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  1. Article ; Online: A General Photocatalytic Strategy for Nucleophilic Amination of Primary and Secondary Benzylic C-H Bonds.

    Ruos, Madeline E / Kinney, R Garrison / Ring, Oliver T / Doyle, Abigail G

    Journal of the American Chemical Society

    2023  Volume 145, Issue 33, Page(s) 18487–18496

    Abstract: ... of primary and secondary benzylic C(sp ...

    Abstract We report a visible-light photoredox-catalyzed method that enables nucleophilic amination of primary and secondary benzylic C(sp
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c04912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A palladium-catalyzed C-H functionalization route to ketones

    Levesque, Taleah M / Kinney, R Garrison / Arndtsen, Bruce A

    Chemical science

    2020  Volume 11, Issue 11, Page(s) 3104–3109

    Abstract: We describe the development of a new palladium-catalyzed method to generate ... ...

    Abstract We describe the development of a new palladium-catalyzed method to generate ketones
    Language English
    Publishing date 2020-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d0sc00085j
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  3. Article ; Online: Preferential N-H⋯:C[double bond splayed right] hydrogen bonding involving ditopic

    Kinney, Zacharias J / Rheingold, Arnold L / Protasiewicz, John D

    RSC advances

    2020  Volume 10, Issue 69, Page(s) 42164–42171

    Abstract: Hydrogen bonding plays a critical role in maintaining order and structure in complex biological and synthetic systems. ...

    Abstract Hydrogen bonding plays a critical role in maintaining order and structure in complex biological and synthetic systems.
    Language English
    Publishing date 2020-11-20
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d0ra08490e
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  4. Article ; Online: A general approach to intermolecular carbonylation of arene C-H bonds to ketones through catalytic aroyl triflate formation.

    Garrison Kinney, R / Tjutrins, Jevgenijs / Torres, Gerardo M / Liu, Nina Jiabao / Kulkarni, Omkar / Arndtsen, Bruce A

    Nature chemistry

    2017  Volume 10, Issue 2, Page(s) 193–199

    Abstract: The development of metal-catalysed methods to functionalize inert C-H bonds has become a dominant ... catalysed C-H bond functionalization in which carbon monoxide is used to drive the generation of high-energy ... electrophiles. This offers a method to couple the useful features of metal-catalysed C-H functionalization ...

    Abstract The development of metal-catalysed methods to functionalize inert C-H bonds has become a dominant research theme in the past decade as an approach to efficient synthesis. However, the incorporation of carbon monoxide into such reactions to form valuable ketones has to date proved a challenge, despite its potential as a straightforward and green alternative to Friedel-Crafts reactions. Here we describe a new approach to palladium-catalysed C-H bond functionalization in which carbon monoxide is used to drive the generation of high-energy electrophiles. This offers a method to couple the useful features of metal-catalysed C-H functionalization (stable and available reagents) and electrophilic acylations (broad scope and selectivity), and synthesize ketones simply from aryl iodides, CO and arenes. Notably, the reaction proceeds in an intermolecular fashion, without directing groups and at very low palladium-catalyst loadings. Mechanistic studies show that the reaction proceeds through the catalytic build-up of potent aroyl triflate electrophiles.
    Language English
    Publishing date 2017-12-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2464596-5
    ISSN 1755-4349 ; 1755-4330
    ISSN (online) 1755-4349
    ISSN 1755-4330
    DOI 10.1038/nchem.2903
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  5. Article: Preferential N–H⋯:C hydrogen bonding involving ditopic NH-containing systems and N-heterocyclic carbenes

    Kinney, Zacharias J / Rheingold, Arnold L / Protasiewicz, John D

    RSC advances. 2020 Nov. 20, v. 10, no. 69

    2020  

    Abstract: ... transfer ([H–C]⁺[X]⁻), or amines from insertion of the carbene into the N–H bond. Yet, there are no ... modes with carbenes: non-traditional hydrogen bonding adducts (X–H⋯:C), salts arising from proton ... both the solid-state (hydrogen bond lengths, NHC interior angles) and solution-state (¹H Δδ of NH signals, ¹³C signals ...

