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Article ; Online: Cistatina C

Adialys Alemán Zamora / Lutgarda María Pérez de Alejo Rodriguez / Yusimí González Alvarez / Carmen Xiomara Moré Chang

Edumecentro, Vol 15, Iss 1, Pp e2559-e

la necesidad de su conocimiento en la atención preventiva de daño renal

2023 Volume 2559

Abstract: El conocimiento y actualización sobre la Cistatina C como marcador de daño renal precoz ... uno de los marcadores sanguíneos convencionales más utilizados es la creatinina, el estudio sanguíneo de Cistatina C ... es en extremo necesario para los profesionales de la salud con vistas a mejorar el diagnóstico ...

Abstract	El conocimiento y actualización sobre la Cistatina C como marcador de daño renal precoz es en extremo necesario para los profesionales de la salud con vistas a mejorar el diagnóstico temprano de enfermedad renal. Las autoras realizaron una revisión bibliográfica actualizada a través de varios estudios científicos, lo que permitió poder informar que aun cuando para la evaluación de la función renal uno de los marcadores sanguíneos convencionales más utilizados es la creatinina, el estudio sanguíneo de Cistatina C no está sometido a diferentes fuentes de variabilidad biológica, ni a factores dependientes del paciente, por lo que sería idóneo tenerlo en cuenta como marcador de función renal precoz.
Keywords	Special aspects of education ; LC8-6691 ; Medicine (General) ; R5-920
Language	Spanish
Publishing date	2023-03-01T00:00:00Z
Publisher	Universidad de Ciencias Médicas de Villa Clara “Dr. Serafín Ruíz de Zárate Ruíz"
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Monitorización de la Función Renal durante el Tratamiento de Hepatitis C: ¿Es realmente necesaria?

Gonzales-Zamora, José A

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru

2023 Volume 43, Issue 2, Page(s) 181–171828

Title translation	Monitoring Kidney Function during the treatment of Hepatitis C: Is it really necessary?
MeSH term(s)	Humans ; Hepatitis C/drug therapy ; Hepacivirus ; Kidney ; Antiviral Agents/adverse effects ; Hepatitis C, Chronic/drug therapy
Chemical Substances	Antiviral Agents
Language	Spanish
Publishing date	2023-08-19
Publishing country	Peru
Document type	Journal Article
ZDB-ID	2058591-3
ISSN	1609-722X ; 1609-722X
ISSN (online)	1609-722X
ISSN	1609-722X
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Article ; Online: Guarea microcarpa C. DC. extract inhibits NLRP3 inflammasome by suppressing its ATPase activity.

Lee, Sojung / Yun, Sojin / Yang, Hyeyun / Lee, Nahyun / Kim, YeJi / Lee, Sumin / Zamora, Nelson A / Montero, Silvia Soto / Yi, Dong-Keun / Kim, Soo-Yong / Choi, Sangho / Choi, Taesoo / Kim, Man S / Lee, Yoonsung / Park, Yong Hwan

Journal of ethnopharmacology

2024 Volume 323, Page(s) 117711

Abstract: ... microcarpa C. DC. extract (GM) exhibited no cytotoxicity and specifically suppressed the activation ...

