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Article: A Worm's Tale or Why to Avoid the Raccoon Latrine: A Case of

Goldman-Yassen, Adam E / Derman, Anna / Madan, Rebecca Pellett / Radmanesh, Alireza

2022 Volume 2022, Page(s) 5199863

Abstract: The raccoon ... ...

Abstract	The raccoon roundworm
Language	English
Publishing date	2022-08-21
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627655-0
ISSN	2090-6870 ; 2090-6862
ISSN (online)	2090-6870
ISSN	2090-6862
DOI	10.1155/2022/5199863
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Article ; Online: Paranasal sinus development and implications for imaging.

Goldman-Yassen, Adam E / Meda, Karthik / Kadom, Nadja

Pediatric radiology

2021 Volume 51, Issue 7, Page(s) 1134–1148

Abstract: Because the paranasal sinuses continue to develop throughout childhood, radiologists encounter significant anatomical variation when confronted with pediatric imaging studies. Knowledge of the stages of sinus growth is vital to differentiate normal ... ...

Abstract	Because the paranasal sinuses continue to develop throughout childhood, radiologists encounter significant anatomical variation when confronted with pediatric imaging studies. Knowledge of the stages of sinus growth is vital to differentiate normal development from abnormally large, hypoplastic or malformed sinuses. Understanding how the paranasal sinuses develop and their expected appearance at different patient ages is important for accurate interpretation of diagnostic imaging. To that end, we provide a brief review of paranasal sinus anatomy and discuss the mechanisms by which each paranasal sinus develops, as well as the implications for imaging. We also provide a practical guide for assessing normal paranasal sinuses in children based on the relationship of the sinuses to anatomical landmarks at various stages of development in order to help pediatric radiologists provide accurate interpretation of diagnostic imaging.
MeSH term(s)	Anatomic Variation ; Child ; Diagnostic Tests, Routine ; Humans ; Paranasal Sinuses/diagnostic imaging ; Radiologists ; Tomography, X-Ray Computed
Language	English
Publishing date	2021-05-12
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	124459-0
ISSN	1432-1998 ; 0301-0449
ISSN (online)	1432-1998
ISSN	0301-0449
DOI	10.1007/s00247-020-04859-y
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Zs.A 927: Show issues

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Article ; Online: James T. Goodrich, MD, PhD.

Bello, Jacqueline A / Goldman-Yassen, Adam E

AJNR. American journal of neuroradiology

2020 Volume 41, Issue 7, Page(s) 1325

Keywords	covid19
Language	English
Publishing date	2020-07-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	603808-6
ISSN	1936-959X ; 0195-6108
ISSN (online)	1936-959X
ISSN	0195-6108
DOI	10.3174/ajnr.A6628
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Zs.A 1580: Show issues

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Article ; Online: Normative distribution of posterior circulation tissue time-to-maximum: Effects of anatomic variation, tracer kinetics, and implications for patient selection in posterior circulation ischemic stroke.

Goldman-Yassen, Adam E / Straka, Matus / Uhouse, Michael / Dehkharghani, Seena

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

2021 Volume 41, Issue 8, Page(s) 1912–1923

Abstract: The generalization of perfusion-based, anterior circulation large vessel occlusion selection criteria to posterior circulation stroke is not straightforward due to physiologic delay, which we posit produces physiologic prolongation of the posterior ... ...

