LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 38

Search options

  1. Article: Mortality risk in older Japanese people based on self-reported dyslipidemia treatment and socioeconomic status: The JAGES cohort study.

    Katsuyama, Yota / Kondo, Katsunori / Kojima, Masayo / Kamiji, Koto / Ide, Kazushige / Iizuka, Genmei / Muto, Go / Uehara, Takanori / Noda, Kazutaka / Ikusaka, Masatomi

    Preventive medicine reports

    2022  Volume 27, Page(s) 101779

    Abstract: Few studies consider socioeconomic status when assessing mortality risk in dyslipidemia cases. This study used cohort data from the 2010 Japan Gerontological Evaluation Study (JAGES), which contains data on older Japanese people, to associate ... ...

    Abstract Few studies consider socioeconomic status when assessing mortality risk in dyslipidemia cases. This study used cohort data from the 2010 Japan Gerontological Evaluation Study (JAGES), which contains data on older Japanese people, to associate socioeconomic status with mortality risk in patients treated for dyslipidemia. In this 6-year longitudinal study, we examined 47,275 older Japanese people aged ≥ 65 years who could independently perform activities of daily living. Patients' background characteristics were classified based on their dyslipidemia treatment status and were assessed using the chi-squared test. The mortality risk was assessed using the Cox proportional hazards model, wherein the objective and explanatory variables were total mortality and self-report of dyslipidemia treatment, respectively. The participants were stratified by sex and age into younger (aged 65-74 years) and older (aged ≥ 75 years) groups of men and women. The results were adjusted, with health condition, health behavior, and socioeconomic status as confounding factors. The adjusted hazard ratios of 5514 people who died during the follow-up who had self-reported dyslipidemia treatment were 0.49 [95% confidence interval (CI) 0.35-0.69] for younger men; 0.57 (95% CI 0.42-0.76) for older men; 0.52 (95% CI 0.34-0.80) for younger women; and 0.47 (95% CI 0.33-0.67) for older women. Older people undergoing treatment for dyslipidemia had factors beneficial for health, such as good socioeconomic status. Despite considering these factors, individuals undergoing dyslipidemia treatment had a negative association with mortality risk.
    Language English
    Publishing date 2022-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785569-7
    ISSN 2211-3355
    ISSN 2211-3355
    DOI 10.1016/j.pmedr.2022.101779
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Predictive validity of the modified Kihon Checklist for the incidence of functional disability among older people: A 3-year cohort study from the JAGES.

    Watanabe, Ryota / Tsuji, Taishi / Ide, Kazushige / Noguchi, Taiji / Yasuoka, Mikako / Kamiji, Koto / Satake, Shosuke / Kondo, Katsunori / Kojima, Masayo

    Geriatrics & gerontology international

    2022  Volume 22, Issue 8, Page(s) 667–674

    Abstract: Aim: The original Kihon Checklist, validated to predict the incidence of functional disability, has been modified to capture both functional ability (can/cannot) and performing state (do/do not). However, the predictive validity of the modified Kihon ... ...

    Abstract Aim: The original Kihon Checklist, validated to predict the incidence of functional disability, has been modified to capture both functional ability (can/cannot) and performing state (do/do not). However, the predictive validity of the modified Kihon Checklist remains unverified. Therefore, this study intends to verify the predictive validity of the modified Kihon Checklist and to clarify whether predictive discrimination differs between the classification method of functional ability and performing state.
    Methods: The participants comprised 67 398 older people who responded to the Japan Gerontological Evaluation Study (2016). They were followed for 3.1 years on average. Cox's proportional hazards model with incidence of functional disability as the endpoint was used to calculate the hazard ratio, adjusted for sex and age. The independent variables were judged by two classification methods, functional ability and performing state, using nine indicators based on the modified Kihon Checklist. Additionally, we examined whether the two classification methods produced different C-index estimates.
    Results: Incidence of functional disability occurred in 6232 participants (9.2%). The adjusted hazard ratio of those to whom the nine indicators applied was significantly higher than that of those to whom they did not. The range of the hazard ratio was 1.50-3.82 for both classification methods. The C-index was slightly higher when the classification was based on performing state than when it was based on on functional ability.
    Conclusions: Although predictive discrimination was slightly higher for the performing state than for functional ability, the predictive validity of the modified Kihon Checklist was confirmed for both. Geriatr Gerontol Int 2022; 22: 667-674.
    MeSH term(s) Activities of Daily Living ; Aged ; Checklist/methods ; Cohort Studies ; Geriatric Assessment/methods ; Humans ; Incidence ; Japan/epidemiology
    Language English
    Publishing date 2022-07-17
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.14439
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Chronic obstructive pulmonary disease and the mortality risk in male older adults: Role of socioeconomic factors.

