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Article ; Audio / Video ; Online: Virtual Face to Face with Dr. Bruce Jarrell

Jarrell, Bruce E. / Gibson, Larry / Lee, Laura / Likowski, Alex

Voting and Elections during COVID-19 Pandemic ; Face to Face with Dr. Bruce Jarrell

2020

Abstract: News release and video of Dr. Bruce Jarrell, UMB Interim President, and Larry Gibson, Professor ...

Abstract	News release and video of Dr. Bruce Jarrell, UMB Interim President, and Larry Gibson, Professor of Law, UM Francis King Carey School of Law, discussing the significant effects of the pandemic on local and national election processes and voting. https://youtu.be/FQepvlS_RCE
Keywords	Coronavirus Disease 2019 (COVID-19) ; University of Maryland ; Baltimore ; COVID-19 (Disease) ; Elections ; Voting ; COVID-19 ; covid19
Language	English
Publishing date	2020-06-18
Publishing country	us
Document type	Article ; Audio / Video ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Predicting premature termination of exercise during Bruce protocol stress echocardiography.

Loh, Julian / Amanullah, Mohammed Rizwan / See, Chai Keat / Tang, Hak Chiaw / Gunasegaran, Kurugulasigamoney / Hamid, Nadira / Lau, Jeffrey / Lee, Chung Yin / Ewe, See Hooi / Ding, Zee Pin / Sahlén, Anders

Echocardiography (Mount Kisco, N.Y.)

2021 Volume 38, Issue 9, Page(s) 1612–1617

Abstract: ... selected to induce volitional exhaustion after a target duration of at least 8 minutes. While the Bruce ... patients not suitable for Bruce protocol which was accurate and yet simple enough to be used as a point ... of-care decision support tool.: Methods and results: We studied data out-patients undergoing Bruce ...

Abstract	Aims: Clinical guidelines recommend that the exercise protocol of a stress echocardiogram is selected to induce volitional exhaustion after a target duration of at least 8 minutes. While the Bruce protocol is very commonly used for clinical stress tests, it is known to be "steep", and many patients therefore fail to reach 8 minutes. We studied predictors of failure and developed a method for identifying patients not suitable for Bruce protocol which was accurate and yet simple enough to be used as a point-of-care decision support tool. Methods and results: We studied data out-patients undergoing Bruce protocol stress echocardiograms (n = 11 086) and analyzed predictors of inappropriate early termination (defined as test duration < 8 min as per current practice guidelines) using logistic regression. A prediction model was constructed as follows: .5 points were given for each of hypertension, diabetes, smoking, and E/e' > 7.9 in the resting echocardiogram; .1 point was added for each 1-unit increment in body mass index; 1 point was added for patient age by decade; 2.0 points were subtracted for male sex (p for all < 0.001). In tests on held-out validation data, the model was well calibrated (in plots of predicted vs actual risk) and discriminated failure versus non-failure well (C-statistic .86 for a score of 6.0 points; p < 0.001). Conclusion: These data may help to standardize protocol selection in stress echocardiography, by identifying patients pre-hoc where Bruce protocol will be inappropriately steep.
MeSH term(s)	Body Mass Index ; Echocardiography, Stress ; Exercise ; Exercise Test ; Humans ; Male
Language	English
Publishing date	2021-09-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	843645-9
ISSN	1540-8175 ; 0742-2822
ISSN (online)	1540-8175
ISSN	0742-2822
DOI	10.1111/echo.15186
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Article ; Online: Comparison of Six-Minute Walk Test and Modified Bruce Treadmill Test in Paediatric Patients With Severe Burns: A Cross-Over Study.

Palackic, Alen / Abazie, Stephanie / Parry, Ingrid / Sen, Soman / Mlcak, Ronald P / Lee, Jong O / Herndon, David N / Branski, Ludwik K / Wolf, Steven E / Spratt, Heidi / Suman, Oscar E

Journal of rehabilitation medicine

2022 Volume 54, Page(s) jrm00305

Abstract: Objective: To compare the six-minute walk test and the Modified Bruce treadmill test in paediatric ... Methods: Participants were assigned to perform the six-minute walk test and the Modified Bruce ... Modified Bruce treadmill test maximum heart rate was 148 ± 24 bpm (range 100-197 bpm; p ≤ 0.05 ...

