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  1. Article: Distal Gastrectomy With Roux-en-Y Reconstruction for a Seriously Dilated Stomach With Gastric Outlet Obstruction Secondary to Sarcina ventriculi: A Case Report.

    Abosheaishaa, Hazem / Nassar, Mahmoud / Baraka, Bahaaeldin / Alfishawy, Mostafa / Sahibzada, Asad

    Cureus

    2023  Volume 15, Issue 2, Page(s) e35523

    Abstract: ... Sarcina ... ...

    Abstract Sarcina ventriculi
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.35523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Endobronchial mucormycosis diagnosed by fiberoptic bronchoscopy.

    Assal, Hebatallah Hany / Hussein, Sabah Ahmed / Mostafa, Ahmed / El-Kareem, Dalia Abd / Alfishawy, Mostafa / Salah, Maged / Mohammed, Habiballah Galal

    IDCases

    2023  Volume 32, Page(s) e01781

    Abstract: Introduction: Endobronchial mucormycosis is very rare with only few cases reported in the literature. Here, we report a rare presentation of pulmonary mucormycosis in a diabetic patient who presented with left lung collapse. Bronchoscopy revealed an ... ...

    Abstract Introduction: Endobronchial mucormycosis is very rare with only few cases reported in the literature. Here, we report a rare presentation of pulmonary mucormycosis in a diabetic patient who presented with left lung collapse. Bronchoscopy revealed an endobronchial growth, mimicking a tumor, causing complete occlusion of the left main bronchus. Histopathology confirmed the diagnosis of invasive mucormycosis.
    Case presentation: Male patient 35 years old with accidental discovered Diabetes Mellitus, complained of hoarseness of voice and dry irritating cough that didn't respond to antitussives and nonspecific treatment. CT chest was done and revealed left total lung collapse. Fiberoptic bronchoscopy was done and revealed total occlusion of the left main bronchus with whitish fungating glistening tissue from which biopsies were obtained. Histopathological examination was consistent with mucormycosis. A trial of medical treatment failed after which the patient was referred for surgical resection.
    Conclusion: Successful treatment of mucormycosis requires early diagnosis; prompt administration of antifungal therapy, and surgical intervention when applicable. Aggressive surgical intervention to remove necrotic tissue is generally accepted as the therapeutic mainstay for endobronchial obstructing mucormycosis.
    Language English
    Publishing date 2023-05-12
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2023.e01781
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  3. Article ; Online: Neuroleptic malignant syndrome following COVID-19 vaccination.

    Alfishawy, Mostafa / Bitar, Zouheir / Elgazzar, Amr / Elzoueiry, Mahmoud

    The American journal of emergency medicine

    2021  Volume 49, Page(s) 408–409

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; Neuroleptic Malignant Syndrome/diagnosis ; Neuroleptic Malignant Syndrome/etiology ; SARS-CoV-2 ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-02-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2021.02.011
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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Massive gastrointestinal bleeding in a patient with COVID-19.

    Mohamed, Mahmoud / Nassar, Mahmoud / Nso, Nso / Alfishawy, Mostafa

    Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

    2021  Volume 22, Issue 2, Page(s) 177–179

    Abstract: Despite the emerging data about the thrombophilic effect of the novel coronavirus [1] , the relation between coagulation disorders and the COVID-19 pandemic is still not well understood. Various studies pointed to the significant role of the COVID-19 ... ...