    Nogimura, Akane / Noguchi, Taiji / Otani, Takahiro / Kamiji, Koto / Yasuoka, Mikako / Watanabe, Ryota / Ojima, Toshiyuki / Kondo, Katsunori / Kojima, Masayo

    Archives of gerontology and geriatrics

    2022  Volume 102, Page(s) 104741

    Abstract: Objective: Chronic obstructive pulmonary disease (COPD) is a common disease among older adults, leading to mortality. Although COPD is also associated with socioeconomic factors, little is known about the impact of COPD on mortality accounting for them. ...

    Abstract Objective: Chronic obstructive pulmonary disease (COPD) is a common disease among older adults, leading to mortality. Although COPD is also associated with socioeconomic factors, little is known about the impact of COPD on mortality accounting for them. We examined the association between COPD and mortality among older male adults, adjusting for socioeconomic factors.
    Methods: This study recruited functionally independent male older adults from the Japan Gerontological Evaluation Study. Participants answered self-reported questionnaires mailed in 2013, followed up to 2016. Participants with COPD were screened as those with higher scores than the upper quantile of the modified International Primary Care Airway Group questionnaire. Regarding individual socioeconomic factors, educational attainment, household equivalized income, living arrangements, and social participation was assessed. The Cox proportional hazards model was applied to examine the association between screened COPD and mortality.
    Results: Data of 6,662 male older adults were analyzed (mean age [standard deviation]: 73.0 [5.8] years). During the observation periods, 394 deaths (5.9%) occurred. Screened COPD was associated with an increased mortality risk, even after adjusting for socioeconomic factors (hazard ratio, 1.56; 95% confidence interval, 1.25-1.94). In the stratified analysis among current smokers, the mortality risk of screened COPD was high in those with lower education, higher income, living alone, and less social participation.
    Conclusions: Those with screened COPD had an increased mortality risk, even after adjusting for socioeconomic factors. The risk was higher among those with lower education and less social relationships. Detection and treatment of COPD should be performed considering individual socioeconomic backgrounds.
    MeSH term(s) Aged ; Humans ; Income ; Male ; Proportional Hazards Models ; Pulmonary Disease, Chronic Obstructive ; Risk Factors ; Socioeconomic Factors
    Language English
    Publishing date 2022-06-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603162-6
    ISSN 1872-6976 ; 0167-4943
    ISSN (online) 1872-6976
    ISSN 0167-4943
    DOI 10.1016/j.archger.2022.104741
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: Association of clinical symptoms and metabolic syndrome-related factors in patients undergoing high tibial osteotomy.

    Azuma, Toshiki / Ueno, Katsuya / Goto, Shinsuke / Sugiki, Syunsuke / Izumoji, Tomo / Kamiji, Mototaka / Kuroda, Kazunari / Takahashi, Masaki / Asa, Ryousuke / Katsuki, Tatsuo / Haba, Toshihiro

    Journal of physical therapy science

    2023  Volume 35, Issue 5, Page(s) 373–378

    Abstract: Purpose] This study aimed to investigate the relationship between clinical outcomes after high tibial osteotomy and metabolic syndrome-related factors, such as hypertension, dyslipidemia, diabetes mellitus, and obesity. [Participants and Methods] A ... ...

    Abstract [Purpose] This study aimed to investigate the relationship between clinical outcomes after high tibial osteotomy and metabolic syndrome-related factors, such as hypertension, dyslipidemia, diabetes mellitus, and obesity. [Participants and Methods] A total of 73 patients (73 knees) who underwent high tibial osteotomy for knee osteoarthritis between 2018 and 2020 were included. We investigated the correlation between metabolic syndrome-related factors and clinical symptom assessment (Japanese Orthopedic Association Score) and examined knee function and lower alignment. [Results] At three months postoperatively, the Japanese Orthopedic Association score showed no main and synergistic effects on metabolic syndrome-related factors, and the preoperative Japanese Orthopedic Association score only showed a main effect on metabolic syndrome-related factors. At 12 months postoperatively, the Japanese Orthopedic Association score showed main and synergistic effects on diabetes mellitus, obesity, hypertension and dislipidemia. [Conclusion] Metabolic syndrome-related factors are associated with poorer clinical outcomes after high tibial osteotomy.
    Language English
    Publishing date 2023-05-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2038898-6
    ISSN 0915-5287
    ISSN 0915-5287
    DOI 10.1589/jpts.35.373
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: In-hospital grouping rehabilitation of hybrid closed-wedge high tibial osteotomy results in shorter hospital stays and better clinical outcomes.