Abstract	Objective: To compare the six-minute walk test and the Modified Bruce treadmill test in paediatric patients with severe burns. Subjects: A total of 67 children, aged 7-17 years, with severe burns. Methods: Participants were assigned to perform the six-minute walk test and the Modified Bruce treadmill test in randomized order on discharge from acute burn care. Primary outcome measure was heart rate. Secondary outcome measures were distance walked, Borg's CR-10 rate of perceived exertion, and maximal oxygen uptake (VO2). Results: A total of 67 participants were enrolled. Thirty-eight patients completed both tests. The mean six-minute walk test maximum heart rate was 135 ± 19 bpm (range 97-180 bpm) and the mean Modified Bruce treadmill test maximum heart rate was 148 ± 24 bpm (range 100-197 bpm; p ≤ 0.05), with a weak positive correlation of R² = 0.14. The mean six-minute walk test maximum distance was 294 ± 124 m (range 55 to 522 m) while the mean Modified Bruce treadmill test maximum distance was 439 ± 181 m (range 53 to 976 m; p ≤ 0.05), with no correlation of R² = 0.006. The mean RPE CR-10 score for the six-minute walk test was 3 ± 2.5 (range 0-10) vs a mean RPE CR-10 score of 10 ± 0 for the Modified Bruce treadmill test. Conclusion: The Modified Bruce treadmill test challenges the cardiorespiratory system significantly more than the six-minute walk test, as reflected by maximum heart rate measurements, and the perception of effort (i.e. rate of perceived exertion) by the patient. When possible, the Modified Bruce treadmill test should be used to assess cardiovascular functional capacity. However, the six-minute walk test may be more clinically feasible for use with paediatric patients with burns, and provides information about submaximal functional exercise capacity.
MeSH term(s)	Humans ; Child ; Walk Test ; Exercise Test ; Cross-Over Studies ; Walking/physiology ; Oxygen ; Burns ; Oxygen Consumption/physiology
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2022-10-19
Publishing country	Sweden
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2039427-5
ISSN	1651-2081 ; 1651-2235 ; 0891-060X ; 1650-1977
ISSN (online)	1651-2081 ; 1651-2235
ISSN	0891-060X ; 1650-1977
DOI	10.2340/jrm.v54.1064
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Article ; Online: Georg von Békésy and Bruce Mer: Early Pioneers of Endoscopic Ear Surgery.

Koen, Nicholas / Remenschneider, Aaron / Lee, Daniel J / Kozin, Elliott D

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

2020 Volume 164, Issue 5, Page(s) 1065–1067

Abstract: ... ear surgery: Georg von Békésy and Bruce Mer. In the 1940s, Dr von Békésy envisioned an endoscope ...

Abstract	The binocular operative microscope has been the workhorse of otologic and neurotologic surgeons since the 1950s. Since its advent, however, surgeons recognized that the operative microscope could not "look around corners" and its line-of-sight technology required soft tissue and bony dissection to enable light to reach the surgical plane. Endoscopic technology has evolved to address many of the limitations of operative microscopy. While the endoscope is often viewed as a recent development in otologic surgery, in the following historical article, we highlight the contributions of two mid-20th century pioneers of endoscopic ear surgery: Georg von Békésy and Bruce Mer. In the 1940s, Dr von Békésy envisioned an endoscope for determining stapes mobility. Dr Mer, with a team of engineers, created an otoendoscope to perform some of the first endoscopic ear procedures in the 1960s. Lessons gleaned from von Békésy and Mer's research include the need for counterculture thinking and the challenges of pioneering ideas beyond technical capacity.
MeSH term(s)	Equipment Design ; History, 20th Century ; Hungary ; Otologic Surgical Procedures/history ; Otologic Surgical Procedures/methods ; Otoscopes/history ; Otoscopy/history ; United States
Language	English
Publishing date	2020-09-29
Publishing country	England
Document type	Biography ; Historical Article ; Journal Article ; Portrait
ZDB-ID	392085-9
ISSN	1097-6817 ; 0161-6439 ; 0194-5998
ISSN (online)	1097-6817
ISSN	0161-6439 ; 0194-5998
DOI	10.1177/0194599820957307
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Book ; Online: Bruce Lee's Fighting Method

Lee, Bruce / Uyehara, M

The Complete Edition

2008

Abstract: ... with digitally-enhanced photography of jeet kune do founder Bruce Lee in his prime, a new chapter by former Lee ... student Ted Wong, and an introduction by Shannon Lee. This renowned compendium once again reclaims ... its place as an integral part of the Lee canon and a necessary addition for collectors and ...

