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  1. Article ; Online: Hippocampal neurodegeneration induces transient endogenous regeneration and long-term exhaustion of the neurogenic niche.

    Dey, Jhilik / Chandra, Sreyashi / Gupta, Jalaj / Tripathi, Prem Prakash

    Journal of cellular physiology

    2024  

    Abstract: The hippocampal dentate gyrus, responds to diverse pathological stimuli through neurogenesis. This phenomenon, observed following brain injury or neurodegeneration, is postulated to contribute to neuronal repair and functional recovery, thereby ... ...

    Abstract The hippocampal dentate gyrus, responds to diverse pathological stimuli through neurogenesis. This phenomenon, observed following brain injury or neurodegeneration, is postulated to contribute to neuronal repair and functional recovery, thereby presenting an avenue for endogenous neuronal restoration. This study investigated the extent of regenerative response in hippocampal neurogenesis by leveraging the well-established kainic acid-induced status epilepticus model in vivo. In our study, we observed the activation and proliferation of neuronal progenitors or neural stem cell (NSC) and their subsequent migration to the injury sites following the seizure. At the injury sites, new neurons (Tuj1+BrdU+ and NeuN+BrdU+) have been generated indicating regenerative and reparative roles of the progenitor cells. We further detected whether this transient neurogenic burst, which might be a response towards an attempt to repair the brain, is associated with persistent long-term exhaustion of the dentate progenitor cells and impairment of adult neurogenesis marked by downregulation of Ki67, HoPX, and Sox2 with BrdU+ cell in the later part of life. Our studies suggest that the adult brain has the constitutive endogenous regenerative potential for brain repair to restore the damaged neurons, meanwhile, in the long term, it accelerates the depletion of the finite NSC pool in the hippocampal neurogenic niche by changing its proliferative and neurogenic capacity. A thorough understanding of the impact of modulating adult neurogenesis will eventually be required to design novel therapeutics to stimulate or assist brain repair while simultaneously preventing the adverse effects of early robust neurogenesis on the proliferative potential of endogenous neuronal progenitors.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.31249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Electrochemical Detection of Alzheimer's Disease Biomarker, β-Secretase Enzyme (BACE1), With One-Step Synthesized Reduced Graphene Oxide.

    Dey, Jhilik / Roberts, Akanksha / Mahari, Subhasis / Gandhi, Sonu / Tripathi, Prem Prakash

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 873811

    Abstract: β-Secretase1 (BACE1) catalyzes the rate-limiting step in the generation of amyloid-β peptides, that is, the principal component involved in the pathology of Alzheimer's disease (AD). Recent research studies show correlation between blood and ... ...

    Abstract β-Secretase1 (BACE1) catalyzes the rate-limiting step in the generation of amyloid-β peptides, that is, the principal component involved in the pathology of Alzheimer's disease (AD). Recent research studies show correlation between blood and cerebrospinal fluid (CSF) levels of BACE1 with the pathophysiology of AD. In this study, we report one-step synthesized reduced graphene oxide (rGO), activated
    Language English
    Publishing date 2022-03-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.873811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Is this the beginning or the end of COVID-19 outbreak in India? A data driven mathematical model-based analysis

    Anupam Singh / Jhilik Dey / Shivam Bhardwaj

    Abstract: India has experienced an early and harshest lockdown from 25th March 2020 in response to the outbreak. However, an accurate estimation of the progression of the spread of infection and the level of preparedness to combat this disease are urgently needed. ...

    Abstract India has experienced an early and harshest lockdown from 25th March 2020 in response to the outbreak. However, an accurate estimation of the progression of the spread of infection and the level of preparedness to combat this disease are urgently needed. Using a data-based mathematical model, our study has made predictions on the number of cases that are expected to rise in India till 14th June 2020. The epidemiological data of daily cases have been utilized from 25th March (i.e., the first day of lockdown) to 23rd April 2020. In the study, we have stimulated two possible scenarios (optimistic and pessimistic) for the prediction. As per the optimistic approach of modelling, COVID-19 may end in the first week of June 2020 with a total of 77,900 infected cases including 2,442 fatalities. However, the results under the pessimistic scenario are a bit scary as it shows that a total of 283,300 infected cases with 10,180 fatalities till 14th June. To win the battle, 10 weeks of complete lockdown is much needed at least in the infected states and the union territories of India. Alternatively, the isolation of clusters (hotspot regions) is required if India wants a resume of some essential activities.
    Keywords covid19
    Publisher medrxiv
    Document type Article ; Online
    DOI 10.1101/2020.04.27.20081422
    Database COVID19

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  4. Article ; Online: Is this beginning or the end of COVID-19 battle in India? A data-driven mathematical model-based analysis of outbreak

    Singh, Anupam / Dey, Jhilik / Bhardwaj, Shivam

    medRxiv

    Abstract: The India has experienced early and harshest lockdown in response to the outbreak from 25th March 2020. However, an accurate estimation of progression of spread of the infection and level of preparedness to combat this disease are urgently needed. Using ... ...

