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Article ; Online: In vivo activities of heparan sulfate differentially modified by NDSTs during development.

Nakato, Eriko / Baker, Sarah / Kinoshita-Toyoda, Akiko / Knudsen, Collin / Lu, Yi-Si / Takemura, Masahiko / Toyoda, Hidenao / Nakato, Hiroshi

Proteoglycan research

2024 Volume 2, Issue 1

Abstract: Heparan sulfate proteoglycans (HSPGs) serve as co-receptors for growth factor signaling during development. It is well known that the level and patterns of sulfate groups of heparan sulfate (HS) chains, or HS fine structures, have a major impact on HSPG ... ...

Abstract	Heparan sulfate proteoglycans (HSPGs) serve as co-receptors for growth factor signaling during development. It is well known that the level and patterns of sulfate groups of heparan sulfate (HS) chains, or HS fine structures, have a major impact on HSPG function. On the other hand, the physiological significance of other structural features of HS, including NS/NA domain organization, remains to be elucidated. A blueprint of the HS domain structures is mainly controlled by HS
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ISSN	2832-3556
ISSN (online)	2832-3556
DOI	10.1002/pgr2.17
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Secondary malignancy after carbon ion radiotherapy in a 15-year-old female with Ewing sarcoma.

Ushida, Eri / Toyoda, Hidemi / Hanaki, Ryo / Amano, Keishiro / Okamoto, Masahiko / Yamada, Seiji / Nojima, Takayuki / Hirayama, Masahiro

Pediatric blood & cancer

2023 Volume 70, Issue 12, Page(s) e30676

Language	English
Publishing date	2023-09-13
Publishing country	United States
Document type	Editorial
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30676
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Article ; Online: Candidates for Intra-Articular Administration Therapeutics and Therapies of Osteoarthritis.

Toyoda, Eriko / Maehara, Miki / Watanabe, Masahiko / Sato, Masato

International journal of molecular sciences

2021 Volume 22, Issue 7

Abstract: Osteoarthritis (OA) of the knee is a disease that significantly decreases the quality of life due to joint deformation and pain caused by degeneration of articular cartilage. Since the degeneration of cartilage is irreversible, intervention from an early ...

Abstract	Osteoarthritis (OA) of the knee is a disease that significantly decreases the quality of life due to joint deformation and pain caused by degeneration of articular cartilage. Since the degeneration of cartilage is irreversible, intervention from an early stage and control throughout life is important for OA treatment. For the treatment of early OA, the development of a disease-modifying osteoarthritis drug (DMOAD) for intra-articular (IA) injection, which is attracting attention as a point-of-care therapy, is desired. In recent years, the molecular mechanisms involved in OA progression have been clarified while new types of drug development methods based on gene sequences have been established. In addition to conventional chemical compounds and protein therapeutics, the development of DMOAD from the new modalities such as gene therapy and oligonucleotide therapeutics is accelerating. In this review, we have summarized the current status and challenges of DMOAD for IA injection, especially for protein therapeutics, gene therapy, and oligonucleotide therapeutics.
MeSH term(s)	Cartilage, Articular/drug effects ; Drug Discovery/methods ; Drug Repositioning/methods ; Humans ; Injections, Intra-Articular/methods ; Knee Joint/drug effects ; Osteoarthritis/drug therapy ; Osteoarthritis, Knee/drug therapy ; Pain/drug therapy
Language	English
Publishing date	2021-03-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22073594
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Article ; Online: Candidates for Intra-Articular Administration Therapeutics and Therapies of Osteoarthritis

Eriko Toyoda / Miki Maehara / Masahiko Watanabe / Masato Sato

International Journal of Molecular Sciences, Vol 22, Iss 3594, p

2021 Volume 3594

Abstract	Osteoarthritis (OA) of the knee is a disease that significantly decreases the quality of life due to joint deformation and pain caused by degeneration of articular cartilage. Since the degeneration of cartilage is irreversible, intervention from an early stage and control throughout life is important for OA treatment. For the treatment of early OA, the development of a disease-modifying osteoarthritis drug (DMOAD) for intra-articular (IA) injection, which is attracting attention as a point-of-care therapy, is desired. In recent years, the molecular mechanisms involved in OA progression have been clarified while new types of drug development methods based on gene sequences have been established. In addition to conventional chemical compounds and protein therapeutics, the development of DMOAD from the new modalities such as gene therapy and oligonucleotide therapeutics is accelerating. In this review, we have summarized the current status and challenges of DMOAD for IA injection, especially for protein therapeutics, gene therapy, and oligonucleotide therapeutics.
Keywords	disease-modifying osteoarthritis drug ; gene therapy ; oligonucleotide therapeutics ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	572
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Potential of Exosomes for Diagnosis and Treatment of Joint Disease: Towards a Point-of-Care Therapy for Osteoarthritis of the Knee.

