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  1. Article ; Conference proceedings: microRNA-124 prevents diabetic retinopathy

    Chen, Ying / Lin, Jihong / Schlotterer, Andrea / Hammes, Hans-Peter

    Diabetologie und Stoffwechsel

    2022  Volume 17, Issue S 01

    Event/congress Diabetes Kongress 2022 - 56. Jahrestagung der DDG, CityCube Berlin, 2022-05-25
    Language German
    Publishing date 2022-05-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2222993-0
    ISSN 1861-9010 ; 1861-9002
    ISSN (online) 1861-9010
    ISSN 1861-9002
    DOI 10.1055/s-0042-1746291
    Database Thieme publisher's database

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  2. Article ; Online: miRNA-124 Prevents Rat Diabetic Retinopathy by Inhibiting the Microglial Inflammatory Response.

    Chen, Ying / Schlotterer, Andrea / Kurowski, Luke / Li, Lin / Dannehl, Marcus / Hammes, Hans-Peter / Lin, Jihong

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Diabetic retinopathy (DR) is characterized by vasoregression and glial activation. miRNA-124 (miR-124) reduces retinal microglial activation and alleviates vasoregression in a neurodegenerative rat model. Our aim was to determine whether miR-124 affects ... ...

    Abstract Diabetic retinopathy (DR) is characterized by vasoregression and glial activation. miRNA-124 (miR-124) reduces retinal microglial activation and alleviates vasoregression in a neurodegenerative rat model. Our aim was to determine whether miR-124 affects vascular and neural damage in the early diabetic retina. Diabetes was induced in 8-week-old
    MeSH term(s) Rats ; Animals ; Diabetic Retinopathy/metabolism ; Microglia/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Rats, Wistar ; Retina/metabolism
    Chemical Substances MicroRNAs ; MIRN124 microRNA, rat
    Language English
    Publishing date 2023-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032291
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  3. Article ; Online: The effect of GLP-1 receptor agonist lixisenatide on experimental diabetic retinopathy.

    Oezer, Kuebra / Kolibabka, Matthias / Gassenhuber, Johann / Dietrich, Nadine / Fleming, Thomas / Schlotterer, Andrea / Morcos, Michael / Wohlfart, Paulus / Hammes, Hans-Peter

    Acta diabetologica

    2023  Volume 60, Issue 11, Page(s) 1551–1565

    Abstract: Aims: Glucagon-like peptide-1 receptor agonists are effective treatments for type 2 diabetes, effectively lowering glucose without weight gain and with low risk for hypoglycemia. However, their influence on the retinal neurovascular unit remains unclear. ...

    Abstract Aims: Glucagon-like peptide-1 receptor agonists are effective treatments for type 2 diabetes, effectively lowering glucose without weight gain and with low risk for hypoglycemia. However, their influence on the retinal neurovascular unit remains unclear. In this study, we analyzed the effects of the GLP-1 RA lixisenatide on diabetic retinopathy.
    Methods: Vasculo- and neuroprotective effects were assessed in experimental diabetic retinopathy and high glucose-cultivated C. elegans, respectively. In STZ-diabetic Wistar rats, acellular capillaries and pericytes (quantitative retinal morphometry), neuroretinal function (mfERG), macroglia (GFAP western blot) and microglia (immunohistochemistry) quantification, methylglyoxal (LC-MS/MS) and retinal gene expressions (RNA-sequencing) were determined. The antioxidant properties of lixisenatide were tested in C. elegans.
    Results: Lixisenatide had no effect on glucose metabolism. Lixisenatide preserved the retinal vasculature and neuroretinal function. The macro- and microglial activation was mitigated. Lixisenatide normalized some gene expression changes in diabetic animals to control levels. Ets2 was identified as a regulator of inflammatory genes. In C. elegans, lixisenatide showed the antioxidative property.
    Conclusions: Our data suggest that lixisenatide has a protective effect on the diabetic retina, most likely due to a combination of neuroprotective, anti-inflammatory and antioxidative effects of lixisenatide on the neurovascular unit.
    MeSH term(s) Rats ; Animals ; Diabetic Retinopathy/drug therapy ; Diabetic Retinopathy/etiology ; Diabetic Retinopathy/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Glucagon-Like Peptide-1 Receptor/agonists ; Caenorhabditis elegans ; Chromatography, Liquid ; Rats, Wistar ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Tandem Mass Spectrometry ; Antioxidants/pharmacology ; Glucose
    Chemical Substances lixisenatide (74O62BB01U) ; Hypoglycemic Agents ; Glucagon-Like Peptide-1 Receptor ; Antioxidants ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-07-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1097676-0
    ISSN 1432-5233 ; 0940-5429
    ISSN (online) 1432-5233
    ISSN 0940-5429
    DOI 10.1007/s00592-023-02135-7
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  4. Article ; Online: Correction: Hybrid Dysgenesis in Drosophila simulans Associated with a Rapid Invasion of the P-Element.