    Abstract Hydrogen bonding plays a critical role in maintaining order and structure in complex biological and synthetic systems. N-heterocyclic carbenes (NHCs) represent one of the most versatile tools in the synthetic chemistry toolbox, yet their potential as neutral carbon hydrogen bond acceptors remains underexplored. This report investigates this capability in a strategic manner, wherein carbene-based hydrogen bonding can be assessed by use of ditopic NH-containing molecules. N–H bonds are unique as there are three established reaction modes with carbenes: non-traditional hydrogen bonding adducts (X–H⋯:C), salts arising from proton transfer ([H–C]⁺[X]⁻), or amines from insertion of the carbene into the N–H bond. Yet, there are no established rules to predict product distributions or the strength of these associations. Here we seek to correlate the hydrogen bond strength of symmetric and asymmetric ditopic secondary amines with 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene (IPr, a representative NHC). In symmetric and asymmetric ditopic amine adducts both the solid-state (hydrogen bond lengths, NHC interior angles) and solution-state (¹H Δδ of NH signals, ¹³C signals of carbenic carbon) can be related to the pKₐ of the parent amine.
    Keywords carbenes ; carbon ; heterocyclic nitrogen compounds ; hydrogen bonding ; salts ; secondary amines
    Language English
    Dates of publication 2020-1120
    Size p. 42164-42171.
    Publishing place The Royal Society of Chemistry
    Document type Article
    Note NAL-light
    ISSN 2046-2069
    DOI 10.1039/d0ra08490e
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Integration of imaging measurements at micro-, meso and macro-scale of the caudal medulla on a postmortem infant subject.

    Magnain, Caroline / Haynes, Robin / Augustinack, Jean / Kinney, Hannah / Zollei, Lilla

    Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition. International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition

    2024  Volume 2023

    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 1524-6965 ; 1065-9889
    ISSN 1524-6965 ; 1065-9889
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  7. Article ; Online: Best shot: A motivational interviewing approach to address vaccine hesitancy in pediatric outpatient settings.

    Jamison, Kristin C / Ahmed, Azza H / Spoerner, Deborah A / Kinney, Daniel

    Journal of pediatric nursing

    2022  Volume 67, Page(s) 124–131

    Abstract: Background: Vaccine hesitancy in parents and childhood vaccine refusal is increasing. A standard of care to address this problem has not been identified.: Purpose: To identify if the use of motivational interviewing by pediatric providers during ... ...

    Abstract Background: Vaccine hesitancy in parents and childhood vaccine refusal is increasing. A standard of care to address this problem has not been identified.
    Purpose: To identify if the use of motivational interviewing by pediatric providers during routine well child visits, when compared to standard of care, would increase vaccine rates in children 0-12 months of age. Factors associated with vaccine hesitancy were also investigated.
    Methods: A quasi-experimental study was completed on a convenience sample of pediatric providers (N = 6) and caregivers of children 0-12 months of age (N = 66). Four providers were trained to use motivational interviewing. During the well child visit the Parent Attitudes About Childhood Vaccines survey was completed, and the motivational interviewing intervention was implemented. Clinic's data were compared with other clinic data of non-trained providers.
    Findings: Vaccine refusal/delays rate was 11.4% among caregivers. Vaccine refusal rate decreased after the intervention (9.00% pre-intervention and 6.40% post-intervention). An ordinal regression identified caregivers with higher vaccine hesitancy scores and more children were more likely to delay or refuse vaccines, while caregivers ≥30 years or with high income were less likely to delay/refuse vaccines. A difference in difference analysis identified that an additional 2.6% of children received vaccines when seen by trained providers compared to non-trained (β = -0.330, OR = 0.719, p = 0.470).
    Discussion: Findings indicate a condensed motivational interviewing education session may be clinically significant in decreasing vaccine hesitancy among this population.
    Applications to practice: A more robust study to confirm these findings is recommended prior to practice implementation.
    MeSH term(s) Child ; Humans ; Motivational Interviewing ; Vaccination ; Outpatients ; Vaccination Hesitancy ; Patient Acceptance of Health Care ; Vaccines ; Parents/education ; Health Knowledge, Attitudes, Practice
    Chemical Substances Vaccines
    Language English
    Publishing date 2022-09-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632731-x
    ISSN 1532-8449 ; 0882-5963
    ISSN (online) 1532-8449
    ISSN 0882-5963
    DOI 10.1016/j.pedn.2022.08.012
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2871: Show issues Location:
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  8. Article ; Online: AAHKS Best Podium Presentation Research Award: Femoral Perforation During Direct Anterior Approach Total Hip Arthroplasty: Incidence, Cohort Characteristics, and Management.

    Kinney, Matthew C / Ho, Henry / Hamilton, William G

    The Journal of arthroplasty

    2022  Volume 37, Issue 8S, Page(s) S721–S726

    Abstract: Background: Cortical perforation during femoral preparation is a recognized complication of total hip arthroplasty (THA) but the incidence, patient characteristics, management, and outcome have not been described for the direct anterior approach (DAA).!# ...

