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  1. Article: Editorial: Women in translational pharmacology: 2021.

    Vengeliene, Valentina / Qin, Lu

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1162722

    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1162722
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  2. Article: mGlu2 mechanism-based interventions to treat alcohol relapse.

    Vengeliene, Valentina / Spanagel, Rainer

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 985954

    Abstract: Recently we identified a deficiency in metabotropic glutamate receptor 2 (mGlu2) function in the corticoaccumbal pathway, as a common pathological mechanism underlying alcohol-seeking and relapse behavior. Based on this mechanism, we hypothesized that ... ...

    Abstract Recently we identified a deficiency in metabotropic glutamate receptor 2 (mGlu2) function in the corticoaccumbal pathway, as a common pathological mechanism underlying alcohol-seeking and relapse behavior. Based on this mechanism, we hypothesized that mGlu2/3 agonists and mGlu2 positive allosteric modulators (PAMs) may be effective in reducing relapse-like behavior. Two mGlu2/3 agonists, LY379268 and LY354740 (a structural analog of LY379268 six-fold more potent in activating mGlu2 over mGluR3), were tested in a well-established rat model of relapse, the alcohol deprivation effect (ADE) with repeated deprivation phases. Since these agonists do not readily discriminate between contributions of mGlu2 and mGluR3, we also tested LY487379, a highly specific PAM that potentiates the effect of glutamate on the mGlu2 with less specificity on other mGlu receptor subtypes. Both LY379268 and LY354740 significantly and dose-dependently reduced the expression of the ADE. No significant changes in water intake, body weight and locomotor activity were observed. Importantly, repeated administration of mGlu2/3 agonist did not lead to tolerance development. mGlu2 PAM LY487379 treatment significantly reduced expression of the ADE in both male and female rats. Combination treatment of mGlu2/3 agonist and PAM had similar effect on relapse-like drinking to that seen in mGlu2/3 agonist treatment alone. Together with other preclinical data showing that PAMs can reduce alcohol-seeking behavior we conclude that mGlu2 PAMs should be considered for clinical trials in alcohol-dependent patients.
    Language English
    Publishing date 2022-09-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.985954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reply to: kynurenic acid and alcohol and cocaine dependence: novel effects and multiple mechanisms?

    Vengeliene, Valentina

    Psychopharmacology

    2017  Volume 234, Issue 1, Page(s) 167–168

    Language English
    Publishing date 2017-01
    Publishing country Germany
    Document type Letter
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-016-4489-1
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  4. Article ; Online: Sex differences in serotonergic control of rat social behaviour.

    Poceviciute, Ieva / Kasperaviciute, Kamile / Buisas, Rokas / Ruksenas, Osvaldas / Vengeliene, Valentina

    Pharmacology, biochemistry, and behavior

    2023  Volume 223, Page(s) 173533

    Abstract: Rationale: There is increasing evidence that enhancement of the salience of social stimuli can have a beneficial effect in managing many psychiatric conditions. There are, however, clear sex-related differences in social behaviour, including the neural ... ...

    Abstract Rationale: There is increasing evidence that enhancement of the salience of social stimuli can have a beneficial effect in managing many psychiatric conditions. There are, however, clear sex-related differences in social behaviour, including the neural mechanisms responsible for different aspects of social functions.
    Objectives: We explored the role of the serotonergic system on rat social behaviour under baseline and under stressful conditions in female and male rats.
    Methods: Rats were treated with the selective serotonin transporter (SERT) inhibitor escitalopram postnatally; a procedure known to cause a long-lasting reduction of serotonergic activity. In adulthood, social behaviour was tested in a social interaction test and in ultrasonic vocalisation (USVs) recording sessions before and after yohimbine-induced stress-like state.
    Results: Our data demonstrated that both female and, to a lesser extent, male escitalopram treated rats, exposed to a novel social situation, had fewer social exploration events and emitted fewer frequency-modulated calls with trills, trills and step calls, suggesting that an impaired function of the serotonergic system reduced the positive valence of social interaction. In a stress-like state, 50 kHz flat calls were increased only in female rats, indicating an increased seeking of social contact. However, the number of flat calls in escitalopram treated female rats was significantly lower compared with control rats.
    Conclusions: These data suggest that females may respond differently to serotonergic pharmacotherapy with respect to enhancement of beneficial effects of social support, especially in stress-related situations.
    MeSH term(s) Rats ; Female ; Male ; Animals ; Vocalization, Animal ; Escitalopram ; Sex Characteristics ; Social Behavior ; Ultrasonics
    Chemical Substances Escitalopram (4O4S742ANY)
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191042-5
    ISSN 1873-5177 ; 0091-3057
    ISSN (online) 1873-5177
    ISSN 0091-3057
    DOI 10.1016/j.pbb.2023.173533
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    Zs.A 1060: Show issues Location:
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  5. Article: Melatonin Reduces Alcohol Drinking in Rats with Disrupted Function of the Serotonergic System.

