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  1. Article ; Online: Maintaining a healthy balance: How endothelial AHR signaling helps regulate tissue homeostasis and protection.

    Tat, Rachel P / Robinson, Christopher M

    Cell host & microbe

    2023  Volume 31, Issue 10, Page(s) 1593–1594

    Abstract: Two recent Nature papers reveal that aryl hydrocarbon receptor (AHR) signaling in endothelial cells plays a vital role in cellular quiescence and tissue homeostasis. These studies highlight the important role endothelial cells of the vasculature system ... ...

    Abstract Two recent Nature papers reveal that aryl hydrocarbon receptor (AHR) signaling in endothelial cells plays a vital role in cellular quiescence and tissue homeostasis. These studies highlight the important role endothelial cells of the vasculature system play in maintaining a healthy barrier that limits inflammation and protects against invading pathogens.
    MeSH term(s) Humans ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism ; Endothelial Cells/metabolism ; Signal Transduction ; Inflammation ; Homeostasis
    Chemical Substances Receptors, Aryl Hydrocarbon
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2023.09.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6578: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Moderate and Severe Traumatic Brain Injury.

    Robinson, Christopher P

    Continuum (Minneapolis, Minn.)

    2021  Volume 27, Issue 5, Page(s) 1278–1300

    Abstract: Purpose of review: Traumatic brain injury (TBI) encompasses a group of heterogeneous manifestations of a disease process with high neurologic morbidity and, for severe TBI, high probability of mortality and poor neurologic outcomes. This article reviews ...

    Abstract Purpose of review: Traumatic brain injury (TBI) encompasses a group of heterogeneous manifestations of a disease process with high neurologic morbidity and, for severe TBI, high probability of mortality and poor neurologic outcomes. This article reviews TBI in neurocritical care, hence focusing on moderate and severe TBI, and includes an up-to-date review of the many variables to be considered in clinical care.
    Recent findings: With advances in medicine and biotechnology, understanding of the impact of TBI has substantially elucidated the distinction between primary and secondary brain injury. Consequently, care of TBI is evolving, with intervention-based modalities targeting multiple physiologic variables. Multimodality monitoring to assess intracranial pressure, cerebral oxygenation, cerebral metabolism, cerebral blood flow, and autoregulation is at the forefront of such advances.
    Summary: Understanding the anatomic and physiologic principles of acute brain injury is necessary in managing moderate to severe TBI. Management is based on the prevention of secondary brain injury from resultant trauma. Care of patients with TBI should occur in a dedicated critical care unit with subspecialty expertise. With the advent of multimodality monitoring and targeted biomarkers in TBI, patient outcomes have a higher probability of improving in the future.
    MeSH term(s) Brain ; Brain Injuries/diagnosis ; Brain Injuries/therapy ; Brain Injuries, Traumatic/diagnosis ; Brain Injuries, Traumatic/therapy ; Cerebrovascular Circulation ; Humans ; Intracranial Pressure ; Monitoring, Physiologic
    Language English
    Publishing date 2021-10-07
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1538-6899
    ISSN (online) 1538-6899
    DOI 10.1212/CON.0000000000001036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Structural biology of nucleic acid replication, recombination and repair.

    Bolt, Edward L / Cooper, Christopher D O / Robinson, Nicholas P

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1155089

    Language English
    Publishing date 2023-03-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1155089
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  4. Article ; Online: Severe COVID-19 and Stroke-Another Piece in the Puzzle.

    Robinson, Christopher P / Busl, Katharina M

    Critical care medicine

    2021  Volume 49, Issue 12, Page(s) 2160–2164

    MeSH term(s) COVID-19/epidemiology ; COVID-19/mortality ; Extracorporeal Membrane Oxygenation ; Female ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Respiration, Artificial ; SARS-CoV-2 ; Severity of Illness Index ; Stroke/epidemiology ; Stroke/mortality
    Language English
    Publishing date 2021-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Editorial

    Edward L. Bolt / Christopher D. O. Cooper / Nicholas P. Robinson

    Frontiers in Molecular Biosciences, Vol

    Structural biology of nucleic acid replication, recombination and repair

    2023  Volume 10

    Keywords replication ; recombination ; DNA repair ; RPA ; molecular biology ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Book: Neuroendocrine disorders in children

    Dattani, Mehul T. / Hindmarsh, Peter C. / Carr, Lucinda / Robinson, Iain C. A. F.

    (Clinics in developmental medicine)

    2016  

    Author's details edited by Mehul T. Dattani, Peter C. Hindmarsh, Lucinda Carr, Iain Caf Robinson
    Series title Clinics in developmental medicine
    Keywords Pediatric neuroendocrinology
    Subject code 618.924
    Language English
    Size xvi, 406 Seiten, Illustrationen, 25 cm
    Publisher Mac Keith Press
    Publishing place London
    Publishing country United States
    Document type Book
    Note Formerly CIP.
    HBZ-ID HT019460256
    ISBN 978-1-909962-50-7 ; 9781909962521 ; 1-909962-50-3 ; 190996252X
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2017 A 1680 available for loan (reading room) Lesesaal EG

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  7. Article ; Online: Neurologic Manifestations of Severe Respiratory Viral Contagions.

