (TRDs) showing cortisol non-suppression to the ... ...

Abstract	The present pilot study assessed the effects of multi-session intermittent theta-burst stimulation (iTBS) applied to the left dorsolateral prefrontal cortex in 17 treatment resistant depressed inpatients (TRDs) showing cortisol non-suppression to the overnight dexamethasone suppression test (DST) at baseline (i.e., maximum post-DST cortisol [COR
Language	English
Publishing date	2024-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	197636-9
ISSN	1873-3360 ; 0306-4530
ISSN (online)	1873-3360
ISSN	0306-4530
DOI	10.1016/j.psyneuen.2024.107037
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Article ; Online: Hypothalamic-prolactin axis regulation in major depressed patients with suicidal behavior.

Duval, Fabrice / Mokrani, Marie-Claude / Danila, Vlad / Lopera, Felix Gonzalez / Erb, Alexis / Tomsa, Mihaela

Psychoneuroendocrinology

2023 Volume 151, Page(s) 106050

Abstract: Background: So far, little is known about the control of hypothalamic-prolactin axis activity by dopamine (DA) and thyrotropin-releasing hormone (TRH) in depressed patients with suicidal behavior disorder (SBD).: Methods: We evaluated prolactin (PRL) ...

Abstract	Background: So far, little is known about the control of hypothalamic-prolactin axis activity by dopamine (DA) and thyrotropin-releasing hormone (TRH) in depressed patients with suicidal behavior disorder (SBD). Methods: We evaluated prolactin (PRL) responses to apomorphine (APO; a DA direct receptor agonist) and 0800 h and 2300 h protirelin (TRH) tests in 50 medication-free euthyroid DSM-5 major depressed inpatients with SBD (either current [n = 22], or in early remission [n = 28]); and 18 healthy hospitalized controls (HCs). Results: Baseline (BL) PRL levels were comparable across the three diagnostic groups. SBDs in early remission did not differ from HCs regarding PRL suppression to APO (PRLs), PRL stimulation to 0800 h and 2300 h TRH tests (∆PRL), and ∆∆PRL values (difference between 2300 h-∆PRL and 0800 h-∆PRL values). Current SBDs showed lower PRLs and ∆∆PRL values than HCs and SBDs in early remission. Further analyses revealed that current SBDs with a history of violent and high-lethality suicide attempts were more likely to exhibit co-occurrence of low ∆∆PRL and PRL Conclusions: Our results suggest that regulation of the hypothalamic-PRL axis is impaired in some depressed patients with current SBD, particularly those who have made serious suicide attempts. Considering the limitations of our study, our findings support the hypothesis that decreased pituitary D2 receptor functionality (possibly adaptive to increased tuberoinfundibular DAergic neuronal activity) together with decreased hypothalamic TRH drive might be a biosignature for high-lethality violent suicide attempts.
MeSH term(s)	Humans ; Prolactin ; Suicidal Ideation ; Hypothalamus ; Thyrotropin-Releasing Hormone ; Dopamine ; Dopamine Agonists
Chemical Substances	Prolactin (9002-62-4) ; Thyrotropin-Releasing Hormone (5Y5F15120W) ; Dopamine (VTD58H1Z2X) ; Dopamine Agonists
Language	English
Publishing date	2023-02-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197636-9
ISSN	1873-3360 ; 0306-4530
ISSN (online)	1873-3360
ISSN	0306-4530
DOI	10.1016/j.psyneuen.2023.106050
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Article: Dopamine Function and Hypothalamic-Pituitary-Thyroid Axis Activity in Major Depressed Patients with Suicidal Behavior.

Duval, Fabrice / Mokrani, Marie-Claude / Danila, Vlad / Erb, Alexis / Gonzalez Lopera, Felix / Tomsa, Mihaela

Brain sciences

2022 Volume 12, Issue 5

Abstract: Involvement of the dopaminergic (DA) and hypothalamic-pituitary-thyroid (HPT) systems in suicidal behavior is still poorly understood. We assessed multihormonal responses to apomorphine (APO; a short acting DA receptor agonist) and 8 AM and 11 PM ... ...

Abstract	Involvement of the dopaminergic (DA) and hypothalamic-pituitary-thyroid (HPT) systems in suicidal behavior is still poorly understood. We assessed multihormonal responses to apomorphine (APO; a short acting DA receptor agonist) and 8 AM and 11 PM protirelin (TRH) tests in 30 medication-free DSM-5 euthyroid major depressed inpatients with suicidal behavior disorder (SBD) (current,
Language	English
Publishing date	2022-05-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci12050621
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Article ; Online: A New Dataset of People Flow in an Industrial Site with UWB and Motion Capture Systems.

