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  1. Book: Magnetic resonance in epilepsy

    Kuzniecky, Ruben I. / Jackson, Graeme D.

    neuroimaging techniques

    2005  

    Author's details Ruben I. Kuzniecky ; Graeme D. Jackson
    Keywords Epilepsy ; Pathology ; Magnetic Resonance Imaging / methods ; Epilepsie ; Gehirn ; Kernspintomografie
    Subject Kernspintomographie ; NMR-Tomographie ; Magnetische Kernresonanztomographie ; MR-Tomographie ; Kernspinresonanztomographie ; MRI ; Magnetic resonance imaging ; IRM ; Magnetresonanztomographie ; Magnetresonanztomografie ; MRT ; NMR-Tomografie ; Nukleare Kernspintomographie ; MR-Bildgebung ; Cerebrum ; Hirn ; Encephalon ; Enzephalon ; Hirngewebe ; Hirnmasse ; Gehirnmasse ; Fallsucht
    Language English
    Size XVII, 442 S. : zahlr. Ill., graph. Darst.
    Edition 2. ed.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT014103292
    ISBN 0-12-431152-0 ; 978-0-12-431152-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 A 320 order for loan Magazin

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  2. Article ; Online: Optimizing Surgical Planning for Epilepsy Patients With Multimodal Neuroimaging and Neurophysiology Integration: A Case Study.

    Gong, Ruxue / Bickel, Stephan / Tostaeva, Gelana / Lado, Fred A / Metha, Ashesh D / Kuzniecky, Ruben I / Bonilha, Leonardo F / Gleichgerrcht, Ezequiel L

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

    2024  

    Abstract: Summary: Current preoperative evaluation of epilepsy can be challenging because of the lack of a comprehensive view of the network's dysfunctions. To demonstrate the utility of our multimodal neurophysiology and neuroimaging integration approach in the ... ...

    Abstract Summary: Current preoperative evaluation of epilepsy can be challenging because of the lack of a comprehensive view of the network's dysfunctions. To demonstrate the utility of our multimodal neurophysiology and neuroimaging integration approach in the presurgical evaluation, we present a proof-of-concept for using this approach in a patient with nonlesional frontal lobe epilepsy who underwent two resective surgeries to achieve seizure control. We conducted a post-hoc investigation using four neuroimaging and neurophysiology modalities: diffusion tensor imaging, resting-state functional MRI, and stereoelectroencephalography at rest and during seizures. We computed region-of-interest-based connectivity for each modality and applied betweenness centrality to identify key network hubs across modalities. Our results revealed that despite seizure semiology and stereoelectroencephalography indicating dysfunction in the right orbitofrontal region, the maximum overlap on the hubs across modalities extended to right temporal areas. Notably, the right middle temporal lobe region served as an overlap hub across diffusion tensor imaging, resting-state functional MRI, and rest stereoelectroencephalography networks and was only included in the resected area in the second surgery, which led to long-term seizure control of this patient. Our findings demonstrated that transmodal hubs could help identify key areas related to epileptogenic network. Therefore, this case presents a promising perspective of using a multimodal approach to improve the presurgical evaluation of patients with epilepsy.
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605640-4
    ISSN 1537-1603 ; 0736-0258
    ISSN (online) 1537-1603
    ISSN 0736-0258
    DOI 10.1097/WNP.0000000000001071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1921: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Book: Magnetic resonance in epilepsy

    Kuzniecky, Ruben I.

    1995  

    Author's details Ruben I. Kuzniecky
    Keywords Epilepsy / pathology ; Magnetic Resonance Imaging / methods ; Epilepsie ; Gehirn ; Kernspintomografie
    Subject Kernspintomographie ; NMR-Tomographie ; Magnetische Kernresonanztomographie ; MR-Tomographie ; Kernspinresonanztomographie ; MRI ; Magnetic resonance imaging ; IRM ; Magnetresonanztomographie ; Magnetresonanztomografie ; MRT ; NMR-Tomografie ; Nukleare Kernspintomographie ; MR-Bildgebung ; Cerebrum ; Hirn ; Encephalon ; Enzephalon ; Hirngewebe ; Hirnmasse ; Gehirnmasse ; Fallsucht
    Language English
    Size XV, 345 S. : Ill., graph. Darst.
    Publisher Raven Press
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT006531260
    ISBN 0-7817-0227-5 ; 978-0-7817-0227-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 A 1209 order for loan Magazin

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  4. Article ; Online: The 3rd Wave of EEG Technology: Exploring the Promise of Ultralong EEG Recordings.

