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  1. Article: N

    Cottin, Lola / Girard, Sarah / Hanan, Garry S / Cibian, Mihaela

    Acta crystallographica. Section E, Crystallographic communications

    2021  Volume 77, Issue Pt 2, Page(s) 117–120

    Abstract: The title compound, ... ...

    Abstract The title compound, C
    Language English
    Publishing date 2021-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041947-8
    ISSN 2056-9890 ; 1600-5368
    ISSN 2056-9890 ; 1600-5368
    DOI 10.1107/S2056989021000141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: N=16 Magicity Revealed at the Proton Drip Line through the Study of ^{35}Ca.

    Lalanne, L / Sorlin, O / Poves, A / Assié, M / Hammache, F / Koyama, S / Suzuki, D / Flavigny, F / Girard-Alcindor, V / Lemasson, A / Matta, A / Roger, T / Beaumel, D / Blumenfeld, Y / Brown, B A / Santos, F De Oliveira / Delaunay, F / de Séréville, N / Franchoo, S /
    Gibelin, J / Guillot, J / Kamalou, O / Kitamura, N / Lapoux, V / Mauss, B / Morfouace, P / Pancin, J / Saito, T Y / Stodel, C / Thomas, J-C

    Physical review letters

    2023  Volume 131, Issue 9, Page(s) 92501

    Abstract: ... mass of ^{35}Ca and the energy of its first 3/2^{+} state are reported. A large N=16 gap of 4.61(11 ... a doubly magic nucleus. The N=16 shell gaps in ^{36}Ca and ^{24}O are of similar amplitude, at both edges ... the calculations underestimate the size of the N=16 gap in ^{36}Ca by 840 keV. ...

    Abstract The last proton bound calcium isotope ^{35}Ca has been studied for the first time, using the ^{37}Ca(p,t)^{35}Ca two neutron transfer reaction. The radioactive ^{37}Ca nuclei, produced by the LISE spectrometer at GANIL, interacted with the protons of the liquid hydrogen target CRYPTA, to produce tritons t that were detected in the MUST2 detector array, in coincidence with the heavy residues Ca or Ar. The atomic mass of ^{35}Ca and the energy of its first 3/2^{+} state are reported. A large N=16 gap of 4.61(11) MeV is deduced from the mass measurement, which together with other measured properties, makes ^{36}Ca a doubly magic nucleus. The N=16 shell gaps in ^{36}Ca and ^{24}O are of similar amplitude, at both edges of the valley of stability. This feature is discussed in terms of nuclear forces involved, within state-of-the-art shell model calculations. Even though the global agreement with data is quite convincing, the calculations underestimate the size of the N=16 gap in ^{36}Ca by 840 keV.
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.131.092501
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  3. Article ; Online: The International Association for the Study of Lung Cancer Thymic Epithelial Tumors Staging Project: Proposals for the N and the M Components for the Forthcoming (Ninth) Edition of the TNM Classification of Malignant Tumors.

    Fang, Wentao / Girard, Nicolas / Cilento, Vanessa / Goren, Emily / Dibaba, Daniel / Ruffini, Enrico / Ahmad, Usman / Appel, Sarit / Bille, Andrea / Boubia, Souheil / Brambilla, Cecilia / Cangir, Ayten Kayi / Detterbeck, Frank / Falkson, Conrad / Filosso, Pier Luigi / Giaccone, Giuseppe / Guerrera, Francesco / Huang, James / Infante, Maurizio /
    Kim, Dong Kwan / Lucchi, Marco / Marino, Mirella / Marom, Edith M / Nicholson, Andrew G / Okumura, Meinoshin / Rami-Porta, Ramon / Rimner, Andreas / Simone, Charles B / Asamura, Hisao

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2023  Volume 19, Issue 1, Page(s) 52–70

    Abstract: ... with cancer and rests on a combination of three components-T for tumor extent, N for nodal involvement, and M ... for distant metastases. This article details the revision of the N and the M components of thymic epithelial ... The N and M components of the eighth edition staging system were verified by a large international ...

