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  1. Article ; Online: How neuropathology can contribute to the understanding of dementia.

    Gelpi, Ellen

    Neurodegenerative disease management

    2016  Volume 6, Issue 3, Page(s) 183–186

    Language English
    Publishing date 2016-06
    Publishing country England
    Document type Journal Article
    ISSN 1758-2032
    ISSN (online) 1758-2032
    DOI 10.2217/nmt-2016-0013
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  2. Article ; Online: Neuropathologie der Demenzen.

    Klotz, Sigrid / Gelpi, Ellen

    Wiener medizinische Wochenschrift (1946)

    2021  Volume 171, Issue 11-12, Page(s) 257–273

    Abstract: Dementia is the clinical consequence of various neurological disorders with a multitude of etiologies. Precise knowledge of the underlying pathologies is essential for an accurate treatment of patients and for the development of suitable disease ... ...

    Title translation Neuropathology of dementia.
    Abstract Dementia is the clinical consequence of various neurological disorders with a multitude of etiologies. Precise knowledge of the underlying pathologies is essential for an accurate treatment of patients and for the development of suitable disease biomarkers. A definite diagnosis of many of the disorders, particularly for neurodegenerative ones, can only be made after a thorough postmortem neuropathological examination. This highlights the importance of performing a brain autopsy and the relevance of a close interaction between clinicians, neuroimaging disciplines and neuropathologists as well as with basic researchers. This article aims to give a brief overview on the neuropathology of dementia focusing on neurodegenerative diseases, to further facilitate interdisciplinary collaboration.
    MeSH term(s) Autopsy ; Brain ; Dementia ; Humans ; Neurodegenerative Diseases ; Neuropathology
    Language German
    Publishing date 2021-06-15
    Publishing country Austria
    Document type Journal Article ; Review
    ZDB-ID 123613-1
    ISSN 1563-258X ; 0254-7945 ; 0043-5341
    ISSN (online) 1563-258X
    ISSN 0254-7945 ; 0043-5341
    DOI 10.1007/s10354-021-00848-4
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  3. Article: Clinical Neuropathology teaching case 3-2015: female or male brain? Anti-ubiquitin visualizes Barr bodies in hippocampal granule cells which allows the determination of gender in human brains.

    Gelpi, Ellen

    Clinical neuropathology

    2015  Volume 34, Issue 3, Page(s) 115–116

    MeSH term(s) Female ; Hippocampus/pathology ; Humans ; Immunohistochemistry ; Male ; Neurons/pathology ; Sex Characteristics ; Sex Chromatin/pathology ; Ubiquitin/metabolism
    Chemical Substances Ubiquitin
    Language English
    Publishing date 2015-02-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603167-5
    ISSN 0722-5091
    ISSN 0722-5091
    DOI 10.5414/np300877
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  4. Article: Diagnostic challenges and pitfalls of myelin oligodendrocyte glycoprotein antibody-associated demyelination: Lessons from neuropathology.

    Höftberger, Romana / Gelpi, Ellen

    Neurology(R) neuroimmunology & neuroinflammation

    2019  Volume 6, Issue 2, Page(s) e544

    MeSH term(s) Demyelinating Diseases ; Encephalitis ; Humans ; Myelin-Oligodendrocyte Glycoprotein ; Neuropathology ; Vasculitis, Central Nervous System
    Chemical Substances Myelin-Oligodendrocyte Glycoprotein
    Language English
    Publishing date 2019-02-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2767740-0
    ISSN 2332-7812
    ISSN 2332-7812
    DOI 10.1212/NXI.0000000000000544
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  5. Article ; Online: Oligomers: a hot topic for neurodegeneration and a note of caution for experimental models.

    Gelpi, Ellen / Colom-Cadena, Martí

    Brain : a journal of neurology

    2019  Volume 142, Issue 2, Page(s) 228–230

    MeSH term(s) Models, Theoretical ; Prion Proteins ; Prions ; alpha-Synuclein ; tau Proteins
    Chemical Substances Prion Proteins ; Prions ; alpha-Synuclein ; tau Proteins
    Language English
    Publishing date 2019-01-29
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awy342
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  6. Article ; Online: Motor neuron involvement expands the neuropathological phenotype of late-onset ataxia in RFC1 mutation (CANVAS).

