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  1. Article ; Online: Magnetic resonance imaging of optic nerve and optic sheath hemorrhages in child abuse.

    Zuccoli, Giulio

    Pediatric radiology

    2021  Volume 51, Issue 6, Page(s) 997–1002

    Abstract: In abusive head trauma victims, optic nerves and optic sheath hemorrhages are commonly associated with retinal hemorrhages. Until now, optic nerve and optic nerve sheath hemorrhages related to abusive head trauma have been identified by exenteration and ... ...

    Abstract In abusive head trauma victims, optic nerves and optic sheath hemorrhages are commonly associated with retinal hemorrhages. Until now, optic nerve and optic nerve sheath hemorrhages related to abusive head trauma have been identified by exenteration and soft-tissue sectioning during postmortem examination. In 2013, we proposed the use of tailored high-resolution susceptibility-weighted imaging (SWI) MRI sequences to depict retinal hemorrhages in lieu of the gold standard dilated fundus exam, in select patients, and in 2017 we showed how the same high-resolution sequences used in the coronal plane can depict ruptured bridging veins in abusive head trauma. This paper describes the new potential diagnostic application of high-resolution axial and coronal SWI in the diagnosis of optic nerve and optic sheath hemorrhages.
    MeSH term(s) Child ; Child Abuse ; Craniocerebral Trauma ; Humans ; Infant ; Magnetic Resonance Imaging ; Optic Nerve/diagnostic imaging ; Retinal Hemorrhage/diagnostic imaging
    Language English
    Publishing date 2021-05-17
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-020-04891-y
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    Zs.A 927: Show issues Location:
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  2. Article ; Online: Novel in vivo depiction of optic nerves hemorrhages in child abuse: a 3D-SWI pilot study.

    Zuccoli, Giulio

    Neuroradiology

    2021  Volume 63, Issue 7, Page(s) 1113–1119

    Abstract: Purpose: Until now, the diagnosis of optic nerves hemorrhages in abusive head trauma (AHT) has been obtained only in the postmortem setting. The aim of the IRB-approved study was to assess the presence of optic nerves hemorrhages in AHT patients using ... ...

    Abstract Purpose: Until now, the diagnosis of optic nerves hemorrhages in abusive head trauma (AHT) has been obtained only in the postmortem setting. The aim of the IRB-approved study was to assess the presence of optic nerves hemorrhages in AHT patients using 3D-SWI.
    Methods: Thirteen children with a final confirmed multidisciplinary diagnosis of AHT underwent coronal and axial 3D-SWI imaging of the orbits. The presence of optic nerve sheath (ONS) hemorrhages was defined by thickening and marked 3D-SWI hypointensity of the ONS, resulting in mass effect upon the CSF space. Optic nerve (ON) hemorrhages were defined by areas of susceptibility artifacts in the ON parenchyma. Superficial siderosis was defined by susceptibility artifact coating the ON. Furthermore, data about post-traumatic deformity of the ONS at the head of the optic nerve were collected.
    Results: The average age of the population was 7.9 ± 5.9 months old. The average GCS was 11.8 ± 4.5. The male to female ratio was 7:6. ONS hemorrhages were identified in 69.2% of cases. Superficial siderosis and ON hemorrhages were identified in 38.5 and 76.9% of cases, respectively. 3D-SWI also depicted traumatic deformity of the ONS at the level of the optic nerve head in 10 cases (76.9%). No statistical correlations were identified between RetCam findings and 3D-SWI findings or GCS and ON hemorrhages.
    Conclusion: This research shows that dedicated MRI with volumetric SWI of the orbits can depict hemorrhages in the ON, ONS, and ONS injury, in AHT victims.
    MeSH term(s) Child ; Child Abuse ; Craniocerebral Trauma/complications ; Craniocerebral Trauma/diagnostic imaging ; Female ; Humans ; Infant ; Male ; Optic Nerve/diagnostic imaging ; Pilot Projects ; Retinal Hemorrhage/diagnostic imaging ; Retinal Hemorrhage/etiology
    Language English
    Publishing date 2021-01-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 123305-1
    ISSN 1432-1920 ; 0028-3940
    ISSN (online) 1432-1920
    ISSN 0028-3940
    DOI 10.1007/s00234-020-02622-6
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  3. Article ; Online: The importance of knowing the typical and atypical imaging findings of Wernicke encephalopathy.

    Zuccoli, Giulio

    Acta neurologica Belgica

    2020  Volume 121, Issue 5, Page(s) 1399–1400

    MeSH term(s) Humans ; Korsakoff Syndrome ; Thiamine/therapeutic use ; Wernicke Encephalopathy/diagnostic imaging
    Chemical Substances Thiamine (X66NSO3N35)
    Language English
    Publishing date 2020-09-23
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-020-01482-4
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  4. Article: Prolonged Hyperperfusion in a Child With ATP1A2 Defect-Related Hemiplegic Migraine.