    Abstract Introduction: Stage classification is an important underpinning of management in patients with cancer and rests on a combination of three components-T for tumor extent, N for nodal involvement, and M for distant metastases. This article details the revision of the N and the M components of thymic epithelial tumors for the ninth edition of the TNM classification of malignant tumors proposed by the Thymic Domain of the International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee.
    Methods: The N and M components of the eighth edition staging system were verified by a large international collaborative data source through a data-driven analysis. A total of 9147 cases were included for analysis, including 7662 thymomas, 1345 thymic carcinomas, and 140 neuroendocrine thymic tumors.
    Results: Lymph node involvement rates were 1.5% in thymomas and 17.6% and 27.7% in thymic carcinomas and neuroendocrine thymic tumors, respectively. Rates of lymph node metastasis were increasingly higher in tumors with higher T stage and higher-grade histologic type. Survival analysis validated the differences in the N and M categories proposed in the eighth edition staging system. Good discrimination in overall survival was detected among pathologic (p)N and pM categories in patients with thymoma and thymic carcinoma.
    Conclusions: No changes are proposed from the eighth edition for the N and M components. The proposed stage classification will provide a useful tool for management of the disease among the global thymic community.
    MeSH term(s) Humans ; Neoplasm Staging ; Lung Neoplasms/pathology ; Thymoma/pathology ; Myeloma Proteins ; Thymus Neoplasms/pathology ; Prognosis ; Neoplasms, Glandular and Epithelial/pathology ; Neuroendocrine Tumors/pathology
    Chemical Substances Myeloma Proteins
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2023.09.1447
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  4. Article ; Online: Interfacial Properties of N

    Bénarouche, Anaïs / Habchi, Johnny / Cagna, Alain / Maniti, Ofelia / Girard-Egrot, Agnès / Cavalier, Jean-François / Longhi, Sonia / Carrière, Frédéric

    Biophysical journal

    2017  Volume 113, Issue 12, Page(s) 2723–2735

    Abstract: ... the intrinsically disordered C-terminal domain of the Hendra virus nucleoprotein (N ...

    Abstract Intrinsically disordered proteins (IDPs) lack stable secondary and tertiary structure under physiological conditions in the absence of their biological partners and thus exist as dynamic ensembles of interconverting conformers, often highly soluble in water. However, in some cases, IDPs such as the ones involved in neurodegenerative diseases can form protein aggregates and their aggregation process may be triggered by the interaction with membranes. Although the interfacial behavior of globular proteins has been extensively studied, experimental data on IDPs at the air/water (A/W) and water/lipid interfaces are scarce. We studied here the intrinsically disordered C-terminal domain of the Hendra virus nucleoprotein (N
    MeSH term(s) Adsorption ; Air ; Intrinsically Disordered Proteins/chemistry ; Intrinsically Disordered Proteins/metabolism ; Muramidase/chemistry ; Nucleoproteins/chemistry ; Nucleoproteins/metabolism ; Phosphatidylcholines/chemistry ; Protein Conformation ; Viral Proteins/chemistry ; Viral Proteins/metabolism ; Water/chemistry
    Chemical Substances Intrinsically Disordered Proteins ; Nucleoproteins ; Phosphatidylcholines ; Viral Proteins ; nucleoprotein, Hendra virus ; Water (059QF0KO0R) ; Muramidase (EC 3.2.1.17)
    Language English
    Publishing date 2017-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2017.10.010
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  5. Article ; Online: N,N′-Bis[2,6-bis(1-methylethyl)phenyl]pyridine-4-carboximidamide toluene hemisolvate

    Lola Cottin / Sarah Girard / Garry S. Hanan / Mihaela Cibian

    Acta Crystallographica Section E: Crystallographic Communications, Vol 77, Iss 2, Pp 117-

    2021  Volume 120

    Abstract: The title compound, C30H39N3·0.5C7H8, is a symmetrically N,N′-disubstituted arylamidine containing ... a 4-pyridyl substituent on the carbon atom of the N–C–N linkage and bulky 2,6-diisopropylphenyl groups ... on the nitrogen atoms. It crystallizes in the Z-anti configuration and its amidine C—N bonds present amine [1.368 ...