Delamare, Mickael / Duval, Fabrice / Boutteau, Remi

Sensors (Basel, Switzerland)

2020 Volume 20, Issue 16

Abstract: Improving performance and safety conditions in industrial sites remains a key objective for most companies. Currently, the main goal is to be able to dynamically locate both people and goods on the site. Security and access regulation to restricted areas ...

Abstract	Improving performance and safety conditions in industrial sites remains a key objective for most companies. Currently, the main goal is to be able to dynamically locate both people and goods on the site. Security and access regulation to restricted areas are often ensured by doors or badge barriers and those have several issues when faced with people being in places they are not supposed to be in or even tools of objects being used incorrectly. In addition to this, a growing use of new devices requires precise information about their location in the environment such as mobile robots or drones. Therefore, it is becoming essential to have the tools to dynamically manage these flows of people and goods. Ultra-wide-band and motion capture solutions will be used to quickly identify people who may be in unauthorized areas or performing tasks which they have been uninstructed to do. In addition to the dynamic tracking of people, this also overcomes some issues associated with moving objects or tools around the production floor. We offer a new set of data that provides precise information on worker movement. This dataset can be used to develop new metrics regarding worker efficiency and safety.
MeSH term(s)	Datasets as Topic ; Environment ; Humans ; Motion ; Movement
Language	English
Publishing date	2020-08-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s20164511
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Article ; Online: Neuroendocrine Response to Apomorphine After Tetrahydrobiopterin Use in a Depressed Teenager With Mild Hyperphenylalaninemia: A Case Report.

Jeanjean, Ludovic Christophe / Duval, Fabrice / Foucher, Jack René / Gendrault, Clément

Journal of clinical psychopharmacology

2020 Volume 40, Issue 4, Page(s) 414–416

MeSH term(s)	Adolescent ; Adrenocorticotropic Hormone/blood ; Apomorphine/pharmacology ; Biopterins/analogs & derivatives ; Biopterins/therapeutic use ; Depression/blood ; Depression/complications ; Depression/drug therapy ; Female ; Humans ; Hydrocortisone/blood ; Phenylalanine/blood ; Phenylketonurias/blood ; Phenylketonurias/complications ; Phenylketonurias/drug therapy ; Prolactin/blood
Chemical Substances	Biopterins ; Phenylalanine (47E5O17Y3R) ; Adrenocorticotropic Hormone (9002-60-2) ; Prolactin (9002-62-4) ; sapropterin (EGX657432I) ; Apomorphine (N21FAR7B4S) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2020-07-22
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	604631-9
ISSN	1533-712X ; 0271-0749
ISSN (online)	1533-712X
ISSN	0271-0749
DOI	10.1097/JCP.0000000000001241
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Article ; Online: First-Dose Methylphenidate-Induced Changes in the Anti-Saccade Task Performance and Outcome in Adults with Attention-Deficit/Hyperactivity Disorder.

Duval, Fabrice / Erb, Alexis / Mokrani, Marie-Claude / Weiss, Thomas / Carcangiu, Roberta

Psychiatric research and clinical practice

2021 Volume 3, Issue 4, Page(s) 146–152

Abstract: Objective: We examined whether the anti-saccade task (AST) performance after the first methylphenidate (MPH) dose could be associated with subsequent clinical outcome in adults with attention-deficit/hyperactivity disorder (ADHD).: Methods: Ninety- ... ...

Abstract	Objective: We examined whether the anti-saccade task (AST) performance after the first methylphenidate (MPH) dose could be associated with subsequent clinical outcome in adults with attention-deficit/hyperactivity disorder (ADHD). Methods: Ninety-seven drug-naive DSM-5 ADHD adults participated in this study. The AST parameters were measured at baseline, after the first MPH-dose (10 mg orally), and 6 months after chronic MPH treatment. Results were compared with those of 50 healthy control (HC) subjects. Results: At baseline, ADHDs showed longer saccadic reaction times and more direction errors than HCs (both Conclusions: Our findings indicate that: (1) impairments of motor planning and response inhibition in adults with ADHD are improved with MPH, and (2) a low direction error percentage after the first MPH-dose may be an independent predictor of remission.ClinicalTrials.gov identifier: NCT03411434.
Language	English
Publishing date	2021-05-19
Publishing country	United States
Document type	Journal Article
ISSN	2575-5609
ISSN (online)	2575-5609
DOI	10.1176/appi.prcp.20210010
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Article: Neuroendocrine Assessment of Dopaminergic Function during Antidepressant Treatment in Major Depressed Patients.