    Abstract Despite the emerging data about the thrombophilic effect of the novel coronavirus [1] , the relation between coagulation disorders and the COVID-19 pandemic is still not well understood. Various studies pointed to the significant role of the COVID-19 induced cytokine storm in development of the hypercoagulable state which leads to serious thromboembolic complications [2,3] . Some studies report the development of severe immune thrombocytopenia induced by the novel coronavirus [4] . Other studies found a correlation between COVID-19 disease and the development of disseminated intravascular coagulation (DIC) [5]. Patients with severe COVID-19 disease have an increased risk for development of gastrointestinal bleeding (GI) which may be related to stress [6] , critical illness or mechanical ventilation [7] . Further studies showed the ability of the novel coronavirus to infect the epithelial cells of the GI tract [8] . Moreover, some data pointed to the ability of the virus even to infect the endothelium of blood vessels [9]. The relation between the COVID-19 pandemic and GI bleeding deserves more studies [10]. We present a case of GI bleeding in a patient with severe COVID-19 disease. We assume that COVID-19 disease can be a predominant factor for the development of DIC and GI bleeding.
    MeSH term(s) Blood Coagulation Disorders ; COVID-19/complications ; Gastrointestinal Hemorrhage/virology ; Humans ; Pandemics
    Language English
    Publishing date 2021-05-14
    Publishing country Egypt
    Document type Case Reports ; Journal Article
    ZDB-ID 2502114-X
    ISSN 2090-2387 ; 1687-1979
    ISSN (online) 2090-2387
    ISSN 1687-1979
    DOI 10.1016/j.ajg.2021.05.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Adrenal Insufficiency in patients with cardiogenic shock: A meta-analysis.

    Nso, Nso / Nassar, Mahmoud / Baraka, Bahaaeldin / Mbome, Yolanda / Alfishawy, Mostafa

    Diabetes & metabolic syndrome

    2021  Volume 15, Issue 6, Page(s) 102274

    Abstract: Background: Adrenal Insufficiency (AI) is rarely observed in patients with cardiogenic shock (CS). We aimed to identify the prevalence of AI in patients with CS and its effect on their clinical outcomes.: Aims: Our study aimed to determine the ... ...

    Abstract Background: Adrenal Insufficiency (AI) is rarely observed in patients with cardiogenic shock (CS). We aimed to identify the prevalence of AI in patients with CS and its effect on their clinical outcomes.
    Aims: Our study aimed to determine the prevalence of AI in CS patients who underwent treatments for CS.
    Methods: The articles concerning AI in CS were extracted for review from PubMed/Medline, Science Direct, World Wide Science.org, and Pro-Quest. The research articles included patients with CS, post-cardiac-arrest shock, out-of-hospital cardiac arrest, and CS after acute myocardial infarction. RStudio (version 1.0.136) was used for analyzing AI in CS patients.
    Results: The search revealed 1463 unique publications, including 256 studies identified after screening the titles and the abstracts. Five observational cohort studies met the eligibility criteria for meta-analysis after the preliminary screening. The included studies reported a corticotropin stimulation test for AI diagnosis. The studies reportedly exhibited a low-to-fair quality. The random-effects pooled estimates indicated a 32% AI prevalence in the setting of CS [95% CI; 21%-45%; I
    Conclusions: This meta-analysis revealed a moderate level prevalence of AI in CS patients.
    MeSH term(s) Adrenal Insufficiency/diagnosis ; Adrenal Insufficiency/epidemiology ; Adrenal Insufficiency/physiopathology ; Cohort Studies ; Humans ; Observational Studies as Topic/methods ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/epidemiology ; Shock, Cardiogenic/physiopathology
    Language English
    Publishing date 2021-09-08
    Publishing country Netherlands
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2021.102274
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  6. Article ; Online: Integrated multiomics analysis to infer COVID-19 biological insights.

    Sameh, Mahmoud / Khalaf, Hossam M / Anwar, Ali Mostafa / Osama, Aya / Ahmed, Eman Ali / Mahgoub, Sebaey / Ezzeldin, Shahd / Tanios, Anthony / Alfishawy, Mostafa / Said, Azza Farag / Mohamed, Maged Salah / Sayed, Ahmed A / Magdeldin, Sameh

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 1802

    Abstract: Three years after the pandemic, we still have an imprecise comprehension of the pathogen landscape and we are left with an urgent need for early detection methods and effective therapy for severe COVID-19 patients. The implications of infection go beyond ...

