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Book ; Thesis: Regulation of leptin receptor in the innate immune response against bacterial pathogens

Cassens, Julia Christina / Plum, Georg / Fabri, Mario

2020

Institution	Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
Author's details	vorgelegt von Julia Christina Cassens ; 1. Gutachter: Privatdozent Dr. med. G. Plum, 2. Gutachter: Universitätsprofessor Dr. med. M. Fabri ; aus dem Institut für Medizinische Mikrobiologie, Immunologie und Hygiene der Universität zu Köln
Subject code	610
Language	English
Size	74 Blätter, Illustrationen, Diagramme
Publishing place	Köln
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Universität zu Köln, 2020
Note	Zusammenfassung in deutscher und englischer Sprache
HBZ-ID	HT020542893
Database	Catalogue ZB MED Medicine, Health

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2020 D 560	order for loan	Magazin

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Article: The Effects of Different Zilpaterol Hydrochloride Feed Supplements and Extended Aging Periods on the Meat Quality of Feedlot Bulls.

Webb, Edward C / Emmenis, Rochelle van / Cassens, Andrew M

Animals : an open access journal from MDPI

2024 Volume 14, Issue 3

Abstract: ... hydrochloride B (ZH-B), both at 105 g ZH/ton, fed from the first day of the finishing period (D ...

Abstract	This study researched the effects of two commercially available zilpaterol hydrochloride (ZH) β-adrenergic agonists, denoted as ZH-A and ZH-B, on the meat quality characteristics of typical South African feedlot bulls (taurine × indicus composites), over extended aging periods of up to 120 days. The effects of ZH were studied to address concerns about the possible adverse effects of ZH on beef quality following extended aging, which typically occurs during the exportation of beef by boat. The completely randomized control study consisted of 3 homogenous experimental groups, with 3 replicates per treatment and 50 bulls per replicate = 450 animals. Treatments were a negative control (CT) with no ZH supplementation added to the basal diet or a basal diet supplemented with either zilpaterol hydrochloride A (ZH-A) or zilpaterol hydrochloride B (ZH-B), both at 105 g ZH/ton, fed from the first day of the finishing period (D
Language	English
Publishing date	2024-01-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani14030361
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Mobilization of blood stem cells using G-CSF without preceding chemotherapy.

Zeller, W / von Stieglitz, J / Dominka, T / Kunde, C / Cassens, U / Zander, A R

Beitrage zur Infusionstherapie = Contributions to infusion therapy

1993 Volume 31, Page(s) 118–123

MeSH term(s)	Antigens, CD/analysis ; Antigens, CD34 ; Breast Neoplasms/blood ; Breast Neoplasms/therapy ; Colony-Forming Units Assay ; Flow Cytometry ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Hematopoietic Stem Cells/drug effects ; Hodgkin Disease/blood ; Hodgkin Disease/therapy ; Humans ; Leukapheresis ; Leukocyte Count/drug effects ; Platelet Count/drug effects
Chemical Substances	Antigens, CD ; Antigens, CD34 ; Granulocyte Colony-Stimulating Factor (143011-72-7)
Language	English
Publishing date	1993
Publishing country	Switzerland
Document type	Journal Article
ISSN	1011-6974
ISSN	1011-6974
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Meat preservation

Cassens, Robert G.

preventing losses and assuring safety

1994

Author's details	Robert G. Cassens
Keywords	Fleisch ; Konservierung
Subject	Fleischspeise
Size	133 S. : Ill., graph. Darst.
Publisher	Food & Nutrition Press
Publishing place	Trumbull, Conn
Publishing country	United States
Document type	Book
HBZ-ID	HT006689791
ISBN	0-917678-34-6 ; 978-0-917678-34-9
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

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958/1778	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: Integrative proteomics and metabolomics profiling to understand the biochemical basis of beef muscle darkening at a slightly elevated pH.

Kiyimba, Frank / Cassens, Drew / Hartson, Steven D / Rogers, Janet / Habiger, Joshua / Mafi, Gretchen G / Ramanathan, Ranjith

Journal of animal science

2023 Volume 101

Abstract: Previous studies investigated the biochemical basis of dark-cutting conditions at elevated muscle pH (above 6), but the molecular basis at slightly above normal pH (between 5.6 and 5.8) is still unclear. The objective was to determine protein and ... ...