    Azuma, Toshiki / Ueno, Katsuya / Sugiki, Syunsuke / Kurokawa, Ryota / Izumoji, Tomo / Yamada, Natsumi / Sakanaka, Ryouko / Watanabe, Yousuke / Kamiji, Mototaka / Kuroda, Kazunari / Takahashi, Masaki / Asa, Ryousuke / Haba, Toshihiro / Goto, Shinsuke

    Journal of physical therapy science

    2023  Volume 35, Issue 8, Page(s) 575–580

    Abstract: Purpose] This study aimed to examine the impact of physiotherapy on various patients who underwent hybrid closed-wedge high tibial osteotomy. [Participants and Methods] Eighty-four patients were divided into three groups: non-weight-bearing, enhanced ... ...

    Abstract [Purpose] This study aimed to examine the impact of physiotherapy on various patients who underwent hybrid closed-wedge high tibial osteotomy. [Participants and Methods] Eighty-four patients were divided into three groups: non-weight-bearing, enhanced recovery after surgery, and grouping exercise. The number of hospital days, distinctions in the duration of cane-walking independence, and postoperative complications were compared among the three groups. Furthermore, the Japanese Orthopaedic Association score and physical function were assessed preoperatively and at 3 and 12 months postoperatively. [Results] There were no considerable differences in postoperative complications among the three groups, and the mean hospital stay was the shortest for the grouping exercise group. At 3 months postoperatively, the grouping exercise group reported less walking pain than the enhanced recovery after surgery group. At 3 and 12 months postoperatively, the grouping exercise group showed greater mean knee extensor strength and a higher mean Japanese Orthopaedic Association score than the non-weight-bearing group. [Conclusion] Grouping exercise therapy, in addition to enhanced recovery after surgery protocol, results in shorter hospital stays, no difference in postoperative complications, and good clinical outcomes.
    Language English
    Publishing date 2023-08-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2038898-6
    ISSN 0915-5287
    ISSN 0915-5287
    DOI 10.1589/jpts.35.575
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Evaluation of intercellular lipid lamellae in the stratum corneum by polarized microscopy.

    Asada, Naoki / Morita, Ryo / Kamiji, Rikae / Kuwajima, Mami / Komorisono, Masahiko / Yamamura, Tatsuo / Ono, Naoaki / Kanaya, Shigehiko / Yoshikawa, Shuichi

    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

    2021  Volume 28, Issue 3, Page(s) 391–401

    Abstract: Background: Intercellular lipids contain a lamellar structure that glows in polarized images. It could be expected that the intercellular lipid content be estimated from the luminance values calculated from polarized images of stratum corneum strips. ... ...

    Abstract Background: Intercellular lipids contain a lamellar structure that glows in polarized images. It could be expected that the intercellular lipid content be estimated from the luminance values calculated from polarized images of stratum corneum strips. Therefore, we attempted to develop a method for simple and rapid evaluation of the intercellular lipid content through a procedure. Herein, we demonstrated a relationship between the luminance value and the amount of ceramides, one of the main components of intercellular lipids.
    Materials and methods: The stratum corneum was collected from the forearm using slides with a pure rubber-based adhesive, which did not produce unnecessary luminescence under polarizing conditions. Images were analyzed using luminance indices. The positive secondary ion peak images were obtained using the time of flight-secondary ion mass spectrometry; the polarized and brightfield images were obtained using a polarized microscope. The ceramide and protein amount was measured by high-performance liquid chromatography and bicinchoninic acid protein assay after microscope imaging. Images and quantitative values were used to construct evaluation models based on a convolutional neural network (CNN).
    Results: There was a correlation between the highlighted areas of the polarized image to overlap with the area where ceramide-derived peak was detected. Evaluation of the CNN-based model of the polarized images predicted the amount of ceramides per unit of stratum corneum.
    Conclusion: The method proposed in the study enabled a large number of specimens to provide a simple, rapid, and efficient evaluation of the intercellular lipid content.
    MeSH term(s) Ceramides/analysis ; Chromatography, High Pressure Liquid ; Epidermis/metabolism ; Humans ; Microscopy
    Chemical Substances Ceramides
    Language English
    Publishing date 2021-11-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1229160-2
    ISSN 1600-0846 ; 0909-752X ; 1397-1344
    ISSN (online) 1600-0846
    ISSN 0909-752X ; 1397-1344
    DOI 10.1111/srt.13109
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Home-Based Frailty Prevention Program for Older Women Participants of Kayoi-No-Ba during the COVID-19 Pandemic: A Feasibility Study.