    Cobb-Pitstick, Katherine / Cummings, Dana D / Zuccoli, Giulio

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    2020  Volume 47, Issue 5, Page(s) 687–688

    MeSH term(s) Child ; Hemiplegia/diagnostic imaging ; Hemiplegia/etiology ; Humans ; Migraine with Aura/complications ; Migraine with Aura/diagnostic imaging ; Mutation ; Pedigree ; Sodium-Potassium-Exchanging ATPase/genetics
    Chemical Substances ATP1A2 protein, human (EC 3.6.1.-) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13)
    Language English
    Publishing date 2020-04-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/cjn.2020.83
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  5. Article: Improved Brain Pathology and Progressive Peripheral Neuropathy in a 15 Year Old Survivor of Infantile Krabbe Disease Treated With Umbilical Cord Transplantation.

    Kofler, Julia / Beltran-Quintero, Maria L / Rugari, Anne / Zuccoli, Giulio / Klotz, Sarah / Escolar, Maria L

    Frontiers in molecular neuroscience

    2022  Volume 15, Page(s) 888231

    Abstract: Objective: Krabbe disease is a fatal leukodystrophy caused by deficiency in galactocerebrosidase enzyme activity. The only currently available therapy is hematopoietic stem cell transplantation with bone marrow or umbilical cord blood (UCBT), which ... ...

    Abstract Objective: Krabbe disease is a fatal leukodystrophy caused by deficiency in galactocerebrosidase enzyme activity. The only currently available therapy is hematopoietic stem cell transplantation with bone marrow or umbilical cord blood (UCBT), which leads to increased lifespan and functional abilities when performed in the preclinical stage. While stabilization of white matter disease has been seen on serial MRI studies, neuropathological changes following transplantation have not been documented so far.
    Materials and methods: We report the first postmortem examination of a 15-year-old female patient with infantile Krabbe disease after UCBT in infancy.
    Results: In contrast to an untreated Krabbe disease brain, which showed severe myelin and oligodendrocyte loss with occasional globoid cells, the transplanted brain displayed markedly improved myelin preservation, but not reaching normal myelination levels. Consistent with the transplanted patient's clinical presentation of pronounced deficits in gross motor skills, corticospinal tracts were most severely affected. No globoid cells or evidence of active demyelination were observed in the central nervous system, indicative of at least partially successful functional restoration. This was corroborated by the identification of male donor-derived cells in the brain by
    Conclusion: Umbilical cord blood transplantation was able to alter the natural disease progression in the central but less so in the peripheral nervous system, possibly due to limited cross-correction of Schwann cells.
    Language English
    Publishing date 2022-07-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2022.888231
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  6. Article: Ketogenic Metabolic Therapy, Without Chemo or Radiation, for the Long-Term Management of

    Seyfried, Thomas N / Shivane, Aditya G / Kalamian, Miriam / Maroon, Joseph C / Mukherjee, Purna / Zuccoli, Giulio

    Frontiers in nutrition

    2021  Volume 8, Page(s) 682243

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-05-31
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2021.682243
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  7. Article ; Online: Venous injury in pediatric abusive head trauma: a pictorial review.

    Vilanilam, George Koshy / Jayappa, Sateesh / Desai, Shivang / Zuccoli, Giulio / Ramakrishnaiah, Raghu H / Choudhary, Arabinda K

    Pediatric radiology

    2021  Volume 51, Issue 6, Page(s) 918–926

    Abstract: Abusive head trauma (AHT) is the leading cause of fatal head injuries in children younger than 2 years. An intracranial pathology can exist even in the setting of a normal physical exam. A delay in the diagnosis of AHT can have serious life-threatening ... ...

    Abstract Abusive head trauma (AHT) is the leading cause of fatal head injuries in children younger than 2 years. An intracranial pathology can exist even in the setting of a normal physical exam. A delay in the diagnosis of AHT can have serious life-threatening consequences for the child and increases the potential the child will be abused again. In this article, we review the traumatic subdural hematoma as well as various morpho-structural patterns of shearing injuries and thrombosis of intracranial bridging veins. This work serves as a summary of patterns of imaging features of intracranial venous injury in AHT, as described in the literature, to facilitate familiarity and early detection of abusive head trauma in the pediatric population. Essentially, in AHT there is a traumatic injury to the bridging vein with either partial or complete tear. This can secondarily result in thrombosis at the terminal end of the bridging vein with blood clots adjacent to the bridging vein.
    MeSH term(s) Child ; Child Abuse/diagnosis ; Craniocerebral Trauma/diagnostic imaging ; Hematoma, Subdural/diagnostic imaging ; Humans ; Infant ; Retrospective Studies ; Vascular System Injuries
    Language English
    Publishing date 2021-04-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-021-05016-9
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    Zs.A 927: Show issues Location:
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  8. Article ; Online: Neuroimaging of retinal hemorrhage utilizing adjunct orbital susceptibility-weighted imaging.

