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Article: The Great Masquerader: Recurrent Ischemic Strokes Secondary to Meningovascular Syphilis in a Man With Cardiovascular Stroke Risk Factors.

Carranza, Octavio / Waheed, Sadia / Yousuf, Fawad

2024 Volume 16, Issue 3, Page(s) e56330

Abstract: A male in his 60s with stroke risk factors presented with confusion and word-finding difficulties. He was diagnosed with acute ischemic stroke in the right basal ganglia. He was started on secondary stroke prevention measures including dual antiplatelet ... ...

Abstract	A male in his 60s with stroke risk factors presented with confusion and word-finding difficulties. He was diagnosed with acute ischemic stroke in the right basal ganglia. He was started on secondary stroke prevention measures including dual antiplatelet therapy and a high-dose statin. A highly reactive rapid plasma reagin (RPR) was performed as part of the workup and found to be positive. Follow-up fluorescent treponemal antibody absorption (TPA) test was also positive, confirming a diagnosis of syphilis. He was discharged home with a scheduled course of antibiotic treatment for tertiary syphilis but returned due to a new episode of transient facial paralysis. Further workup and physical exam findings revealed the patient had neurosyphilis. He was started on the appropriate antibiotic therapy, which significantly improved his confusion and prevented new episodes of stroke.
Language	English
Publishing date	2024-03-17
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.56330
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Rapid Detection of Cd

Sadia, Maria / Khan, Jehangir / Khan, Rizwan / Kamran, Abdul Waheed / Zahoor, Muhammad / Ullah, Riaz / Bari, Ahmed / Ali, Essam A

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 8

Abstract: Herein, a novel optical chemosensor, ( ...

Abstract	Herein, a novel optical chemosensor, (
Language	English
Publishing date	2023-04-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28083635
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Article: Neurologic Sequela of COVID-19: Guillain-Barré Syndrome Following Johnson & Johnson COVID-19 Vaccination.

Carranza, Octavio / Babici, Denis / Waheed, Sadia / Yousuf, Fawad

Cureus

2022 Volume 14, Issue 4, Page(s) e24252

Abstract: Guillain-Barré syndrome after Pfizer and Astra-Zeneca vaccinations against COVID-19 has been previously reported in the literature. The objective of this study was to report the first case of Guillain-Barré following the COVID-19 vaccination with the ... ...

Abstract	Guillain-Barré syndrome after Pfizer and Astra-Zeneca vaccinations against COVID-19 has been previously reported in the literature. The objective of this study was to report the first case of Guillain-Barré following the COVID-19 vaccination with the Johnson & Johnson COVID-19 vaccine. We report the case of a 53-year-old female who presented to the Emergency Department complaining of bilateral lower extremity weakness, paresthesias, and gait difficulties 14 days after having received the Johnson & Johnson COVID-19 vaccination. MRI of the lumbar spine with and without contrast revealed enhancement of the cauda equina nerve roots suggestive of acute inflammatory demyelinating polyradiculoneuropathy. Cerebrospinal fluid (CSF) analysis reported mildly elevated protein low white blood cells (WBCs). Ganglioside (GM1 and GQ1b) antibodies were reported as negative. After intravenous immunoglobulin (IVIg), the patient had significant improvement in her weakness and paresthesia and was discharged home. The case was reported to the Centers for Disease Control and Prevention (CDC) Vaccine Adverse Event Reporting System. Guillain-Barré syndrome after COVID-19 immunization remains a rare complication. A clear mechanism of disease has not been clarified; however, it is believed that there could be some type of molecular mimicry between the spike glycoprotein produced with the help of the vaccines and proteins in the myelin sheath.
Language	English
Publishing date	2022-04-18
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.24252
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Article ; Online: Changes in Corneal Biomechanical Properties after Laser-Assisted <em>in situ</em> Keratomileusis and Photorefractive Keratectomy in Myopia.