    Abstract Three years after the pandemic, we still have an imprecise comprehension of the pathogen landscape and we are left with an urgent need for early detection methods and effective therapy for severe COVID-19 patients. The implications of infection go beyond pulmonary damage since the virus hijacks the host's cellular machinery and consumes its resources. Here, we profiled the plasma proteome and metabolome of a cohort of 57 control and severe COVID-19 cases using high-resolution mass spectrometry. We analyzed their proteome and metabolome profiles with multiple depths and methodologies as conventional single omics analysis and other multi-omics integrative methods to obtain the most comprehensive method that portrays an in-depth molecular landscape of the disease. Our findings revealed that integrating the knowledge-based and statistical-based techniques (knowledge-statistical network) outperformed other methods not only on the pathway detection level but even on the number of features detected within pathways. The versatile usage of this approach could provide us with a better understanding of the molecular mechanisms behind any biological system and provide multi-dimensional therapeutic solutions by simultaneously targeting more than one pathogenic factor.
    MeSH term(s) Humans ; COVID-19 ; Multiomics ; Proteome ; Knowledge ; Knowledge Bases
    Chemical Substances Proteome
    Language English
    Publishing date 2023-01-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-28816-5
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  7. Article: Fungal brain abscesses caused by

    Ibrahim, Hamdy / ALfishawy, Mostafa / Ali, Attaa / Maksod, Safwat Abdel / Khorshed, Magdy / Rady, Hanan / Alsisi, Ahmed / Mohamed, Adel / Alkassas, Omar / Haron, Marwa / Saied, Suzan

    The Egyptian journal of internal medicine

    2023  Volume 35, Issue 1, Page(s) 5

    Abstract: Unusual fungal agents that exist environmentally as saprophytes can often lead to opportunistic infections, hyalohyphomycosis is a group of fungal infections caused by fungi characterized by hyaline septate hyphae and can infect both immunocompetent as ... ...

    Abstract Unusual fungal agents that exist environmentally as saprophytes can often lead to opportunistic infections, hyalohyphomycosis is a group of fungal infections caused by fungi characterized by hyaline septate hyphae and can infect both immunocompetent as well as immunocompromised patients, and
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Case Reports
    ISSN 1110-7782
    ISSN 1110-7782
    DOI 10.1186/s43162-022-00183-z
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  8. Article ; Online: New-onset Type 1 Diabetes Mellitus with Diabetic Ketoacidosis and Pancreatitis in a Patient with COVID-19.

    Alfishawy, Mostafa / Nassar, Mahmoud / Mohamed, Mahmoud / Fatthy, Moataz / Elmessiery, Riem M

    Scientific African

    2021  Volume 13, Page(s) e00915

    Abstract: Coronavirus Disease 2019 (COVID-19) had struck the world with health and economic catastrophes and recently with unusual autoimmune presentations, including new-onset Type 1 Diabetes. Herein we present a 17-year-old male patient who presented to the ... ...

    Abstract Coronavirus Disease 2019 (COVID-19) had struck the world with health and economic catastrophes and recently with unusual autoimmune presentations, including new-onset Type 1 Diabetes. Herein we present a 17-year-old male patient who presented to the outptient clinic with fever, palpitation, and cough of four-week duration; he was referred to the emergency room and was found to have DKA. CT of the chest showed ground-glass opacities suggestive of COVID-19 pneumonia, and abdominal cuts showed dilated intrahepatic biliary radicles with pancreatic loculations suggestive of pancreatitis. The patient was admitted to the ICU, started on intravenous fluids and insulin infusion then COVID-19 PCR returned positive. We hypothesize that SARS-CoV-2 has a vital role in eliciting an autoimmune response triggering type 1 diabetes, and further studies are needed to confirm this hypothesis. SARS-CoV-2 may cause pancreatitis, and the first presentation could be high blood sugar or DKA.
    Language English
    Publishing date 2021-08-03
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2468-2276
    ISSN (online) 2468-2276
    DOI 10.1016/j.sciaf.2021.e00915
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  9. Article: Internal Carotid Artery Stenosis Presenting with Limb Shaking TIA.