Abstract	Vividly illustrating the techniques of a legendary innovator, this definitive examination explains how to survive attacks on the street, increase training awareness, and develop body movements. Originally compiled as a four-volume series, this revised edition breathes new life into a classic work with digitally-enhanced photography of jeet kune do founder Bruce Lee in his prime, a new chapter by former Lee student Ted Wong, and an introduction by Shannon Lee. This renowned compendium once again reclaims its place as an integral part of the Lee canon and a necessary addition for collectors and
Language	English
Size	Online-Ressource (645 p.)
Publisher	Black Belt Communications
Publishing place	Chicago
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9780897501705 ; 0897501705
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: The BRUCE-ATR Signaling Axis Is Required for Accurate DNA Replication and Suppression of Liver Cancer Development.

Ge, Chunmin / Vilfranc, Chrystelle L / Che, Lixiao / Pandita, Raj K / Hambarde, Shashank / Andreassen, Paul R / Niu, Liang / Olowokure, Olugbenga / Shah, Shimul / Waltz, Susan E / Zou, Lee / Wang, Jiang / Pandita, Tej K / Du, Chunying

Hepatology (Baltimore, Md.)

2019 Volume 69, Issue 6, Page(s) 2608–2622

Abstract: ... of such regulation on liver cancer remain unclear. The ubiquitin conjugase BRUCE (BIR Repeat containing ... strand break repair through homologous recombination. Here we demonstrate the functions for BRUCE in ATR ... activation in vitro and liver tumor suppression in vivo. BRUCE is recruited to induced DNA damage sites ...

Abstract	Replication fork stability during DNA replication is vital for maintenance of genomic stability and suppression of cancer development in mammals. ATR (ataxia-telangiectasia mutated [ATM] and RAD3-related) is a master regulatory kinase that activates the replication stress response to overcome replication barriers. Although many downstream effectors of ATR have been established, the upstream regulators of ATR and the effect of such regulation on liver cancer remain unclear. The ubiquitin conjugase BRUCE (BIR Repeat containing Ubiquitin-Conjugating Enzyme) is a guardian of chromosome integrity and activator of ATM signaling, which promotes DNA double-strand break repair through homologous recombination. Here we demonstrate the functions for BRUCE in ATR activation in vitro and liver tumor suppression in vivo. BRUCE is recruited to induced DNA damage sites. Depletion of BRUCE inhibited multiple ATR-dependent signaling events during replication stress, including activation of ATR itself, phosphorylation of its downstream targets CHK1 and RPA, and the mono-ubiquitination of FANCD2. Consequently, BRUCE deficiency resulted in stalled DNA replication forks and increased firing of new replication origins. The in vivo impact of BRUCE loss on liver tumorigenesis was determined using the hepatocellular carcinoma model induced by genotoxin diethylnitrosamine. Liver-specific knockout of murine Bruce impaired ATR activation and exacerbated inflammation, fibrosis and hepatocellular carcinoma, which exhibited a trabecular architecture, closely resembling human hepatocellular carcinoma (HCC). In humans, the clinical relevance of BRUCE down-regulation in liver disease was found in hepatitis, cirrhosis, and HCC specimens, and deleterious somatic mutations of the Bruce gene was found in human hepatocellular carcinoma in the Cancer Genome Atlas database. Conclusion: These findings establish a BRUCE-ATR signaling axis in accurate DNA replication and suppression of liver cancer in mice and humans and provides a clinically relevant HCC mouse model.
MeSH term(s)	Animals ; Ataxia Telangiectasia Mutated Proteins/genetics ; Carcinogenesis ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; DNA Repair/genetics ; DNA Replication/genetics ; Disease Models, Animal ; Female ; Gene Expression Regulation, Neoplastic ; Genomic Instability ; Humans ; Inhibitor of Apoptosis Proteins/genetics ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Male ; Mice ; Mice, Knockout ; Random Allocation ; Sensitivity and Specificity ; Signal Transduction/genetics ; Tumor Suppressor Proteins/genetics
Chemical Substances	BIRC6 protein, mouse ; Inhibitor of Apoptosis Proteins ; Tumor Suppressor Proteins ; Atr protein, mouse (EC 2.7.1.-) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1)
Language	English
Publishing date	2019-03-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.30529
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Book ; Online: Stanley Melbourne Bruce