Abstract	Previous studies investigated the biochemical basis of dark-cutting conditions at elevated muscle pH (above 6), but the molecular basis at slightly above normal pH (between 5.6 and 5.8) is still unclear. The objective was to determine protein and metabolite profiles to elucidate postmortem muscle darkening at slightly elevated pH. Loins were selected based on the criteria established in our laboratory before sample collections, such as pH less than 5.8, L* values (muscle lightness) less than 38, and not discounted by the grader (high-pH beef with dark color are discounted and not sold in retail stores). Six bright red loins (longissimus lumborum) at normal-pH (average pH = 5.57) and six dark-colored strip loins at slightly elevated pH (average pH = 5.70) from A maturity carcasses were obtained within 72-h postmortem from a commercial beef purveyor. Surface color, oxygen consumption, metmyoglobin reducing activity, protein, and metabolite profiles were determined on normal-pH and dark-colored steaks at slightly elevated pH. Enzymes related to glycogen metabolism and glycolytic pathways were more differently abundant than metabolites associated with these pathways. The results indicated that oxygen consumption and metmyoglobin reducing activity were greater (P < 0.05) in darker steaks than normal-pH steaks. Enzymes involved with glycogen catabolic pathways and glycogen storage disease showed lower abundance in dark beef. The tricarboxylic acid metabolite, aconitic acid, was overabundant in darker-colored beef than normal-pH beef, but glucose derivative metabolites were less abundant. The majority of glycogenolytic proteins and metabolites reported as overabundant in the previous dark-cutting studies at high pH (>6.4) also did not show significant differences in the current study. Therefore, our data suggest enzymes involved in glycogen metabolism, in part, create a threshold for muscle darkening than metabolites.
MeSH term(s)	Cattle ; Animals ; Metmyoglobin/chemistry ; Muscle, Skeletal/metabolism ; Red Meat/analysis ; Proteomics ; Color ; Glycogen/metabolism ; Hydrogen-Ion Concentration ; Meat
Chemical Substances	Metmyoglobin (12772-23-5) ; Glycogen (9005-79-2)
Language	English
Publishing date	2023-01-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.1093/jas/skac376
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Listeria monocytogenes and Other Listeria spp. in Meat and Meat Products A Review.

Johnson, Jennifer L / Doyle, Michael P / Cassens, Robert G

Journal of food protection

2019 Volume 53, Issue 1, Page(s) 81–91

Abstract: Long known as an animal pathogen, Listeria monocytogenes has recently been recognized as a important foodborne agent in human disease. The widespread distribution of L. monocytogenes and other Listeria spp. in nature and an association with domestic ... ...

Abstract	Long known as an animal pathogen, Listeria monocytogenes has recently been recognized as a important foodborne agent in human disease. The widespread distribution of L. monocytogenes and other Listeria spp. in nature and an association with domestic livestock makes the occasional presence of these bacteria on raw meats almost unavoidable. Contamination of ready-to-eat meat products with L. monocytogenes poses a special threat to public health because of the organism's ability to grow at refrigeration temperatures and its pathogenicity within certain segments of the population. This paper reviews the prevalence of Listeria spp. in meat and meat products, analyzes the potential for survival and growth of listeriae on fresh meats and during meat processing, and addresses the effect of various meat preservation parameters on L. monocytogenes .
Language	English
Publishing date	2019-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	243284-5
ISSN	1944-9097 ; 0362-028X
ISSN (online)	1944-9097
ISSN	0362-028X
DOI	10.4315/0362-028X-53.1.81
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Rate Constant and Activation Energy for Formation of a Nitrosoascorbic Acid Intermediate Compound.

Izumi, Kenjiro / Cassens, Robert G / Greaser, Marion L

Journal of food protection

2019 Volume 48, Issue 4, Page(s) 346–350

Abstract: The rate of decomposition of nitrite as a result of its reaction with ascorbic acid was determined from spectrophotometric measurements at various pH values and temperatures. The reaction proceeded initially as second order. The product was ... ...

