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  1. Article ; Online: BAP1 depletion in human B-lymphoblast cells affects the production of innate immune cytokines and chemokines.

    Takagi-Kimura, Misato / Tada, Akio / Kijima, Takashi / Kubo, Shuji / Ohmuraya, Masaki / Yoshikawa, Yoshie

    Genes to cells : devoted to molecular & cellular mechanisms

    2022  Volume 27, Issue 12, Page(s) 731–740

    Abstract: BRCA1 associated protein 1 (BAP1) is a ubiquitin C-terminal hydrolase that deubiquitinates histone H2AK119ub and other proteins and regulates the expression of multiple genes. The knockout of this tumor suppressor gene results in severe thymic atrophy, ... ...

    Abstract BRCA1 associated protein 1 (BAP1) is a ubiquitin C-terminal hydrolase that deubiquitinates histone H2AK119ub and other proteins and regulates the expression of multiple genes. The knockout of this tumor suppressor gene results in severe thymic atrophy, complete loss of the T cell lineage, and abnormal B cell development in mice. In the current study, we investigated in vitro effects of BAP1 knockout on cytokine and chemokine production using the human B-lymphoblast cell line TSCE5. We confirmed that knockout changed the production of innate immune-associated genes and their receptors. The CCL19, CCR7, CCL2, and CXCR5 genes associated with T and B cell migration were upregulated. Knockout cells producing high levels of CCL19 showed acceleration of actin polymerization, which is essential for cell migration. CD69, PTPRC, and TLR3 genes that activate inflammation were downregulated. The tumor necrosis factor ligand genes TNF, LTA, and TNFSF10 were downregulated by knockout. In knockout cells, TNFα production was strongly downregulated upon the addition of H
    MeSH term(s) Humans ; Mice ; Animals ; Ubiquitin Thiolesterase/genetics ; Cytokines/genetics ; Mice, Knockout ; Chemokines/genetics ; Immunity, Innate ; Tumor Suppressor Proteins/genetics
    Chemical Substances Ubiquitin Thiolesterase (EC 3.4.19.12) ; Cytokines ; Chemokines ; BAP1 protein, human ; Tumor Suppressor Proteins ; BAP1 protein, mouse
    Language English
    Publishing date 2022-11-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330000-3
    ISSN 1365-2443 ; 1356-9597
    ISSN (online) 1365-2443
    ISSN 1356-9597
    DOI 10.1111/gtc.12988
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4539: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article: Application of cultured autogenous periosteal cell sheets for periodontal and alveolar bone regeneration.

    Okuda, Kazuhiro / Nagata, Masaki / Takagi, Ritsuo / Nakata, Koh / Yoshie, Hiromasa

    Nihon rinsho. Japanese journal of clinical medicine

    2018  Volume 73 Suppl 5, Page(s) 473–478

    MeSH term(s) Alveolar Ridge Augmentation/methods ; Bone Regeneration ; Cells, Cultured ; Humans ; Tissue Engineering/methods
    Language Japanese
    Publishing date 2018-11-19
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 429: Show issues Location:
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  3. Article ; Online: Author Correction: Performance and usefulness of a novel automated immunoassay HISCL SARS-CoV-2 Antigen assay kit for the diagnosis of COVID-19.

    Saito, Kaori / Ai, Tomohiko / Kawai, Akinori / Matsui, Jun / Fukushima, Yoshiyuki / Kikukawa, Norihiro / Kyoutou, Takuya / Chonan, Masayoshi / Kawakami, Takeaki / Hosaka, Yoshie / Misawa, Shigeki / Takagi, Haruhi / Matsushita, Yasushi / Hiki, Makoto / Okuzawa, Atsushi / Hori, Satoshi / Naito, Toshio / Miida, Takashi / Takahashi, Kazuhisa /
    Tabe, Yoko

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 23968

    Language English
    Publishing date 2021-12-08
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-03518-y
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  4. Article: Management of pregnancy complicated by ankylosing spondylitis: A case report and literature review.