    Poceviciute, Ieva / Buisas, Rokas / Ruksenas, Osvaldas / Vengeliene, Valentina

    Journal of personalized medicine

    2022  Volume 12, Issue 3

    Abstract: The reason for the limited treatment success of substance-use-related problems may be a causal heterogeneity of this disorder that, at least partly, is manifested as differences in substance-use motives between individuals. The aim of the present study ... ...

    Abstract The reason for the limited treatment success of substance-use-related problems may be a causal heterogeneity of this disorder that, at least partly, is manifested as differences in substance-use motives between individuals. The aim of the present study was to assess if rats with pharmacologically induced differences in the function of the serotonergic system would respond differently to melatonin treatment compared to control rats with respect to voluntary alcohol consumption. To achieve this goal, we treated rats neonatally with the selective serotonin transporter (SERT) inhibitor escitalopram. This procedure has been reported to cause long-lasting sleep abnormalities in rodents. The study demonstrated that during adulthood, rats that had been treated with escitalopram tended to drink higher amounts of alcohol compared to control rats. Further, administration of melatonin significantly decreased the alcohol intake in escitalopram-treated animals but caused only a slight, nonsignificant reduction in the alcohol consumption by control rats. In conclusion, our data support the therapeutic potential of melatonin as a treatment for alcohol use disorder. However, interindividual differences between alcohol users may considerably modify the outcome of the melatonin treatment, whereby patients that manifest lower sleep quality due to disruption of serotonergic activity are more likely to benefit from this treatment.
    Language English
    Publishing date 2022-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12030355
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  6. Article ; Online: The role of ghrelin in drug and natural reward.

    Vengeliene, Valentina

    Addiction biology

    2013  Volume 18, Issue 6, Page(s) 897–900

    Abstract: Ghrelin is a protein that has been given special attention in both nutrition and addiction research during the last decade. Consequently, a vast amount of information has been accumulated concerning the role of ghrelin in natural and drug reward. We are ... ...

    Abstract Ghrelin is a protein that has been given special attention in both nutrition and addiction research during the last decade. Consequently, a vast amount of information has been accumulated concerning the role of ghrelin in natural and drug reward. We are now in the position to ask whether the ghrelin system could be targeted to treat maladaptive behaviours such as obesity and drug addiction. Indeed, ghrelin research has demonstrated that blocking the activity of ghrelin receptors may be effective in reducing the consumption of both food and drugs of abuse. This review will give a short overview of our current knowledge about the ghrelin system in the context of drug and natural rewards as well as the possibility of developing potential ghrelin-based treatments.
    MeSH term(s) Animals ; Appetite Regulation/physiology ; Behavior, Addictive/metabolism ; Feeding Behavior/physiology ; Ghrelin/metabolism ; Ghrelin/physiology ; Humans ; Obesity/metabolism ; Receptors, Ghrelin/antagonists & inhibitors ; Receptors, Ghrelin/physiology ; Reward ; Substance-Related Disorders/metabolism
    Chemical Substances Ghrelin ; Receptors, Ghrelin
    Language English
    Publishing date 2013-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1324314-7
    ISSN 1369-1600 ; 1355-6215
    ISSN (online) 1369-1600
    ISSN 1355-6215
    DOI 10.1111/adb.12114
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    Zs.A 4586: Show issues Location:
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  7. Article ; Online: A multiscale study of the effects of a diet containing CdSe/ZnS-COOH quantum dots on Salmo trutta fario L.: Potential feed-related nanotoxicity.

    Skrodenytė-Arbačiauskienė, Vesta / Butrimienė, Renata / Kalnaitytė-Vengelienė, Agnė / Bagdonas, Saulius / Montvydienė, Danguolė / Stankevičiūtė, Milda / Sauliutė, Gintarė / Jokšas, Kęstutis / Kazlauskienė, Nijolė / Karitonas, Rolandas / Matviienko, Nataliia / Jurgelėnė, Živilė

    The Science of the total environment

    2023  Volume 906, Page(s) 167696

    Abstract: Quantum dots (QDs) receive widespread attention in industrial and biomedical fields, but the risks posed by the use of nanoparticles to aquatic organisms and the associated toxicological effects are still not well understood. In this study, effects of ... ...