Maehara, Miki / Toyoda, Eriko / Takahashi, Takumi / Watanabe, Masahiko / Sato, Masato

International journal of molecular sciences

2021 Volume 22, Issue 5

Abstract: In the knee joint, articular cartilage injury can often lead to osteoarthritis of the knee (OAK). Currently, no point-of-care treatment can completely address OAK symptoms and regenerate articular cartilage to restore original functions. While various ... ...

Abstract	In the knee joint, articular cartilage injury can often lead to osteoarthritis of the knee (OAK). Currently, no point-of-care treatment can completely address OAK symptoms and regenerate articular cartilage to restore original functions. While various cell-based therapies are being developed to address OAK, exosomes containing various components derived from their cells of origin have attracted attention as a cell-free alternative. The potential for exosomes as a novel point-of-care treatment for OAK has been studied extensively, especially in the context of intra-articular treatments. Specific exosomal microRNAs have been identified as possibly effective in treating cartilage defects. Additionally, exosomes have been studied as biomarkers through their differences in body fluid composition between joint disease patients and healthy subjects. Exosomes themselves can be utilized as a drug delivery system through their manipulation and encapsulation of specific contents to be delivered to specific cells. Through the combination of exosomes with tissue engineering, novel sustained release drug delivery systems are being developed. On the other hand, many of the functions and activities of exosomes are unknown and challenges remain for clinical applications. In this review, the possibilities of intra-articular treatments utilizing exosomes and the challenges in using exosomes in therapy are discussed.
MeSH term(s)	Animals ; Autophagy ; Biomarkers ; Cartilage, Articular/physiology ; Chondrocytes/metabolism ; Delayed-Action Preparations ; Disease Models, Animal ; Drug Delivery Systems ; Exosomes/chemistry ; Exosomes/ultrastructure ; Humans ; Injections, Intra-Articular ; Joint Diseases/diagnosis ; Joint Diseases/therapy ; Macrophages/physiology ; MicroRNAs/administration & dosage ; MicroRNAs/therapeutic use ; Osteoarthritis, Knee/diagnosis ; Osteoarthritis, Knee/therapy ; Point-of-Care Systems ; Regeneration
Chemical Substances	Biomarkers ; Delayed-Action Preparations ; MicroRNAs
Language	English
Publishing date	2021-03-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22052666
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Article: Effects of Tofogliflozin and Anagliptin Alone or in Combination on Glucose Metabolism and Atherosclerosis-Related Markers in Patients with Type 2 Diabetes Mellitus.

Nomura, Shosaku / Shouzu, Akira / Taniura, Takehito / Okuda, Yoshinori / Omoto, Seitaro / Suzuki, Masahiko / Ito, Tomoki / Toyoda, Nagaoki

Clinical pharmacology : advances and applications

2023 Volume 15, Page(s) 41–55

Abstract: Purpose: In people with type 2 diabetes mellitus (T2DM), both glucose metabolism abnormalities and atherosclerosis risk are significant concerns. This study aims to investigate the effects of the sodium-glucose cotransporter 2 inhibitor tofogliflozin ( ... ...