    Watanabe, Ryota / Kojima, Masayo / Yasuoka, Mikako / Kimura, Chieko / Kamiji, Koto / Otani, Takahiro / Tsujimura, Shoko / Fujita, Hitomi / Nogimura, Akane / Ozeki, Sae / Osawa, Aiko / Arai, Hidenori

    International journal of environmental research and public health

    2022  Volume 19, Issue 11

    Abstract: This study presents a single-arm intervention that aimed to determine the feasibility of a three-month home-based exercise program to prevent the progression of frailty during COVID-19. We recruited four groups of Kayoi-no-ba, or community salons for ... ...

    Abstract This study presents a single-arm intervention that aimed to determine the feasibility of a three-month home-based exercise program to prevent the progression of frailty during COVID-19. We recruited four groups of Kayoi-no-ba, or community salons for frailty prevention, and a total of 69 community-dwelling older women who belonged to one of the Kayoi-no-ba in a preliminary study for a follow-up study. The intervention program was developed on the basis of the 5A approach, and the focus group by the volunteer leaders of Kayoi-no-ba. We adapted the National Center for Geriatrics and Gerontology Home Exercise Program for Older People for 10-min daily home-based exercise. For feasibility outcomes, 91.3% of the participants completed the intervention program, whereas the percentage of exercise performed was 86.5% during the intervention period. For health-related outcomes, the five times sit-to-stand test exhibited significant improvement after the intervention. The results of feasibility outcomes indicate that the program may be feasible due to the high rates of completion and exercise performed. Additionally, improvement was noted for the health indicators of the five times sit-to-stand test, which may help prevent frailty. The feasibility trial has provided the necessary data to design a future-cluster randomized controlled trial.
    MeSH term(s) Aged ; COVID-19/epidemiology ; COVID-19/prevention & control ; Exercise Therapy/methods ; Feasibility Studies ; Female ; Follow-Up Studies ; Frailty/prevention & control ; Humans ; Pandemics/prevention & control
    Language English
    Publishing date 2022-05-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19116609
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Comparison of frailty associated factors between older adult patients with rheumatoid arthritis and community dwellers.

    Ozeki, Sae / Takeuchi, Kenji / Yasuoka, Mikako / Kamiji, Koto / Kojima, Toshihisa / Waguri-Nagaya, Yuko / Ojima, Toshiyuki / Kondo, Katsunori / Wakai, Kenji / Kojima, Masayo

    Archives of gerontology and geriatrics

    2021  Volume 96, Page(s) 104455

    Abstract: Purpose: To determine whether frailty associated factors differ between community dwellers and older adult patients with rheumatoid arthritis (RA).: Methods: We used the cross-sectional data for patients with RA from the RA epidemiological quality-of- ...

    Abstract Purpose: To determine whether frailty associated factors differ between community dwellers and older adult patients with rheumatoid arthritis (RA).
    Methods: We used the cross-sectional data for patients with RA from the RA epidemiological quality-of-life study (n = 210, mean age 71.8 ± 3.7 years) and community dwellers from the Japan Gerontological Evaluation Study (n = 53,255, mean age 71.7 ± 4.0 years). Frailty status was assessed using the Kihon Checklist (KCL), and the primary outcome was frailty (KCL score ≥8 points). Information on predictor variables, including age, sex, marital status, educational level, body mass index (BMI), drinking and smoking status and social participation were obtained from a standardized questionnaire. We employed Poisson regression to calculate the prevalence ratio (PR) of frailty according to its predictors.
    Results: We found frailty in 37.6% of the patients with RA and 15.7% of the community dwellers. In the multivariate models, BMI and social participation were independently associated with frailty in patients with RA (BMI <18.5: PR, 1.62; 95% confidence interval [CI] 1.09-2.41. BMI ≥25.0: PR, 1.81; 95% CI 1.20-2.71. Active social participation: PR, 0.61; 95% CI 0.42-0.87) and community dwellers (BMI <18.5: PR, 1.77; 95% CI 1.67-1.88. BMI ≥25.0: PR, 1.27; 95% CI 1.22-1.33. Active social participation: PR, 0.46; 95% CI 0.44-0.48). All other predictors were significantly associated with frailty in the community dwellers.
    Conclusion: Maintaining appropriate body weight and participating in social activities are important for preventing frailty in patients with RA as well as community dwellers.
    MeSH term(s) Aged ; Arthritis, Rheumatoid/epidemiology ; Cross-Sectional Studies ; Frail Elderly ; Frailty/epidemiology ; Humans ; Japan/epidemiology ; Social Participation ; Surveys and Questionnaires
    Language English
    Publishing date 2021-06-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603162-6
    ISSN 1872-6976 ; 0167-4943
    ISSN (online) 1872-6976
    ISSN 0167-4943
    DOI 10.1016/j.archger.2021.104455
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: The role of ghrelin and ghrelin analogues in wasting disease.