    Midorikawa, Asumi / Wang, Liangcheng / Kuwata, Tomoyuki / Taniguchi, Yoshie / Horiuchi, Isao / Matsushita, Chikako / Chikazawa, Kenro / Takagi, Kenjiro

    Clinical case reports

    2019  Volume 7, Issue 4, Page(s) 766–769

    Abstract: Pregnancy complicated by ankylosing spondylitis is rare. Labor assistance and instrumental delivery may be difficult due to hip stiffness. Restriction in lumbar flexion may cause difficulties in administering neuraxial analgesia. Difficult intubation for ...

    Abstract Pregnancy complicated by ankylosing spondylitis is rare. Labor assistance and instrumental delivery may be difficult due to hip stiffness. Restriction in lumbar flexion may cause difficulties in administering neuraxial analgesia. Difficult intubation for general anesthesia due to limited neck mobility is another potential risk that must be considered.
    Language English
    Publishing date 2019-03-06
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.2085
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  5. Article ; Online: Hypertension is a characteristic complication of X-linked hypophosphatemia.

    Nakamura, Yoshie / Takagi, Masaki / Takeda, Ryojun / Miyai, Kentaro / Hasegawa, Yukihiro

    Endocrine journal

    2017  Volume 64, Issue 3, Page(s) 283–289

    Abstract: X-linked hypophosphatemia (XLH) is a group of rare disorders caused by defective proximal tubular reabsorption of phosphate. Mutations in the PHEX gene are responsible for the majority of cases. There are very few reports of long-term complications of ... ...

    Abstract X-linked hypophosphatemia (XLH) is a group of rare disorders caused by defective proximal tubular reabsorption of phosphate. Mutations in the PHEX gene are responsible for the majority of cases. There are very few reports of long-term complications of XLH other than skeletal and dental diseases. The aim of this study was to identify the phenotypic presentation of XLH during adulthood including complications other than skeletal and dental diseases. The clinical and biochemical phenotype of 22 adult patients with a PHEX gene mutation were examined retrospectively from their medical records. 6 patients had hypertension. The average age of hypertension onset was 29.0 years. Secondary hyperparathyroidism preceded the development of hypertension in 5 patients. 1 patient developed tertiary hyperparathyroidism. 15 patients had nephrocalcinosis. 2 patients had chronic renal dysfunction. Patients with hypertension had a significantly lower eGFR (p=0.010) compared to patients without hypertension. No significant difference was found in any other parameters. To examine the genotype-phenotype correlation, 10 adult males were chosen for analysis. No significant genotype-phenotype correlation analysis was revealed in any of the complications. However, there was a possibility that the age at nephrocalcinosis onset was younger in the non-missense mutation group than in the missense mutation group (p=0.063). This study corroborated the view that early-onset hypertension could be one of the characteristic complications seen in XLH patients. Considering the limited number of our patients, further study is necessary to address a potential cause of hypertension. XLH patients require careful lifelong treatment.
    MeSH term(s) Adolescent ; Adult ; Age of Onset ; Bone Density Conservation Agents/therapeutic use ; Child ; Child, Preschool ; Dietary Supplements ; Familial Hypophosphatemic Rickets/diet therapy ; Familial Hypophosphatemic Rickets/genetics ; Familial Hypophosphatemic Rickets/physiopathology ; Female ; Hospitals, Pediatric ; Humans ; Hydroxycholecalciferols/therapeutic use ; Hyperparathyroidism, Secondary/epidemiology ; Hyperparathyroidism, Secondary/etiology ; Hyperparathyroidism, Secondary/prevention & control ; Hypertension/epidemiology ; Hypertension/etiology ; Hypertension/prevention & control ; Male ; Medical Records ; Mutation ; Nephrocalcinosis/epidemiology ; Nephrocalcinosis/etiology ; Nephrocalcinosis/prevention & control ; PHEX Phosphate Regulating Neutral Endopeptidase/genetics ; Phosphates/therapeutic use ; Prevalence ; Retrospective Studies ; Tokyo/epidemiology ; Young Adult
    Chemical Substances Bone Density Conservation Agents ; Hydroxycholecalciferols ; Phosphates ; PHEX Phosphate Regulating Neutral Endopeptidase (EC 3.4.24.-) ; PHEX protein, human (EC 3.4.24.-) ; alfacalcidol (URQ2517572)
    Language English
    Publishing date 2017-03-31
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1151918-6
    ISSN 1348-4540 ; 0918-8959
    ISSN (online) 1348-4540
    ISSN 0918-8959
    DOI 10.1507/endocrj.EJ16-0199
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.207: Show issues Location:
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  6. Article: Sugar-responsive transcription factor bZIP3 affects leaf shape in Arabidopsis plants.