    Bhatia, Aashim / Mirsky, David M / Mankad, Kshitij / Zuccoli, Giulio / Panigrahy, Ashok / Nischal, Ken K

    Pediatric radiology

    2021  Volume 51, Issue 6, Page(s) 991–996

    Abstract: Retinal hemorrhages are an integral part of the evaluation of abusive head trauma (AHT). Timely detection of retinal hemorrhage not only facilitates the diagnosis of AHT, but has the potential to prevent further abuse to the child and the siblings and to ...

    Abstract Retinal hemorrhages are an integral part of the evaluation of abusive head trauma (AHT). Timely detection of retinal hemorrhage not only facilitates the diagnosis of AHT, but has the potential to prevent further abuse to the child and the siblings and to identify the abuser. The gold standard for diagnosing retinal hemorrhage is a dilated fundoscopy exam, which requires pharmacological dilation. As such, there is a small percentage of patients for whom the dilated fundoscopy exam might be delayed. Evolving literature suggests that MRI, specifically susceptibility-weighted imaging (SWI), of the orbits might provide an alternative diagnostic tool for noninvasively detecting retinal hemorrhages, particularly when there is a delay in administering the dilated fundoscopy exam. In this paper we review the utility of SWI for detecting retinal hemorrhages in abusive head trauma, including discussion of diagnostic limitations and future research.
    MeSH term(s) Child ; Child Abuse/diagnosis ; Craniocerebral Trauma/complications ; Craniocerebral Trauma/diagnostic imaging ; Humans ; Infant ; Magnetic Resonance Imaging ; Neuroimaging ; Retinal Hemorrhage/diagnostic imaging
    Language English
    Publishing date 2021-03-12
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-020-04897-6
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  9. Article ; Online: Synthetic Brain MRI: Review of Current Concepts and Future Directions.

    Gonçalves, Fabrício Guimarães / Serai, Suraj D / Zuccoli, Giulio

    Topics in magnetic resonance imaging : TMRI

    2018  Volume 27, Issue 6, Page(s) 387–393

    Abstract: Synthetic magnetic resonance imaging is a novel imaging technique that allows generating multiple contrast-weighted images based on relaxivity measurements of tissue properties in a single acquisition using a multiecho, multidelay saturation recovery ... ...

    Abstract Synthetic magnetic resonance imaging is a novel imaging technique that allows generating multiple contrast-weighted images based on relaxivity measurements of tissue properties in a single acquisition using a multiecho, multidelay saturation recovery spin-echo sequence. The synthetic images can be generated postacquisition from the parametric tissue maps, which can be beneficial to reduce scan time and improve patient throughput. Based on relaxometry maps, synthetic magnetic resonance imaging can also perform brain tissue segmentation and myelin quantification without additional scan time. The quantitative analysis may have implications for understanding and monitoring of the evolution of the maturation process. Similarly, the myelination process is vitally important to central nervous system functioning. Measuring myelin volume could provide relevant information for the diagnosis and treatment of patients with myelination disorders.
    MeSH term(s) Brain/diagnostic imaging ; Brain/pathology ; Brain Diseases/diagnostic imaging ; Brain Diseases/pathology ; Child ; Humans ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Imaging/trends
    Language English
    Publishing date 2018-12-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1112716-8
    ISSN 1536-1004 ; 0899-3459
    ISSN (online) 1536-1004
    ISSN 0899-3459
    DOI 10.1097/RMR.0000000000000189
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  10. Article ; Online: Rapidly Destructive Autoimmune Labyrinthitis Associated With Ulcerative Colitis.

    Hwang, Misun / Zuccoli, Giulio

    Pediatric neurology

    2015  Volume 53, Issue 4, Page(s) 375–376

    MeSH term(s) Adolescent ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/pathology ; Autoimmune Diseases/physiopathology ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/pathology ; Colitis, Ulcerative/physiopathology ; Follow-Up Studies ; Hearing Loss, Sensorineural/drug therapy ; Hearing Loss, Sensorineural/pathology ; Hearing Loss, Sensorineural/physiopathology ; Hearing Loss, Sensorineural/surgery ; Humans ; Labyrinthitis/drug therapy ; Labyrinthitis/pathology ; Labyrinthitis/physiopathology ; Magnetic Resonance Imaging ; Male
    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2015.03.023
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