Humayun, Sadia / Bangash, Yumna Waheed / Ishaq, Mazhar / Yasmeen, Habiba

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2023 Volume 33, Issue 9, Page(s) 1023–1027

Abstract: Objective: To compare changes in corneal biomechanical properties after laser-assisted in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) in low and moderate myopia by Ocular Response Analyzer.: Study design: Quasi-experimental ... ...

Abstract	Objective: To compare changes in corneal biomechanical properties after laser-assisted in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) in low and moderate myopia by Ocular Response Analyzer. Study design: Quasi-experimental study. Place and Duration of the Study: Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi, Pakistan, between September 2020 and April 2022. Methodology: Myopic correction was done in forty-six eyes of twenty-three patients by PRK, and forty-seven eyes of twenty-four patients by LASIK. Corneal hysteresis (CH) and corneal resistance factor (CRF) were measured using Ocular Response Analyzer (ORA), pre-operatively, and then 1, 3, and 6 months, postoperatively. The relationship between the amount of myopia treated and biomechanical properties was also studied. Results: CRF and CH were decreased significantly after LASIK and PRK. A signiﬁcantly larger decrease in CRF was observed after LASIK as compared to PRK at 6 months (Mann-Whitney U test: CRF, p = 0.02); however, decrease in CH was not statistically signiﬁcant between LASIK and PRK at 6 months period (Mann-Whitney U test: CH, p = 0.388). A significant correlation was observed between the changes in biomechanical properties and extent of myopic correction after LASIK and PRK. Conclusion: Biomechanical strength of the cornea was significantly reduced by PRK and LASIK, which was also dependent on the spherical equivalent (SEQ) of myopic correction. A significantly larger change in CRF was observed after LASIK as compared to post PRK. Key words: Myopia, Laser in situ keratomileusis, Photorefractive keratectomy, Cornea, Biomechanics.
MeSH term(s)	Humans ; Keratomileusis, Laser In Situ ; Photorefractive Keratectomy ; Cornea/surgery ; Myopia/surgery ; Lasers
Language	English
Publishing date	2023-06-21
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2023.09.1023
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Article ; Online: An in silico study to unveil potential drugs and vaccine chimera for HBV capsid assembly protein: combined molecular docking and dynamics simulation approach.

Ismail, Saba / Waheed, Yasir / Ahmad, Sajjad / Ahsan, Omar / Abbasi, Sumra Wajid / Sadia, Khulah

Journal of molecular modeling

2022 Volume 28, Issue 2, Page(s) 51

Abstract: Humans are a major reservoir of the hepatitis B virus (HBV), therefore promising treatment and control vaccination strategies are needed to eradicate the virus. Though promising drugs and vaccines are available against HBV, still efforts are required to ... ...