    Lado, Fred A / Kuzniecky, Ruben

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

    2022  Volume 41, Issue 3, Page(s) 193–194

    MeSH term(s) Humans ; Electroencephalography
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605640-4
    ISSN 1537-1603 ; 0736-0258
    ISSN (online) 1537-1603
    ISSN 0736-0258
    DOI 10.1097/WNP.0000000000001073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1921: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Utility of magnetic resonance spectroscopic imaging for human epilepsy.

    Pan, Jullie W / Kuzniecky, Ruben I

    Quantitative imaging in medicine and surgery

    2015  Volume 5, Issue 2, Page(s) 313–322

    Abstract: This review discusses the potential utility of broad based use of magnetic resonance (MR) spectroscopic imaging for human epilepsy and seizure localization. The clinical challenges are well known to the epilepsy community, intrinsic in the variability of ...

    Abstract This review discusses the potential utility of broad based use of magnetic resonance (MR) spectroscopic imaging for human epilepsy and seizure localization. The clinical challenges are well known to the epilepsy community, intrinsic in the variability of location, volumetric size and network extent of epileptogenic tissue in individual patients. The technical challenges are also evident, with high performance requirements in multiple steps, including magnet homogeneity, detector performance, sequence design, speed of acquisition in addition to large territory spectral processing. We consider how MR spectroscopy and spectroscopic imaging has been informative for epilepsy thus far, with specific attention to what is measured, the interpretation of such measurements and technical performance challenges. Examples are shown from medial temporal lobe and neocortical epilepsies are considered from 4T, 7T and most recently 3T.
    Language English
    Publishing date 2015-03-25
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2653586-5
    ISSN 2223-4306 ; 2223-4292
    ISSN (online) 2223-4306
    ISSN 2223-4292
    DOI 10.3978/j.issn.2223-4292.2015.01.03
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intracranial EEG Validation of Single-Channel Subgaleal EEG for Seizure Identification.

    Pacia, Steven V / Doyle, Werner K / Friedman, Daniel / Bacher, Daniel H / Kuzniecky, Ruben I

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

    2020  Volume 39, Issue 4, Page(s) 283–288

    Abstract: Purpose: A device that provides continuous, long-term, accurate seizure detection information to providers and patients could fundamentally alter epilepsy care. Subgaleal (SG) EEG is a promising modality that offers a minimally invasive, safe, and ... ...

    Abstract Purpose: A device that provides continuous, long-term, accurate seizure detection information to providers and patients could fundamentally alter epilepsy care. Subgaleal (SG) EEG is a promising modality that offers a minimally invasive, safe, and accurate means of long-term seizure monitoring.
    Methods: Subgaleal EEG electrodes were placed, at or near the cranial vertex, simultaneously with intracranial EEG electrodes in 21 epilepsy patients undergoing intracranial EEG studies for up to 13 days. A total of 219, 10-minute single-channel SGEEG samples, including 138 interictal awake or sleep segments and 81 seizures (36 temporal lobe, 32 extra-temporal, and 13 simultaneous temporal/extra-emporal onsets) were reviewed by 3 expert readers blinded to the intracranial EEG results, then analyzed for accuracy and interrater reliability.
    Results: Using a single-channel of SGEEG, reviewers accurately identified 98% of temporal and extratemporal onset, intracranial, EEG-verified seizures with a sensitivity of 98% and specificity of 99%. All focal to bilateral tonic--clonic seizures were correctly identified.
    Conclusions: Single-channel SGEEG, placed at or near the vertex, reliably identifies focal and secondarily generalized seizures. These findings demonstrate that the SG space at the cranial vertex may be an appropriate site for long-term ambulatory seizure monitoring.
    MeSH term(s) Electrocorticography ; Electroencephalography/methods ; Epilepsy/diagnosis ; Epilepsy, Temporal Lobe/diagnosis ; Humans ; Reproducibility of Results ; Seizures/diagnosis
    Language English
    Publishing date 2020-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605640-4
    ISSN 1537-1603 ; 0736-0258
    ISSN (online) 1537-1603
    ISSN 0736-0258
    DOI 10.1097/WNP.0000000000000774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1921: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Epilepsy and malformations of cortical development: new developments.