Abstract	The generalization of perfusion-based, anterior circulation large vessel occlusion selection criteria to posterior circulation stroke is not straightforward due to physiologic delay, which we posit produces physiologic prolongation of the posterior circulation perfusion time-to-maximum (Tmax). To assess normative Tmax distributions, patients undergoing CTA/CTP for suspected ischemic stroke between 1/2018-3/2019 were retrospectively identified. Subjects with any cerebrovascular stenoses, or with follow-up MRI or final clinical diagnosis of stroke were excluded. Posterior circulation anatomic variations were identified. CTP were processed in RAPID and segmented in a custom pipeline permitting manually-enforced arterial input function (AIF) and perfusion estimations constrained to pre-specified vascular territories. Seventy-one subjects (mean 64 ± 19 years) met inclusion. Median Tmax was significantly greater in the cerebellar hemispheres (right: 3.0 s, left: 2.9 s) and PCA territories (right: 2.9 s; left: 3.3 s) than in the anterior circulation (right: 2.4 s; left: 2.3 s, p < 0.001). Fetal PCA disposition eliminated ipsilateral PCA Tmax delays (p = 0.012). Median territorial Tmax was significantly lower with basilar versus any anterior circulation AIF for all vascular territories (p < 0.001). Significant baseline delays in posterior circulation Tmax are observed even without steno-occlusive disease and vary with anatomic variation and AIF selection. The potential for overestimation of at-risk volumes in the posterior circulation merits caution in future trials.
MeSH term(s)	Acute Disease ; Aged ; Anatomic Variation ; Blood Circulation Time ; Brain/blood supply ; Brain/diagnostic imaging ; Cerebrovascular Circulation/physiology ; Female ; Humans ; Ischemic Stroke/physiopathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Patient Selection ; Perfusion Imaging ; Posterior Cerebral Artery/diagnostic imaging ; Posterior Cerebral Artery/physiopathology ; Retrospective Studies ; Tomography, X-Ray Computed
Language	English
Publishing date	2021-01-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	604628-9
ISSN	1559-7016 ; 0271-678X
ISSN (online)	1559-7016
ISSN	0271-678X
DOI	10.1177/0271678X20982395
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Zs.A 1663: Show issues

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Article ; Online: Vessel wall imaging with advanced flow suppression in the characterization of intracranial aneurysms following flow diversion with Pipeline embolization device.

Raz, Eytan / Goldman-Yassen, Adam / Derman, Anna / Derakhshani, Ahrya / Grinstead, John / Dehkharghani, Seena

Journal of neurointerventional surgery

2022 Volume 14, Issue 12, Page(s) 1264–1269

Abstract: Background: High-resolution vessel wall MRI (VWI) is increasingly used to characterize intramural disorders of the intracranial vasculature unseen by conventional arteriography.: Objective: To evaluate the use of VWI for surveillance of flow diverter ...

Abstract	Background: High-resolution vessel wall MRI (VWI) is increasingly used to characterize intramural disorders of the intracranial vasculature unseen by conventional arteriography. Objective: To evaluate the use of VWI for surveillance of flow diverter (FD) treated aneurysms. Materials and methods: Retrospective study of 28 aneurysms (in 21 patients) treated with a FD (mean 57 years; 14 female). All examinations included VWI and a contemporaneously obtained digital subtraction angiogram. Multiplanar pre- and post-gadolinium 3D, variable flip-angle T1 black-blood VWI was obtained using delay alternating nutation for tailored excitation (DANTE) at 3T. 3D time-of-flight MR angiography (MRA) was also carried out. Images were assessed for in-stent stenosis, aneurysm occlusion, presence and pattern/distribution of aneurysmal or parent vessel gadolinium enhancement. Results: The VWI-MRI was performed on average at 361±259 days after the intervention. Follow-up DSA was performed at 338±254 days postintervention. Good or excellent black-blood angiographic quality was recorded in 22/28 (79%) pre-contrast and 21/28 (75%) post-contrast VWI, with no cases excluded for image quality. Aneurysm enhancement was noted in 24/28 (85.7%) aneurysms, including in 79% of angiographically occluded aneurysms and 100% of angiographically non-occluded aneurysms. Enhancement of the stented parent-vessel wall occurred significantly more often when aneurysm enhancement was present (92% vs 33%, p=0.049). Conclusion: Advanced VWI produces excellent depiction of FD-treated aneurysms, with robust evaluation of the parent vessel and aneurysm wall to an extent not achievable with conventional MRI/MRA. Gadolinium enhancement may, however, continue even after enduring catheter angiographic occlusion, confounding interpretation, and requiring cognizance of this potentially prolonged effect in such patients.
MeSH term(s)	Humans ; Female ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/therapy ; Gadolinium ; Contrast Media ; Retrospective Studies ; Magnetic Resonance Angiography/methods ; Embolization, Therapeutic/methods ; Cerebral Angiography ; Angiography, Digital Subtraction/methods
Chemical Substances	Gadolinium (AU0V1LM3JT) ; Contrast Media
Language	English
Publishing date	2022-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/neurintsurg-2021-018086
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Zs.A 6845: Show issues