Abstract	Ethnopharmacological relevance: Guarea genus comprises tropical and subtropical terrestrial herbs inhabiting Central and South America. These plants, including Guarea guidonia (L.) Sleumer, have anti-inflammatory, analgesic, antibacterial, antiviral, and immune-enhancing properties. Aim of the study: Although various species of the Guarea genus are known for their medicinal properties, comprehensive data on their anti-inflammatory effects remain limited. Therefore, we investigated the NLRP3 inflammasome-inhibiting effects of the Guarea genus in this study. Materials and methods: To evaluate the anti-inflammatory activities of 18 members of the Guarea genus, we treated NLRP3 inflammasome activators with their extracts in LPS-primed J774A.1 and THP-1 cells. Cell viability was determined by water soluble tetrazolium salt (WST) and cytokine production, protein expression, and nuclear fractionation were determined by western blotting. Reactive oxygen species (ROS) production and apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) oligomerization were measured using confocal microscopic analysis. Inflammation-induced zebrafish was used in the in vivo experiments. Results: Among the 18 Guarea members tested, Guarea microcarpa C. DC. extract (GM) exhibited no cytotoxicity and specifically suppressed the activation of the NLRP3 inflammasome, but not of the AIM2 or NLRC4 inflammasomes, by inhibiting the ATPase activity of NLRP3. This was achieved without affecting NF-κB signaling, potassium efflux, or intracellular ROS production, all of which are involved in NLRP3 activation. The reduced ATPase activity of NLRP3 led to decreased ASC oligomerization. Furthermore, GM exhibited anti-inflammatory effects in vivo. Additionally, GM treatment alleviated inflammation at the organismal level in an LPS-induced inflammation model using zebrafish embryos. Conclusion: Our results demonstrate the anti-inflammatory effects of GM via suppressing the NLRP3 inflammasome. Therefore, GM can be a potential therapeutic candidate for various inflammatory diseases caused by aberrant NLRP3 inflammasome activation.
MeSH term(s)	Animals ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Zebrafish ; Reactive Oxygen Species/metabolism ; Lipopolysaccharides/pharmacology ; Caspase 1/metabolism ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Inflammation/drug therapy ; NF-kappa B/metabolism ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Adenosine Triphosphatases ; Interleukin-1beta/metabolism
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Reactive Oxygen Species ; Lipopolysaccharides ; Caspase 1 (EC 3.4.22.36) ; Anti-Inflammatory Agents ; NF-kappa B ; Anti-Inflammatory Agents, Non-Steroidal ; Adenosine Triphosphatases (EC 3.6.1.-) ; Interleukin-1beta
Language	English
Publishing date	2024-01-03
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.117711
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Article ; Online: C-kit-derived CD11b

Plenter, R J / Coulombe, M G / Roybal, H M / Lin, C M / Gill, R G / Zamora, M R / Grazia, T J

Cellular immunology

2019 Volume 347, Page(s) 104023

Abstract: Autologous C-kit ...

Abstract	Autologous C-kit
MeSH term(s)	Abatacept/pharmacology ; Allografts ; Animals ; CD11b Antigen/metabolism ; Calcineurin Inhibitors ; Cardiomyopathies/mortality ; Cardiomyopathies/surgery ; Cyclosporine/pharmacology ; Female ; Graft Rejection/immunology ; Graft Survival/immunology ; Heart Transplantation/methods ; Immunosuppressive Agents/pharmacology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Myeloid Cells/immunology ; Proto-Oncogene Proteins c-kit/metabolism ; Stem Cell Transplantation ; Stem Cells/physiology ; Transplantation, Homologous
Chemical Substances	CD11b Antigen ; Calcineurin Inhibitors ; Immunosuppressive Agents ; Itgam protein, mouse ; Abatacept (7D0YB67S97) ; Cyclosporine (83HN0GTJ6D) ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
Language	English
Publishing date	2019-12-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80094-6
ISSN	1090-2163 ; 0008-8749
ISSN (online)	1090-2163
ISSN	0008-8749
DOI	10.1016/j.cellimm.2019.104023
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Article ; Online: Alpha-galactosylceramide as adjuvant induces protective cell-mediated immunity against Leishmania mexicana infection in vaccinated BALB/c mice.

Diupotex, Mariana / Zamora-Chimal, Jaime / Cervantes-Sarabia, Rocely Buenaventura / Salaiza-Suazo, Norma / Becker, Ingeborg

Cellular immunology

2023 Volume 386, Page(s) 104692

Abstract: ... of amastigotes (100 μg) against Leishmania mexicana infection in BALB/c mice. The prophylactic vaccination led ...