    Kuzniecky, Ruben

    Current opinion in neurology

    2015  Volume 28, Issue 2, Page(s) 151–157

    Abstract: Purpose of review: Malformations of cortical development (MCD) are increasingly recognized as causes of epilepsy and neurodevelopmental disorders. This review summarizes recent developments in the classification, specifically focusing on how genetic and ...

    Abstract Purpose of review: Malformations of cortical development (MCD) are increasingly recognized as causes of epilepsy and neurodevelopmental disorders. This review summarizes recent developments in the classification, specifically focusing on how genetic and cellular pathway advances are changing our understanding of MCD and how this applies to clinical care.
    Recent findings: Recent studies have shown that mutations can have variable impact on not only the pattern of MCD but also the location of cortical involvement. Regulatory G protein GPR56 mutations can selectively cause polymicrogyria in the Sylvian fissure bilaterally. In addition, recent data suggest that somatic mutations can be detected in about 30% of patients with diffuse and focal MCD but the majority are not detectable with common sequencing. Similarly, MRI at higher field is able to detect abnormalities not seen on clinical scanners. The classification scheme and pathogenesis of MCD converge by common genes affecting similar pathways, which, in turn, modify the classification of these disorders. These advances are impacting treatment and genetic management.
    Summary: The classification of MCD in epilepsy has progressed from simple correlations with syndromes and imaging data to molecular pathways underscoring the significance of common mechanism in brain maldevelopment and epilepsy.
    MeSH term(s) Animals ; Cerebral Cortex/growth & development ; Developmental Disabilities/diagnosis ; Developmental Disabilities/genetics ; Developmental Disabilities/pathology ; Epilepsy/diagnosis ; Epilepsy/pathology ; Humans ; Magnetic Resonance Imaging/methods ; Malformations of Cortical Development/diagnosis ; Malformations of Cortical Development/genetics ; Malformations of Cortical Development/pathology ; Mutation/genetics
    Language English
    Publishing date 2015-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000000175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2524: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: EEG Abnormalities and Their Radiographic Correlates in a COVID-19 Inpatient Cohort.

    Hwang, Sean T / Ballout, Ahmad A / Sonti, Anup N / Kapyur, Amitha / Kirsch, Claudia / Singh, Neeraj / Markowitz, Noah / Leung, Tung Ming / Chong, Derek J / Temes, Richard / Pacia, Steven V / Kuzniecky, Ruben I / Najjar, Souhel

    Neurology. Clinical practice

    2022  Volume 12, Issue 1, Page(s) 52–59

    Abstract: Background and objectives: To identify the prevalence of EEG abnormalities in patients with coronavirus disease 2019 (COVID-19) with neurologic changes, their associated neuroimaging abnormalities, and rates of mortality.: Methods: A retrospective ... ...

