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  1. Article ; Online: Exploring Current Molecular Targets in the Treatment of Neovascular Age-Related Macular Degeneration toward the Perspective of Long-Term Agents.

    Fragiotta, Serena / Bassis, Lorena / Abdolrahimzadeh, Barmak / Marino, Alessandra / Sepe, Massimiliano / Abdolrahimzadeh, Solmaz

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: Long-lasting anti-vascular endothelial growth factor (anti-VEGF) agents have become an option to reduce treatment frequency, with ongoing research exploring optimal responses and safety profiles. This review delves into molecular targets, pharmacological ...

    Abstract Long-lasting anti-vascular endothelial growth factor (anti-VEGF) agents have become an option to reduce treatment frequency, with ongoing research exploring optimal responses and safety profiles. This review delves into molecular targets, pharmacological aspects, and strategies for achieving effective and enduring disease control in neovascular age-related macular degeneration (AMD). The molecular pathways involved in macular neovascularization, including angiogenesis and arteriogenesis, are explored. VEGF, PlGF, Ang-1, and Ang-2 play crucial roles in regulating angiogenesis, influencing vessel growth, maturation, and stability. The complex interplay of these factors, along with growth factors like TGFβ and bFGF, contributes to the pathogenesis of neovascular membranes. Current anti-VEGF therapies, including bevacizumab, ranibizumab, aflibercept, brolucizumab, and faricimab, are discussed with a focus on their pharmacokinetics and clinical applications. Strategies to achieve sustained disease control in AMD involve smaller molecules, increased drug dosages, and novel formulations. This narrative review provides a comprehensive overview of the molecular targets and pharmacological aspects of neovascular AMD treatment.
    MeSH term(s) Humans ; Macular Degeneration/drug therapy ; Macular Degeneration/metabolism ; Angiogenesis Inhibitors/therapeutic use ; Angiogenesis Inhibitors/pharmacology ; Molecular Targeted Therapy/methods ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Animals ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/metabolism
    Chemical Substances Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Unusual choroidal vessels in neurofibromatosis type 1 observed with near-infrared reflectance and spectral domain optical coherence tomography.

    Abdolrahimzadeh, Solmaz / Parisi, Francesco / Abdolrahimzadeh, Barmak / Cruciani, Filippo

    Acta ophthalmologica

    2016  Volume 94, Issue 8, Page(s) e815–e816

    MeSH term(s) Choroid/blood supply ; Choroid Diseases/diagnostic imaging ; European Continental Ancestry Group ; Female ; Humans ; Infrared Rays ; Middle Aged ; Neurofibromatosis 1/diagnostic imaging ; Retrospective Studies ; Tomography, Optical Coherence/methods
    Language English
    Publishing date 2016-12
    Publishing country England
    Document type Letter
    ZDB-ID 2408333-1
    ISSN 1755-3768 ; 1755-375X
    ISSN (online) 1755-3768
    ISSN 1755-375X
    DOI 10.1111/aos.13193
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    In stock of ZB MED Cologne/Königswinter

    Ul I Zs.90: Show issues Location:
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  3. Article: Bilateral diffuse choroidal hemangioma in Sturge Weber syndrome: A case report highlighting the role of multimodal imaging and a brief review of the literature.

    Formisano, Martina / Abdolrahimzadeh, Barmak / Mollo, Roberto / Bruni, Pietro / Malagola, Romualdo / Abdolrahimzadeh, Solmaz

    Journal of current ophthalmology

    2018  Volume 31, Issue 2, Page(s) 242–249

    Abstract: Purpose: To present a patient with bilateral choroidal hemangioma in Sturge-Weber syndrome (SWS) and highlight multimodal imaging techniques for early detection and management of ocular alterations.: Methods: A 37-year-old woman with diagnosis of SWS ...

