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  1. Article: Neurologische Langzeitfolgen von COVID-19

    Bremer, Benno / Franke, Christiana

    Neurologie up2date

    2024  Volume 07, Issue 01, Page(s) 45–63

    Keywords COVID-19 ; Post-COVID-19-Syndrom ; Fatigue ; kognitive Störung ; SARS-CoV-2
    Language German
    Publishing date 2024-03-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2511-3658 ; 2511-3453
    ISSN (online) 2511-3658
    ISSN 2511-3453
    DOI 10.1055/a-1927-4006
    Database Thieme publisher's database

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  2. Article ; Online: Letter to the Editor: Comment on Mulder J et al. (2021) indirect immunofluorescence for detecting anti-neuronal autoimmunity in CSF after COVID-19 - possibilities and pitfalls.

    Franke, Christiana / Prüss, Harald

    Brain, behavior, and immunity

    2021  Volume 94, Page(s) 475

    MeSH term(s) Autoimmunity ; COVID-19 ; Fluorescent Antibody Technique, Indirect ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-02-25
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2021.02.014
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  3. Article ; Online: Neurological manifestations of post-COVID-19 syndrome S1-guideline of the German society of neurology.

    Franke, Christiana / Berlit, Peter / Prüss, Harald

    Neurological research and practice

    2022  Volume 4, Issue 1, Page(s) 28

    Abstract: Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to COVID-19 (COrona VIrus Disease-2019). SARS-CoV-2 acute infection may be associated with an increased incidence of neurological manifestations such as encephalopathy ... ...

    Abstract Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to COVID-19 (COrona VIrus Disease-2019). SARS-CoV-2 acute infection may be associated with an increased incidence of neurological manifestations such as encephalopathy and encephalomyelitis, ischemic stroke and intracerebral hemorrhage, anosmia and neuromuscular diseases. Neurological manifestations are commonly reported during the post-acute phase and are also present in Long-COVID (LCS) and post-COVID-19 syndrome (PCS). In October 2020, the German Society of Neurology (DGN, Deutsche Gesellschaft für Neurologie) published the first guideline on the neurological manifestations of COVID-19. In December 2021 this S1 guideline was revised and guidance for the care of patients with post-COVID-19 syndrome regarding neurological manifestations was added. This is an abbreviated version of the post-COVID-19 syndrome chapter of the guideline issued by the German Neurological society and published in the Guideline repository of the AWMF (Working Group of Scientific Medical Societies; Arbeitsgemeinschaft wissenschaftlicher Medizinischer Fachgesellschaften).
    Language English
    Publishing date 2022-07-18
    Publishing country England
    Document type Journal Article
    ISSN 2524-3489
    ISSN (online) 2524-3489
    DOI 10.1186/s42466-022-00191-y
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  4. Article ; Online: Manifestationen im Zentralnervensystem nach COVID-19.

    Gerhard, Ameli / Prüß, Harald / Franke, Christiana

    Der Nervenarzt

    2022  Volume 93, Issue 8, Page(s) 769–778

    Abstract: Numerous diseases of the central nervous system (CNS), especially in the postacute phase after an infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been described. These include neuroimmunologically mediated diseases, such ... ...

    Title translation Manifestations of the central nervous system after COVID-19.
    Abstract Numerous diseases of the central nervous system (CNS), especially in the postacute phase after an infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been described. These include neuroimmunologically mediated diseases, such as encephalopathy, encephalitis, myelitis, acute disseminated encephalomyelitis (ADEM), acute necrotizing hemorrhagic leukoencephalitis (ANHLE) and neuromyelitis optica spectrum disorder (NMOSD) as well as others, such as posterior reversible encephalopathy syndrome (PRES), opsoclonus myoclonus ataxia (OMA) and cerebrovascular diseases. A parainfectious or postinfectious association is discussed but the pathophysiological mechanisms are so far unknown. Underlying mechanisms could be a virus-triggered overactivation of the immune system with hyperinflammation and cytokine storm but possibly also the development of specific autoantibodies against CNS tissue. Direct damage due to the invasion of SARS-CoV‑2 into the brain or spinal cord does not seem to play a relevant role. An exact clinical phenotyping and initiation of additional diagnostics are recommended, also to rule out other causes. To date no medicinal treatment options for CNS manifestations of long COVID exist; however, first results regarding inflammation and autoimmunity are promising and could lead to new treatment approaches.
    MeSH term(s) COVID-19/complications ; Central Nervous System ; Humans ; Nervous System Diseases/etiology ; Posterior Leukoencephalopathy Syndrome ; SARS-CoV-2 ; Post-Acute COVID-19 Syndrome
    Language German
    Publishing date 2022-05-12
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 123291-5
    ISSN 1433-0407 ; 0028-2804
    ISSN (online) 1433-0407
    ISSN 0028-2804
    DOI 10.1007/s00115-022-01294-2
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  5. Article ; Online: Sequential treatment of progressive multifocal leukoencephalopathy with intravenous immunoglobulins and pembrolizumab.