    Abstract The India has experienced early and harshest lockdown in response to the outbreak from 25th March 2020. However, an accurate estimation of progression of spread of the infection and level of preparedness to combat this disease are urgently needed. Using a data-based mathematical model, our study has made predictions on the number of cases that are expected to rise in India till 14th June 2020. The epidemiological data of daily cases have been utilized from 25th March (i.e., the first day of lockdown) to 23rd April 2020. In the study, we have stimulated two possible scenarios (optimistic and pessimistic) for the prediction. As per the optimistic approach of modeling, COVID-19 may end in the first week of June 2020 with a total of 77,900 infected cases including 2,442 fatalities. However, the results under the pessimistic scenario are bit scary. The results show that a total of 283,300 infected cases with 10,180 fatalities till 14th June. To win the battle, 10 weeks of complete lockdown is much needed at least in the infected states and the union territories of India. Alternatively, the isolation of clusters (hotspot regions) is required if India wants resume some essential activities.
    Keywords covid19
    Language English
    Publishing date 2020-05-03
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.04.27.20081422
    Database COVID19

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  5. Article ; Online: Recalibrating the Existence of New Neurons in Adult Brain.

    Dey, Jhilik / Alam, Md Tanjim / Chandra, Sreyashi / Gandhi, Sonu / Tripathi, Prem Prakash

    ACS chemical neuroscience

    2019  Volume 10, Issue 5, Page(s) 2091–2093

    Abstract: New neurons were shown to born throughout adulthood, a process known as neurogenesis. Last year, the human hippocampal neurogenesis field was flipped on its head by a paper in Nature from Sorrells et al. questioning the presence of human hippocampal ... ...

    Abstract New neurons were shown to born throughout adulthood, a process known as neurogenesis. Last year, the human hippocampal neurogenesis field was flipped on its head by a paper in Nature from Sorrells et al. questioning the presence of human hippocampal neurogenesis during adulthood ( Sorrells, S.F. et al.  2018 Nature , 555 , 377 - 381 ). Now, a new study by Moreno-Jiménez et al. reported that human brain can make new neurons well beyond middle age until the tenth decade of their life, and earlier studies have failed to find the neurogenesis due to its flawed methods. This paper also finds that production of new neurons drastically drops in patients suffering from Alzheimer's disease. Here, we discuss key findings of this paper, emphasizing how improved protocols and tissue preservation lead to visualization of adult neurogenesis and further highlighting in what way this drop of neurogenesis in Alzheimer's disease brain could possibly open new roads to therapy.
    MeSH term(s) Adult ; Alzheimer Disease ; Brain ; Child ; Hippocampus ; Humans ; Middle Aged ; Neurogenesis ; Neurons
    Language English
    Publishing date 2019-04-22
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.9b00196
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  6. Article ; Online: Healthy Gut, Healthy Brain: The Gut Microbiome in Neurodegenerative Disorders.

    Chandra, Sreyashi / Alam, Md Tanjim / Dey, Jhilik / Sasidharan, Baby C Pulikkaparambil / Ray, Upasana / Srivastava, Amit K / Gandhi, Sonu / Tripathi, Prem P

    Current topics in medicinal chemistry

    2020  Volume 20, Issue 13, Page(s) 1142–1153

    Abstract: Background: The central nervous system (CNS) known to regulate the physiological conditions of human body, also itself gets dynamically regulated by both the physiological as well as pathological conditions of the body. These conditions get changed ... ...

    Abstract Background: The central nervous system (CNS) known to regulate the physiological conditions of human body, also itself gets dynamically regulated by both the physiological as well as pathological conditions of the body. These conditions get changed quite often, and often involve changes introduced into the gut microbiota which, as studies are revealing, directly modulate the CNS via a crosstalk. This cross-talk between the gut microbiota and CNS, i.e., the gut-brain axis (GBA), plays a major role in the pathogenesis of many neurodegenerative disorders such as Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS) and Huntington's disease (HD).
    Objective: We aim to discuss how gut microbiota, through GBA, regulate neurodegenerative disorders such as PD, AD, ALS, MS and HD.
    Methods: In this review, we have discussed the present understanding of the role played by the gut microbiota in neurodegenerative disorders and emphasized the probable therapeutic approaches being explored to treat them.
    Results: In the first part, we introduce the GBA and its relevance, followed by the changes occurring in the GBA during neurodegenerative disorders and then further discuss its role in the pathogenesis of these diseases. Finally, we discuss its applications in possible therapeutics of these diseases and the current research improvements being made to better investigate this interaction.
    Conclusion: We concluded that alterations in the intestinal microbiota modulate various activities that could potentially lead to CNS disorders through interactions via the GBA.
    MeSH term(s) Animals ; Brain/drug effects ; Brain/pathology ; Brain/physiology ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Microbiome/physiology ; Humans ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/microbiology ; Neurodegenerative Diseases/pathology ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/pharmacology
    Chemical Substances Neuroprotective Agents
    Language English
    Publishing date 2020-04-13
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/1568026620666200413091101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5572: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Neuroinvasion of SARS-CoV-2 may play a role in the breakdown of the respiratory center of the brain.