Lee, David

Australian internationalist

2010

Abstract: Stanley Melbourne Bruce was at the centre of Imperial politics for more than two decades ... from the early 1920s until the end of the Second World War. This new biography presents Bruce as a consistent ... internationalist. Educated in Melbourne and Cambridge, Bruce, as a businessman, was alive to the importance ...

Author's details	David Lee
Abstract	Stanley Melbourne Bruce was at the centre of Imperial politics for more than two decades from the early 1920s until the end of the Second World War. This new biography presents Bruce as a consistent internationalist. Educated in Melbourne and Cambridge, Bruce, as a businessman, was alive to the importance of international commerce, and particularly Anglo-Australian trade. This lay at the core of his internationalism, which took the form in the 1920s of encouraging the political and economic integration of the British Empire. Bruce's punitive treatment of militant Australian trade unionists and
Keywords	Prime ministers ; Australia
Language	English
Size	Online-Ressource (x, 246 p.), ill
Publisher	Continuum
Publishing place	London ;New York
Document type	Book ; Online
Note	Includes bibliographical references and index
ISBN	0826445667 ; 9780826445667 ; 9780826445667
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Bruce, David

Lee, Sidney / Dingwall, Helen M

Oxford dictionary of national biography v.8

2004

Author's details	Sidney Lee, rev. Helen M. Dingwall
MeSH term(s)	Physicians ; History, 17th Century ; History of Medicine
Keywords	England
Language	English
Size	p. 287.
Publisher	Oxford University Press
Publishing place	Oxford ; New York
Document type	Article
ISBN	019861411X ; 9780198614111
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Modality determines VO2max achieved in self-paced exercise tests: validation with the Bruce protocol.

Hanson, Nicholas J / Scheadler, Cory M / Lee, Taylor L / Neuenfeldt, Noah C / Michael, Timothy J / Miller, Michael G

European journal of applied physiology

2016 Volume 116, Issue 7, Page(s) 1313–1319

Abstract: Purpose: The Bruce protocol is traditionally used to assess maximal cardiorespiratory fitness ... The purpose of this study was to compare SPVs, utilizing two different modes, with the Bruce (treadmill ... testing protocol. The first visit consisted of the Bruce protocol test, and the remaining visits entailed ...

Abstract	Purpose: The Bruce protocol is traditionally used to assess maximal cardiorespiratory fitness (VO2max), but may have limitations, such as an unknown duration and large work rate increases. The use of self-paced VO2max tests (SPVs) may be beneficial if they are able to elicit similar maximal values in a set period of time. In addition, differences in modality between SPVs have not been explored. The purpose of this study was to compare SPVs, utilizing two different modes, with the Bruce (treadmill) protocol. Method: Thirteen healthy, recreationally active individuals (eight men, five women) volunteered and participated in three different laboratory visits with each utilizing a different VO2max testing protocol. The first visit consisted of the Bruce protocol test, and the remaining visits entailed a maximal SPV on a treadmill (TM SPV) and a cycle ergometer (CE SPV). Results: There were no differences in VO2max values between the TM SPV and the Bruce protocol tests (55.6 ± 4.9 vs. 56.2 ± 6.8, respectively; p = .510). As expected, the CE SPV (48.3 ± 7.6) was significantly lower than the other two tests (p < .001). Conclusion: The TM SPV was as effective in eliciting an accurate VO2max as the Bruce protocol and did so with less incline and in less time suggesting that there are no changes in the limits of VO2max even when the test is self-paced and perceptually regulated.
MeSH term(s)	Exercise Test/methods ; Female ; Humans ; Male ; Oxygen Consumption/physiology ; Perception/physiology ; Physical Endurance/physiology ; Physical Exertion/physiology ; Pulmonary Gas Exchange/physiology ; Reproducibility of Results ; Sensitivity and Specificity ; Young Adult
Language	English
Publishing date	2016-07
Publishing country	Germany
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Validation Studies
ZDB-ID	124793-1
ISSN	1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
ISSN (online)	1439-6327 ; 1432-1025
ISSN	0301-5548 ; 1439-6319
DOI	10.1007/s00421-016-3384-0
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Article ; Online: Epstein-Barr virus-encoded microRNA BART15-3p promotes cell apoptosis partially by targeting BRUCE.