Abstract	Purpose: In people with type 2 diabetes mellitus (T2DM), both glucose metabolism abnormalities and atherosclerosis risk are significant concerns. This study aims to investigate the effects of the sodium-glucose cotransporter 2 inhibitor tofogliflozin (TOFO) and the dipeptidyl peptidase-4 inhibitor anagliptin (ANA) on markers of glucose metabolism and atherosclerosis when administered individually or in combination. Methods: Fifty T2DM patients were divided into two groups (receiving either TOFO or ANA monotherapy) and observed for 12 weeks (observation points: 0 and 12 weeks). The TOFO and ANA groups were then further treated with ANA and TOFO, respectively, and the patients were observed for an additional 36 weeks (observation points: 24 and 48 weeks). Therapeutic effects and various biomarkers were compared between the two groups at the observation points. Results: Combination therapy led to significant improvements in HbA1c levels and atherosclerosis markers. Additionally, the TOFO pretreatment group exhibited significant reductions in sLOX-1 and IL-6 levels. Conclusion: The increase in sLOX-1 and IL-6 levels, which indicates the response of scavenger receptors to oxidized low-density lipoproteins in people with T2DM, is mitigated following TOFO and ANA combination therapy. TOFO alone or in combination with ANA may be beneficial for preventing atherosclerosis development in people with T2DM, in addition to its effect on improving HbA1c levels.
Language	English
Publishing date	2023-05-25
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2520726-X
ISSN	1179-1438
ISSN	1179-1438
DOI	10.2147/CPAA.S409786
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Article ; Online: Serological and histopathological assessment of galactose-deficient immunoglobulin A1 deposition in kidney allografts: A multicenter prospective observational study.

Sofue, Tadashi / Oguchi, Hideyo / Yazawa, Masahiko / Tsujita, Makoto / Futamura, Kenta / Nishihira, Morikuni / Toyoda, Mariko / Kano, Toshiki / Suzuki, Hitoshi

PloS one

2023 Volume 18, Issue 2, Page(s) e0281945

Abstract: Background: Recurrent immunoglobulin A (IgA) nephropathy is an important risk factor for kidney allograft loss. However, there is no classification system for IgA deposition in kidney allografts based on serological and histopathological evaluation of ... ...

Abstract	Background: Recurrent immunoglobulin A (IgA) nephropathy is an important risk factor for kidney allograft loss. However, there is no classification system for IgA deposition in kidney allografts based on serological and histopathological evaluation of galactose-deficient IgA1 (Gd-IgA1). This study aimed to establish a classification system for IgA deposition in kidney allografts based on serological and histological evaluation of Gd-IgA1. Methods: This multicenter prospective study included 106 adult kidney transplant recipients in whom an allograft biopsy was performed. Serum and urinary Gd-IgA1 levels were investigated in 46 transplant recipients who were IgA-positive and classified into four subgroups according to the presence or absence of mesangial Gd-IgA1 (KM55 antibody) deposits and C3. Results: Minor histological changes without an acute lesion were observed in recipients with IgA deposition. Fourteen (30%) of the 46 IgA-positive recipients were KM55-positive and 18 (39%) were C3-positive. The C3 positivity rate was higher in the KM55-positive group. Serum and urinary Gd-IgA1 levels were significantly higher in KM55-positive/C3-positive recipients than in the other three groups with IgA deposition. Disappearance of IgA deposits was confirmed in 10 of 15 IgA-positive recipients in whom a further allograft biopsy was performed. The serum Gd-IgA1 level at the time of enrollment was significantly higher in recipients in whom IgA deposition continued than in those in whom it disappeared (p = 0.02). Conclusions: The population with IgA deposition after kidney transplantation is serologically and pathologically heterogeneous. Serological and histological assessment of Gd-IgA1 is useful for identifying cases that should be carefully observed.
MeSH term(s)	Adult ; Humans ; Galactose ; Prospective Studies ; Immunoglobulin A ; Kidney/pathology ; Glomerulonephritis, IGA/pathology ; Allografts/pathology
Chemical Substances	galactosyl-deficient IgA1 ; Galactose (X2RN3Q8DNE) ; Immunoglobulin A
Language	English
Publishing date	2023-02-16
Publishing country	United States
Document type	Multicenter Study ; Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0281945
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Potential of Exosomes for Diagnosis and Treatment of Joint Disease