Abstract	Adjuvants represent a promising strategy to improve vaccine effectiveness against infectious diseases such as leishmaniasis. Vaccination with the invariant natural killer T cell ligand α-galactosylceramide (αGalCer) has been used successfully as adjuvant, generating a Th1-biased immunomodulation. This glycolipid enhances experimental vaccination platforms against intracellular parasites including Plasmodium yoelii and Mycobacterium tuberculosis. In the present study, we assessed the protective immunity induced by a single-dose intraperitoneal injection of αGalCer (2 μg) co-administrated with a lysate antigen of amastigotes (100 μg) against Leishmania mexicana infection in BALB/c mice. The prophylactic vaccination led to 5.0-fold reduction of parasite load at the infection site, compared to non-vaccinated mice. A predominant pro-inflammatory response was observed in challenged vaccinated mice, represented by a 1.9 and 2.8-fold-increase of IL-1β and IFN-γ producing cells, respectively, in the lesions, and by 23.7-fold-increase of IFN-γ production in supernatants of restimulated splenocytes, all compared to control groups. The co-administration of αGalCer also stimulated the maturation of splenic dendritic cells and modulated a Th1-skewed immune response, with high amounts of IFN-γ production in serum. Furthermore, peritoneal cells of αGalCer-immunized mice exhibited an elevated expression of Ly6G and MHCII. These findings indicate that αGalCer improves protection against cutaneous leishmaniasis, supporting evidence for its potential use as adjuvant in Leishmania-vaccines.
MeSH term(s)	Mice ; Animals ; Leishmania mexicana ; Mice, Inbred BALB C ; Immunity, Cellular ; Adjuvants, Immunologic/pharmacology ; Leishmaniasis, Cutaneous ; Antigens, Protozoan
Chemical Substances	alpha-galactosylceramide ; Adjuvants, Immunologic ; Antigens, Protozoan
Language	English
Publishing date	2023-02-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80094-6
ISSN	1090-2163 ; 0008-8749
ISSN (online)	1090-2163
ISSN	0008-8749
DOI	10.1016/j.cellimm.2023.104692
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Article ; Online: Expansion of the cytochrome C oxidase subunit I database and description of four new lobose testate amoebae species (Amoebozoa; Arcellinida).

Ribeiro, Giulia M / Useros, Fernando / Dumack, Kenneth / González-Miguéns, Rubén / Siemensma, Ferry / Porfírio-Sousa, Alfredo L / Soler-Zamora, Carmen / Pedro Barbosa Alcino, João / Lahr, Daniel J G / Lara, Enrique

European journal of protistology

2023 Volume 91, Page(s) 126013

Abstract: Arcellinida is ascending in importance in protistology, but description of their diversity still presents multiple challenges. Furthermore, applicable tools for surveillance of these organisms are still in developing stages. Importantly, a good database ... ...

Abstract	Arcellinida is ascending in importance in protistology, but description of their diversity still presents multiple challenges. Furthermore, applicable tools for surveillance of these organisms are still in developing stages. Importantly, a good database that sets a correspondence between molecular barcodes and species morphology is lacking. Cytochrome oxidase (COI) has been suggested as the most relevant marker for species discrimination in Arcellinida. However, some major groups of Arcellinida are still lacking a COI sequence. Here we expand the database of COI marker sequences for Arcellinids, using single-cell PCR, transcriptomics, and database scavenging. In the present work, we added 24 new Arcellinida COI sequences to the database, covering all unsampled infra- and suborders. Additionally, we added six new SSUrRNA sequences and described four new species using morphological, morphometrical, and molecular evidence: Heleopera steppica, Centropyxis blatta, Arcella uspiensis, and Cylindrifflugia periurbana. This new database will provide a new starting point to address new research questions from shell evolution, biogeography, and systematics of arcellinids.
MeSH term(s)	Amoeba ; Electron Transport Complex IV/genetics ; Phylogeny ; Amoebozoa ; Lobosea
Chemical Substances	Electron Transport Complex IV (EC 1.9.3.1)
Language	English
Publishing date	2023-08-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047872-0
ISSN	1618-0429 ; 0932-4739
ISSN (online)	1618-0429
ISSN	0932-4739
DOI	10.1016/j.ejop.2023.126013
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Article ; Online: Allopregnanolone Promotes Migration and Invasion of Human Glioblastoma Cells through the Protein Tyrosine Kinase c-Src Activation.