    Hill, Tom / Schlötterer, Christian / Betancourt, Andrea J

    PLoS genetics

    2016  Volume 12, Issue 5, Page(s) e1006058

    Abstract: This corrects the article DOI: 10.1371/journal.pgen.1005920.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pgen.1005920.].
    Language English
    Publishing date 2016-05-11
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1006058
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  5. Article: Protective Effects of Transient Glucose Exposure in Adult

    Murillo, Katharina / Samigullin, Azat / Humpert, Per M / Fleming, Thomas / Özer, Kübra / Schlotterer, Andrea / Hammes, Hans-Peter / Morcos, Michael

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 1

    Abstract: ... C. ... ...

    Abstract C. elegans
    Language English
    Publishing date 2022-01-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11010160
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  6. Article ; Online: (with research data) Hybrid Dysgenesis in Drosophila simulans Associated with a Rapid Invasion of the P-Element.

    Hill, Tom / Schlötterer, Christian / Betancourt, Andrea J

    PLoS genetics

    2016  Volume 12, Issue 3, Page(s) e1005920

    Abstract: In a classic example of the invasion of a species by a selfish genetic element, the P-element was horizontally transferred from a distantly related species into Drosophila melanogaster. Despite causing 'hybrid dysgenesis', a syndrome of abnormal ... ...

    Abstract In a classic example of the invasion of a species by a selfish genetic element, the P-element was horizontally transferred from a distantly related species into Drosophila melanogaster. Despite causing 'hybrid dysgenesis', a syndrome of abnormal phenotypes that include sterility, the P-element spread globally in the course of a few decades in D. melanogaster. Until recently, its sister species, including D. simulans, remained P-element free. Here, we find a hybrid dysgenesis-like phenotype in the offspring of crosses between D. simulans strains collected in different years; a survey of 181 strains shows that around 20% of strains induce hybrid dysgenesis. Using genomic and transcriptomic data, we show that this dysgenesis-inducing phenotype is associated with the invasion of the P-element. To characterize this invasion temporally and geographically, we survey 631 D. simulans strains collected on three continents and over 27 years for the presence of the P-element. We find that the D. simulans P-element invasion occurred rapidly and nearly simultaneously in the regions surveyed, with strains containing P-elements being rare in 2006 and common by 2014. Importantly, as evidenced by their resistance to the hybrid dysgenesis phenotype, strains collected from the latter phase of this invasion have adapted to suppress the worst effects of the P-element.
    MeSH term(s) Animals ; Crosses, Genetic ; DNA Transposable Elements/genetics ; Drosophila melanogaster/genetics ; Drosophila simulans/genetics ; Evolution, Molecular ; Hybridization, Genetic ; Infertility/genetics ; Introduced Species ; Phenotype ; Phylogeny
    Chemical Substances DNA Transposable Elements
    Language English
    Publishing date 2016-03-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1005920
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  7. Article ; Online: miRNA-124 Prevents Rat Diabetic Retinopathy by Inhibiting the Microglial Inflammatory Response