Miki Maehara / Eriko Toyoda / Takumi Takahashi / Masahiko Watanabe / Masato Sato

International Journal of Molecular Sciences, Vol 22, Iss 5, p

Towards a Point-of-Care Therapy for Osteoarthritis of the Knee

2021 Volume 2666

Abstract	In the knee joint, articular cartilage injury can often lead to osteoarthritis of the knee (OAK). Currently, no point-of-care treatment can completely address OAK symptoms and regenerate articular cartilage to restore original functions. While various cell-based therapies are being developed to address OAK, exosomes containing various components derived from their cells of origin have attracted attention as a cell-free alternative. The potential for exosomes as a novel point-of-care treatment for OAK has been studied extensively, especially in the context of intra-articular treatments. Specific exosomal microRNAs have been identified as possibly effective in treating cartilage defects. Additionally, exosomes have been studied as biomarkers through their differences in body fluid composition between joint disease patients and healthy subjects. Exosomes themselves can be utilized as a drug delivery system through their manipulation and encapsulation of specific contents to be delivered to specific cells. Through the combination of exosomes with tissue engineering, novel sustained release drug delivery systems are being developed. On the other hand, many of the functions and activities of exosomes are unknown and challenges remain for clinical applications. In this review, the possibilities of intra-articular treatments utilizing exosomes and the challenges in using exosomes in therapy are discussed.
Keywords	exosome ; point-of-care therapy ; osteoarthritis of the knee ; cartilage regeneration ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Serological and histopathological assessment of galactose-deficient immunoglobulin A1 deposition in kidney allografts

Tadashi Sofue / Hideyo Oguchi / Masahiko Yazawa / Makoto Tsujita / Kenta Futamura / Morikuni Nishihira / Mariko Toyoda / Toshiki Kano / Hitoshi Suzuki

PLoS ONE, Vol 18, Iss 2, p e

A multicenter prospective observational study.

2023 Volume 0281945

Abstract: Background Recurrent immunoglobulin A (IgA) nephropathy is an important risk factor for kidney allograft loss. However, there is no classification system for IgA deposition in kidney allografts based on serological and histopathological evaluation of ... ...

Abstract	Background Recurrent immunoglobulin A (IgA) nephropathy is an important risk factor for kidney allograft loss. However, there is no classification system for IgA deposition in kidney allografts based on serological and histopathological evaluation of galactose-deficient IgA1 (Gd-IgA1). This study aimed to establish a classification system for IgA deposition in kidney allografts based on serological and histological evaluation of Gd-IgA1. Methods This multicenter prospective study included 106 adult kidney transplant recipients in whom an allograft biopsy was performed. Serum and urinary Gd-IgA1 levels were investigated in 46 transplant recipients who were IgA-positive and classified into four subgroups according to the presence or absence of mesangial Gd-IgA1 (KM55 antibody) deposits and C3. Results Minor histological changes without an acute lesion were observed in recipients with IgA deposition. Fourteen (30%) of the 46 IgA-positive recipients were KM55-positive and 18 (39%) were C3-positive. The C3 positivity rate was higher in the KM55-positive group. Serum and urinary Gd-IgA1 levels were significantly higher in KM55-positive/C3-positive recipients than in the other three groups with IgA deposition. Disappearance of IgA deposits was confirmed in 10 of 15 IgA-positive recipients in whom a further allograft biopsy was performed. The serum Gd-IgA1 level at the time of enrollment was significantly higher in recipients in whom IgA deposition continued than in those in whom it disappeared (p = 0.02). Conclusions The population with IgA deposition after kidney transplantation is serologically and pathologically heterogeneous. Serological and histological assessment of Gd-IgA1 is useful for identifying cases that should be carefully observed.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synthesis of FAU-Zeolite Membrane by a Secondary Growth Method: Influence of Seeding on Membrane Growth and Its Performance in the Dehydration of Isopropyl Alcohol-Water Mixture.

Matsukata, Masahiko / Sekine, Yasushi / Kikuchi, Eiichi / Sakai, Motomu / Subramanian, Bharathi / Toyoda, Makoto / Furuhata, Taisuke

ACS omega

2021 Volume 6, Issue 14, Page(s) 9834–9842

Abstract: Y-type zeolite membranes were prepared on a porous tubular α-alumina support by a secondary growth process. Various experimental conditions such as seed size, pH of seed solution, and degassing of support were examined for understanding their influence ... ...

Abstract	Y-type zeolite membranes were prepared on a porous tubular α-alumina support by a secondary growth process. Various experimental conditions such as seed size, pH of seed solution, and degassing of support were examined for understanding their influence on the membrane deposition process. The experimental results showed that the potential of alumina support surface and the USY seed slurry plays a significant role in controlling the electrostatic interaction between seed particles and support surface and also the aggregation of USY seed particles in the slurry. In addition, we also noted the significance of the capillary forces working at the three-phase interface on the support surface and is a key factor that governs the seeding behavior onto the tubular support surface. Optimization of these parameters resulted in crack-free compact membranes that were able to effectively separate a mixture of isopropyl alcohol and water in a vapor-phase separation process.
Language	English
Publishing date	2021-03-31
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.1c00513
Database	MEDical Literature Analysis and Retrieval System OnLINE

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