Zamora-Sánchez, Carmen J / Bello-Alvarez, Claudia / Rodríguez-Dorantes, Mauricio / Camacho-Arroyo, Ignacio

International journal of molecular sciences

2022 Volume 23, Issue 9

Abstract: ... of the enzymes involved in its metabolism (AKR1C1-4), and the role of the c-Src kinase in 3α-THP effects in GBs ... activated c-Src protein at 10 min (U251 cells) and 15 min (U87 and LN229 cells). Interestingly ... the pharmacological inhibition of c-Src decreases the promoting effects of 3α-THP on cell migration and invasion ...

Abstract	Glioblastomas (GBs) are the most aggressive and common primary malignant brain tumors. Steroid hormone progesterone (P4) and its neuroactive metabolites, such as allopregnanolone (3α-THP) are synthesized by neural, glial, and malignant GB cells. P4 promotes cellular proliferation, migration, and invasion of human GB cells at physiological concentrations. It has been reported that 3α-THP promotes GB cell proliferation. Here we investigated the effects of 3α-THP on GB cell migration and invasion, the participation of the enzymes involved in its metabolism (AKR1C1-4), and the role of the c-Src kinase in 3α-THP effects in GBs. 3α-THP 100 nM promoted migration and invasion of U251, U87, and LN229 human-derived GB cell lines. We observed that U251, LN229, and T98G cell lines exhibited a higher protein content of AKR1C1-4 than normal human astrocytes. AKR1C1-4 silencing did not modify 3α-THP effects on migration and invasion. 3α-THP activated c-Src protein at 10 min (U251 cells) and 15 min (U87 and LN229 cells). Interestingly, the pharmacological inhibition of c-Src decreases the promoting effects of 3α-THP on cell migration and invasion. Together, these data indicate that 3α-THP promotes GB migration and invasion through c-Src activation.
MeSH term(s)	CSK Tyrosine-Protein Kinase/metabolism ; Cell Proliferation ; Glioblastoma/metabolism ; Humans ; Pregnanolone/metabolism ; Pregnanolone/pharmacology ; Protein-Tyrosine Kinases
Chemical Substances	Pregnanolone (BXO86P3XXW) ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; CSK Tyrosine-Protein Kinase (EC 2.7.10.2)
Language	English
Publishing date	2022-04-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23094996
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Article: Polygenic Markers in Patients Diagnosed of Autosomal Dominant Hypercholesterolemia in Catalonia: Distribution of Weighted LDL-c-Raising SNP Scores and Refinement of Variant Selection.

Martín-Campos, Jesús M / Ruiz-Nogales, Sheila / Ibarretxe, Daiana / Ortega, Emilio / Sánchez-Pujol, Elisabet / Royuela-Juncadella, Meritxell / Vila, Àlex / Guerrero, Carolina / Zamora, Alberto / Soler I Ferrer, Cristina / Arroyo, Juan Antonio / Carreras, Gemma / Martínez-Figueroa, Susana / Roig, Rosa / Plana, Núria / Blanco-Vaca, Francisco / Xarxa d'Unitats de Lípids I Arteriosclerosi Xula

Biomedicines

2020 Volume 8, Issue 9

Abstract: Familial hypercholesterolemia (FH) is associated with mutations in the low-density lipoprotein (LDL) receptor ( ...

Abstract	Familial hypercholesterolemia (FH) is associated with mutations in the low-density lipoprotein (LDL) receptor (
Language	English
Publishing date	2020-09-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines8090353
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Article: Antimicrobial and anti-inflammatory activity of Cystatin C on human gingival fibroblast incubated with

Blancas-Luciano, Blanca Esther / Becker-Fauser, Ingeborg / Zamora-Chimal, Jaime / Delgado-Domínguez, José / Ruíz-Remigio, Adriana / Leyva-Huerta, Elba Rosa / Portilla-Robertson, Javier / Fernández-Presas, Ana María

PeerJ

2022 Volume 10, Page(s) e14232

Abstract: ... of : Conclusions: Cystatin C inhibits the growth of P. gingivalis and decreases the inflammatory cytokines, ROS ...