Abstract	Humans are a major reservoir of the hepatitis B virus (HBV), therefore promising treatment and control vaccination strategies are needed to eradicate the virus. Though promising drugs and vaccines are available against HBV, still efforts are required to enrich the therapy options. Herein, the HBV assembly protein was explored to identify novel targets for future use against HBV. Computer-aided drug designing and immune-informatics techniques were employed for the identification of putative inhibitors and vaccine ensemble against HBV using capsid assembly protein. The identified drug molecule binds with high affinity to the active pocket of the protein, and several epitopes are scanned in the protein sequence. The drug molecule, besides being a good putative inhibitor, has acceptable drug-like properties. A multi-epitope vaccine is also constructed to overcome the limitations of weakly immunogenic epitopes. In contrast to the MHC II level, the set of predicted epitopes has been recognized to interact with significant numbers of HLA alleles of MHC I. Selected epitopes are extremely virulent, antigenic, nontoxic, nonallergic, have suitable affinity to bind with the prevailing DRB*0101 allele, and also spectacle 86% mediocre population coverage. A multi-epitope peptide-based vaccine chimera having 73 amino acids was designed. It emerged as substantially immunogenic, thermally stable, robust in producing cellular as well as humoral immune responses, and had competent physicochemical properties to analyze in vitro and in vivo studies. The capsid assembly protein is a in more stable nature in the presence of the drug molecule compared to the TLR3 receptor in the vaccine presence. These particulars were confirmed by exposing the docked molecules to absolute and relative binding free energy approaches of MMGBSA/PBSA. The purpose to investigate the interactions between the vaccine and a representative TLR3 immune receptor can reveal the intermolecular affinity and possible presentation mechanism of the vaccine by TLR3 to the host immune system. It was revealed that the vaccine is showing a very good affinity of binding for the TLR3 and forming a network of hydrophobic and hydrophilic interactions. Overall, the findings of this study are promising and might be useful for further experimental validations.
MeSH term(s)	Amino Acid Sequence ; Antiviral Agents/chemistry ; Binding Sites ; Capsid Proteins/chemistry ; Capsid Proteins/immunology ; Catalytic Domain ; Cluster Analysis ; Computational Biology/methods ; Databases, Factual ; Drug Design ; Epitopes, T-Lymphocyte/chemistry ; Epitopes, T-Lymphocyte/immunology ; Hepatitis B Vaccines/chemistry ; Hepatitis B Vaccines/immunology ; Hepatitis B virus/immunology ; Humans ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Binding ; Structure-Activity Relationship
Chemical Substances	Antiviral Agents ; Capsid Proteins ; Epitopes, T-Lymphocyte ; Hepatitis B Vaccines ; Ligands
Language	English
Publishing date	2022-02-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1284729-X
ISSN	0948-5023 ; 1610-2940
ISSN (online)	0948-5023
ISSN	1610-2940
DOI	10.1007/s00894-022-05042-w
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Article ; Online: Intraocular Pressure Changes in Myopic Patients Undergoing Laser <em>In-Situ Keratomileusis</em> and Photorefractive Keratectomy.

Humayun, Sadia / Bangash, Yumna Waheed / Ishaq, Mazhar / Shah, Aizaz Ali

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2023 Volume 33, Issue 10, Page(s) 1148–1152

Abstract: Objective: To assess the variation in intraocular pressure measurements between Ocular Response Analyzer (ORA) and Goldmann Applanation Tonometer (GAT) in myopic patients undergoing laser assisted in-situ keratomileusis (LASIK) and photorefractive ... ...

Abstract	Objective: To assess the variation in intraocular pressure measurements between Ocular Response Analyzer (ORA) and Goldmann Applanation Tonometer (GAT) in myopic patients undergoing laser assisted in-situ keratomileusis (LASIK) and photorefractive keratectomy (PRK). Study design: Quasi-experimental study. Place and Duration of the Study: Armed Forces Institute of Ophthalmology (AFIO), National University of Medical Sciences, Rawalpindi, Pakistan, between September 2020 and 2021. Methodology: Myopic patients undergoing LASIK and PRK during the study period were selected. Baseline examinations and postoperative follow-ups were carried out to measure intraocular pressure at 1, 3, and 6 months after LASIK or PRK, using Goldmann Applanation Tonometer (GAT) and Ocular Response Analyzer, corneal compensated IOP (ORA IOPcc). Results: One hundred and thirteen eyes underwent myopic refractive surgery, LASIK (n = 60) or PRK (n = 53). Mean age of patients was 23.6 ± 4.11 years in the PRK group and 24.4 ± 5.94 years in LASIK group. For the PKR group, the GAT IOP value increased at 1-month (p <0.001), decreased at 3-month (p <0.001) and further decreased at 6-month (p <0.001) follow-up postoperatively. In the LASIK group, the GAT IOP value decreased at all time points (p <0.001). In both groups, the mean ORA IOPcc value increased at 1 month (p <0.001), decreased at 3-month (p <0.001) and further decreased at 6-month (p <0.001) follow-up postoperatively. The IOP mean values were generally found to be higher when measured using ORA as compared with GAT. Conclusion: Corneal refractive surgery markedly decreased IOP. This decrease in IOP was observed more after LASIK than after PRK. ORA was less likely to underestimate the intraocular pressure than GAT. Key words: Myopia, Laser in-situ keratomileusis, Photorefractive keratectomy, Tonometery ocular, Intraocular pressure.
MeSH term(s)	Humans ; Young Adult ; Adult ; Photorefractive Keratectomy ; Keratomileusis, Laser In Situ ; Intraocular Pressure ; Lasers, Excimer/therapeutic use ; Tonometry, Ocular ; Cornea/surgery ; Myopia/surgery
Language	English
Publishing date	2023-10-06
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2023.10.1148
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Article ; Online: Assessment of knowledge regarding hand hygiene among healthcare workers at a cantonment-based public sector hospital in Pakistan

