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  1. Article ; Online: Inflammation as a Source of Cardiac Injury After Subarachnoid Hemorrhage.

    Zhang, Xiaolu Linda / Schaedel, Jessica F / Ahmad, Aftab / Wagener, Brant M

    Neurocritical care

    2023  

    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-023-01893-0
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    Zs.A 6538: Show issues Location:
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  2. Article ; Online: An Ounce of Prevention May Prevent Hospitalization.

    Barker, Andrew B / Wagener, Brant M

    Physiological reviews

    2020  Volume 100, Issue 3, Page(s) 1347–1348

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Estrone/analogs & derivatives ; Fibrinolysin ; Hospitalization ; Humans ; Pandemics ; Pneumonia, Viral ; Risk Factors ; SARS-CoV-2
    Chemical Substances Estrone (2DI9HA706A) ; Fibrinolysin (EC 3.4.21.7) ; estropipate (SVI38UY019)
    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 209902-0
    ISSN 1522-1210 ; 0031-9333
    ISSN (online) 1522-1210
    ISSN 0031-9333
    DOI 10.1152/physrev.00017.2020
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  3. Article: Massive Trauma and Resuscitation Strategies.

    Galbraith, Carter M / Wagener, Brant M / Chalkias, Athanasios / Siddiqui, Shahla / Douin, David J

    Anesthesiology clinics

    2023  Volume 41, Issue 1, Page(s) 283–301

    Abstract: Massive trauma remains the leading cause of mortality among people aged younger than 45 years. In this review, we discuss the initial care and diagnosis of trauma patients followed by a comparison of resuscitation strategies. We discuss various ... ...

    Abstract Massive trauma remains the leading cause of mortality among people aged younger than 45 years. In this review, we discuss the initial care and diagnosis of trauma patients followed by a comparison of resuscitation strategies. We discuss various strategies including use of whole blood and component therapy, examine viscoelastic techniques for management of coagulopathy, and consider the benefits and limitations of the resuscitation strategies and consider a series of questions that will be important for researchers to answer to provide the best and most cost-effective therapy for severely injured patients.
    MeSH term(s) Humans ; Resuscitation ; Wounds and Injuries/mortality ; Wounds and Injuries/therapy
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2228899-5
    ISSN 2210-3538 ; 1932-2275 ; 0889-8537
    ISSN (online) 2210-3538
    ISSN 1932-2275 ; 0889-8537
    DOI 10.1016/j.anclin.2022.10.008
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  4. Article: Anesthesiology Articles Published in 2020: A Review and Characterization of COVID-19 Versus Non-COVID-19 Publications in Top Anesthesiology Journals.

    Egbaria, Jamal K / Kofskey, Alexander M / Boyd, Carter J / Wagener, Brant

    Cureus

    2022  Volume 14, Issue 4, Page(s) e23943

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on the practice of medicine worldwide, particularly in anesthesiology. As the clinical realm has rapidly adjusted to the realities of the pandemic, anesthesiology literature ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on the practice of medicine worldwide, particularly in anesthesiology. As the clinical realm has rapidly adjusted to the realities of the pandemic, anesthesiology literature has also changed significantly to reflect this. The purpose of this study was to characterize the effects the COVID-19 pandemic has had on anesthesiology literature. Specifically, it was hypothesized that the COVID-19-related literature in the anesthesiology community would gain more interest than non-COVID-19-related articles. A total of 15 anesthesiology-related journals with the highest impact factor in 2019, according to the Journal Citation Reports (JCR),
    Language English
    Publishing date 2022-04-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.23943
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  6. Article ; Online: Altered response to Toll-like receptor 4 activation in fibromyalgia: A low-dose, human experimental endotoxemia pilot study.