    Sanagi, Miho / Lu, Yu / Aoyama, Shoki / Morita, Yoshie / Mitsuda, Nobutaka / Ikeda, Miho / Ohme-Takagi, Masaru / Sato, Takeo / Yamaguchi, Junji

    Plant biotechnology (Tokyo, Japan)

    2019  Volume 35, Issue 2, Page(s) 167–170

    Abstract: Sugars are essential for plant metabolism, growth and development. Plants must therefore manage their growth and developmental processes in response to sugar availability. Sugar signaling pathways constitute a complicated molecular network and are ... ...

    Abstract Sugars are essential for plant metabolism, growth and development. Plants must therefore manage their growth and developmental processes in response to sugar availability. Sugar signaling pathways constitute a complicated molecular network and are associated with global transcriptional regulation. However, the molecular mechanisms underlying sugar signaling remain largely unclear. This study reports that the protein basic-region leucine zipper 3 (bZIP3) is a novel sugar-responsive transcription factor in Arabidopsis plants. The expression of
    Language English
    Publishing date 2019-12-02
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2210142-1
    ISSN 1347-6114 ; 1342-4580
    ISSN (online) 1347-6114
    ISSN 1342-4580
    DOI 10.5511/plantbiotechnology.18.0410a
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  7. Article ; Online: Management of pregnancy complicated by ankylosing spondylitis

    Asumi Midorikawa / Liangcheng Wang / Tomoyuki Kuwata / Yoshie Taniguchi / Isao Horiuchi / Chikako Matsushita / Kenro Chikazawa / Kenjiro Takagi

    Clinical Case Reports, Vol 7, Iss 4, Pp 766-

    A case report and literature review

    2019  Volume 769

    Abstract: Key Clinical Message Pregnancy complicated by ankylosing spondylitis is rare. Labor assistance and instrumental delivery may be difficult due to hip stiffness. Restriction in lumbar flexion may cause difficulties in administering neuraxial analgesia. ... ...

    Abstract Key Clinical Message Pregnancy complicated by ankylosing spondylitis is rare. Labor assistance and instrumental delivery may be difficult due to hip stiffness. Restriction in lumbar flexion may cause difficulties in administering neuraxial analgesia. Difficult intubation for general anesthesia due to limited neck mobility is another potential risk that must be considered.
    Keywords ankylosing spondylitis ; cesarean section ; obstetrics anesthesia ; pregnancy ; vaginal delivery ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Author Correction

    Kaori Saito / Tomohiko Ai / Akinori Kawai / Jun Matsui / Yoshiyuki Fukushima / Norihiro Kikukawa / Takuya Kyoutou / Masayoshi Chonan / Takeaki Kawakami / Yoshie Hosaka / Shigeki Misawa / Haruhi Takagi / Yasushi Matsushita / Makoto Hiki / Atsushi Okuzawa / Satoshi Hori / Toshio Naito / Takashi Miida / Kazuhisa Takahashi /
    Yoko Tabe

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    Performance and usefulness of a novel automated immunoassay HISCL SARS-CoV-2 Antigen assay kit for the diagnosis of COVID-19

    2021  Volume 1

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Solitary Fibrous Tumor of the Kidney Developing Local Recurrence.

    Usuba, Wataru / Sasaki, Hideo / Yoshie, Hidekazu / Kitajima, Kazuki / Kudo, Hiroya / Nakazawa, Ryuto / Sato, Yuichi / Takagi, Masayuki / Chikaraishi, Tatsuya

    Case reports in urology

    2016  Volume 2016, Page(s) 2426874

    Abstract: Solitary fibrous tumor (SFT) of the kidney is a rare entity and usually displays a favorable prognosis. We herein report a second case of renal SFT developing local recurrence. A 50-year-old man was referred to our hospital because of a left renal mass. ... ...