Saleh Ahmed / Khola Waheed Khan / Sabeeh Ilyas / Sadia Nadeem

BioMedica, Vol 38, Iss 3, Pp 173-

2022 Volume 176

Abstract: Background and Objective: Hand hygiene is regarded as one of the most important strategies in limiting infections and hospital-acquired diseases in healthcare settings. Adopting an optimal and scientifically validated technique of maintaining hand ... ...

Abstract	Background and Objective: Hand hygiene is regarded as one of the most important strategies in limiting infections and hospital-acquired diseases in healthcare settings. Adopting an optimal and scientifically validated technique of maintaining hand hygiene in healthcare centers is considered the safest and cost-effective method to prevent infection transmission to and from the patients. The present study was planned to determine the knowledge of healthcare workers about hand hygiene using the standard questionnaire in a local tertiary care hospital. Methods: It was a cross-sectional survey conducted at the Pakistan Ordnance Factories Hospital, Wah Cantonment, Pakistan, for 3 months. By adopting purposive sampling, a total of 165 healthcare professionals were recruited for the study. “Hand Hygiene Knowledge Questionnaire for Healthcare Workers,” published by World Health Organization (WHO), was used for data collection. Each subject filled out the questionnaire by himself/herself. Data were entered and analyzed in Statistical Package for the Social Sciences version 22.0. Results: It was observed that only 11 (6.6%) subjects had good knowledge of hand hygiene according to the standard guidelines, while majority of the respondents (58.2%) had a moderate level of knowledge according to the WHO criteria. There was no statistical difference in the scores among medical doctors and nurses. Conclusion: The level of knowledge about hand hygiene among healthcare workers is unsatisfactory. It calls for effective reinforcement through repeated training and awareness seminars as a part of routine work to inculcate this habit for better infection control in hospital settings.
Keywords	Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	360
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	Discover STM Publishing Ltd
Document type	Article ; Online
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Article: Folk Knowledge and Perceptions about the Use of Wild Fruits and Vegetables-Cross-Cultural Knowledge in the Pipli Pahar Reserved Forest of Okara, Pakistan.

Jabeen, Sadia / Arshad, Fahim / Harun, Nidaa / Waheed, Muhammad / Alamri, Saud / Haq, Shiekh Marifatul / Vitasović-Kosić, Ivana / Fatima, Kaneez / Chaudhry, Abdul Shakoor / Bussmann, Rainer W

Plants (Basel, Switzerland)

2024 Volume 13, Issue 6

Abstract: Wild fruits and vegetables (WFVs) have been vital to local communities for centuries and make an important contribution to daily life and income. However, traditional knowledge of the use of wild fruits is at risk of being lost due to inadequate ... ...

Abstract	Wild fruits and vegetables (WFVs) have been vital to local communities for centuries and make an important contribution to daily life and income. However, traditional knowledge of the use of wild fruits is at risk of being lost due to inadequate documentation. This study aimed to secure this knowledge through intermittent field visits and a semi-structured questionnaire. Using various ethnobotanical data analysis tools and SPSS (IBM 25), this study identified 65 WFV species (52 genera and 29 families). These species, mostly consumed as vegetables (49%) or fruits (43%), were predominantly herbaceous (48%) in wild and semi-wild habitats (67%). 20 WFVs were known to local communities (highest RFC),
Language	English
Publishing date	2024-03-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants13060832
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Article ; Online: Progress on global hepatitis elimination targets.