    Abstract Purpose: To present a patient with bilateral choroidal hemangioma in Sturge-Weber syndrome (SWS) and highlight multimodal imaging techniques for early detection and management of ocular alterations.
    Methods: A 37-year-old woman with diagnosis of SWS presented to our unit. The patient had been treated with pulsed dye laser for bilateral nevus flammeus and had right leptomeningeal angiomatosis. She had glaucoma, but ultrasound biomicroscopy did not show anterior chamber or ciliary body alterations.
    Results: Enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT) showed bilateral diffuse choroidal hemangiomas in both eyes with choroidal thickness above 1000 μm. B-scan ultrasound examination showed diffuse choroidal hemangioma in both eyes, with a choroidal thickness of 1.53 mm and 1.94 mm in the right and left eye (RE, LE), respectively. Peripapillary retinal nerve fiber evaluation showed thinning of the retinal nerve fiber layer in both eyes.
    Conclusions: This report highlights multimodal imaging techniques for the critical assessment of patients with SWS, especially in rare cases with bilateral choroidal hemangioma of the choroid. Novel imaging modalities enable optimal management and follow-up of rare conditions, and our case adds further evidence to the existing literature.
    Language English
    Publishing date 2018-11-07
    Publishing country India
    Document type Case Reports
    ISSN 2452-2325
    ISSN 2452-2325
    DOI 10.1016/j.joco.2018.10.001
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  4. Article ; Online: An Update on Oculodermal Melanocytosis and Rare Associated Conditions.

    Plateroti, Andrea Maria / Scavella, Vittorio / Abdolrahimzadeh, Barmak / Plateroti, Rocco / Rahimi, Siavash

    Seminars in ophthalmology

    2017  Volume 32, Issue 4, Page(s) 524–528

    Abstract: Oculodermal melanocytosis (ODM) is a rare disease, which is characterized by hyperpigmentation of facial skin and several parts of the eye, such as the sclera, conjunctiva, cornea, iris, ciliary body, and choroid. The condition usually affects the Asian ... ...

    Abstract Oculodermal melanocytosis (ODM) is a rare disease, which is characterized by hyperpigmentation of facial skin and several parts of the eye, such as the sclera, conjunctiva, cornea, iris, ciliary body, and choroid. The condition usually affects the Asian female population. The most typical presenting ocular sign is iris heterocromia. Iris hyperpigmentation may be associated with iris mammillations, which are dome-shaped protuberations of the iris surface. They are linked to a higher risk of malignant transformation when present in patients with ODM. Glaucoma is a complication of ODM and is caused by angle abnormalities or mechanical occlusion by melanocytes in an open irido-corneal angle. Choroidal and ciliary body melanoma have a higher incidence in this condition characterized by melanocytosis. Patients presenting ODM should undergo routine ophthalmological examination in order to carefully monitor for glaucoma and melanoma.
    MeSH term(s) Choroid/pathology ; Ciliary Body/pathology ; Humans ; Melanocytes/pathology ; Melanoma/diagnosis ; Melanosis/diagnosis ; Skin Neoplasms/diagnosis ; Uveal Neoplasms/diagnosis
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 632820-9
    ISSN 1744-5205 ; 0882-0538
    ISSN (online) 1744-5205
    ISSN 0882-0538
    DOI 10.3109/08820538.2015.1118133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2153: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: A review of the role of ultrasound biomicroscopy in glaucoma associated with rare diseases of the anterior segment.

    Mannino, Giuseppe / Abdolrahimzadeh, Barmak / Calafiore, Silvia / Anselmi, Gianmario / Mannino, Cristina / Lambiase, Alessandro

    Clinical ophthalmology (Auckland, N.Z.)

    2016  Volume 10, Page(s) 1453–1459

    Abstract: Ultrasound biomicroscopy is a non-invasive imaging technique, which allows high-resolution evaluation of the anatomical features of the anterior segment of the eye regardless of optical media transparency. This technique provides diagnostically ... ...

    Abstract Ultrasound biomicroscopy is a non-invasive imaging technique, which allows high-resolution evaluation of the anatomical features of the anterior segment of the eye regardless of optical media transparency. This technique provides diagnostically significant information in vivo for the cornea, anterior chamber, chamber angle, iris, posterior chamber, zonules, ciliary body, and lens, and is of great value in assessment of the mechanisms of glaucoma onset. The purpose of this paper is to review the use of ultrasound biomicroscopy in the diagnosis and management of rare diseases of the anterior segment such as mesodermal dysgenesis of the neural crest, iridocorneal endothelial syndrome, phakomatoses, and metabolic disorders.
    Language English
    Publishing date 2016-07-29
    Publishing country New Zealand
    Document type Journal Article ; Review
    ISSN 1177-5467
    ISSN 1177-5467
    DOI 10.2147/OPTH.S112166
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  6. Article: Neurofibromatosis: an update of ophthalmic characteristics and applications of optical coherence tomography.

    Abdolrahimzadeh, Barmak / Piraino, Domenica Carmen / Albanese, Giorgio / Cruciani, Filippo / Rahimi, Siavash

    Clinical ophthalmology (Auckland, N.Z.)