    Abstract Background and objectives: To identify the prevalence of EEG abnormalities in patients with coronavirus disease 2019 (COVID-19) with neurologic changes, their associated neuroimaging abnormalities, and rates of mortality.
    Methods: A retrospective case series of 192 adult COVID-19-positive inpatients with EEG performed between March and June 2020 at 4 hospitals: 161 undergoing continuous, 24 routine, and 7 reduced montage EEG. Study indication, epilepsy history, intubation status, administration of sedatives or antiseizure medications (ASMs), metabolic abnormalities, neuroimaging pathology associated with epileptiform abnormalities, and in-hospital mortality were analyzed.
    Results: EEG indications included encephalopathy (54.7%), seizure (18.2%), coma (17.2%), focal deficit (5.2%), and abnormal movements (4.6%). Epileptiform abnormalities occurred in 39.6% of patients: focal intermittent epileptiform discharges in 25.0%, lateralized periodic discharges in 6.3%, and generalized periodic discharges in 19.3%. Seizures were recorded in 8 patients, 3 with status epilepticus. ASM administration, epilepsy history, and older age were associated with epileptiform abnormalities. Only 26.3% of patients presented with any epileptiform abnormality, 37.5% with electrographic seizures, and 25.7% patients with clinical seizures had known epilepsy. Background findings included generalized slowing (88.5%), focal slowing (15.6%), burst suppression (3.6%), attenuation (3.1%), and normal EEG (3.1%). Neuroimaging pathology was identified in 67.1% of patients with epileptiform abnormalities, over two-thirds acute. In-hospital mortality was 39.5% for patients with epileptiform abnormalities and 36.2% for those without. Risk factors for mortality were coma and ventilator support at time of EEG.
    Discussion: This article highlights the range of EEG abnormalities frequently associated with acute neuroimaging abnormalities in COVID-19. Mortality rates were high, particularly for patients in coma requiring mechanical ventilation. These findings may guide the prognosis and management of patients with COVID-19 and neurologic changes.
    Language English
    Publishing date 2022-09-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2645818-4
    ISSN 2163-0933 ; 2163-0402
    ISSN (online) 2163-0933
    ISSN 2163-0402
    DOI 10.1212/CPJ.0000000000001136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Malformations of cortical development and epilepsy, part 1: diagnosis and classification scheme.

    Kuzniecky, Ruben I

    Reviews in neurological diseases

    2006  Volume 3, Issue 4, Page(s) 151–162

    Abstract: Malformations of cortical development (MCDs) are a common cause of epilepsy, although seizures are not always the most prominent neurologic manifestation of these disorders. In localization-related epilepsy, certain features should create a strong ... ...

    Abstract Malformations of cortical development (MCDs) are a common cause of epilepsy, although seizures are not always the most prominent neurologic manifestation of these disorders. In localization-related epilepsy, certain features should create a strong suspicion that an MCD is the underlying cause; these include developmental delay and static focal neurologic deficits, a family history of developmental delay or epilepsy, frequent seizures from onset, and episodes of focal status epilepticus. MCDs can be classified according to a number of different criteria emphasizing clinical phenotype, imaging findings, pathology, or genetic defects. The overall classification of MCDs is based on the 3 fundamental events of cortical formation: 1) proliferation of neurons and glia in the ventricular and subventricular zones; 2) multidirectional migration of immature but postmitotic neurons to the developing cerebral cortex; and 3) cortical organization. Among the most common and distinct syndromes and entities affecting patients with MCDs and epilepsy are focal cortical dysplasia, hemimegalencephaly, tuberous sclerosis, classical lissencephaly, periventricular nodular heterotopia, focal subcortical heterotopia, polymicrogyria, and schizencephaly, all of which are discussed herein.
    MeSH term(s) Cerebral Cortex/abnormalities ; Cerebral Cortex/growth & development ; Cerebral Cortex/pathology ; Electroencephalography ; Epilepsy/classification ; Epilepsy/diagnosis ; Epilepsy/etiology ; Epilepsy/pathology ; Humans
    Language English
    Publishing date 2006
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1545-2913
    ISSN 1545-2913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Conference proceedings: Report from the 2004 AES Annual Meeting. Highlights from the 58th Annual Meeting of the American Epilepsy Society, December 3-7, 2004, New Orleans, LA.

    Kuzniecky, Ruben I

    Reviews in neurological diseases

    2005  Volume 2, Issue 2, Page(s) 88–90

    MeSH term(s) Animals ; Aromatase Inhibitors/pharmacology ; Aromatase Inhibitors/therapeutic use ; Complementary Therapies/methods ; Complementary Therapies/trends ; Disease Models, Animal ; Epilepsy/drug therapy ; Gonadal Steroid Hormones/antagonists & inhibitors ; Gonadal Steroid Hormones/biosynthesis ; Humans ; Melatonin/pharmacology ; Melatonin/therapeutic use ; Myristica fragrans/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Treatment Outcome
    Chemical Substances Aromatase Inhibitors ; Gonadal Steroid Hormones ; Plant Extracts ; Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2005
    Publishing country United States
    Document type Congresses
    ISSN 1545-2913
    ISSN 1545-2913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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