    Ying Chen / Andrea Schlotterer / Luke Kurowski / Lin Li / Marcus Dannehl / Hans-Peter Hammes / Jihong Lin

    International Journal of Molecular Sciences, Vol 24, Iss 2291, p

    2023  Volume 2291

    Abstract: Diabetic retinopathy (DR) is characterized by vasoregression and glial activation. miRNA-124 (miR-124) reduces retinal microglial activation and alleviates vasoregression in a neurodegenerative rat model. Our aim was to determine whether miR-124 affects ... ...

    Abstract Diabetic retinopathy (DR) is characterized by vasoregression and glial activation. miRNA-124 (miR-124) reduces retinal microglial activation and alleviates vasoregression in a neurodegenerative rat model. Our aim was to determine whether miR-124 affects vascular and neural damage in the early diabetic retina. Diabetes was induced in 8-week-old Wistar rats by streptozotocin (STZ) injection. At 16 and 20 weeks, the diabetic rats were intravitreally injected with miR-124 mimic, and retinae were analyzed at 24 weeks. Microvascular damage was identified by evaluating pericyte loss and acellular capillary (AC) formation. Müller glial activation was assessed by glial fibrillary acidic protein (GFAP) immunofluorescence staining. Microglial activation was determined by immunofluorescent staining of ionized calcium-binding adaptor molecule 1 (Iba1) in whole mount retinae. The neuroretinal function was assessed by electroretinography. The expression of inflammation-associated genes was evaluated by qRT-PCR. A wound healing assay was performed to quantitate the mobility of microglial cells. The results showed that miR-124 treatment alleviated diabetic vasoregression by reducing AC formation and pericyte loss. miR-124 blunted Müller glial- and microglial activation in diabetic retinae and ameliorated neuroretinal function. The retinal expression of inflammatory factors including Tnf-α , Il-1β , Cd74 , Ccl2 , Ccl3 , Vcam1 , Tgf-β1 , Arg1 , and Il-10 was reduced by miR-124 administration. The elevated mobility of microglia upon high glucose exposure was normalized by miR-124. The expression of the transcription factor PU.1 and lipid raft protein Flot1 was downregulated by miR-124. In rat DR, miR-124 prevents vasoregression and glial activation, improves neuroretinal function, and modulates microglial activation and inflammatory responses.
    Keywords miR-124 ; microglia ; vasoregression ; diabetic retinopathy ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 571
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Sulforaphane and Vitamin E Protect From Glucotoxic Neurodegeneration and Lifespan Reduction In C. Elegans.

    Schlotterer, Andrea / Masri, Benan / Humpert, M / Krämer, Bernhard Karl / Hammes, Hans-Peter / Morcos, Michael

    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

    2020  Volume 129, Issue 12, Page(s) 887–894

    Abstract: Caenorhabditis ... ...

    Abstract Caenorhabditis elegans
    MeSH term(s) Animals ; Antioxidants/administration & dosage ; Antioxidants/pharmacology ; Caenorhabditis elegans ; Disease Models, Animal ; Drug Therapy, Combination ; Glycation End Products, Advanced/drug effects ; Hyperglycemia/drug therapy ; Hyperglycemia/metabolism ; Isothiocyanates/administration & dosage ; Isothiocyanates/pharmacology ; Longevity/drug effects ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/metabolism ; Sulfoxides/administration & dosage ; Sulfoxides/pharmacology ; Vitamin E/administration & dosage ; Vitamin E/pharmacology
    Chemical Substances Antioxidants ; Glycation End Products, Advanced ; Isothiocyanates ; Sulfoxides ; Vitamin E (1406-18-4) ; sulforaphane (GA49J4310U)
    Language English
    Publishing date 2020-06-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1225416-2
    ISSN 1439-3646 ; 0947-7349
    ISSN (online) 1439-3646
    ISSN 0947-7349
    DOI 10.1055/a-1158-9248
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  9. Article ; Online: Quantifying Selection with Pool-Seq Time Series Data.