    2016  Volume 10, Page(s) 851–860

    Abstract: Neurofibromatosis (NF) is a multisystem disorder and tumor predisposition syndrome caused by genetic mutation on chromosome 17-17q11.2 in NF type 1 (NF1), and on chromosome 22-22q12.2 in NF type 2. The disorder is characterized by considerable ... ...

    Abstract Neurofibromatosis (NF) is a multisystem disorder and tumor predisposition syndrome caused by genetic mutation on chromosome 17-17q11.2 in NF type 1 (NF1), and on chromosome 22-22q12.2 in NF type 2. The disorder is characterized by considerable heterogeneity of clinical expression. NF1 is the form with the most characteristic ocular manifestations. Lisch nodules of the iris are among the well-known diagnostic criteria for the disease. Glaucoma and associated globe enlargement have been described in a significant proportion of patients with NF1 and orbital-facial involvement. Optic nerve glioma may cause strabismus and proptosis, and palpebral neurofibroma may reach considerable size and occasionally show malignant transformation. Near infrared reflectance has greatly contributed to enhancing our knowledge on choroidal alterations in NF1. Indeed, some authors have proposed to include these among the diagnostic criteria. Optical coherence tomography has given new insight on retinal alterations and is a noninvasive tool in the management of optic nerve gliomas in children. Ocular manifestations in NF type 2 can range from early-onset cataracts in up to 80% of cases to optic nerve hamartomas and combined pigment epithelial and retinal hamartomas.
    Language English
    Publishing date 2016-05-13
    Publishing country New Zealand
    Document type Journal Article ; Review
    ISSN 1177-5467
    ISSN 1177-5467
    DOI 10.2147/OPTH.S102830
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Spectral domain optical coherence tomography and B-scan ultrasonography in the evaluation of retinal tears in acute, incomplete posterior vitreous detachment.

    Abdolrahimzadeh, Solmaz / Piraino, Domenica Carmen / Scavella, Vittorio / Abdolrahimzadeh, Barmak / Cruciani, Filippo / Gharbiya, Magda / Recupero, Santi Maria

    BMC ophthalmology

    2016  Volume 16, Page(s) 60

    Abstract: Background: The purpose of this study was to evaluate the extension and traction effects of posterior vitreous detachment (PVD) complicated with retinal tears using spectral domain optical coherence tomography (OCT) and B-scan ultrasonography.: ... ...

    Abstract Background: The purpose of this study was to evaluate the extension and traction effects of posterior vitreous detachment (PVD) complicated with retinal tears using spectral domain optical coherence tomography (OCT) and B-scan ultrasonography.
    Methods: Complete ophthalmological examination, B-scan ultrasonography and spectral domain OCT were performed in patients with acute PVD and retinal tears. Vitreous detachment was classified as complete or incomplete, based on extent of posterior pole or peripheral vitreous detachment. Retinal tear location and persistent traction on the retinal flap was evaluated with B-scan ultrasonography and OCT. Categorical data were evaluated with Fisher's exact test. Statistical significance was considered as P < 0.05.
    Results: Twenty-six eyes of 25 patients were assessed. Four eyes (15 %) presented complete PVD with detachment at the posterior pole and periphery. 22 eyes (85 %) presented incomplete PVD with detachment in the periphery. Twenty eyes presented retinal tears in the superior quadrants with respect to only 6 in the inferior quadrants (p = 0.006). There was a higher incidence of retinal tears in the pre with respect to post-equatorial areas (19 vs 7 eyes, p = 0.019). B-scan ultrasonography and OCT revealed persistent traction on the retinal tear flap in 19 and 15 eyes, respectively.
    Conclusions: In acute PVD, retinal tears are prevalently associated with peripheral vitreous detachment. The impact of complete or incomplete PVD can be of clinical value when evaluating patients with retinal tears.
    MeSH term(s) Acute Disease ; Aged ; Female ; Humans ; Male ; Middle Aged ; Ophthalmoscopy/methods ; Retinal Perforations/diagnostic imaging ; Retinal Perforations/pathology ; Tomography, Optical Coherence/methods ; Ultrasonography/methods ; Vitreous Detachment/diagnostic imaging ; Vitreous Detachment/pathology
    Language English
    Publishing date 2016-05-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050436-6
    ISSN 1471-2415 ; 1471-2415
    ISSN (online) 1471-2415
    ISSN 1471-2415
    DOI 10.1186/s12886-016-0242-0
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