    Kamiji, Mayra M / Inui, Akio

    Current opinion in clinical nutrition and metabolic care

    2008  Volume 11, Issue 4, Page(s) 443–451

    Abstract: Purpose of review: The purpose of this review is to summarize recent studies that investigated the role of ghrelin and ghrelin analogs in wasting conditions.: Recent findings: Numerous studies have demonstrated potential beneficial effects exerted by ...

    Abstract Purpose of review: The purpose of this review is to summarize recent studies that investigated the role of ghrelin and ghrelin analogs in wasting conditions.
    Recent findings: Numerous studies have demonstrated potential beneficial effects exerted by ghrelin in a number of diseases associated with wasting. Besides ghrelin's orexigenic effect, anabolic as well as anti-inflammatory activity mediated by ghrelin have been investigated in wasting conditions such as cancer, diabetes mellitus, malabsorptive diseases, chronic obstructive pulmonary disease, anorexia nervosa, renal failure, liver failure, and chronic heart failure. Encouraging results have been obtained from experimental studies and a few clinical trials using subcutaneous administration of ghrelin and ghrelin agonists in cachexia. In-vitro studies have shown ghrelin and des-acyl ghrelin biological activities on proliferation of tumor cells and abnormal tissues.
    Summary: The recent studies support the possible positive effects of ghrelin in therapeutic approaches and adjunct treatment of a number of diseases associated with wasting. Utilization of agonists of the ghrelin receptor growth hormone secretagogue-1a is a promising approach for clinical use. Randomized and placebo-controlled studies, including large number of patients are further required.
    MeSH term(s) Cachexia/drug therapy ; Chronic Disease ; Energy Intake/drug effects ; Energy Metabolism/drug effects ; Ghrelin/analogs & derivatives ; Ghrelin/physiology ; Ghrelin/therapeutic use ; Humans ; Wasting Syndrome/drug therapy
    Chemical Substances Ghrelin
    Language English
    Publishing date 2008-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1460178-3
    ISSN 1473-6519 ; 1363-1950
    ISSN (online) 1473-6519
    ISSN 1363-1950
    DOI 10.1097/MCO.0b013e328303dee4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Book ; Online: Building a model of the brain

    Shimoura, Renan Oliveira / Pena, Rodrigo F. O. / Lima, Vinicius / Kamiji, Nilton L. / Girardi-Schappo, Mauricio / Roque, Antonio C.

    from detailed connectivity maps to network organization

    2021  

    Abstract: The field of computational modeling of the brain is advancing so rapidly that now it is possible to model large scale networks representing different brain regions with a high level of biological detail in terms of numbers and synapses. For a ... ...

    Abstract The field of computational modeling of the brain is advancing so rapidly that now it is possible to model large scale networks representing different brain regions with a high level of biological detail in terms of numbers and synapses. For a theoretician approaching a neurobiological question, it is important to analyze the pros and cons of each of the models available. Here, we provide a tutorial review on recent models for different brain circuits, which are based on experimentally obtained connectivity maps. We discuss particularities that may be relevant to the modeler when choosing one of the reviewed models. The objective of this review is to give the reader a fair notion of the computational models covered, with emphasis on the corresponding connectivity maps, and how to use them.

    Comment: 35 pages, 5 figures
    Keywords Physics - Biological Physics ; Condensed Matter - Disordered Systems and Neural Networks ; Nonlinear Sciences - Adaptation and Self-Organizing Systems ; Quantitative Biology - Neurons and Cognition
    Subject code 612
    Publishing date 2021-06-07
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

To top