    Reyes-Leiva, David / Aldecoa, Iban / Gelpi, Ellen / Rojas-García, Ricard

    Brain pathology (Zurich, Switzerland)

    2022  Volume 32, Issue 4, Page(s) e13051

    Abstract: Neuropathological features in brainstem, cerebellum and spinal cord. In addition to cerebellar, vestibullar nuclei and spinal cord posterior columns involvement, a moderate reduction of motor neurons in hypoglossal nucleus and anterior horn of the ... ...

    Abstract Neuropathological features in brainstem, cerebellum and spinal cord. In addition to cerebellar, vestibullar nuclei and spinal cord posterior columns involvement, a moderate reduction of motor neurons in hypoglossal nucleus and anterior horn of the thoracic spinal cord was present.
    MeSH term(s) Ataxia ; Cerebellar Ataxia/genetics ; Humans ; Motor Neurons/pathology ; Mutation ; Phenotype ; Replication Protein C/genetics
    Chemical Substances RFC1 protein, human ; Replication Protein C (EC 3.6.4.-)
    Language English
    Publishing date 2022-01-09
    Publishing country Switzerland
    Document type Case Reports ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1051484-3
    ISSN 1750-3639 ; 1015-6305
    ISSN (online) 1750-3639
    ISSN 1015-6305
    DOI 10.1111/bpa.13051
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  7. Article: Clinical Neuropathology image 1-2017: incidental schwannoma of the posterior root.

    Gelpi, Ellen / Vicente-Pascual, Mikel

    Clinical neuropathology

    2017  Volume 36 2017, Issue 1, Page(s) 3–4

    MeSH term(s) Aged, 80 and over ; Autopsy ; Female ; Humans ; Incidental Findings ; Neurilemmoma/pathology ; Peripheral Nervous System Neoplasms/pathology ; Spinal Nerve Roots/pathology ; Thoracic Vertebrae
    Language English
    Publishing date 2017-01
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 603167-5
    ISSN 0722-5091
    ISSN 0722-5091
    DOI 10.5414/NP301010
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  8. Article ; Online: Rapidly Progressive Corticobasal Degeneration Mimicking Brainstem Encephalitis.

    Moura, João / Oliveira, Vanessa / Sardoeira, Ana / Pinto, Miguel / Gelpi, Ellen / Taipa, Ricardo / Santos, Ernestina

    Movement disorders clinical practice

    2022  Volume 10, Issue 2, Page(s) 300–306

    Abstract: Background: Corticobasal degeneration (CBD) may have a rapidly progressive (RP) clinical course, mimicking other neurological conditions.: Objectives: To describe a neuropathologically proven case of RP-CBD in a patient initially diagnosed with ... ...

    Abstract Background: Corticobasal degeneration (CBD) may have a rapidly progressive (RP) clinical course, mimicking other neurological conditions.
    Objectives: To describe a neuropathologically proven case of RP-CBD in a patient initially diagnosed with immune-mediated brainstem encephalitis.
    Methods: Retrospective data collection from electronic records and authorized video material.
    Results: A 51-year-old man presented with bilateral ptosis, diplopia, and dysphagia. The diagnostic workup was negative for myasthenic syndromes. He progressively developed cognitive dysfunction with frontal release signs and asymmetric parkinsonism. Cerebrospinal fluid evaluation revealed 4 leukocytes/uL, 0.32 g/L proteins, 0.85 g/L glucose, and absent oligoclonal bands. Weakly positive anti-PNMA2 (Ma2/Ta) antibodies were present, and magnetic resonance imaging showed a T2 hyperintensity involving the midbrain and pons. Based on these features, the diagnosis of immune-mediated brainstem encephalitis was considered. The patient did not improve after several cycles of methylprednisolone, intravenous immunoglobulin, and plasma exchange. At 1 year after onset, he developed horizontal and vertical gaze limitation and worsening of the parkinsonism and cognitive dysfunction. By age 53, he was severely disabled, requiring percutaneous gastrostomy for feeding. Anti-IgLON5 was negative. He fulfilled the clinical criteria for probable progressive supranuclear palsy. He died from pneumonia at age 54. The neuropathological examination revealed a 4-repeat tauopathy with features of CBD with extensive involvement of the brainstem.
    Conclusions: RP-CBD may resemble brainstem encephalitis. The severity of brainstem and upper spinal cord pathology in the postmortem examination correlated with the clinical and imaging features.
    Language English
    Publishing date 2022-12-15
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13633
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  9. Article ; Online: Which parameters influence cognitive, psychiatric and long-term seizure outcome in mesial temporal lobe epilepsy after selective amygdalohippocampectomy?