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Article ; Online: Metabolic Magnetic Resonance Imaging in Neuroimaging: Magnetic Resonance Spectroscopy, Sodium Magnetic Resonance Imaging and Chemical Exchange Saturation Transfer.

Hampton, Daniel G / Goldman-Yassen, Adam E / Sun, Phillip Zhe / Hu, Ranliang

Seminars in ultrasound, CT, and MR

2021 Volume 42, Issue 5, Page(s) 452–462

Abstract: Magnetic resonance (MR) is a powerful and versatile technique that offers much more beyond conventional anatomic imaging and has the potential of probing in vivo metabolism. Although MR spectroscopy (MRS) predates clinical MR imaging (MRI), its clinical ... ...

Abstract	Magnetic resonance (MR) is a powerful and versatile technique that offers much more beyond conventional anatomic imaging and has the potential of probing in vivo metabolism. Although MR spectroscopy (MRS) predates clinical MR imaging (MRI), its clinical application has been limited by technical and practical challenges. Other MR techniques actively being developed for in vivo metabolic imaging include sodium concentration imaging and chemical exchange saturation transfer. This article will review some of the practical aspects of MRS in neuroimaging, introduce sodium MRI and chemical exchange saturation transfer MRI, and highlight some of their emerging clinical applications.
MeSH term(s)	Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Neuroimaging ; Sodium
Chemical Substances	Sodium (9NEZ333N27)
Language	English
Publishing date	2021-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1353113-x
ISSN	1558-5034 ; 0887-2171
ISSN (online)	1558-5034
ISSN	0887-2171
DOI	10.1053/j.sult.2021.07.003
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Zs.A 1594: Show issues

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Article ; Online: Highly time-resolved 4D MR angiography using golden-angle radial sparse parallel (GRASP) MRI.

Goldman-Yassen, Adam E / Raz, Eytan / Borja, Maria J / Chen, Duan / Derman, Anna / Dogra, Siddhant / Block, Kai Tobias / Dehkharghani, Seena

Scientific reports

2022 Volume 12, Issue 1, Page(s) 15099

Abstract: Current dynamic MRA techniques are limited by temporal resolution and signal-to-noise penalties. GRASP, a fast and flexible MRI technique combining compressed-sensing, parallel imaging, and golden-angle radial sampling, acquires volumetric data ... ...