    Abstract The title compound, C30H39N3·0.5C7H8, is a symmetrically N,N′-disubstituted arylamidine containing a 4-pyridyl substituent on the carbon atom of the N–C–N linkage and bulky 2,6-diisopropylphenyl groups on the nitrogen atoms. It crystallizes in the Z-anti configuration and its amidine C—N bonds present amine [1.368 (1) Å] and imine [1.286 (1) Å] features. Intramolecular hydrogen bonds are present in the structure together with intermolecular N—H.N and C—H.N interactions linking the molecules in chains along the a- and c-axis directions.
    Keywords crystal structure ; bulky arylamidine ; hydrogen bonding ; Chemistry ; QD1-999
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher International Union of Crystallography
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Plasma Chemical Synthesis of Valuable Fuels and Chemicals from n-Hexane and Its Mixture with Methanol and Ethanol

    Banerjee, Avishek / Golsztajn, Andrew / Girard-Lauriault, Pierre-Luc

    ACS sustainable chemistry & engineering. 2022 Aug. 15, v. 10, no. 34

    2022  

    Abstract: Among several emerging technologies that are focused on finding sustainable routes for reforming heavy oils and/or alcohols into valuable fuels and complex chemicals, non-thermal plasma shows promise both due to its non-equilibrium nature and its ability ...

    Abstract Among several emerging technologies that are focused on finding sustainable routes for reforming heavy oils and/or alcohols into valuable fuels and complex chemicals, non-thermal plasma shows promise both due to its non-equilibrium nature and its ability to use intermittent renewable electricity. In this work, we investigate its interaction with organic compounds as a “green” process for simultaneously synthesizing hydrogen, cracking heavy oils, and producing more valuable, complex chemicals. A pin-to-plate microsecond-pulsed argon plasma was used at temperatures of 20, 0, and −20 °C. Using 390 kJ/kg of specific energy input, we were able to achieve a conversion efficiency of 771.4 mmol/kW h for the treatment of the hexane–ethanol mixture at 0 °C. It is concluded that the production of H₂ and other lower fuels (gas hydrocarbons) can be increased by the addition of alcohols in our reforming processes. At 0 °C, the production efficiency and selectivity of gas products were found to be higher compared to other temperatures. A low temperature of −20 °C showed the highest production efficiency for liquid products. Product formation was observed to mainly undergo dissociation and dehydrogenation, whose reaction pathway is also discussed.
    Keywords dehydrogenation ; dissociation ; ethanol ; green chemistry ; hexane ; hydrogen ; liquids ; methanol ; renewable electricity ; specific energy ; synthesis ; temperature
    Language English
    Dates of publication 2022-0815
    Size p. 11358-11366.
    Publishing place American Chemical Society
    Document type Article
    ISSN 2168-0485
    DOI 10.1021/acssuschemeng.2c03405
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Nanoscaffold effects on the performance of air-cathodes for microbial fuel cells: Sustainable Fe/N-carbon electrocatalysts for the oxygen reduction reaction under neutral pH conditions.

    Iannaci, Alessandro / Ingle, Swapnil / Domínguez, Carlota / Longhi, Mariangela / Merdrignac-Conanec, Odile / Ababou-Girard, Soraya / Barrière, Frédéric / Colavita, Paula E

    Bioelectrochemistry (Amsterdam, Netherlands)

    2021  Volume 142, Page(s) 107937

    Abstract: ... mesoporous, possess high specific surface area and display N-sites (N/C of 3-5 at%) and Fe-centers (Fe/C < 1 ... than those of Pt/C cathodes, at a fraction of the materials costs. Therefore, the proposed Fe/N-carbon catalysts ...

    Abstract Nanostructured electrocatalysts for microbial fuel cell air-cathodes were obtained via use of conductive carbon blacks for the synthesis of high performing 3D conductive networks. We used two commercially available nanocarbons, Black Pearls 2000 and multiwalled carbon nanotubes, as conductive scaffolds for the synthesis of nanocomposite electrodes by combining: a hydrothermally carbonized resin, a sacrificial polymeric template, a nitrogenated organic precursor and iron centers. The resulting materials are micro-mesoporous, possess high specific surface area and display N-sites (N/C of 3-5 at%) and Fe-centers (Fe/C < 1.5at.%) at the carbon surface as evidenced from characterization methods. Voltammetry studies of oxygen reduction reaction activity were carried out at neutral pH, which is relevant to microbial fuel cell applications, and activity trends are discussed in light of catalyst morphology and composition. Tests of the electrocatalyst using microbial fuel cell devices indicate that optimization of the nanocarbon scaffold for the Pt-free carbon-based electrocatalysts results in maximum power densities that are 25% better than those of Pt/C cathodes, at a fraction of the materials costs. Therefore, the proposed Fe/N-carbon catalysts are promising and sustainable high-performance cathodic materials for microbial fuel cells.
    MeSH term(s) Bioelectric Energy Sources/microbiology ; Catalysis ; Electric Conductivity ; Nanotubes, Carbon/chemistry ; Nanotubes, Carbon/microbiology
    Chemical Substances Nanotubes, Carbon
    Language English
    Publishing date 2021-08-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2010650-6
    ISSN 1878-562X ; 0302-4598 ; 1567-5394
    ISSN (online) 1878-562X
    ISSN 0302-4598 ; 1567-5394
    DOI 10.1016/j.bioelechem.2021.107937
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  8. Article ; Online: Evidence of a Large Diversity of N-acyl-Homoserine Lactones in Symbiotic Vibrio fischeri Strains Associated with the Squid Euprymna scolopes.