    Abstract Quantum dots (QDs) receive widespread attention in industrial and biomedical fields, but the risks posed by the use of nanoparticles to aquatic organisms and the associated toxicological effects are still not well understood. In this study, effects of the 7-day dietary exposure of Salmo trutta fario L. juveniles to CdSe/ZnS-COOH QDs were evaluated at molecular, cellular, physiological and whole-organism levels. Fish feeding with QDs-contaminated feed resulted in an increased somatic index of the liver, a genotoxic effect on peripheral blood erythrocytes, altered enzyme activity and decreased MDA level. Furthermore, Cd levels in the gills and liver tissues of the exposed fish were found to be significantly higher than in those of the control fish. Alpha diversity indexes of the gut microbiota of the QDs-exposed S. trutta fario L. individuals exhibited a decreasing trend. The principal coordinate analysis (PCoA) showed that the gut microbiota of the control fish was significantly different from that of the fish exposed to QDs (p < 0.05). Additionally, the linear discriminant analysis (LDA) performed using an effect size (LEfSe) algorithm unveiled 19 significant taxonomic differences at different taxonomic levels between the control group and the QDs-exposed group. In the QDs-exposed group, the relative abundance of the genus Citrobacter (Proteobacteria phylum) in the gut microbiota was found to be significantly increased whereas that of the genus Mycoplasma (Tenericutes phylum) significantly decreased compared to the control group. In summary, QDs-contaminated diet affects the gut microbiota of fish by significantly changing the relative abundance of some taxa, potentially leading to dysbiosis. This, together with morphophysiological, cytogenetic and biochemical changes, poses a risk to fish health.
    MeSH term(s) Animals ; Quantum Dots/toxicity ; Cadmium Compounds/toxicity ; Selenium Compounds/toxicity ; Sulfides/toxicity ; Sulfides/chemistry ; Zinc Compounds/toxicity ; Diet
    Chemical Substances zinc sulfide (KPS085631O) ; Cadmium Compounds ; Selenium Compounds ; Sulfides ; Zinc Compounds
    Language English
    Publishing date 2023-10-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.167696
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
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  8. Article ; Online: Translational approach to understanding momentary factors associated with alcohol consumption.

    Vengeliene, Valentina / Foo, Jerome Clifford / Kim, Jinhyuk

    British journal of pharmacology

    2020  Volume 177, Issue 17, Page(s) 3878–3897

    Abstract: Multiple interindividual and intra-individual factors underlie variability in drinking motives, challenging clinical translatability of animal research and limiting treatment success of substance use-related problems. Intra-individual variability refers ... ...

    Abstract Multiple interindividual and intra-individual factors underlie variability in drinking motives, challenging clinical translatability of animal research and limiting treatment success of substance use-related problems. Intra-individual variability refers to time-dependent continuous and discrete changes within the individual and in substance use research is studied as momentary variation in the internal states (craving, stressed, anxious, impulsive and tired) and response to external triggers (stressors, drug-associated environmental cues and social encounters). These momentary stimuli have a direct impact on behavioural decisions and may be triggers and predictors of substance consumption. They also present potential targets for real-time behavioural and pharmacological interventions. In this review, we provide an overview of the studies demonstrating different momentary risk factors associated with increased probability of alcohol drinking in humans and changes in alcohol seeking and consumption in animals. The review also provides an overview of pharmacological interventions related to every individual risk factor.
    MeSH term(s) Alcohol Drinking ; Anxiety ; Craving ; Cues ; Humans ; Motivation
    Language English
    Publishing date 2020-07-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15180
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  9. Article ; Online: Adverse social experiences in adolescent rats result in persistent sex-dependent effects on alcohol-seeking behavior.

    Surakka, Akseli / Vengeliene, Valentina / Skorodumov, Ivan / Meinhardt, Marcus / Hansson, Anita C / Spanagel, Rainer

    Alcoholism, clinical and experimental research

    2021  Volume 45, Issue 7, Page(s) 1468–1478

    Abstract: Background: Accumulating clinical evidence suggests that women with prior exposure to adverse childhood experiences are more susceptible to heavy drinking and other health-related behaviors. Yet, preclinical studies investigating sex-dependent effects ... ...

