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  1. Article ; Online: Rheumatoid Arthritis Associated With Anti-Signal Recognition Particle Immune-Mediated Necrotizing Myopathy: A Case Report.

    Belkhribchia, Mohamed Reda / Lobrinus, Johannes Alexander / Semlil, Lamyaa / Chauveau, Nicolas / Ajrinija, Abdelaziz / Egervari, Kristof / Ennhaili, Zine Elabidine

    Journal of investigative medicine high impact case reports

    2024  Volume 12, Page(s) 23247096241231646

    Abstract: Immune-mediated necrotizing myopathy (IMNM) is a rare subtype of idiopathic inflammatory myopathy that is characterized by severe subacute proximal weakness, myofiber necrosis, and significantly elevated serum creatine kinase. Anti-signal recognition ... ...

    Abstract Immune-mediated necrotizing myopathy (IMNM) is a rare subtype of idiopathic inflammatory myopathy that is characterized by severe subacute proximal weakness, myofiber necrosis, and significantly elevated serum creatine kinase. Anti-signal recognition particle (SRP) and anti-3-hydroxy-3-methylglutaryl-coenzyme-A reductase autoantibodies have been found in about two-thirds of patients with IMNM. This myopathy is usually idiopathic and there is a scarce literature concerning its association with connective tissue diseases. Herein, we report an unusual case of a young woman who presented with both rheumatoid arthritis and severe anti-SRP IMNM. Thankfully to a therapeutic protocol combining rituximab and cyclophosphamide, an important improvement was achieved, and notably no serious side effect was observed.
    MeSH term(s) Female ; Humans ; Signal Recognition Particle ; Myositis/diagnosis ; Myositis/drug therapy ; Autoimmune Diseases ; Muscular Diseases ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy
    Chemical Substances Signal Recognition Particle
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2710326-2
    ISSN 2324-7096 ; 2324-7096
    ISSN (online) 2324-7096
    ISSN 2324-7096
    DOI 10.1177/23247096241231646
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  2. Article ; Online: A tumor like no other.

    Corniola, Marco V / Egervari, Kristof / Vargas, Maria I / Meling, Torstein R

    Journal of neurosurgical sciences

    2021  Volume 67, Issue 1, Page(s) 130–132

    Language English
    Publishing date 2021-03-11
    Publishing country Italy
    Document type Letter
    ZDB-ID 193139-8
    ISSN 1827-1855 ; 0390-5616 ; 0026-4881
    ISSN (online) 1827-1855
    ISSN 0390-5616 ; 0026-4881
    DOI 10.23736/S0390-5616.21.05345-5
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    Uk I Zs.241: Show issues Location:
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  3. Article: Extradural Spinal Meningioma Mimicking a Schwannoma: Magnetic Resonance Imaging Findings.

    Garaud, Sarah / Boto, José / Egervari, Kristof / Vargas, Maria Isabel

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    2021  Volume 49, Issue 3, Page(s) 467–469

    MeSH term(s) Humans ; Magnetic Resonance Imaging/methods ; Meningeal Neoplasms/diagnostic imaging ; Meningeal Neoplasms/pathology ; Meningioma/diagnostic imaging ; Neurilemmoma/diagnostic imaging ; Neurilemmoma/pathology
    Language English
    Publishing date 2021-06-02
    Publishing country England
    Document type Letter
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/cjn.2021.120
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    Zs.A 1203: Show issues Location:
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  4. Article: Pediatric Posterior Fossa ATRT: A Case Report, New Treatment Strategies and Perspectives.

    Paun, Luca / Lavé, Alexandre / Jannelli, Gianpaolo / Egervari, Kristof / Janssen, Insa / Schaller, Karl / von Bueren, André O / Bartoli, Andrea

    Brain sciences

    2023  Volume 13, Issue 5

    Abstract: Posterior fossa atypical teratoid rhabdoid tumor (ATRT) is a rare childhood tumor usually associated with a dismal prognosis. Although upfront surgical gross total resection (GTR) has classically been the first line of treatment, new multimodal ... ...

    Abstract Posterior fossa atypical teratoid rhabdoid tumor (ATRT) is a rare childhood tumor usually associated with a dismal prognosis. Although upfront surgical gross total resection (GTR) has classically been the first line of treatment, new multimodal treatments, including two-stage surgery, are showing promising results in terms of overall survival (OS) and complication rate. We present a case of a 9-month-old child treated with two-staged surgery and chemotherapy. When deemed risky, multimodal treatments, including staged surgeries, can be a safe alternative to reduce surgical mortality and morbidity. At 23 months old, the patient had normal global development and no major impact on quality of life. We, therefore, discuss the most recent advancements from a treatment perspective, including molecular targeting.
    Language English
    Publishing date 2023-04-24
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13050712
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  5. Article ; Online: When Crouching Gait Reveals Crohn's Disease.