    Girard, Léa / Blanchet, Elodie / Stien, Didier / Baudart, Julia / Suzuki, Marcelino / Lami, Raphaël

    Microbes and environments

    2019  Volume 34, Issue 1, Page(s) 99–103

    Abstract: Vibrio fischeri possesses a complex AHL-mediated Quorum-sensing (QS) system including two pathways, LuxI/R (3-oxo-C6-HSL and C6-HSL) and AinS/R (C8-HSL), which are important for the regulation of physiological traits. Diverse QS-dependent functional ... ...

    Abstract Vibrio fischeri possesses a complex AHL-mediated Quorum-sensing (QS) system including two pathways, LuxI/R (3-oxo-C6-HSL and C6-HSL) and AinS/R (C8-HSL), which are important for the regulation of physiological traits. Diverse QS-dependent functional phenotypes have been described in V. fischeri; however, AHL diversity is still underestimated. In the present study, we investigated AHL diversity in five symbiotic V. fischeri strains with distinct phenotypic properties using UHPLC-HRMS/MS. The results obtained (1) revealed an unexpectedly high diversity of signaling molecules, (2) emphasized the complexity of QS in V. fischeri, and (3) highlight the importance of understanding the specificity of AHL-mediated QS.
    MeSH term(s) Acyl-Butyrolactones/chemistry ; Acyl-Butyrolactones/metabolism ; Aliivibrio fischeri/chemistry ; Aliivibrio fischeri/genetics ; Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Decapodiformes/microbiology ; Gene Expression Regulation, Bacterial ; Genetic Variation ; Phenotype ; Quorum Sensing ; Species Specificity ; Symbiosis
    Chemical Substances Acyl-Butyrolactones ; Bacterial Proteins
    Language English
    Publishing date 2019-02-13
    Publishing country Japan
    Document type Journal Article
    ISSN 1347-4405
    ISSN (online) 1347-4405
    DOI 10.1264/jsme2.ME18145
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  9. Article ; Online: Characterization of N-glycosylation and amino acid sequence features of immunoglobulins from swine.

    Lopez, Paul G / Girard, Lauren / Buist, Marjorie / de Oliveira, Andrey Giovanni Gomes / Bodnar, Edward / Salama, Apolline / Soulillou, Jean-Paul / Perreault, Hélène

    Glycoconjugate journal

    2016  Volume 33, Issue 1, Page(s) 79–91

    Abstract: The primary goal of this study was to develop a method to study the N-glycosylation of IgG ... from swine in order to detect epitopes containing N-glycolylneuraminic acid (Neu5Gc) and/or terminal ... on electrophoretic gel, and bands corresponding to the N-glycosylated heavy chains were cut off the gel and subjected ...