    Abstract Solitary fibrous tumor (SFT) of the kidney is a rare entity and usually displays a favorable prognosis. We herein report a second case of renal SFT developing local recurrence. A 50-year-old man was referred to our hospital because of a left renal mass. An abdominal CT detected a large renal tumor and radical nephrectomy was performed with a possible diagnosis of renal cell carcinoma. The resected tumor size was measured at 17 × 11 × 8 cm. Grossly, necrosis was observed in central lesion of the tumor but hemorrhage was not observed. Microscopically, the tumor consisted of spindle-shaped cells with scant cytoplasm accompanied by hyalinized collagenous tissue, which displayed hemangiopericytomatous patterns. The cellularity was normal and nuclear pleomorphism was not observed. Ki-67 labeling index was less than 3%. The pathological diagnosis of SFT was made without obvious malignant findings. Three years after the surgery, a follow-up CT scan detected a mass lesion in the tumor bed. Surgical resection was performed and the resected tumor was compatible with local recurrence of the SFT without obvious malignant findings. Renal SFT should be carefully monitored even in the absence of obvious malignant findings.
    Language English
    Publishing date 2016-04-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2627659-8
    ISSN 2090-6978 ; 2090-696X
    ISSN (online) 2090-6978
    ISSN 2090-696X
    DOI 10.1155/2016/2426874
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  10. Article ; Online: The TGN/EE SNARE protein SYP61 and the ubiquitin ligase ATL31 cooperatively regulate plant responses to carbon/nitrogen conditions in Arabidopsis.

    Hasegawa, Yoko / Huarancca Reyes, Thais / Uemura, Tomohiro / Baral, Anirban / Fujimaki, Akari / Luo, Yongming / Morita, Yoshie / Saeki, Yasushi / Maekawa, Shugo / Yasuda, Shigetaka / Mukuta, Koki / Fukao, Yoichiro / Tanaka, Keiji / Nakano, Akihiko / Takagi, Junpei / Bhalerao, Rishikesh P / Yamaguchi, Junji / Sato, Takeo

    The Plant cell

    2021  Volume 34, Issue 4, Page(s) 1354–1374

    Abstract: Ubiquitination is a post-translational modification involving the reversible attachment of the small protein ubiquitin to a target protein. Ubiquitination is involved in numerous cellular processes, including the membrane trafficking of cargo proteins. ... ...

    Abstract Ubiquitination is a post-translational modification involving the reversible attachment of the small protein ubiquitin to a target protein. Ubiquitination is involved in numerous cellular processes, including the membrane trafficking of cargo proteins. However, the ubiquitination of the trafficking machinery components and their involvement in environmental responses are not well understood. Here, we report that the Arabidopsis thaliana trans-Golgi network/early endosome localized SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) protein SYP61 interacts with the transmembrane ubiquitin ligase ATL31, a key regulator of resistance to disrupted carbon (C)/nitrogen/(N)-nutrient conditions. SYP61 is a key component of membrane trafficking in Arabidopsis. The subcellular localization of ATL31 was disrupted in knockdown mutants of SYP61, and the insensitivity of ATL31-overexpressing plants to high C/low N-stress was repressed in these mutants, suggesting that SYP61 and ATL31 cooperatively function in plant responses to nutrient stress. SYP61 is ubiquitinated in plants, and its ubiquitination level is upregulated under low C/high N-nutrient conditions. These findings provide important insights into the ubiquitin signaling and membrane trafficking machinery in plants.
    MeSH term(s) Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Carbon/metabolism ; Nitrogen/metabolism ; SNARE Proteins/metabolism ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; trans-Golgi Network/metabolism
    Chemical Substances Arabidopsis Proteins ; SNARE Proteins ; Ubiquitin ; Carbon (7440-44-0) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2021-12-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 623171-8
    ISSN 1532-298X ; 1040-4651
    ISSN (online) 1532-298X
    ISSN 1040-4651
    DOI 10.1093/plcell/koac014
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    In stock of ZB MED Bonn / Germany

    Z 4952: Show issues

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