    Berner, Amandine / Coen, Matteo / Egervari, Kristof / Lobrinus, Johannes Alexander / Grosjean, Alicia / Gressot, Pablo / Ribeiro Da Costa, Rui / Farhoumand, Pauline Darbellay / Serratrice, Jacques

    The American journal of medicine

    2023  Volume 137, Issue 5, Page(s) 414–416

    MeSH term(s) Humans ; Crohn Disease/complications ; Gait ; Male ; Adult ; Female
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2023.11.009
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    In stock of ZB MED Cologne/Königswinter

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  6. Article: Melanocytic colonization of choroid plexus papilloma: A previously undocumented source of pigment storage in the plexogenic epithelium.

    Egervari, Kristof / Lobrinus, Johannes A / Merkler, Doron / Vajtai, Istvan

    Clinical neuropathology

    2019  Volume 38, Issue 5, Page(s) 249–252

    MeSH term(s) Adolescent ; Brain Neoplasms/pathology ; Humans ; Male ; Melanocytes/pathology ; Papilloma, Choroid Plexus/pathology ; Parietal Lobe/pathology
    Language English
    Publishing date 2019-07-10
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 603167-5
    ISSN 0722-5091
    ISSN 0722-5091
    DOI 10.5414/NP301200
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    Zs.A 1745: Show issues Location:
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  7. Article ; Online: Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV.

    Di Liberto, Giovanni / Egervari, Kristof / Kreutzfeldt, Mario / Schürch, Christian M / Hewer, Ekkehard / Wagner, Ingrid / Du Pasquier, Renaud / Merkler, Doron

    Brain : a journal of neurology

    2022  Volume 145, Issue 8, Page(s) 2730–2741

    Abstract: Glial cell activation is a hallmark of several neurodegenerative and neuroinflammatory diseases. During HIV infection, neuroinflammation is associated with cognitive impairment, even during sustained long-term suppressive antiretroviral therapy. However, ...

    Abstract Glial cell activation is a hallmark of several neurodegenerative and neuroinflammatory diseases. During HIV infection, neuroinflammation is associated with cognitive impairment, even during sustained long-term suppressive antiretroviral therapy. However, the cellular subsets contributing to neuronal damage in the CNS during HIV infection remain unclear. Using post-mortem brain samples from eight HIV patients and eight non-neurological disease controls, we identify a subset of CNS phagocytes highly enriched in LGALS3, CTSB, GPNMB and HLA-DR, a signature identified in the context of ageing and neurodegeneration. In HIV patients, the presence of this phagocyte phenotype was associated with synaptic stripping, suggesting an involvement in the pathogenesis of HIV-associated neurocognitive disorder. Taken together, our findings elucidate some of the molecular signatures adopted by CNS phagocytes in HIV-positive patients and contribute to the understanding of how HIV might pave the way to other forms of cognitive decline in ageing HIV patient populations.
    MeSH term(s) Brain/pathology ; Brain/virology ; HIV Infections/complications ; HIV Infections/metabolism ; HIV Infections/pathology ; Humans ; Membrane Glycoproteins ; Neurocognitive Disorders ; Neurons/pathology ; Neurons/virology ; Phagocytes/metabolism ; Phagocytes/pathology ; Synapses/pathology ; Synapses/virology
    Chemical Substances GPNMB protein, human ; Membrane Glycoproteins
    Language English
    Publishing date 2022-07-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awac102
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  8. Article ; Online: Bridging the Gap: Immunotherapy in Progressive Multifocal Leukoencephalopathy: A New Hope?

    Born, Tristan / Vassallo, Paola / Golshayan, Dela / Di Liberto, Giovanni / Brouland, Jean-Philippe / Egervari, Kristof / Merkler, Doron / Du Pasquier, Renaud A / Bernard-Valnet, Raphael

    Neurology

    2023  Volume 101, Issue 13, Page(s) e1382–e1386

    Abstract: Progressive multifocal leukoencephalopathy (PML) is a severe infection of the CNS occurring in immunocompromised individuals in which large demyelinating lesions are induced by polyomavirus JC (JCV). In the absence of effective antiviral treatment, ... ...

    Abstract Progressive multifocal leukoencephalopathy (PML) is a severe infection of the CNS occurring in immunocompromised individuals in which large demyelinating lesions are induced by polyomavirus JC (JCV). In the absence of effective antiviral treatment, control of the infection relies on restoring anti-JCV immunity. Thus, particularly in long-standing immunocompromising conditions such as organ transplantation, lymphoproliferative disorders, or idiopathic lymphopenia, new strategies to boost anti-JCV immune responses are needed. Here, we report the case of a patient developing PML in the context of kidney transplantation who received recombinant human interleukin 7 to foster immune responses against JCV. We give an overview of the immunologic mechanisms underlying the development of PML and immune restoration within the CNS after JCV infection. Immunotherapeutic strategies developed based on current understanding of the disease hold promise in managing patients with PML.
    MeSH term(s) Humans ; Leukoencephalopathy, Progressive Multifocal/therapy ; JC Virus ; Immunotherapy ; Kidney Transplantation ; Immunocompromised Host
    Language English
    Publishing date 2023-07-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000207533
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    Zs.MO 374: Show issues

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  9. Article ; Online: Methylation profiling-based diagnosis of radiologically suspected congenital glioma.