    Robinson, Christopher P / Busl, Katharina M

    Critical care explorations

    2020  Volume 2, Issue 4, Page(s) e0107

    Abstract: Endemic and pandemic viral respiratory infections have recently emerged as a critical topic of investigation given the recent severe acute respiratory syndrome coronavirus-2 outbreak. Data from such outbreaks indicate that severe systemic comorbidities ... ...

    Abstract Endemic and pandemic viral respiratory infections have recently emerged as a critical topic of investigation given the recent severe acute respiratory syndrome coronavirus-2 outbreak. Data from such outbreaks indicate that severe systemic comorbidities including acute neurologic illness are associated with illness and lead to significant outcome differences. Herein, we will discuss the neurologic manifestations of severe viral respiratory infections including coronavirus, influenza, respiratory syncytial virus, metapneumovirus, and enterovirus.
    Data sources: PubMed and EMBASE were searched by two independent investigators up to March 2020.
    Study selection: Data selection included preclinical and clinical studies detailing neurologic manifestations of viral respiratory infections.
    Data extraction and synthesis: Two independent investigators reviewed and extracted the data.
    Conclusions: Neurologic manifestations including seizures, status epilepticus, encephalitis, critical illness neuromyopathy, acute disseminated encephalomyelitis, acute necrotizing encephalitis, Guillan-Barré syndrome, transverse myelitis, and acute flaccid myelitis have all been associated with severe viral respiratory infections. Having an understanding of the direct neurotropism of such viruses is imperative to understanding pathogenesis, clinical presentation, and potential treatment paradigms aimed at improving morbidity and mortality.
    Keywords covid19
    Language English
    Publishing date 2020-04-29
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Viral-Bacterial Interactions That Impact Viral Thermostability and Transmission.

    Robledo Gonzalez, Lorimar / Tat, Rachel P / Greaves, Justin C / Robinson, Christopher M

    Viruses

    2023  Volume 15, Issue 12

    Abstract: Enteric viruses are significant human pathogens that commonly cause foodborne illnesses worldwide. These viruses initiate infection in the gastrointestinal tract, home to a diverse population of intestinal bacteria. In a novel paradigm, data indicate ... ...

    Abstract Enteric viruses are significant human pathogens that commonly cause foodborne illnesses worldwide. These viruses initiate infection in the gastrointestinal tract, home to a diverse population of intestinal bacteria. In a novel paradigm, data indicate that enteric viruses utilize intestinal bacteria to promote viral replication and pathogenesis. While mechanisms underlying these observations are not fully understood, data suggest that some enteric viruses bind directly to bacteria, stabilizing the virion to retain infectivity. Here, we discuss the current knowledge of these viral-bacterial interactions and examine the impact of these interactions on viral transmission.
    MeSH term(s) Humans ; Enterovirus ; Viruses ; Enterovirus Infections ; Gastrointestinal Tract/pathology ; Bacteria/metabolism
    Language English
    Publishing date 2023-12-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15122415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Health Resource and Cost Savings Achieved in a Multidisciplinary Lung Cancer Clinic.

    Stone, Christopher J L / Johnson, Ana P / Robinson, Danielle / Katyukha, Andriy / Egan, Rylan / Linton, Sophia / Parker, Christopher / Robinson, Andrew / Digby, Geneviève C

    Current oncology (Toronto, Ont.)

    2021  Volume 28, Issue 3, Page(s) 1681–1695

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Canada ; Cost Savings ; Health Resources ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/therapy ; Retrospective Studies
    Language English
    Publishing date 2021-04-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol28030157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4305: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Meningitis and encephalitis management in the ICU.

    Robinson, Christopher P / Busl, Katharina M

    Current opinion in critical care

    2019  Volume 25, Issue 5, Page(s) 423–429

    Abstract: Purpose of review: Management of patients with meningitis and encephalitis oftentimes requires ICU level of care. This article is an update on management for meningitis and encephalitis with focus on clinical care in the ICU. Information provided is ... ...

    Abstract Purpose of review: Management of patients with meningitis and encephalitis oftentimes requires ICU level of care. This article is an update on management for meningitis and encephalitis with focus on clinical care in the ICU. Information provided is based on a review of recent studies with focus on studies since 2017.
    Recent findings: Advances in diagnostic and treatment approach for different pathogens are presented. Nosocomial meningitis now constitutes a major part of brain infections seen in ICUs in the developed world. Advances in ICU care of central nervous system (CNS) infections include application of newer diagnostic methods, improved understanding and delivery of antibiotics to the CNS, infection prevention for nosocomial infections, and application of neuromonitoring where indicated.
    Summary: Advances in diagnostics and therapeutic approach to CNS infections are continually made. For intensivists, focus on neuromonitoring and brain resuscitation in critically ill patients with CNS infections may present a path to enhance preservation of brain function and improve outcomes. VIDEO ABSTRACT: http://links.lww.com/COCC/A22.
    MeSH term(s) Critical Care ; Cross Infection/prevention & control ; Encephalitis/therapy ; Humans ; Intensive Care Units ; Meningitis/therapy
    Language English
    Publishing date 2019-06-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4999: Show issues Location:
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