    Taus, Thomas / Futschik, Andreas / Schlötterer, Christian

    Molecular biology and evolution

    2017  Volume 34, Issue 11, Page(s) 3023–3034

    Abstract: Allele frequency time series data constitute a powerful resource for unraveling mechanisms of adaptation, because the temporal dimension captures important information about evolutionary forces. In particular, Evolve and Resequence (E&R), the whole- ... ...

    Abstract Allele frequency time series data constitute a powerful resource for unraveling mechanisms of adaptation, because the temporal dimension captures important information about evolutionary forces. In particular, Evolve and Resequence (E&R), the whole-genome sequencing of replicated experimentally evolving populations, is becoming increasingly popular. Based on computer simulations several studies proposed experimental parameters to optimize the identification of the selection targets. No such recommendations are available for the underlying parameters selection strength and dominance. Here, we introduce a highly accurate method to estimate selection parameters from replicated time series data, which is fast enough to be applied on a genome scale. Using this new method, we evaluate how experimental parameters can be optimized to obtain the most reliable estimates for selection parameters. We show that the effective population size (Ne) and the number of replicates have the largest impact. Because the number of time points and sequencing coverage had only a minor effect, we suggest that time series analysis is feasible without major increase in sequencing costs. We anticipate that time series analysis will become routine in E&R studies.
    MeSH term(s) Adaptation, Biological/genetics ; Adaptation, Physiological/genetics ; Alleles ; Biological Evolution ; Computer Simulation ; Evolution, Molecular ; Gene Frequency/genetics ; Genome ; Models, Genetic ; Polymorphism, Single Nucleotide/genetics ; Selection, Genetic ; Sequence Analysis, DNA/methods ; Sequence Analysis, DNA/statistics & numerical data ; Whole Genome Sequencing/methods
    Language English
    Publishing date 2017-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 998579-7
    ISSN 1537-1719 ; 0737-4038
    ISSN (online) 1537-1719
    ISSN 0737-4038
    DOI 10.1093/molbev/msx225
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  10. Article ; Online: Reconciling Differences in Pool-GWAS Between Populations: A Case Study of Female Abdominal Pigmentation in Drosophila melanogaster.

    Endler, Lukas / Betancourt, Andrea J / Nolte, Viola / Schlötterer, Christian

    Genetics

    2015  Volume 202, Issue 2, Page(s) 843–855

    Abstract: The degree of concordance between populations in the genetic architecture of a given trait is an important issue in medical and evolutionary genetics. Here, we address this problem, using a replicated pooled genome-wide association study approach (Pool- ... ...

    Abstract The degree of concordance between populations in the genetic architecture of a given trait is an important issue in medical and evolutionary genetics. Here, we address this problem, using a replicated pooled genome-wide association study approach (Pool-GWAS) to compare the genetic basis of variation in abdominal pigmentation in female European and South African Drosophila melanogaster. We find that, in both the European and the South African flies, variants near the tan and bric-à-brac 1 (bab1) genes are most strongly associated with pigmentation. However, the relative contribution of these loci differs: in the European populations, tan outranks bab1, while the converse is true for the South African flies. Using simulations, we show that this result can be explained parsimoniously, without invoking different causal variants between the populations, by a combination of frequency differences between the two populations and dominance for the causal alleles at the bab1 locus. Our results demonstrate the power of cost-effective, replicated Pool-GWAS to shed light on differences in the genetic architecture of a given trait between populations.
    MeSH term(s) Animals ; Drosophila melanogaster/genetics ; Female ; Genetics, Population ; Genome-Wide Association Study ; Phenotype ; Pigmentation/genetics ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci
    Language English
    Publishing date 2015-12-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1534/genetics.115.183376
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