    Bräutigam, Konstantin / Piechowiak, Eike / Slavova, Nedelina / Mosimann, Beatrice / Merkler, Doron / Egervari, Kristof / Hewer, Ekkehard

    Brain tumor pathology

    2020  Volume 38, Issue 1, Page(s) 78–80

    MeSH term(s) Adult ; Autopsy ; Brain/diagnostic imaging ; Brain/embryology ; Brain/pathology ; Brain Neoplasms/congenital ; Brain Neoplasms/diagnosis ; Brain Neoplasms/embryology ; Brain Neoplasms/pathology ; DNA Methylation/genetics ; Female ; Fetal Diseases/diagnosis ; Fetal Diseases/genetics ; Fetal Diseases/pathology ; Genome-Wide Association Study ; Glioma/congenital ; Glioma/diagnosis ; Glioma/embryology ; Glioma/pathology ; Humans ; Magnetic Resonance Imaging ; Pregnancy ; Prenatal Diagnosis
    Language English
    Publishing date 2020-10-16
    Publishing country Japan
    Document type Case Reports ; Letter
    ZDB-ID 1193775-0
    ISSN 1861-387X ; 1433-7398 ; 0914-8108
    ISSN (online) 1861-387X
    ISSN 1433-7398 ; 0914-8108
    DOI 10.1007/s10014-020-00384-w
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    Zs.A 4555: Show issues Location:
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  10. Article ; Online: ChatGPT in glioma adjuvant therapy decision making: ready to assume the role of a doctor in the tumour board?

    Haemmerli, Julien / Sveikata, Lukas / Nouri, Aria / May, Adrien / Egervari, Kristof / Freyschlag, Christian / Lobrinus, Johannes A / Migliorini, Denis / Momjian, Shahan / Sanda, Nicolae / Schaller, Karl / Tran, Sebastien / Yeung, Jacky / Bijlenga, Philippe

    BMJ health & care informatics

    2023  Volume 30, Issue 1

    Abstract: Objective: To evaluate ChatGPT's performance in brain glioma adjuvant therapy decision-making.: Methods: We randomly selected 10 patients with brain gliomas discussed at our institution's central nervous system tumour board (CNS TB). Patients' ... ...

    Abstract Objective: To evaluate ChatGPT's performance in brain glioma adjuvant therapy decision-making.
    Methods: We randomly selected 10 patients with brain gliomas discussed at our institution's central nervous system tumour board (CNS TB). Patients' clinical status, surgical outcome, textual imaging information and immuno-pathology results were provided to ChatGPT V.3.5 and seven CNS tumour experts. The chatbot was asked to give the adjuvant treatment choice, and the regimen while considering the patient's functional status. The experts rated the artificial intelligence-based recommendations from 0 (complete disagreement) to 10 (complete agreement). An intraclass correlation coefficient agreement (ICC) was used to measure the inter-rater agreement.
    Results: Eight patients (80%) met the criteria for glioblastoma and two (20%) were low-grade gliomas. The experts rated the quality of ChatGPT recommendations as poor for diagnosis (median 3, IQR 1-7.8, ICC 0.9, 95% CI 0.7 to 1.0), good for treatment recommendation (7, IQR 6-8, ICC 0.8, 95% CI 0.4 to 0.9), good for therapy regimen (7, IQR 4-8, ICC 0.8, 95% CI 0.5 to 0.9), moderate for functional status consideration (6, IQR 1-7, ICC 0.7, 95% CI 0.3 to 0.9) and moderate for overall agreement with the recommendations (5, IQR 3-7, ICC 0.7, 95% CI 0.3 to 0.9). No differences were observed between the glioblastomas and low-grade glioma ratings.
    Conclusions: ChatGPT performed poorly in classifying glioma types but was good for adjuvant treatment recommendations as evaluated by CNS TB experts. Even though the ChatGPT lacks the precision to replace expert opinion, it may serve as a promising supplemental tool within a human-in-the-loop approach.
    MeSH term(s) Humans ; Brain Neoplasms/drug therapy ; Brain Neoplasms/pathology ; Artificial Intelligence ; Glioma/pathology ; Glioma/surgery ; Decision Making
    Language English
    Publishing date 2023-07-03
    Publishing country England
    Document type Journal Article
    ISSN 2632-1009
    ISSN (online) 2632-1009
    DOI 10.1136/bmjhci-2023-100775
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