Abstract	Current dynamic MRA techniques are limited by temporal resolution and signal-to-noise penalties. GRASP, a fast and flexible MRI technique combining compressed-sensing, parallel imaging, and golden-angle radial sampling, acquires volumetric data continuously and can be reconstructed post hoc for user-defined applications. We describe a custom pipeline to retrospectively reconstruct ultrahigh temporal resolution, dynamic MRA from GRASP imaging obtained in the course of routine practice. GRASP scans were reconstructed using a custom implementation of the GRASP algorithm and post-processed with MeVisLab (MeVis Medical Solutions AG, Germany). Twenty consecutive examinations were scored by three neuroradiologists for angiographic quality of specific vascular segments and imaging artifacts using a 4-point scale. Unsubtracted images, baseline-subtracted images, and a temporal gradient dataset were available in 2D and 3D reconstructions. Distinct arterial and capillary phases were identified in all reconstructions, with a median of 2 frames (IQR1-3 and 2-3, respectively). Median rating for vascular segments was 3 (excellent) in all reconstructions and for nearly all segments, with excellent intraclass correlation (range 0.91-1.00). No cases were degraded by artifacts. GRASP-MRI obtained in routine practice can be seamlessly repurposed to produce high quality 4D MRA with 1-2-s resolved isotropic cerebrovascular angiography. Further exploration into diagnostic accuracy in disease-specific applications is warranted.
MeSH term(s)	Angiography ; Contrast Media ; Image Enhancement/methods ; Image Interpretation, Computer-Assisted/methods ; Imaging, Three-Dimensional/methods ; Magnetic Resonance Imaging/methods ; Retrospective Studies
Chemical Substances	Contrast Media
Language	English
Publishing date	2022-09-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-18191-y
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Article ; Online: Psychosis spectrum symptoms among individuals with schizophrenia-associated copy number variants and evidence of cerebellar correlates of symptom severity.

Sefik, Esra / Guest, Ryan M / Aberizk, Katrina / Espana, Roberto / Goines, Katrina / Novacek, Derek M / Murphy, Melissa M / Goldman-Yassen, Adam E / Cubells, Joseph F / Ousley, Opal / Li, Longchuan / Shultz, Sarah / Walker, Elaine F / Mulle, Jennifer G

Psychiatry research

2024 Volume 335, Page(s) 115867

Abstract: The 3q29 deletion (3q29Del) is a copy number variant (CNV) with one of the highest effect sizes for psychosis-risk (>40-fold). Systematic research offers avenues for elucidating mechanism; however, compared to CNVs like 22q11.2Del, 3q29Del remains ... ...

Abstract	The 3q29 deletion (3q29Del) is a copy number variant (CNV) with one of the highest effect sizes for psychosis-risk (>40-fold). Systematic research offers avenues for elucidating mechanism; however, compared to CNVs like 22q11.2Del, 3q29Del remains understudied. Emerging findings indicate that posterior fossa abnormalities are common among carriers, but their clinical relevance is unclear. We report the first in-depth evaluation of psychotic symptoms in participants with 3q29Del (N=23), using the Structured Interview for Psychosis-Risk Syndromes, and compare this profile to 22q11.2Del (N=31) and healthy controls (N=279). We also explore correlations between psychotic symptoms and posterior fossa abnormalities. Cumulatively, 48% of the 3q29Del sample exhibited a psychotic disorder or attenuated positive symptoms, with a subset meeting criteria for clinical high-risk. 3q29Del had more severe ratings than controls on all domains and only exhibited less severe ratings than 22q11.2Del in negative symptoms; ratings demonstrated select sex differences but no domain-wise correlations with IQ. An inverse relationship was identified between positive symptoms and cerebellar cortex volume in 3q29Del, documenting the first clinically-relevant neuroanatomical connection in this syndrome. Our findings characterize the profile of psychotic symptoms in the largest 3q29Del sample reported to date, contrast with another high-impact CNV, and highlight cerebellar involvement in psychosis-risk.
MeSH term(s)	Humans ; Female ; Male ; Schizophrenia/complications ; Schizophrenia/genetics ; DNA Copy Number Variations/genetics ; DiGeorge Syndrome ; Psychotic Disorders/complications ; Psychotic Disorders/genetics ; Psychotic Disorders/diagnosis
Language	English
Publishing date	2024-03-21
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2024.115867
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Zs.A 1541: Show issues

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Article ; Online: Torcular Dural Sinus Malformation: Fetal and Postnatal Imaging Findings and Their Associations With Clinical Outcomes.