Abstract	The rate of decomposition of nitrite as a result of its reaction with ascorbic acid was determined from spectrophotometric measurements at various pH values and temperatures. The reaction proceeded initially as second order. The product was nitrosoascorbic acid, and it was formed with an increasing rate constant with decreasing pH. The rate was proportional to the concentration of nitrite from pH 4.2 to 5.38. As the reaction proceeded further at lower pH and higher temperature, it deviated from the second order reaction plot, giving kinetic evidence that the formation of 2,3-dinitrosoascorbic acid occurred more easily at low pH and high temperature. The activation energy for formation of nitrosoascorbic acid decreased with increasing pH from 10.90 Kcal/M at pH 4.35 to 6.46 Kcal/M at pH 5.49. Apparently there are two different reactions in the activation energy; i.e., the reaction of nitrous acid with the undissociated form of ascorbic acid (high activation energy) and the reaction of nitrous acid with once dissociated ascorbic acid (low activation energy). The significance of the reaction of nitrite with ascorbic acid at the pH values encountered in meats cured with nitrite and ascorbate is emphasized in terms of low activation energy and heating which increase the rate constant.
Language	English
Publishing date	2019-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	243284-5
ISSN	1944-9097 ; 0362-028X
ISSN (online)	1944-9097
ISSN	0362-028X
DOI	10.4315/0362-028X-48.4.346
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Kinetics of CD34+ Cells in Blood and Leukapheresis Products of G-GSF-Mobilized Patients and Related Donors

Cassens, U. / Gutensohn, K. / Peters, C. / Kühnl, P. / Zander, A. / Sibrowski, W.

Transfusion Medicine and Hemotherapy

1995 Volume 22, Issue S1, Page(s) 125–128

Abstract: ... durch Verabrei-chung von 2×12μg G-CSF/kg Körpergewicht (Patienten) und 2×5 μg G-CSF/kg Körpergewicht ... Die Kinetik der CD34+ Zellen zeigt ein Maximum im Blut und in Leukaphereseprodukten nach 5 Tagen G ...

Abstract	Hintergrund: Da es nur wenig schlüssige Daten über die Leukapherese-induzierten Veränderungen der CD34+ Zellen im Blut gibt, untersuchten wir das jeweilige Ver-hältnis der CD34+ Zellen im Blut vor und nach den Apheresen und den Gehalt an CD34+ Zellen in den Leukaphereseprodukten. Methode: Es wurden insgesamt 51 Leukapheresen bei 20 Patienten und Verwand-tenspendern durchgeführt und untersucht. Progenitorzellen wurden durch Verabrei-chung von 2×12μg G-CSF/kg Körpergewicht (Patienten) und 2×5 μg G-CSF/kg Körpergewicht (Verwandtenspender) mobilisiert. Ergebnisse: Die durchfluβzytometrische Analyse ergab für beide Gruppen für auf-einanderfolgende Apheresen eine Verminderung der CD34+ Zellen im Blut und in Leukaphereseprodukten. Der Abfall der CD34+ Zellen im Blut zeigte für Patienten (-34,8%) und Verwandtenspender (-34,3%) eine ähnliche Kinetik. Die Regres-sionsanalyse ergab eine Korrelation von r=0,75 zwischen CD34+ Zellen im Blut und Produkt und r-0,24 zwischen Leukozyten im Blut und CD34+ Zellen im Pro-dukt. Schluβfolgerungen: Die Ergebnisse unterstreichen die Wichtigkeit des CD34+ Monitorings im Blut zur Abschätzung der Effizienz von Apheresen. Die Kinetik der CD34+ Zellen zeigt ein Maximum im Blut und in Leukaphereseprodukten nach 5 Tagen G-CSF-Mobilisierung mit täglichem Abfall der CD34+ Zellen im Blut und in Leukaphereseprodukten.
Keywords	Periphere Blutprogenitorzellen (PBPC) ; CD34+ Zellen ; Durchfluβzytometrische Analyse ; PBPC-Apherese ; G-CSF-Mobilisierung
Language	English
Publisher	S. Karger AG
Publishing place	Basel
Publishing country	Switzerland
Document type	Article ; Online
ISSN	1660-3818 ; 1660-3796 ; 1660-3796
ISSN (online)	1660-3818
ISSN	1660-3796
DOI	10.1159/000322055
Database	Karger publisher's database

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Article ; Online: Inhibition of Botulinum Toxin Formation in Bacon by Acid Development.

Tanaka, N / Traisman, E / Lee, M H / Cassens, R G / Foster, E M

Journal of food protection

2019 Volume 43, Issue 6, Page(s) 450–457

Abstract: Lactobacillus plantarum , as a producer of lactic acid, and sucrose as a fermentable carbohydrate were evaluated for use in lowering the amount of or eliminating sodium nitrite in bacon. This work was limited to effect on antibotulinal properties. ... ...

