LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 2927

Search options

  1. Article ; Online: IgA Nephropathy with Macroproteinuria and a GFR of 20-30 ml/min/1.73 m

    Wang, Ying / Jiang, Shimin / Zou, Guming / Zhuo, Li / Li, Wenge

    Journal of the renin-angiotensin-aldosterone system : JRAAS

    2022  Volume 2022, Page(s) 9162427

    Abstract: ... a baseline eGFR of 15-20 ml/min/1.73m: Conclusion: Contingent on monitoring serum creatinine and potassium ... levels, IgAN with macroproteinuria and a GFR of 20-30 ml/min/1.73m ...

    Abstract Introduction: There has been controversy about renin-angiotensin system (RAS) inhibition in IgAN patients with advanced (stage 4) chronic kidney disease (CKD). Therefore, we investigated the effect of RAS blockade in these patients.
    Methods: Renal specimens of 50 IgAN patients who underwent renal biopsy during stage 4 CKD between 2010 and 2020, were stained using immunohistochemistry to detect the expression of RAS receptors (AT1R, AT2R, MasR, and MrgD). The primary endpoint was a composite of end-stage renal disease (ESRD) and death. Main baseline information and the administration of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) were collected.
    Results: During a median follow-up time of 25.5 months, 21 (42.0%) patients reached ESRD and none died. Six patients had a baseline eGFR of 15-20 ml/min/1.73m
    Conclusion: Contingent on monitoring serum creatinine and potassium levels, IgAN with macroproteinuria and a GFR of 20-30 ml/min/1.73m
    MeSH term(s) Humans ; Renin-Angiotensin System ; Glomerulonephritis, IGA/complications ; Glomerulonephritis, IGA/drug therapy ; Glomerulonephritis, IGA/pathology ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Angiotensin Receptor Antagonists/pharmacology ; Angiotensin Receptor Antagonists/therapeutic use ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/drug therapy ; Renal Insufficiency, Chronic
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Angiotensin Receptor Antagonists
    Language English
    Publishing date 2022-12-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2086948-4
    ISSN 1752-8976 ; 1470-3203
    ISSN (online) 1752-8976
    ISSN 1470-3203
    DOI 10.1155/2022/9162427
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: P2P Botnet Detection Using Min-Vertex Cover

    Lei Xu / XiaoLong Xu / Yue Zhuo

    Journal of Networks, Vol 7, Iss 8, Pp 1176-

    2012  Volume 1181

    Abstract: P2P botnet is one of the most critical threats to the current Internet security. In this paper, we propose a session-based analysis and minimum vertex cover mining detecting model for core nodes of P2P botnets. This model is focused on solving the core ... ...

    Abstract P2P botnet is one of the most critical threats to the current Internet security. In this paper, we propose a session-based analysis and minimum vertex cover mining detecting model for core nodes of P2P botnets. This model is focused on solving the core nodes of botnet and has a good performance when the characteristics of botnet are changed to avoid detecting. The simulation experiments reveal that when the session detection rate is at 50% and session falsepositive rate is at 29%, the core node detection rate still remains 98.9%, and the false-positive rate of core node is only 4.87%.
    Keywords Network security ; Botnet detection ; Session analysis ; Minimum vertex cove ; Core nodes ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q
    Language English
    Publishing date 2012-08-01T00:00:00Z
    Publisher Academy Publisher
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Long-term plasticity of NMDA GluN2B (NR2B) receptor in anterior cingulate cortical synapses.

    Zhuo, Min

    Molecular pain

    2024  Volume 20, Page(s) 17448069241230258

    Abstract: The anterior cingulate cortex (ACC) is a key cortical area for pain perception, emotional fear and anxiety. Cortical excitation is thought to be the major mechanism for chronic pain and its related emotional disorders such as anxiety and depression. ... ...

    Abstract The anterior cingulate cortex (ACC) is a key cortical area for pain perception, emotional fear and anxiety. Cortical excitation is thought to be the major mechanism for chronic pain and its related emotional disorders such as anxiety and depression. GluN2B (or called NR2B) containing NMDA receptors play critical roles for such excitation. Not only does the activation of GluN2B contributes to the induction of the postsynaptic form of LTP (post-LTP), long-term upregulation of GluN2B subunits through tyrosine phosphorylation were also detected after peripheral injury. In addition, it has been reported that presynaptic NMDA receptors may contribute to the modulation of the release of glutamate from presynaptic terminals in the ACC. It is believed that inhibiting subtypes of NMDA receptors and/or downstream signaling proteins may serve as a novel therapeutic mechanism for future treatment of chronic pain, anxiety, and depression.
    MeSH term(s) Humans ; Gyrus Cinguli/metabolism ; N-Methylaspartate/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Chronic Pain/metabolism ; Synapses/metabolism ; Long-Term Potentiation/physiology
    Chemical Substances N-Methylaspartate (6384-92-5) ; Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2024-01-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2174252-2
    ISSN 1744-8069 ; 1744-8069
    ISSN (online) 1744-8069
    ISSN 1744-8069
    DOI 10.1177/17448069241230258
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Silent synapses in pain-related anterior cingulate cortex.