Choi, Hoyun / Lee, Hanna / Kim, Sae Rom / Gho, Yong Song / Lee, Suk Kyeong

Journal of virology

2013 Volume 87, Issue 14, Page(s) 8135–8144

Abstract: ... containing ubiquitin-conjugating enzyme (BRUCE) mRNAs. The luciferase reporter assay showed that only the 3' ... untranslated region (UTR) of BRUCE was affected by miR-BART15-3p. Two putative seed-matched sites for miR-BART15-3p ... were evident on the BRUCE 3' UTR. The results of a mutation study indicated that miR-BART15-3p ...

Abstract	Epstein-Barr Virus (EBV) generates a variety of viral microRNAs (miRNAs) by processing the BHRF1 and BamHI A rightward (BART) transcripts. BART miRNAs are expressed in all cells latently infected with EBV, but the functions of most BART miRNAs remain unknown. The results of a cell proliferation assay revealed that miR-BART15-3p inhibited cell proliferation. Fluorescence-activated cell sorting following staining with annexin V or propidium iodide showed that miR-BART15-3p promoted apoptosis. Furthermore, the inhibitor for miR-BART15-3p increased cell growth and reduced apoptosis in EBV-infected cells. Using bioinformatic analyses, we predicted that miR-BART15-3p may target the antiapoptotic B-cell lymphoma 2 (BCL2), BCL2L2, DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 (DDX42), and baculovirus inhibitor of apoptosis repeat-containing ubiquitin-conjugating enzyme (BRUCE) mRNAs. The luciferase reporter assay showed that only the 3' untranslated region (UTR) of BRUCE was affected by miR-BART15-3p. Two putative seed-matched sites for miR-BART15-3p were evident on the BRUCE 3' UTR. The results of a mutation study indicated that miR-BART15-3p hybridized only with the first seed-matched site on the BRUCE 3' UTR. miR-BART15-3p downregulated the BRUCE protein in EBV-negative cells, while the inhibitor for miR-BART15-3p upregulated the BRUCE protein in EBV-infected cells without affecting the BRUCE mRNA level. miR-BART15-3p was secreted from EBV-infected gastric carcinoma cells, and the level of miR-BART15-3p was 2- to 16-fold higher in exosomes than in the corresponding cells. Our data suggest that miR-BART15-3p can induce apoptosis partially by inhibiting the translation of the apoptosis inhibitor BRUCE. Further study is warranted to understand the role of miR-BART15-3p in the EBV life cycle.
MeSH term(s)	Analysis of Variance ; Annexin A5 ; Apoptosis/physiology ; Blotting, Western ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Computational Biology ; DNA Primers/genetics ; Flow Cytometry ; Herpesvirus 4, Human/genetics ; Humans ; Inhibitor of Apoptosis Proteins/metabolism ; Luciferases ; MicroRNAs/genetics ; MicroRNAs/metabolism ; MicroRNAs/pharmacology ; Microscopy, Electron, Transmission ; Plasmids/genetics ; Propidium ; RNA Interference ; Reverse Transcriptase Polymerase Chain Reaction
Chemical Substances	Annexin A5 ; BIRC6 protein, human ; DNA Primers ; Inhibitor of Apoptosis Proteins ; MicroRNAs ; Propidium (36015-30-2) ; Luciferases (EC 1.13.12.-)
Language	English
Publishing date	2013-05-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.03159-12
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