Goldman-Yassen, Adam E / Shifrin, Anna / Mirsky, David M / Vossough, Arastoo / Licht, Daniel J / Feygin, Tamara

Pediatric neurology

2022 Volume 135, Page(s) 28–37

Abstract: Background: Torcular dural sinus malformations (tDSMs) are rare vascular malformations that present in fetuses and infants. Existing data on prognostic imaging features, as well as the associated morbidity and mortality, are limited and variable. We ... ...

Abstract	Background: Torcular dural sinus malformations (tDSMs) are rare vascular malformations that present in fetuses and infants. Existing data on prognostic imaging features, as well as the associated morbidity and mortality, are limited and variable. We therefore reviewed cases of tDSMs diagnosed on fetal magnetic resonance imaging (MRI) at our referral center to identify pre- and postnatal MRI imaging features associated with long-term outcomes. Methods: We searched our imaging database for fetal and postnatal MRI reports of tDSM cases. The electronic medical record was then reviewed for pre- and postnatal clinical data, including follow-up imaging. Neurological outcomes were characterized using the previously reported scale based on the Bicêtre Score. Imaging features association with outcome scores were compared using the Fisher exact test. Results: Sixteen cases of tDMS diagnosed by fetal MRI with postnatal clinical follow-up were identified, 11 of whom underwent postnatal MRI. The majority of cases of tDSM (73%) decreased in size or resolved on postnatal follow-up study without treatment. Restricted diffusion and parenchymal hemorrhage on fetal MRI were the only imaging features identified significantly associated with unfavorable neurological outcome or death, present in two patients with poor outcomes (two of two) and only one with a normal outcome (one of 14) (P = 0.025). Conclusions: Findings of tDSM on fetal MRI most often regress and/or resolve with normal or mild neurological outcomes, with the most significant predictor of poor outcome being the presence of parenchymal injury on fetal MRI. In addition, a subset will present with venolymphatic malformations.
MeSH term(s)	Central Nervous System Vascular Malformations/diagnostic imaging ; Cranial Sinuses/diagnostic imaging ; Female ; Fetus ; Follow-Up Studies ; Humans ; Infant ; Magnetic Resonance Imaging/methods ; Pregnancy ; Ultrasonography, Prenatal/methods
Language	English
Publishing date	2022-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	639164-3
ISSN	1873-5150 ; 0887-8994
ISSN (online)	1873-5150
ISSN	0887-8994
DOI	10.1016/j.pediatrneurol.2022.07.004
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Zs.A 2260: Show issues

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Article ; Online: A Worm’s Tale or Why to Avoid the Raccoon Latrine

Adam E. Goldman-Yassen / Anna Derman / Rebecca Pellett Madan / Alireza Radmanesh

Case Reports in Radiology, Vol

A Case of Baylisascaris procyonis Meningoencephalitis

2022 Volume 2022

Abstract: The raccoon roundworm Baylisascaris procyonis (B. procyonis) may infect humans to cause severe or fatal meningoencephalitis, as well as ocular and visceral larva migrans. Young children are at greater risk for cerebral larva migrans with severe ... ...

Abstract	The raccoon roundworm Baylisascaris procyonis (B. procyonis) may infect humans to cause severe or fatal meningoencephalitis, as well as ocular and visceral larva migrans. Young children are at greater risk for cerebral larva migrans with severe meningoencephalitis, and early empiric therapy may improve outcomes. Familiarity with characteristic brain imaging findings may prompt earlier diagnosis, particularly in the setting of CSF eosinophilia. We report a case of a 19-month-old boy who presented with truncal ataxia and was found to have peripheral and CSF eosinophilia. MRI demonstrated symmetric, confluent T2 hyperintense signal in the cerebral and cerebellar deep white mater, which helped differentiate B. procyonis meningoencephalitis from other infectious and non-infectious causes of eosinophilic meningoencephalitis. Early recognition and treatment of B. procyonis meningoencephalitis are important for improved outcomes, and careful review of neuroimaging can play a critical role in suggesting the diagnosis.
Keywords	Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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