    Zhuo, Min

    Molecular pain

    2023  Volume 19, Page(s) 17448069231179011

    Abstract: Synaptic plasticity such as Long-term potentiation (LTP) is a key mechanism for learning in central synapses including the cortex. There are two least two major forms of LTPs: presynaptic LTP and postsynaptic LTP. For postsynaptic LTP, the potentiation ... ...

    Abstract Synaptic plasticity such as Long-term potentiation (LTP) is a key mechanism for learning in central synapses including the cortex. There are two least two major forms of LTPs: presynaptic LTP and postsynaptic LTP. For postsynaptic LTP, the potentiation of AMPA receptor-mediated responses through protein phosphorylation is thought to be a key mechanism. Silent synapses have been reported in the hippocampus, but it is thought to be mainly present in the cortex during early development, and may contribute to maturation of the cortical circuit. However, recent several lines of evidence demonstrate that silent synapses may exist in mature synapses of adult cortex, and they can be recruited by LTP-inducing protocols, as well as chemical-induced LTP. In pain-related cortical regions, silent synapses may not only contribute to cortical excitation after peripheral injury, but also the recruitment of new cortical circuits as well. Thus, it is proposed that silent synapses and modification of functional AMPA receptors and NMDA receptors may play important roles in chronic pain, including phantom pain.
    MeSH term(s) Adult ; Humans ; Gyrus Cinguli ; Chronic Pain ; Long-Term Potentiation ; Neuronal Plasticity ; Receptors, AMPA ; Synapses
    Chemical Substances Receptors, AMPA
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2174252-2
    ISSN 1744-8069 ; 1744-8069
    ISSN (online) 1744-8069
    ISSN 1744-8069
    DOI 10.1177/17448069231179011
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Cortical synaptic basis of consciousness.

    Zhuo, Min

    The European journal of neuroscience

    2023  Volume 59, Issue 5, Page(s) 796–806

    Abstract: Consciousness is one of final questions for humans to tackle in neuroscience. Due to a lack of understanding of basic brain networks and mechanisms of functions, our knowledge of consciousness mainly stays at a theoretical level. Recent studies using ... ...

    Abstract Consciousness is one of final questions for humans to tackle in neuroscience. Due to a lack of understanding of basic brain networks and mechanisms of functions, our knowledge of consciousness mainly stays at a theoretical level. Recent studies using brain imaging in humans and modern neuroscience techniques in animal studies reveal the basic brain network for consciousness. The projection from the thalamus to different cortical regions forms a network of activities to maintain consciousness in humans and animals. These feedback and feedforward circuits maintain consciousness even in certain brain injury conditions. Pterions and ion channels that contribute to these circuit neural activities are targets for drugs and manipulations that affect consciousness such as anesthetic agents. Synaptic plasticity that trains synapses during learning and information recall modified the circuits and contributes to a high level of consciousness in a certain population.
    MeSH term(s) Animals ; Humans ; Consciousness ; Neuronal Plasticity ; Brain ; Thalamus ; Learning ; Synapses
    Language English
    Publishing date 2023-11-27
    Publishing country France
    Document type Journal Article
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.16198
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2548: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Anterior cingulate cortex and insomnia: A cingulate-striatum connection.

    Chen, Qi-Yu / Zhuo, Min

    Neuron

    2024  Volume 112, Issue 8, Page(s) 1202–1204

    Abstract: Insomnia is an important comorbidity of chronic pain. In this issue of Neuron, Li et al. report that chronic-pain-induced insomnia is mediated by the pyramidal neurons in the anterior cingulate cortex and their dopaminergic projections to the dorsal ... ...

    Abstract Insomnia is an important comorbidity of chronic pain. In this issue of Neuron, Li et al. report that chronic-pain-induced insomnia is mediated by the pyramidal neurons in the anterior cingulate cortex and their dopaminergic projections to the dorsal medial striatum.
    MeSH term(s) Humans ; Gyrus Cinguli/physiology ; Sleep Initiation and Maintenance Disorders ; Corpus Striatum ; Pyramidal Cells ; Neostriatum ; Chronic Pain
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2024.03.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 92: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Book ; Online: Molecular Pain

    Zhuo, Min

    2007  

    Author's details edited by Min Zhuo
    Keywords Neurobiology ; Neurology ; Pain Medicine
    Language English
    Publisher Springer New York
    Publishing place New York, NY
    Document type Book ; Online
    HBZ-ID TT050386975
    ISBN 978-0-387-75268-6 ; 978-0-387-75269-3 ; 0-387-75268-4 ; 0-387-75269-2
    DOI 10.1007/978-0-387-75269-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Glutamate acts as a key neurotransmitter for itch in the mammalian spinal cord.