    Abstract Background: Accumulating clinical evidence suggests that women with prior exposure to adverse childhood experiences are more susceptible to heavy drinking and other health-related behaviors. Yet, preclinical studies investigating sex-dependent effects of adolescent adverse social experiences (ASEs) on later alcohol-seeking behavior are lacking. This is mainly due to the unavailability of valid animal models and a shortage of studies that compare effects in males and females. Therefore, we sought to investigate the sex-dependent effects of ASE on adult alcohol-seeking behavior, locomotion, and reward sensitivity in male and female rats.
    Methods: We recently developed a rat model for childhood/adolescent peer rejection that allows us to study the long-term consequences of ASEs. Adolescent Wistar rats were reared from postnatal day (pd) 21 to pd 50 either within a group of Fischer 344 rats (ASE) or within a group of Wistar rats (control). Wistar rats housed with Fischer 344 rats do not reciprocate social play in adolescence. This reduced play across adolescence mimics peer rejection and results in chronic dysregulation of social and pain-related behaviors. We tested adult male and female rats in the reinstatement paradigm for cue-induced alcohol-seeking behavior, circadian locomotor activity, and sucrose consumption long after the termination of the peer rejection condition.
    Results: Peer rejection induced persistent sex-dependent changes in alcohol cue-induced reinstatement. Females showed an increased reinstatement effect while peer-rejected males demonstrated a decrease. Sex differences were observed in locomotor activity or reward sensitivity to sucrose.
    Conclusions: Peer rejection has long-lasting sex-dependent consequences on alcohol-seeking behavior without affecting locomotion or sweet reward sensitivity. Our results suggest that peer-rejected female rats represent a vulnerable population in which to study relapse-like behaviors that are similar to clinical findings, while males seem to buffer the peer rejection effect and demonstrate resilience to later life alcohol-seeking behaviors, as measured by the reinstatement effect. Finally, we provide a novel approach to investigate the molecular and neurobiological underpinnings of ASEs on alcohol and other drug-seeking behaviors.
    MeSH term(s) Age Factors ; Alcohol Drinking/psychology ; Animals ; Behavior, Animal ; Circadian Rhythm ; Drug-Seeking Behavior ; Ethanol/administration & dosage ; Female ; Male ; Motor Activity ; Psychological Distance ; Rats ; Rats, Inbred F344 ; Rats, Wistar ; Sex Factors ; Sucrose/administration & dosage
    Chemical Substances Ethanol (3K9958V90M) ; Sucrose (57-50-1)
    Language English
    Publishing date 2021-07-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 428999-7
    ISSN 1530-0277 ; 0145-6008
    ISSN (online) 1530-0277
    ISSN 0145-6008
    DOI 10.1111/acer.14640
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    Zs.A 1375: Show issues Location:
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  10. Article ; Online: The Anticonvulsant Lamotrigine Reduces Bout-Like Alcohol Drinking in Rats.

    Poceviciute, Ieva / Buisas, Rokas / Danelius, Tadas / Dulinskas, Redas / Ruksenas, Osvaldas / Vengeliene, Valentina

    Alcohol and alcoholism (Oxford, Oxfordshire)

    2021  Volume 57, Issue 2, Page(s) 242–245

    Abstract: We used an optical lickometer system to study drinking microstructure and effect of lamotrigine in voluntary alcohol-drinking rats. We showed that, similar to humans, animals differ by their drinking microstructure where some consume alcohol exclusively ... ...

    Abstract We used an optical lickometer system to study drinking microstructure and effect of lamotrigine in voluntary alcohol-drinking rats. We showed that, similar to humans, animals differ by their drinking microstructure where some consume alcohol exclusively in a bout-like patterns. The study suggests that anticonvulsants, such as lamotrigine, may be one treatment strategy specifically affecting this type of drinking.
    MeSH term(s) Alcohol Drinking/drug therapy ; Animals ; Anticonvulsants/pharmacology ; Anticonvulsants/therapeutic use ; Ethanol ; Lamotrigine ; Rats
    Chemical Substances Anticonvulsants ; Ethanol (3K9958V90M) ; Lamotrigine (U3H27498KS)
    Language English
    Publishing date 2021-10-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 604956-4
    ISSN 1464-3502 ; 0309-1635 ; 0735-0414
    ISSN (online) 1464-3502
    ISSN 0309-1635 ; 0735-0414
    DOI 10.1093/alcalc/agab073
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