    Jones, Chloe / Parkitny, Luke / Strath, Larissa / Wagener, Brant M / Barker, Andrew / Younger, Jarred

    Brain, behavior, & immunity - health

    2023  Volume 34, Page(s) 100707

    Abstract: In this pilot study, a human intravenous injection of low-dose endotoxin (lipopolysaccharide, LPS) model was used to test if fibromyalgia is associated with altered immune responses to Toll-like receptor 4 (TLR4) activation. Eight women with moderately- ... ...

    Abstract In this pilot study, a human intravenous injection of low-dose endotoxin (lipopolysaccharide, LPS) model was used to test if fibromyalgia is associated with altered immune responses to Toll-like receptor 4 (TLR4) activation. Eight women with moderately-severe fibromyalgia and eight healthy women were administered LPS at 0.1 ng/kg in session one and 0.4 ng/kg in session two. Blood draws were collected hourly to characterize the immune response. The primary analytes of interest, leptin and fractalkine, were assayed via commercial radioimmunoassay and enzyme-linked immunosorbent assay kits, respectively. Exploratory analyses were performed on 20 secreted cytokine assays by multiplex cytokine panels, collected hourly. Exploratory analyses were also performed on testosterone, estrogen, and cortisol levels, collected hourly. Additionally, standard clinical complete blood counts with differential (CBC-D) were collected before LPS administration and at the end of the session. The fibromyalgia group demonstrated enhanced leptin and suppressed fractalkine responses to LPS administration. In the exploratory analyses, the fibromyalgia group showed a lower release of IFN-γ, CXCL10, IL-17A, and IL-12 and higher release of IL-15, TARC, MDC, and eotaxin than the healthy group. The results of this study suggest that fibromyalgia may involve an altered immune response to TLR4 activation.
    Language English
    Publishing date 2023-11-17
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3546
    ISSN (online) 2666-3546
    DOI 10.1016/j.bbih.2023.100707
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  7. Article ; Online: Fibrinolytic or anti-plasmin (nafamostat) therapy for COVID-19: A timing challenge for clinicians.

    Ji, Hong-Long / Wagener, Brant M / Ness, Timothy J / Zhao, Runzhen

    Pulmonary pharmacology & therapeutics

    2021  Volume 70, Page(s) 102055

    MeSH term(s) Benzamidines/therapeutic use ; Fibrinolysin/therapeutic use ; Guanidines/therapeutic use ; Humans ; COVID-19 Drug Treatment
    Chemical Substances Benzamidines ; Guanidines ; Fibrinolysin (EC 3.4.21.7) ; nafamostat (Y25LQ0H97D)
    Language English
    Publishing date 2021-07-13
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 1399707-5
    ISSN 1522-9629 ; 1094-5539
    ISSN (online) 1522-9629
    ISSN 1094-5539
    DOI 10.1016/j.pupt.2021.102055
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    Zs.A 2389: Show issues Location:
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  8. Article ; Online: COVID-19 and Long-Term Outcomes: Lessons from Other Critical Care Illnesses and Potential Mechanisms.