    Abstract Background: Cortical perforation during femoral preparation is a recognized complication of total hip arthroplasty (THA) but the incidence, patient characteristics, management, and outcome have not been described for the direct anterior approach (DAA).
    Methods: A database query of all primary and conversion DAA THAs performed by a single surgeon from 2009 to 2021 was used to identify hips that sustained a recognized intraoperative femoral perforation. Radiographs were used to assess stem subsidence, Dorr femur type, and Canal Flare Index.
    Results: Among 3,973 THAs, 16 patients (0.4%) sustained perforations during broaching including 8 males and 8 females with a mean age at surgery of 65.6 (range 41-81) years and a mean body mass index of 31.0 (range 19.0-44.4). Two hips were converted to longer primary cementless stems to bypass the perforation. For the remaining 14, the broach was redirected and the same primary stem was implanted. Limited weight-bearing (6 patients) or protected weight-bearing as tolerated with a walker/cane (10 patients) was advised postoperatively. At a mean follow-up of 18.7 (range 4-105) months, all stems were stable with no fractures, subsidence, or revisions. Factors associated with perforation included difficulty with exposure (body mass index >40 or a contracture), measurable osteoporosis (Canal Flare Index <3.0), and abnormal proximal femoral anatomy due to prior trauma, retained hardware, or Perthes disease.
    Conclusion: In this case series, isolated perforation of an otherwise intact femur during DAA was successfully managed with redirection of the broach, implantation of a primary stem that achieved axial/rotational stability, and protected weight-bearing.
    Level of evidence: IV, Case Series.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Hip/adverse effects ; Awards and Prizes ; Female ; Femur/diagnostic imaging ; Femur/surgery ; Hip Prosthesis/adverse effects ; Humans ; Incidence ; Male ; Middle Aged ; Prosthesis Design ; Retrospective Studies
    Language English
    Publishing date 2022-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632770-9
    ISSN 1532-8406 ; 0883-5403
    ISSN (online) 1532-8406
    ISSN 0883-5403
    DOI 10.1016/j.arth.2022.02.110
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2134: Show issues Location:
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  9. Article ; Online: Feeding and contaminant patterns of sub-arctic and arctic ringed seals: Potential insight into climate change-contaminant interactions.

    Facciola, Nadia / Houde, Magali / Muir, Derek C G / Ferguson, Steven H / McKinney, Melissa A

    Environmental pollution (Barking, Essex : 1987)

    2022  Volume 313, Page(s) 120108

    Abstract: To provide insight into how climate-driven diet shifts may impact contaminant exposures of Arctic species, we compared feeding ecology and contaminant concentrations in ringed seals (Pusa hispida) from two Canadian sub-Arctic (Nain at 56.5°N, Arviat at ... ...

    Abstract To provide insight into how climate-driven diet shifts may impact contaminant exposures of Arctic species, we compared feeding ecology and contaminant concentrations in ringed seals (Pusa hispida) from two Canadian sub-Arctic (Nain at 56.5°N, Arviat at 61.1°N) and two Arctic sites (Sachs Harbour at 72.0 °N, Resolute Bay at 74.7 °N). In the sub-Arctic, empirical evidence of changing prey fish communities has been documented, while less community change has been reported in the Arctic to date, suggesting current sub-Arctic conditions may be a harbinger of future Arctic conditions. Here, Indigenous partners collected tissues from subsistence-harvested ringed seals in 2018. Blubber fatty acids (FAs) and muscle stable isotopes (δ
    MeSH term(s) Animals ; Canada ; Climate Change ; Fatty Acids ; Fluorocarbons ; Halogenated Diphenyl Ethers/analysis ; Mercury/analysis ; Metals, Heavy ; Persistent Organic Pollutants ; Phoca
    Chemical Substances Fatty Acids ; Fluorocarbons ; Halogenated Diphenyl Ethers ; Metals, Heavy ; Mercury (FXS1BY2PGL)
    Language English
    Publishing date 2022-09-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2022.120108
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    Zs.A 2599: Show issues Location:
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  10. Article ; Online: Family Functioning Profiles in Emerging Adults: Associations with Personal and Parental Psychological Problems.

    McKinney, Cliff / Rogers, Mary M / Stearns, Melanie / Steele, Ellen H

    Child psychiatry and human development

    2022  

    Abstract: Although recent research has examined family profiles in younger children, emerging adults have not been examined as extensively despite evidence that families continue to be important to emerging adults. The current study examined family functioning ... ...

    Abstract Although recent research has examined family profiles in younger children, emerging adults have not been examined as extensively despite evidence that families continue to be important to emerging adults. The current study examined family functioning profiles and associated psychological problems of both offspring and parents from the perspective of 585 college-attending emerging adults. Results supported six profiles where lower functioning groups generally had more psychological problems relative to higher functioning groups and with specific maternal and paternal differences. The current study advances family functioning research by demonstrating that family profiles can be identified and associated with psychological problems for both parents and emerging adults.
    Language English
    Publishing date 2022-10-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 223895-0
    ISSN 1573-3327 ; 0009-398X
    ISSN (online) 1573-3327
    ISSN 0009-398X
    DOI 10.1007/s10578-022-01459-9
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