    Boesl, Fabian / Allers, Kristina / Herm, Juliane / Scheider, Thomas / Franke, Christiana

    Journal of neurovirology

    2022  Volume 28, Issue 2, Page(s) 335–338

    Abstract: Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease of the CNS caused by the human polyomavirus 2 (JCV). PML predominantly occurs in immunocompromised patients. To date, no specific antiviral treatment exists, leaving only ... ...

    Abstract Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease of the CNS caused by the human polyomavirus 2 (JCV). PML predominantly occurs in immunocompromised patients. To date, no specific antiviral treatment exists, leaving only restoration of the immune system as possible treatment. In 2019, the monoclonal antibody pembrolizumab was reported as a potential treatment option in PML in a case series. Following case reports could not thoroughly confirm a positive outcome. Pembrolizumab targets the inhibitory programmed cell death protein 1 (PD-1) receptor on lymphocytes and is associated with beneficial expansion of pre-existing virus-specific T cells. Here we describe a patient with PML who benefited from combined treatment with intravenous immunoglobulins, maraviroc, and pembrolizumab.
    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; JC Virus ; Leukoencephalopathy, Progressive Multifocal/complications
    Chemical Substances Antibodies, Monoclonal, Humanized ; Immunoglobulins, Intravenous ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2022-03-23
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1283265-0
    ISSN 1538-2443 ; 1355-0284
    ISSN (online) 1538-2443
    ISSN 1355-0284
    DOI 10.1007/s13365-022-01059-2
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  6. Article: A Neurological Outpatient Clinic for Patients With Post-COVID-19 Syndrome - A Report on the Clinical Presentations of the First 100 Patients.

    Boesl, Fabian / Audebert, Heinrich / Endres, Matthias / Prüss, Harald / Franke, Christiana

    Frontiers in neurology

    2021  Volume 12, Page(s) 738405

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    Language English
    Publishing date 2021-09-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.738405
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  7. Book ; Online: Historische Grundlagen der mobilen Gesellschaft

    Damm, Veit / Henrich-Franke, Christian

    Technologien der Verkehrslenkung und drahtloser Information auf Straßen und Wasserwegen in Europa

    (Historische Dimensionen Europäischer Integration ; Band 35)

    2023  

    Series title Historische Dimensionen Europäischer Integration ; Band 35
    Keywords HB, 1QFE
    Language German
    Size 1 electronic resource (304 pages)
    Publisher Nomos Verlagsgesellschaft mbH and Company KG
    Publishing place Baden-Baden
    Document type Book ; Online
    Note German
    HBZ-ID HT030378974
    ISBN 9783748937289 ; 3748937288
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Neuroimmunologie von COVID‑19.

    Skripuletz, Thomas / Möhn, Nora / Franke, Christiana / Prüß, Harald

    Der Nervenarzt

    2021  Volume 92, Issue 6, Page(s) 521–530

    Abstract: Many neuroimmunological diseases, such as encephalopathy, encephalitis, myelitis and acute disseminated encephalomyelitis (ADEM) have occurred more frequently after infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which ... ...

    Title translation Neuroimmunology of COVID-19.
    Abstract Many neuroimmunological diseases, such as encephalopathy, encephalitis, myelitis and acute disseminated encephalomyelitis (ADEM) have occurred more frequently after infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which indicates a parainfectious or postinfectious association. The most likely underlying mechanisms include virus-triggered overactivation of the immune system with hyperinflammation and cytokine storm but potentially also the development of specific autoantibodies against central nervous system (CNS) tissue. These were predominantly detected in the cerebrospinal fluid of severely ill coronavirus disease 2019 (COVID-19) patients. In contrast, direct damage after invasion of SARS-CoV‑2 into the brain and spinal cord does not seem to play a relevant role. Susceptibility to infection with SARS-CoV‑2 in patients with multiple sclerosis, myasthenia or other neuroimmunological diseases including the risk for severe disease courses, is not determined by the administered immunotherapy but by known risk factors, such as age, comorbidities and the disease-related degree of disability. Therefore, immunotherapy in these patients should not be delayed or discontinued. The contribution of neuroimmunological mechanisms to long-term sequelae after survival of a COVID-19 illness, such as fatigue, impairment of memory, sleep dysfunction or anxiety, will require long-term clinical follow-up, preferentially in COVID-19 register studies.
    MeSH term(s) Brain Diseases ; COVID-19 ; Encephalitis ; Humans ; Neuroimmunomodulation ; SARS-CoV-2
    Language German
    Publishing date 2021-03-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 123291-5
    ISSN 1433-0407 ; 0028-2804
    ISSN (online) 1433-0407
    ISSN 0028-2804
    DOI 10.1007/s00115-021-01077-1
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  9. Article ; Online: Characteristic functional connectome related to Post-COVID-19 syndrome.