Abstract	Lactobacillus plantarum , as a producer of lactic acid, and sucrose as a fermentable carbohydrate were evaluated for use in lowering the amount of or eliminating sodium nitrite in bacon. This work was limited to effect on antibotulinal properties. Organoleptic effects were not considered. Slices of bacon were inoculated with spores of Clostridium botulinum types A and B with or without simultaneous inoculation with a culture of L. plantarum , vacuum-packaged and incubated at 27 C. Samples were taken after various periods of incubation and assayed for botulinal toxin. We found that (a) sodium nitrite alone, at 120 ppm, did not give bacon extended protection against development of botulinum toxin if a fermentable carbon source (sucrose in these instances) was not present; (b) without added lactic acid bacteria, the effectiveness of 120 ppm of sodium nitrite plus sugar was variable and depended upon growth of naturally contaminating bacteria and (c) lactic acid bacteria with an adequate amount of sucrose gave good protection against development of botulinal toxin. Upon temperature abuse, acid was produced and growth of C. botulinum was inhibited. Because the protective properties against development of botulinal toxin in the sugar-lactic acid bacteria system were not dependent on the presence of nitrite, nitrite can be lowered to the level necessary to make organoleptically acceptable products without sacrificing safety, thus less nitrosamine formation may be achieved.
Language	English
Publishing date	2019-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	243284-5
ISSN	1944-9097 ; 0362-028X
ISSN (online)	1944-9097
ISSN	0362-028X
DOI	10.4315/0362-028X-43.6.450
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Storage and Transportation of "HIV" RNA in Plasma Samples up to 45°C in a Lyophilized Stabilizer.

Weidner, Jürgen / Hünger, Frank / Odaibo, Georgina / Olaleye, David / Reichelt, Doris / Greve, Burkhard / Cassens, Uwe

Clinical laboratory

2019 Volume 65, Issue 8

Abstract: Background: Blood or plasma samples from rural areas are often transported under suboptimal conditions to central laboratories. The negative influence of different storage temperatures during transportation as well as long transportation times on the ... ...

Abstract	Background: Blood or plasma samples from rural areas are often transported under suboptimal conditions to central laboratories. The negative influence of different storage temperatures during transportation as well as long transportation times on the stability of unprotected HIV RNA is well known. Therefore, the correct and reliable quantification of HIV RNA might be very difficult. A stabilization solution for the storage and transportation of plasma samples was developed which stabilizes RNA for seven days up to 45°C without viral load changes. Methods: Blood samples from HIV positive individuals were collected into EDTA containing tubes. The isolated plasma samples in Germany were pipetted into pre-prepared RNA stabilization tubes and incubated for seven days at 45°C. HIV-1 RNA quantification was performed on a HIV-1 LCx m 2000 system from Abbott and a Qiagen/Artus HI Virus-1 RG RT-PCR Kit on a Rotor-Gene Q PCR machine. In addition, plasma samples were collected and tested using existing SOP for storage and transportation in Nigeria. Plasma samples were treated with and without stabilization solution and the AMPLICOR HIV-1 MONITORTM test was used to determine viral load. Results: Seventy-four stabilized plasma samples were tested in Germany and results were compared to those tested unprotected within two hours. No significant changes of viral load were detected up to seven days and 45°C in case of stabilized samples. In contrast RNA of the same unprotected samples was no longer detectable after one day at 45°C. Additionally, 22 plasma samples were investigated on day zero and under field conditions in Nigeria without changes of the viral load after seven days under given temperature conditions. Conclusions: No cooling chain is necessary for the storage and/or transportation of plasma samples treated with the new RNA stabilization solution for up to seven days. The use of this solution to preserve plasma RNA will be very helpful in countries where the environmental temperature is higher than 30°C, thus addressing the problem of unreliable viral load results due to suboptimal storage or transportation conditions. Further, the costs of storage and transportation of samples for viral load quantification could be significantly reduced.
MeSH term(s)	Freeze Drying ; Germany ; HIV Infections/blood ; HIV Infections/virology ; HIV-1/genetics ; HIV-1/physiology ; Hot Temperature ; Humans ; RNA Stability/genetics ; RNA, Viral/blood ; RNA, Viral/genetics ; Reproducibility of Results ; Specimen Handling/instrumentation ; Specimen Handling/methods ; Time Factors ; Viral Load/genetics
Chemical Substances	RNA, Viral
Language	English
Publishing date	2019-08-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2019.190126
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.MO 25: Show issues

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