Abstract	Background: Periodontal disease is considered one of the most prevalent chronic infectious diseases, often leading to the disruption of tooth-supporting tissues, including alveolar bone, causing tooth mobility and loss. Methods: P. gingivalis Results: Cystatin Cinhibited the growth of Conclusions: Cystatin C inhibits the growth of P. gingivalis and decreases the inflammatory cytokines, ROS, and NO production during infection of HGFs with
MeSH term(s)	Humans ; Porphyromonas gingivalis ; Interleukin-10/pharmacology ; Reactive Oxygen Species/pharmacology ; Cystatin C/pharmacology ; Nitric Oxide/pharmacology ; Cytokines/pharmacology ; Periodontal Diseases ; Anti-Inflammatory Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Fibroblasts
Chemical Substances	Interleukin-10 (130068-27-8) ; Reactive Oxygen Species ; Cystatin C ; Nitric Oxide (31C4KY9ESH) ; Cytokines ; Anti-Inflammatory Agents ; Anti-Infective Agents
Language	English
Publishing date	2022-10-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.14232
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Article ; Online: Basal procalcitonin, C-reactive protein, interleukin-6, and presepsin for prediction of mortality in critically ill septic patients: a systematic review and meta-analysis.

Molano-Franco, Daniel / Arevalo-Rodriguez, Ingrid / Muriel, Alfonso / Del Campo-Albendea, Laura / Fernández-García, Silvia / Alvarez-Méndez, Ana / Simancas-Racines, Daniel / Viteri, Andres / Sanchez, Guillermo / Fernandez-Felix, Borja / Lopez-Alcalde, Jesus / Solà, Ivan / Osorio, Dimelza / Khan, Khalid Saeed / Nuvials, Xavier / Ferrer, Ricard / Zamora, Javier

Diagnostic and prognostic research

2023 Volume 7, Issue 1, Page(s) 15

Abstract: ... PCT), C-reactive protein (CRP), interleukin-6 (IL-6), and presepsin (sCD14) are independent prognostic ...

Abstract	Background: Numerous biomarkers have been proposed for diagnosis, therapeutic, and prognosis in sepsis. Previous evaluations of the value of biomarkers for predicting mortality due to this life-threatening condition fail to address the complexity of this condition and the risk of bias associated with prognostic studies. We evaluate the predictive performance of four of these biomarkers in the prognosis of mortality through a methodologically sound evaluation. Methods: We conducted a systematic review a systematic review and meta-analysis to determine, in critically ill adults with sepsis, whether procalcitonin (PCT), C-reactive protein (CRP), interleukin-6 (IL-6), and presepsin (sCD14) are independent prognostic factors for mortality. We searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials up to March 2023. Only Phase-2 confirmatory prognostic factor studies among critically ill septic adults were included. Random effects meta-analyses pooled the prognostic association estimates. Results: We included 60 studies (15,681 patients) with 99 biomarker assessments. Quality of the statistical analysis and reporting domains using the QUIPS tool showed high risk of bias in > 60% assessments. The biomarker measurement as a continuous variable in models adjusted by key covariates (age and severity score) for predicting mortality at 28-30 days showed a null or near to null association for basal PCT (pooled OR = 0.99, 95% CI = 0.99-1.003), CRP (OR = 1.01, 95% CI = 0.87 to 1.17), and IL-6 (OR = 1.02, 95% CI = 1.01-1.03) and sCD14 (pooled HR = 1.003, 95% CI = 1.000 to 1.006). Additional meta-analyses accounting for other prognostic covariates had similarly null findings. Conclusion: Baseline, isolated measurement of PCT, CRP, IL-6, and sCD14 has not been shown to help predict mortality in critically ill patients with sepsis. The role of these biomarkers should be evaluated in new studies where the patient selection would be standardized and the measurement of biomarker results. Trial registration: PROSPERO (CRD42019128790).
Language	English
Publishing date	2023-08-03
Publishing country	England
Document type	Journal Article ; Review
ISSN	2397-7523
ISSN (online)	2397-7523
DOI	10.1186/s41512-023-00152-2
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