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  1. Book ; Thesis: Umweltmedizinische Studien in Gebieten erhöhter Schadstoffexposition

    Hölzer, Jürgen

    unter besonderer Berücksichtigung des Belastungs- und Effektmonitorings perfluorierter Verbindungen und polyzyklischer aromatischer Kohlenwasserstoffe

    2014  

    Author's details von Dr. med. Jürgen Hölzer
    Language German ; English
    Size Blätter in getrennter Zählung, Diagramme
    Publishing place Bochum
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Habilitationsschrift, Ruhr-Universität Bochum, 2015
    Note Enthält 8 Zeitschriftenartikel in englischer Sprache
    HBZ-ID HT018937916
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 E 736 order for loan Magazin

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  2. Article: Gut Signals and Gut Feelings: Science at the Interface of Data and Beliefs.

    Holzer, Peter

    Frontiers in behavioral neuroscience

    2022  Volume 16, Page(s) 929332

    Language English
    Publishing date 2022-07-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2022.929332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Constipation Caused by Anti-calcitonin Gene-Related Peptide Migraine Therapeutics Explained by Antagonism of Calcitonin Gene-Related Peptide's Motor-Stimulating and Prosecretory Function in the Intestine.

    Holzer, Peter / Holzer-Petsche, Ulrike

    Frontiers in physiology

    2022  Volume 12, Page(s) 820006

    Abstract: The development of small-molecule calcitonin gene-related peptide (CGRP) receptor antagonists (gepants) and of monoclonal antibodies targeting the CGRP system has been a major advance in the management of migraine. In the randomized controlled trials ... ...

    Abstract The development of small-molecule calcitonin gene-related peptide (CGRP) receptor antagonists (gepants) and of monoclonal antibodies targeting the CGRP system has been a major advance in the management of migraine. In the randomized controlled trials before regulatory approval, the safety of these anti-CGRP migraine therapeutics was considered favorable and to stay within the expected profile. Post-approval real-world surveys reveal, however, constipation to be a major adverse event which may affect more than 50% of patients treated with erenumab (an antibody targeting the CGRP receptor), fremanezumab or galcanezumab (antibodies targeting CGRP). In this review article we address the question whether constipation caused by inhibition of CGRP signaling can be mechanistically deduced from the known pharmacological actions and pathophysiological implications of CGRP in the digestive tract. CGRP in the gut is expressed by two distinct neuronal populations: extrinsic primary afferent nerve fibers and distinct neurons of the intrinsic enteric nervous system. In particular, CGRP is a major messenger of enteric sensory neurons which in response to mucosal stimulation activate both ascending excitatory and descending inhibitory neuronal pathways that enable propulsive (peristaltic) motor activity to take place. In addition, CGRP is able to stimulate ion and water secretion into the intestinal lumen. The motor-stimulating and prosecretory actions of CGRP combine in accelerating intestinal transit, an activity profile that has been confirmed by the ability of CGRP to induce diarrhea in mice, dogs and humans. We therefore conclude that the constipation elicited by antibodies targeting CGRP or its receptor results from interference with the physiological function of CGRP in the small and large intestine in which it contributes to the maintenance of peristaltic motor activity, ion and water secretion and intestinal transit.
    Language English
    Publishing date 2022-01-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.820006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Beobachtung der gesundheitlichen Entwicklung von Kindern und Müttern nach hoher Belastung mit PFOA - Arnsberg Kohorte

    Joswig, Matthias / Goeken, N. / Mogwitz, U. / Schaub, S. / Wilhelm, Michael / Hölzer, Jürgen

    Forschungskennzahl 3710 61 22 2

    (Umwelt & Gesundheit ; 2015,11 ; UBA-FB ; 002038 ; Umweltforschungsplan des Bundesministeriums für Umwelt, Naturschutz, Bau und Reaktorsicherheit)

    2015  

    Author's details von M. Joswig, N. Goeken, U. Mogwitz, S. Schaub, M. Wilhelm, J. Hölzer (Ruhr-Universität Bochum, Bochum)
    Series title Umwelt & Gesundheit ; 2015,11
    UBA-FB ; 002038
    Umweltforschungsplan des Bundesministeriums für Umwelt, Naturschutz, Bau und Reaktorsicherheit
    Collection
    Subject code 610
    Language German
    Size 1 Online-Ressource (XVI, 166 Seiten), Diagramme
    Publisher Umweltbundesamt
    Publishing place Dessau-Roßlau
    Publishing country Germany
    Document type Book ; Online
    Note Zusammenfassung in englischer Sprache vorhanden
    HBZ-ID HT018869430
    DOI 10.4126/FRL01-006399657
    Database Repository for Life Sciences

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  5. Article: Development of a Polyethylene Glycol/Polymethyl Methacrylate-Based Binder System for a Borosilicate Glass Filler Suitable for Injection Molding.

    Zürn, Martin / Schrage, Annika / Antusch, Steffen / Bohn, Nicole / Holzer, Peter / Hanemann, Thomas

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 6

    Abstract: Powder injection molding is an established, cost effective and often near-net-shape mass production process for metal or ceramic parts with complex geometries. This paper deals with the extension of the powder injection molding process chain towards the ... ...