    Chen, Qi-Yu / Zhuo, Min

    Molecular pain

    2023  Volume 19, Page(s) 17448069231152101

    Abstract: Itch sensation is one of the major sensory experiences of humans and animals. Recent studies using genetic deletion techniques have proposed that gastrin-releasing peptide (GRP) is a key neurotransmitter for itch in the spinal cord. However, these ... ...

    Abstract Itch sensation is one of the major sensory experiences of humans and animals. Recent studies using genetic deletion techniques have proposed that gastrin-releasing peptide (GRP) is a key neurotransmitter for itch in the spinal cord. However, these studies are mainly based on behavioral responses and lack direct electrophysiological evidence that GRP indeed mediates itch information between primary afferent fibers and spinal dorsal horn neurons. In this review, we reviewed recent studies using different experimental approaches and proposed that glutamate but not GRP acts as the key neurotransmitter in the primary afferents in the transmission of itch. GRP is more likely to serve as an itch-related neuromodulator. In the cerebral cortex, we propose that the anterior cingulate cortex (ACC) plays a significant role in both itch and pain sensations. Only behavioral measurement of itch (scratching) is not sufficient for itch measurement, since scratching the itching area also produces pleasure. Integrative experimental approaches as well as better behavioral scoring models are needed to help to understand the neuronal mechanism of itch and aid future treatment for patients with pruritic diseases.
    MeSH term(s) Animals ; Humans ; Glutamic Acid ; Pruritus ; Neurotransmitter Agents ; Gastrin-Releasing Peptide/genetics ; Spinal Cord ; Mammals
    Chemical Substances Glutamic Acid (3KX376GY7L) ; Neurotransmitter Agents ; Gastrin-Releasing Peptide (80043-53-4)
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2174252-2
    ISSN 1744-8069 ; 1744-8069
    ISSN (online) 1744-8069
    ISSN 1744-8069
    DOI 10.1177/17448069231152101
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Cortical plasticity as synaptic mechanism for chronic pain.

    Zhuo, Min

    Journal of neural transmission (Vienna, Austria : 1996)

    2019  Volume 127, Issue 4, Page(s) 567–573

    Abstract: Adult brain structures such as the hippocampus are highly plastic to learning and gaining new experiences. Recent studies reveal that cortical areas that respond to sensory noxious stimuli (stimuli that cause pain in humans) are also highly plastic, like ...

    Abstract Adult brain structures such as the hippocampus are highly plastic to learning and gaining new experiences. Recent studies reveal that cortical areas that respond to sensory noxious stimuli (stimuli that cause pain in humans) are also highly plastic, like the learning-related hippocampus. Long-term potentiation (LTP), a key cellular model for learning and memory, is reported in the anterior cingulate cortex (ACC) and insular cortex (IC), two key cortical areas for pain perception. ACC and IC LTP exist in at least two major forms: presynaptically expressed LTP, and postsynaptically expressed LTP (post-LTP). In this short review, I will review, recent progress made in cortical LTPs, and explore potential roles of other forms of LTPs such as synaptic tagging. Their contribution to chronic pain as well as emotional changes caused by injury will be discussed.
    MeSH term(s) Cerebral Cortex/physiopathology ; Chronic Pain/physiopathology ; Humans ; Long-Term Potentiation/physiology ; Neuronal Plasticity/physiology ; Pain Perception/physiology ; Synaptic Transmission/physiology
    Language English
    Publishing date 2019-09-06
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 184163-4
    ISSN 1435-1463 ; 0300-9564
    ISSN (online) 1435-1463
    ISSN 0300-9564
    DOI 10.1007/s00702-019-02071-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.150: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Highly Specific Sulfadiazine Detection Using a Two-Dimensional Europium-Organic Coordination Polymer.

    Min, Hui / Zhu, Zhuo-Hang / Min, Yu-Jiao / Yao, Binling / Cheng, Peng

    ChemPlusChem

    2024  , Page(s) e202400038

    Abstract: Sulfadiazine (SFZ) is an inexpensive large-consumption antibiotic used for treat bacterial infections but an excess of residues in food can be harmful. Fast and specific luminescence detection of SFZ is highly challenging because of the interference of ... ...

    Abstract Sulfadiazine (SFZ) is an inexpensive large-consumption antibiotic used for treat bacterial infections but an excess of residues in food can be harmful. Fast and specific luminescence detection of SFZ is highly challenging because of the interference of structurally similar antibiotics. In this work, we develop a two-dimensional europium-organic coordination polymer with excellent luminescence and water stability for highly specific detection of SFZ in the range of 0-0.2 mM. Structural analysis shows that the high stability of coordination polymer is due to the high coordination number of europium ion and the special chelating coordination structure of ligand. The experiment results revealed that the high selectivity and effectively luminescence quenched behaviour of coordination polymer toward SFZ is caused by highly efficient inner filter effect.
    Language English
    Publishing date 2024-03-18
    Publishing country Germany
    Document type Journal Article
    ISSN 2192-6506
    ISSN (online) 2192-6506
    DOI 10.1002/cplu.202400038
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top