    Arbov, Eli / Tayara, Alia / Wu, Songwei / Rich, Thomas C / Wagener, Brant M

    American journal of respiratory cell and molecular biology

    2022  Volume 67, Issue 3, Page(s) 275–283

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that is currently causing a pandemic and has been termed coronavirus disease (COVID-19). The elderly or those with preexisting conditions like diabetes, hypertension, ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that is currently causing a pandemic and has been termed coronavirus disease (COVID-19). The elderly or those with preexisting conditions like diabetes, hypertension, coronary heart disease, chronic obstructive pulmonary disease, cerebrovascular disease, or kidney dysfunction are more likely to develop severe cases when infected. Patients with COVID-19 admitted to the ICU have higher mortality than non-ICU patients. Critical illness has consistently posed a challenge not only in terms of mortality but also in regard to long-term outcomes of survivors. Patients who survive acute critical illness including, but not limited to, pulmonary and systemic insults associated with acute respiratory distress syndrome, pneumonia, systemic inflammation, and mechanical ventilation, will likely suffer from post-ICU syndrome, a phenomenon of cognitive, psychiatric, and/or physical disability after treatment in the ICU. Post-ICU morbidity and mortality continue to be a cause for concern when considering large-scale studies showing 12-month mortality risks of 11.8-21%. Previous studies have demonstrated that multiple mechanisms, including cytokine release, mitochondrial dysfunction, and even amyloids, may lead to end-organ dysfunction in patients. We hypothesize that COVID-19 infection will lead to post-ICU syndrome via potentially similar mechanisms as other chronic critical illnesses and cause long-term morbidity and mortality in patients. We consider a variety of mechanisms and questions that not only consider the short-term impact of the COVID-19 pandemic but its long-term effects that may not yet be imagined.
    MeSH term(s) Aged ; COVID-19 ; Critical Care ; Critical Illness ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-03-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2021-0374PS
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    Zs.A 2851: Show issues Location:
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  9. Article ; Online: Lung endothelium, tau, and amyloids in health and disease.

    Balczon, Ron / Lin, Mike T / Voth, Sarah / Nelson, Amy R / Schupp, Jonas C / Wagener, Brant M / Pittet, Jean-Francois / Stevens, Troy

    Physiological reviews

    2023  Volume 104, Issue 2, Page(s) 533–587

    Abstract: Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and function. Lung capillaries in particular represent a unique vascular niche, with a thin yet highly restrictive alveolar-capillary barrier that optimizes gas ... ...

    Abstract Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and function. Lung capillaries in particular represent a unique vascular niche, with a thin yet highly restrictive alveolar-capillary barrier that optimizes gas exchange. Capillary endothelium surveys the blood while simultaneously interpreting cues initiated within the alveolus and communicated via immediately adjacent type I and type II epithelial cells, fibroblasts, and pericytes. This cell-cell communication is necessary to coordinate the immune response to lower respiratory tract infection. Recent discoveries identify an important role for the microtubule-associated protein tau that is expressed in lung capillary endothelia in the host-pathogen interaction. This endothelial tau stabilizes microtubules necessary for barrier integrity, yet infection drives production of cytotoxic tau variants that are released into the airways and circulation, where they contribute to end-organ dysfunction. Similarly, beta-amyloid is produced during infection. Beta-amyloid has antimicrobial activity, but during infection it can acquire cytotoxic activity that is deleterious to the host. The production and function of these cytotoxic tau and amyloid variants are the subject of this review. Lung-derived cytotoxic tau and amyloid variants are a recently discovered mechanism of end-organ dysfunction, including neurocognitive dysfunction, during and in the aftermath of infection.
    MeSH term(s) Humans ; Multiple Organ Failure/metabolism ; Lung/metabolism ; Endothelium, Vascular/metabolism ; Amyloid/chemistry ; Amyloid/metabolism ; Amyloid beta-Peptides/metabolism
    Chemical Substances Amyloid ; Amyloid beta-Peptides
    Language English
    Publishing date 2023-08-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 209902-0
    ISSN 1522-1210 ; 0031-9333
    ISSN (online) 1522-1210
    ISSN 0031-9333
    DOI 10.1152/physrev.00006.2023
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  10. Article ; Online: The Role of

    Wagener, Brant M / Hu, Ruihan / Wu, Songwei / Pittet, Jean-Francois / Ding, Qiang / Che, Pulin

    Toxins

    2021  Volume 13, Issue 11

    Abstract: Pseudomonas (P.) ... ...

    Abstract Pseudomonas (P.) aeruginosa
    MeSH term(s) Bacteremia/microbiology ; Cytoskeleton/pathology ; Edema/metabolism ; Humans ; Lung/physiopathology ; Pseudomonas Infections/physiopathology ; Pseudomonas aeruginosa/physiology ; Virulence Factors/physiology
    Chemical Substances Virulence Factors
    Language English
    Publishing date 2021-11-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins13110776
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