    Jud, Judith / Stefanits, Harald / Gelpi, Ellen / Quinot, Valérie / Aull-Watschinger, Susanne / Czech, Thomas / Dorfer, Christian / Rössler, Karl / Baumgartner, Christoph / Kasprian, Gregor / Watschinger, Clara / Moser, Doris / Brugger, Jonas / Pataraia, Ekaterina

    Journal of neurology

    2024  

    Abstract: Background: We aimed to analyze potentially prognostic factors which could have influence on postoperative seizure, neuropsychological and psychiatric outcome in a cohort of patients with mesial temporal lobe epilepsy (MTLE) due to hippocampal sclerosis ...

    Abstract Background: We aimed to analyze potentially prognostic factors which could have influence on postoperative seizure, neuropsychological and psychiatric outcome in a cohort of patients with mesial temporal lobe epilepsy (MTLE) due to hippocampal sclerosis (HS) after selective amygdalohippocampectomy (SAHE) via transsylvian approach.
    Methods: Clinical variables of 171 patients with drug-resistant MTLE with HS (88 females) who underwent SAHE between 1994 and 2019 were evaluated using univariable and multivariable logistic regression models, to investigate which of the explanatory parameters can best predict the outcome.
    Results: At the last available follow-up visit 12.3 ± 6.3 years after surgery 114 patients (67.9%) were seizure-free. Left hemispheric MTLE was associated with worse postoperative seizure outcome at first year after surgery (OR = 0.54, p = 0.01), female sex-with seizure recurrence at years 2 (OR = 0.52, p = 0.01) and 5 (OR = 0.53, p = 0.025) and higher number of preoperative antiseizure medication trials-with seizure recurrence at year 2 (OR = 0.77, p = 0.0064), whereas patients without history of traumatic brain injury had better postoperative seizure outcome at first year (OR = 2.08, p = 0.0091). All predictors lost their predictive value in long-term course. HS types had no prognostic influence on outcome. Patients operated on right side performed better in verbal memory compared to left (VLMT 1-5 p < 0.001, VLMT 7 p = 0.001). Depression occurred less frequently in seizure-free patients compared to non-seizure-free patients (BDI-II Z = - 2.341, p = 0.019).
    Conclusions: SAHE gives an improved chance of achieving good postoperative seizure, psychiatric and neuropsychological outcome in patients with in MTLE due to HS. Predictors of short-term outcome don't predict long-term outcome.
    Language English
    Publishing date 2024-04-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-024-12343-y
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  10. Article ; Online: Focal Subthalamic Atrophy after Long-Term Deep Brain Stimulation in Parkinson's Disease.

    Gelpi, Ellen / Haberler, Christine / Micko, Alexander / Polt, Andrea / Amon, Andreas / Rössler, Karl / Alesch, François

    Movement disorders : official journal of the Movement Disorder Society

    2021  Volume 36, Issue 8, Page(s) 1987–1989

    MeSH term(s) Atrophy ; Deep Brain Stimulation ; Humans ; Neuropsychological Tests ; Parkinson Disease/therapy ; Subthalamic Nucleus
    Language English
    Publishing date 2021-06-12
    Publishing country United States
    Document type Letter
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.28653
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