Waheed, Yasir

World journal of gastroenterology

2022 Volume 27, Issue 47, Page(s) 8199–8200

Abstract: In 2016, the World Health Assembly adopted a Global Health Sector Strategy on viral hepatitis ...

Abstract	In 2016, the World Health Assembly adopted a Global Health Sector Strategy on viral hepatitis, with targets set for the years 2020 and 2030 to achieve hepatitis elimination. The main target of hepatitis elimination strategy is to reduce the incidence of hepatitis B virus (HBV) and hepatitis C virus (HCV) by 90% and mortality by 65% in 2030. In last 5 years, the number of people receiving HCV treatment has increased from 1 million to 9.4 million; however, this number is far from the 2030 target of 40 million people receiving HCV treatment. HBV and HCV incidence rates are down from 1.4 million to 1.1 million annual deaths but this is far from the 2030 target of < 0.5 million deaths. The coronavirus disease 2019 pandemic has severely affected the efforts in the fight against hepatitis. No major donor has committed to investing in the fight against hepatitis. Time is running out. There is a need to speed up efforts in the fight against hepatitis to achieve hepatitis elimination by 2030.
MeSH term(s)	Antiviral Agents/therapeutic use ; COVID-19 ; Global Health ; Hepacivirus ; Hepatitis B/diagnosis ; Hepatitis B/drug therapy ; Hepatitis B/epidemiology ; Hepatitis C/diagnosis ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Hepatitis, Viral, Human/drug therapy ; Humans ; SARS-CoV-2
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2022-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v27.i47.8199
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Article ; Online: Fault Tolerant DHT-Based Routing in MANET.

Zahid, Saleem / Ullah, Kifayat / Waheed, Abdul / Basar, Sadia / Zareei, Mahdi / Biswal, Rajesh Roshan

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 11

Abstract: In Distributed Hash Table (DHT)-based Mobile Ad Hoc Networks (MANETs), a logical structured network (i.e., follows a tree, ring, chord, 3D, etc., structure) is built over the ad hoc physical topology in a distributed manner. The logical structures guide ... ...

Abstract	In Distributed Hash Table (DHT)-based Mobile Ad Hoc Networks (MANETs), a logical structured network (i.e., follows a tree, ring, chord, 3D, etc., structure) is built over the ad hoc physical topology in a distributed manner. The logical structures guide routing processes and eliminate flooding at the control and the data plans, thus making the system scalable. However, limited radio range, mobility, and lack of infrastructure introduce frequent and unpredictable changes to network topology, i.e., connectivity/dis-connectivity, node/link failure, network partition, and frequent merging. Moreover, every single change in the physical topology has an associated impact on the logical structured network and results in unevenly distributed and disrupted logical structures. This completely halts communication in the logical network, even physically connected nodes would not remain reachable due to disrupted logical structure, and unavailability of index information maintained at anchor nodes (ANs) in DHT networks. Therefore, distributed solutions are needed to tolerate faults in the logical network and provide end-to-end connectivity in such an adversarial environment. This paper defines the scope of the problem in the context of DHT networks and contributes a Fault-Tolerant DHT-based routing protocol (FTDN). FTDN, using a cross-layer design approach, investigates network dynamics in the physical network and adaptively makes arrangements to tolerate faults in the logically structured DHT network. In particular, FTDN ensures network availability (i.e., maintains connected and evenly distributed logical structures and ensures access to index information) in the face of failures and significantly improves performance. Analysis and simulation results show the effectiveness of the proposed solutions.
Language	English
Publishing date	2022-06-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22114280
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