    Abstract Powder injection molding is an established, cost effective and often near-net-shape mass production process for metal or ceramic parts with complex geometries. This paper deals with the extension of the powder injection molding process chain towards the usage of a commercially available borosilicate glass and the realization of glass compounds with huge densities. The whole process chain consists of the individual steps of compounding, molding, debinding, and sintering. The first part, namely, the search for a suitable feedstock composition with a very high solid load and reliable molding properties, is mandatory for the successful manufacture of a dense glass part. The most prominent feature is the binder composition and the related comprehensive rheological characterization. In this work, a binder system consisting of polyethylene glycol and polymethylmethacrylate with stearic acid as a surfactant was selected and its suitability for glass injection molding was evaluated. The influence of all feedstock components on processing and of the process steps on the final sintered part was investigated for sintered glass parts with densities around 99% of the theoretical value.
    Language English
    Publishing date 2024-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17061396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Tachykinins

    Andrews, P. L. / Holzer, Peter

    (Handbook of experimental pharmacology ; 164)

    2004  

    Author's details contributors P. L. R. Andrews ... Ed. Peter Holzer
    Series title Handbook of experimental pharmacology ; 164
    Collection
    Keywords Tachykinins ; Receptors, Tachykinin ; Tachykinine ; Rezeptor ; Antagonist
    Subject Widersacher
    Language German
    Size XII, 569 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT014066694
    ISBN 3-540-20690-6 ; 978-3-540-20690-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 2801 order for loan Magazin
    2004 A 6685 order for loan Magazin

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  7. Book: Wirbelsäulenanalysen bei Schülern

    Holzer, Hans Peter

    automatische Haltungsbeurteilung

    1998  

    Author's details Hans Peter Holzer
    Keywords Schüler ; Haltungsschaden ; Diagnose ; Wirbelsäulenkrankheit
    Subject Ärztliche Diagnose ; Wirbelsäulenerkrankung ; Wirbelsäulenbelastung ; Schuljugend ; Haltungsschäden
    Language German
    Size 115 S. : Ill., graph. Darst.
    Publisher Maudrich
    Publishing place Wien u.a.
    Publishing country Austria
    Document type Book
    HBZ-ID HT009126402
    ISBN 3-85175-703-3 ; 978-3-85175-703-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 7075 order for loan Magazin

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  8. Article ; Online: Naloxegol increases frequency of bowel movements and combats inadequate response to laxatives.

    Holzer, Peter

    Evidence-based medicine

    2015  Volume 20, Issue 1, Page(s) 5

    MeSH term(s) Analgesics, Opioid/adverse effects ; Constipation/drug therapy ; Female ; Humans ; Male ; Morphinans/administration & dosage ; Narcotic Antagonists/administration & dosage ; Polyethylene Glycols/administration & dosage ; Receptors, Opioid, mu/antagonists & inhibitors
    Chemical Substances Analgesics, Opioid ; Morphinans ; Narcotic Antagonists ; Receptors, Opioid, mu ; Polyethylene Glycols (30IQX730WE)
    Language English
    Publishing date 2015-02
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 1324346-9
    ISSN 1473-6810 ; 1356-5524
    ISSN (online) 1473-6810
    ISSN 1356-5524
    DOI 10.1136/ebmed-2014-110071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4793: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Book ; Thesis: Dioxine, Furane und andere Organochlorverbindungen im Blut von Feuerwehrleuten

    Hölzer, Jürgen

    eine prospektive Querschnittstudie

    1995  

    Author's details vorgelegt von Jürgen Hölzer
    Language German
    Size XIV, 166 Bl. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bochum, Univ., Diss., 1995
    HBZ-ID HT006787343
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    96 E 205 order for loan Magazin

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  10. Article ; Online: Acid-sensing ion channels in gastrointestinal function.

    Holzer, Peter

    Neuropharmacology

    2015  Volume 94, Page(s) 72–79

    Abstract: Gastric acid is of paramount importance for digestion and protection from pathogens but, at the same time, is a threat to the integrity of the mucosa in the upper gastrointestinal tract and may give rise to pain if inflammation or ulceration ensues. ... ...

    Abstract Gastric acid is of paramount importance for digestion and protection from pathogens but, at the same time, is a threat to the integrity of the mucosa in the upper gastrointestinal tract and may give rise to pain if inflammation or ulceration ensues. Luminal acidity in the colon is determined by lactate production and microbial transformation of carbohydrates to short chain fatty acids as well as formation of ammonia. The pH in the oesophagus, stomach and intestine is surveyed by a network of acid sensors among which acid-sensing ion channels (ASICs) and acid-sensitive members of transient receptor potential ion channels take a special place. In the gut, ASICs (ASIC1, ASIC2, ASIC3) are primarily expressed by the peripheral axons of vagal and spinal afferent neurons and are responsible for distinct proton-gated currents in these neurons. ASICs survey moderate decreases in extracellular pH and through these properties contribute to a protective blood flow increase in the face of mucosal acid challenge. Importantly, experimental studies provide increasing evidence that ASICs contribute to gastric acid hypersensitivity and pain under conditions of gastritis and peptic ulceration but also participate in colonic hypersensitivity to mechanical stimuli (distension) under conditions of irritation that are not necessarily associated with overt inflammation. These functional implications and their upregulation by inflammatory and non-inflammatory pathologies make ASICs potential targets to manage visceral hypersensitivity and pain associated with functional gastrointestinal disorders. This article is part of the Special Issue entitled 'Acid-Sensing Ion Channels in the Nervous System'.
    MeSH term(s) Acid Sensing Ion Channels/metabolism ; Animals ; Gastrointestinal Tract/metabolism ; Humans ; Inflammation/metabolism ; Pain/metabolism
    Chemical Substances Acid Sensing Ion Channels
    Language English
    Publishing date 2015-01-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2014.12.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.242: Show issues Location:
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