    Dey, Jhilik / Alam, Md T / Chandra, Sreyashi / Gupta, Jalaj / Ray, Upasana / Srivastava, Amit K / Tripathi, Prem P

    Journal of medical virology

    2020  Volume 93, Issue 3, Page(s) 1296–1303

    Abstract: The recent outbreak of the novel coronavirus, SARS-CoV-2, has emerged to be highly pathogenic in nature. Although lungs are considered as the primary infected organs by SARS-CoV-2, some of the other organs, including the brain, have also been found to be ...

    Abstract The recent outbreak of the novel coronavirus, SARS-CoV-2, has emerged to be highly pathogenic in nature. Although lungs are considered as the primary infected organs by SARS-CoV-2, some of the other organs, including the brain, have also been found to be affected. Here, we have discussed how SARS-CoV-2 might infect the brain. The infection of the respiratory center in the brainstem could be hypothesized to be responsible for the respiratory failure in many COVID-19 patients. The virus might gain entry through the olfactory bulb and invade various parts of the brain, including the brainstem. Alternatively, the entry might also occur from peripheral circulation into the central nervous system by compromising the blood-brain barrier. Finally, yet another possible entry route could be its dispersal from the lungs into the vagus nerve via the pulmonary stretch receptors, eventually reaching the brainstem. Therefore, screening neurological symptoms in COVID-19 patients, especially toward the breakdown of the respiratory center in the brainstem, might help us better understand this disease.
    MeSH term(s) Animals ; Brain/pathology ; Brain/physiopathology ; Brain/virology ; COVID-19/pathology ; COVID-19/physiopathology ; COVID-19/virology ; Cytokines/metabolism ; Humans ; Inflammation ; Neural Pathways/physiopathology ; Neural Pathways/virology ; Neurons/virology ; Respiratory Center/pathology ; Respiratory Center/physiopathology ; Respiratory Center/virology ; Respiratory Insufficiency ; SARS-CoV-2/pathogenicity ; Viral Tropism
    Chemical Substances Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-09-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26521
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    Zs.A 1320: Show issues Location:
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  8. Article ; Online: Neuroinvasion of SARS‐CoV‐2 may play a role in the breakdown of the respiratory center of the brain

    Dey, Jhilik / Alam, Md T. / Chandra, Sreyashi / Gupta, Jalaj / Ray, Upasana / Srivastava, Amit K. / Tripathi, Prem P.

    Journal of Medical Virology ; ISSN 0146-6615 1096-9071

    2020  

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/jmv.26521
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Neuroinvasion of SARS-CoV-2 may play a role in the breakdown of respiratory center of the brain

    Dey, Jhilik / Alam, Md Tanjim / Chandra, Sreyashi / Gupta, Jalaj / Ray, Upasana / Srivastava, Amit Kumar / Tripathi, Prem Prakash

    J. med. virol

    Abstract: The recent outbreak of the novel coronavirus, SARS-CoV-2 has emerged to be highly pathogenic in nature. Although lungs are considered as the primary infected organs by SARS-CoV-2, some of the other organs including the brain have also been found to be ... ...

    Abstract The recent outbreak of the novel coronavirus, SARS-CoV-2 has emerged to be highly pathogenic in nature. Although lungs are considered as the primary infected organs by SARS-CoV-2, some of the other organs including the brain have also been found to be affected. Here, we have discussed how SARS-CoV-2 might infect the brain. The infection of the respiratory center in the brainstem could be hypothesized to be responsible for the respiratory failure in many COVID-19 patients. The virus might gain entry through the olfactory bulb and invade various parts of the brain including the brainstem. Alternatively, entry might also occur from peripheral circulation into the central nervous system (CNS) by compromising the blood-brain barrier. Finally, yet another possible entry route could be its dispersal from the lungs into the vagus nerve, via the pulmonary stretch receptors, eventually reaching the brainstem. Therefore, screening neurological symptoms in COVID-19 patients, especially towards the breakdown of the respiratory center in the brainstem might help us better understand this disease. This article is protected by copyright. All rights reserved.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #763238
    Database COVID19

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