    Abstract The primary goal of this study was to develop a method to study the N-glycosylation of IgG from swine in order to detect epitopes containing N-glycolylneuraminic acid (Neu5Gc) and/or terminal galactose residues linked in α1-3 susceptible to cause xenograft-related problems. Samples of immunoglobulin were isolated from porcine serum using protein-A affinity chromatography. The eluate was then separated on electrophoretic gel, and bands corresponding to the N-glycosylated heavy chains were cut off the gel and subjected to tryptic digestion. Peptides and glycopeptides were separated by reversed phase liquid chromatography and fractions were collected for matrix-assisted laser desorption/ionization time-of-flight mass spectrometric (MALDI-TOF-MS) analysis. Overall no α1-3 galactose was detected, as demonstrated by complete susceptibility of terminal galactose residues to β-galactosidase digestion. Neu5Gc was detected on singly sialylated structures. Two major N-glycopeptides were found, EEQFNSTYR and EAQFNSTYR as determined by tandem MS (MS/MS), as previously reported by Butler et al. (Immunogenetics, 61, 2009, 209-230), who found 11 subclasses for porcine IgG. Out of the 11, ten include the sequence corresponding to EEQFNSTYR, and only one codes for EAQFNSTYR. In this study, glycosylation patterns associated with both chains were slightly different, in that EEQFNSTYR had a higher content of galactose. The last step of this study consisted of peptide-mapping the 11 reported porcine IgG sequences. Although there was considerable overlap, at least one unique tryptic peptide was found per IgG sequence. The workflow presented in this manuscript constitutes the first study to use MALDI-TOF-MS in the investigation of porcine IgG structural features.
    MeSH term(s) Amino Acid Sequence ; Animals ; Glycosylation ; Immunoglobulin G/chemistry ; Immunoglobulin G/metabolism ; Molecular Sequence Data ; Neuraminic Acids/chemistry ; Neuraminic Acids/metabolism ; Protein Processing, Post-Translational ; Swine
    Chemical Substances Immunoglobulin G ; Neuraminic Acids ; N-glycolylneuraminic acid (1113-83-3)
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 283770-5
    ISSN 1573-4986 ; 0282-0080
    ISSN (online) 1573-4986
    ISSN 0282-0080
    DOI 10.1007/s10719-015-9637-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: N-myristoyltransferases inhibitory activity of ellagitannins from Terminalia bentzoë (L.) L. f. subsp. bentzoë.

    Apel, Cécile / Bignon, Jérôme / Garcia-Alvarez, María Concepción / Ciccone, Sarah / Clerc, Patricia / Grondin, Isabelle / Girard-Valenciennes, Emmanuelle / Smadja, Jacqueline / Lopes, Philippe / Frédérich, Michel / Roussi, Fanny / Meinnel, Thierry / Giglione, Carmela / Litaudon, Marc

    Fitoterapia

    2018  Volume 131, Page(s) 91–95

    Abstract: N-myristoylation (Myr) is an eukaryotic N-terminal co- or post-translational protein modification ... in which the enzyme N-myristoyltransferase (NMT) transfers a fatty acid (C14:0) to the N-terminal glycine residues ... of cancer or infectious diseases. As part of an on-going project to identify natural Homo sapiens N ...

    Abstract N-myristoylation (Myr) is an eukaryotic N-terminal co- or post-translational protein modification in which the enzyme N-myristoyltransferase (NMT) transfers a fatty acid (C14:0) to the N-terminal glycine residues of several cellular key proteins. Depending on the cellular context, NMT may serve as a molecular target in anticancer or anti-infectious therapy, and drugs that inhibit this enzyme may be useful in the treatment of cancer or infectious diseases. As part of an on-going project to identify natural Homo sapiens N-myristoyltransferase 1 inhibitors (HsNMT1), two ellagitannins, punicalagin (1) and isoterchebulin (2), along with eschweilenol C (3) and ellagic acid (4) were isolated from the bark of Terminalia bentzoë (L.) L. f. subsp. bentzoë. Their structures were determined by means of spectroscopic analyses and comparison with literature data. Punicalagin (1) and isoterchebulin (2) showed significant inhibitory activity towards HsNMT1, and also against Plasmodium falciparum NMT (PfNMT) both in vitro and in cellulo, opening alternative paths for new NMT inhibitors development. This is the first report identifying natural products from a botanical source as inhibitors of HsNMT and PfNMT.
    MeSH term(s) Acyltransferases/antagonists & inhibitors ; Cell Line, Tumor ; France ; Humans ; Hydrolyzable Tannins/isolation & purification ; Hydrolyzable Tannins/pharmacology ; Molecular Structure ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Bark/chemistry ; Plasmodium falciparum/drug effects ; Reunion ; Terminalia/chemistry
    Chemical Substances Hydrolyzable Tannins ; Phytochemicals ; isoterchebulin ; punicalagin (65995-63-3) ; Acyltransferases (EC 2.3.-) ; glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97)
    Language English
    Publishing date 2018-10-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 412385-2
    ISSN 1873-6971 ; 0367-326X
    ISSN (online) 1873-6971
    ISSN 0367-326X
    DOI 10.1016/j.fitote.2018.10.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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