    Javaid, Awad / Alfishawy, Mostafa

    Case reports in neurological medicine

    2016  Volume 2016, Page(s) 3656859

    Abstract: Internal carotid artery (ICA) stenosis may lead to a wide range of clinical symptoms. We describe the case of a 66-year-old female who experienced a transient ischemic attack (TIA) with episodes of limb shaking caused by ICA stenosis. After epilepsy had ... ...

    Abstract Internal carotid artery (ICA) stenosis may lead to a wide range of clinical symptoms. We describe the case of a 66-year-old female who experienced a transient ischemic attack (TIA) with episodes of limb shaking caused by ICA stenosis. After epilepsy had been suspected and ruled out, studies of her left ICA showed extensive blockage as a result of atherosclerosis. Magnetic resonance angiography (MRA) revealed total occlusion of the left ICA and the patient was eventually medically managed due to the strong possibility of surgical complications. We reported this patient's clinical course to shed light on a rare manifestation of carotid stenosis that may be confused with other diagnoses if not closely scrutinized.
    Language English
    Publishing date 2016-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2629909-4
    ISSN 2090-6676 ; 2090-6668
    ISSN (online) 2090-6676
    ISSN 2090-6668
    DOI 10.1155/2016/3656859
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  10. Article ; Online: The association between COVID-19 and type 1 diabetes mellitus: A systematic review.

    Nassar, Mahmoud / Nso, Nso / Baraka, Bahaaeldin / Alfishawy, Mostafa / Mohamed, Mahmoud / Nyabera, Akwe / Sachmechi, Issac

    Diabetes & metabolic syndrome

    2021  Volume 15, Issue 1, Page(s) 447–454

    Abstract: Background: /Aim: Various reports of the occurrence of type 1 diabetes mellitus (T1DM) in patients with COVID-19 have been published, denoting an association between both diseases. Therefore, we conducted this systematic review to summarize the ... ...

    Abstract Background: /Aim: Various reports of the occurrence of type 1 diabetes mellitus (T1DM) in patients with COVID-19 have been published, denoting an association between both diseases. Therefore, we conducted this systematic review to summarize the prevalence of T1DM in COVID-19 patients and to identify the clinical presentations and outcomes in this patient population.
    Materials and methods: Up to 10/27/2020, Medline, Embase, cochrane and google scholar databases were searched for original studies investigating the association between COVID-19 and T1DM. A manual search was conducted to identify missing studies. The quality of included studies was analyzed by the National Institute of Health (NIH) risk of bias tool. Outcomes included length of hospital stay, hospitalization, intensive care unit (ICU) admission, diabetic ketoacidosis (DKA), severe hypoglycemia, and death.
    Results: Fifteen studies were included in the qualitative analysis. Included studies reported data of both adult and pediatric patients. The prevalence of T1DM in COVID-19 patients ranged from 0.15% to 28.98%, while the rate of COVID-19 in patients with T1DM ranged from 0% to 16.67%. Dry cough, nausea, vomiting, fever and elevated blood glucose levels were the most commonly reported presentations. The investigated outcomes varied widely among studied populations.
    Conclusions: The prevalence of T1DM in patients with COVID-19 ranged from 0.15% to 28.98%. The most common presentation of COVID-19 in patients with T1DM included fever, dry cough, nausea and vomiting, elevated blood glucose and diabetic ketoacidosis. The outcomes of COVID-19 in terms of length of hospital stay, hospitalization, ICU admission, DKA rate, and severe hypoglycemia were reported variably in included studies. Due to the heterogeneous study populations and the presence of many limitations, more studies are still warranted to reach a definitive conclusion.
    MeSH term(s) Blood Glucose/metabolism ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/epidemiology ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/diagnosis ; Diabetes Mellitus, Type 1/epidemiology ; Humans ; Length of Stay/trends
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2021-02-10
    Publishing country Netherlands
    Document type Journal Article ; Systematic Review
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2021.02.009
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