    Bungenberg, Julia / Hohenfeld, Christian / Costa, Ana S / Heine, Josephine / Schwichtenberg, Katia / Hartung, Tim / Franke, Christiana / Binkofski, Ferdinand / Schulz, Jörg B / Finke, Carsten / Reetz, Kathrin

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 4997

    Abstract: Post-COVID-19 syndrome is a serious complication following SARS-CoV-2 infection, characterized primarily by fatigue and cognitive complaints. Although first metabolic and structural imaging alterations in Post-COVID-19 syndrome have been identified, ... ...

    Abstract Post-COVID-19 syndrome is a serious complication following SARS-CoV-2 infection, characterized primarily by fatigue and cognitive complaints. Although first metabolic and structural imaging alterations in Post-COVID-19 syndrome have been identified, their functional consequences remain unknown. Thus, we explored the impact of Post-COVID-19 syndrome on the functional connectome of the brain providing a deeper understanding of pathophysiological mechanisms. In a cross-sectional observational study, resting-state functional magnetic resonance imaging data of 66 patients with Post-COVID-19 syndrome after mild infection (mean age 42.3 years, 57 female) and 57 healthy controls (mean age 42.1 years, 38 female) with a mean time of seven months after acute COVID-19 were analysed using a graph theoretical approach. Network features were quantified using measures including mean distance, nodal degree, betweenness and Katz centrality, and compared between both groups. Graph measures were correlated with clinical measures quantifying fatigue, cognitive function, affective symptoms and sleep disturbances. Alterations were mainly found in the brainstem, olfactory cortex, cingulate cortex, thalamus and cerebellum on average seven months after SARS-CoV-2 infection. Additionally, strong correlations between fatigue severity, cognitive functioning and daytime sleepiness from clinical scales and graph measures were observed. Our study confirms functional relevance of brain imaging changes in Post-COVID-19 syndrome as mediating factors for persistent symptoms and improves our pathophysiological understanding.
    MeSH term(s) Adult ; Female ; Humans ; Connectome/methods ; COVID-19 ; Cross-Sectional Studies ; Fatigue/etiology ; Magnetic Resonance Imaging/methods ; Post-Acute COVID-19 Syndrome ; SARS-CoV-2 ; Male
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-54554-3
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  10. Article ; Online: Cognitive decline in post-COVID-19 syndrome does not correspond with persisting neuronal or astrocytic damage.

    Boesl, Fabian / Goereci, Yasemin / Schweitzer, Finja / Finke, Carsten / Schild, Ann-Katrin / Bittner, Stefan / Steffen, Falk / Schröder, Maria / Quitschau, Anneke / Heine, Josephine / Warnke, Clemens / Franke, Christiana

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5326

    Abstract: Cognitive impairment is the most frequent symptom reported in post-COVID-19 syndrome (PCS). Aetiology of cognitive impairment in PCS is still to be determined. Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) are increased in ... ...

    Abstract Cognitive impairment is the most frequent symptom reported in post-COVID-19 syndrome (PCS). Aetiology of cognitive impairment in PCS is still to be determined. Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) are increased in acute COVID-19. Their role as biomarkers in other neurological disorders is under debate. We analysed serum levels of NfL and GFAP as markers for neuronal and astrocytic damage in 53 patients presenting to a PCS Neurology outpatient clinic. Only individuals with self-reported cognitive complaints were included. In these individuals, cognitive complaints were further assessed by comprehensive neuropsychological assessment (NPA). Patients were categorized into subgroups of subjective cognitive decline, single domain impairment, or multi-domain impairment. Serum NfL was in normal range, however an increase of serum GFAP was detected in 4% of patients. Serum NfL and GFAP levels correlated with each other, even when adjusting for patient age (r = 0.347, p = 0.012). NPA showed deficits in 70%; 40% showing impairment in several tested domains. No significant differences were found between serum NfL- and GFAP-levels comparing patients with subjective cognitive decline, single domain impairment, or multi-domain impairment. Persistent neuronal or astrocytic damage did not correlate with cognitive impairment in PCS.
    MeSH term(s) Humans ; COVID-19/complications ; Post-Acute COVID-19 Syndrome ; Cognitive Dysfunction/etiology ; Ambulatory Care Facilities ; Intermediate Filaments
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55881-1
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