Duval, Fabrice / Mokrani, Marie-Claude / Erb, Alexis / Gonzalez Lopera, Felix / Danila, Vlad / Tomsa, Mihaela

Brain sciences

2021 Volume 11, Issue 4

Abstract: The effects of antidepressants on dopamine (DA) receptor sensitivity in the mesolimbic-hypothalamic system have yielded contradictory results. The postsynaptic DA receptor function was evaluated by the cortisol response to apomorphine (APO; 0.75 mg SC) ... ...

Abstract	The effects of antidepressants on dopamine (DA) receptor sensitivity in the mesolimbic-hypothalamic system have yielded contradictory results. The postsynaptic DA receptor function was evaluated by the cortisol response to apomorphine (APO; 0.75 mg SC) in 16 drug-free DSM-5 major depressed inpatients and 18 healthy hospitalized control (HC) subjects. Cortisol response to the dexamethasone suppression test (DST) was also measured. After two and four weeks of antidepressant treatment (ADT), the DST and APO test were repeated in all patients. Cortisol response to APO (∆COR) was not influenced by the hypothalamic-pituitary-adrenal (HPA) axis activity, as assessed by the DST. Pre-treatment ∆COR values did not differ significantly between patients and HCs. During ADT, ∆COR values were lower than in HCs at week 2 and 4. After four weeks of treatment, among the eight patients who had blunted ∆COR values, seven were subsequent remitters, while among the eight patients who had normal ∆COR values, seven were non-remitters. Considering the limitations of our study, the results suggest that following chronic ADT, the desensitization of postsynaptic DA receptors connected with the regulation of the HPA axis at the hypothalamic level is associated with clinical remission. These results could reflect increased DA levels in the mesolimbic pathway.
Language	English
Publishing date	2021-03-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci11040425
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Article ; Online: À propos d’un cas d’exacerbation sévère d’acouphènes lors d’un syndrome d’arrêt à la venlafaxine.

Meyer, Guillaume / Erb, Alexis / Michel, Bruno / Hingray, Coraline / Duval, Fabrice / Javelot, Hervé

Therapie

2020 Volume 76, Issue 5, Page(s) 483–486

Title translation	Tinnitus and venlafaxine discontinuation syndrome.
MeSH term(s)	Humans ; Substance Withdrawal Syndrome ; Tinnitus ; Venlafaxine Hydrochloride/adverse effects
Chemical Substances	Venlafaxine Hydrochloride (7D7RX5A8MO)
Language	French
Publishing date	2020-06-26
Publishing country	France
Document type	Letter
ZDB-ID	603474-3
ISSN	1958-5578 ; 0040-5957
ISSN (online)	1958-5578
ISSN	0040-5957
DOI	10.1016/j.therap.2020.06.009
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Article ; Online: Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics.

Corre, Béatrice / El Janati Elidrissi, Yassine / Duval, Justine / Quilhot, Mailys / Lefebvre, Gaëtan / Ecomard, Solène / Lemaître, Fabrice / Garcia, Zacarias / Bohineust, Armelle / Russo, Erica / Bousso, Philippe

iScience

2023 Volume 26, Issue 2, Page(s) 106068

Abstract: T cells become activated following one or multiple contacts with antigen-presenting cells. Calcium influx is a key signaling event elicited during these cellular interactions; however, it is unclear whether T cells recall and integrate calcium signals ... ...

Abstract	T cells become activated following one or multiple contacts with antigen-presenting cells. Calcium influx is a key signaling event elicited during these cellular interactions; however, it is unclear whether T cells recall and integrate calcium signals elicited during temporally separated contacts. To study the integration of calcium signals, we designed a programmable, multiplex illumination strategy for temporally patterned optogenetics (TEMPO). We found that a single round of calcium elevation was insufficient to promote nuclear factor of activated T cells (NFAT) activity and cytokine production in a T cell line. However, robust responses were detected after a second identical stimulation even when signals were separated by several hours. Our results suggest the existence of a biochemical memory of calcium signals in T cells that favors signal integration during temporally separated contacts and promote cytokine production. As illustrated here, TEMPO is a versatile approach for dissecting temporal integration in defined signaling pathways.
Language	English
Publishing date	2023-01-26
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.106068
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