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Article ; Online: Neuroprotective Therapeutic Potential of microRNA-149-5p against Murine Ischemic Stroke.

Vahidi, Samira / Bigdeli, Mohammad-Reza / Shahsavarani, Hosein / Ahmadloo, Salma / Roghani, Mehrdad

2024

Abstract: Ischemic stroke resulting from blockade of brain vessels lacks effective treatments, prompting exploration for potential therapies. Among promising candidates, microRNA-149 (miR-149) has been investigated for its role in alleviating oxidative stress, ... ...

Abstract	Ischemic stroke resulting from blockade of brain vessels lacks effective treatments, prompting exploration for potential therapies. Among promising candidates, microRNA-149 (miR-149) has been investigated for its role in alleviating oxidative stress, inflammation, and neurodegeneration associated with ischemic conditions. To evaluate its therapeutic effect, male Wistar rats were categorized into five groups, each consisting of 27 rats: sham, MCAO, lentiviral control, lentiviral miR-149, and miR149-5p mimic. Treatments were microinjected intracerebroventricularly (ICV) (right side), and ischemia was induced using middle cerebral artery occlusion (MCAO) procedure. Post-MCAO, neurological function, histopathological changes, blood-brain barrier (BBB) permeability, cerebral edema, and mRNA levels of Fas ligand (Faslg) and glutamate ionotropic NMDA receptor 1 (GRIN1) were assessed, alongside biochemical assays. MiR-149 administration improved neurological function, reduced brain damage, preserved BBB integrity, and attenuated cerebral edema. Upregulation of miR149-5p decreased Faslg and GRIN1 expression in ischemic brain regions. MiR-149 also reduced oxidative stress, enhanced antioxidant activity, decreased caspase-1 and - 3 activity, and modulated inflammatory factors in ischemic brain regions. Moreover, DNA fragmentation as an index of cell death decreased following miR-149 treatment. In conclusion, the study underscores miR-149 potential as a neuroprotective agent against ischemic stroke, showcasing its efficacy in modulating various mechanisms and supporting its candidacy as a promising therapeutic target for innovative strategies in stroke treatment.
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-024-04159-8
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Article ; Online: Pro-Apoptotic and Anti-Angiogenesis Effects of Olive Leaf Extract on Spontaneous Mouse Mammary Tumor Model by Balancing Vascular Endothelial Growth Factor and Endostatin Levels.

Milanizadeh, Sara / Reza Bigdeli, Mohammad

Nutrition and cancer

2019 Volume 71, Issue 8, Page(s) 1374–1381

Abstract: It has been proven that olive associated products such as olive leaf extract (OLE) causes significant reduction in cancer cells viability and proliferation. Female BALB/c adult mice were divided into four groups. Three days prior to oral treatments, ... ...

Abstract	It has been proven that olive associated products such as olive leaf extract (OLE) causes significant reduction in cancer cells viability and proliferation. Female BALB/c adult mice were divided into four groups. Three days prior to oral treatments, tumors were transplanted. First group were treated with distilled water and other three groups were received, respectively, 75, 150, and 225 mg/kg/day of OLE for three weeks. For assessment of anti-angiogenesis and pro-apoptotic effect of OLE on tumor tissue, tumor volume, cell mitosis and apoptosis, and also vascular endothelial growth factor (VEGF) and endostatin levels were assessed. OLE treatment with 150 and 225 mg/kg/day lead to significant reduction in tumor volume and cell mitosis compared with the control group, while the same doses significantly increase tumor cell apoptosis. OLE treatment with 150 mg/kg/day increase endostatin levels, while the same dose did not significantly decrease VEGF levels. The VEGF level is significantly reduced by the treatment with OLE 225 mg/kg/day for three weeks. Although, further studies are needed to clarify anti-angiogenesis and anti-apoptotic mechanism of OLE, consumption of OLE polyphenols after tumor transplantation reduced spontaneous mouse mammary tumor growth.
MeSH term(s)	Animals ; Apoptosis ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Disease Models, Animal ; Endostatins/metabolism ; Female ; Mice ; Mice, Inbred BALB C ; Neovascularization, Pathologic/drug therapy ; Olea/chemistry ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Endostatins ; Plant Extracts ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2019-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	424433-3
ISSN	1532-7914 ; 0163-5581
ISSN (online)	1532-7914
ISSN	0163-5581
DOI	10.1080/01635581.2019.1609054
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Zs.A 1496: Show issues

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Article ; Online: Determination of spermine and spermidine in meat with a ratiometric fluorescence nanoprobe and a combinational logic gate.

Abbasi-Moayed, Samira / Bigdeli, Arafeh / Hormozi-Nezhad, Mohammad Reza

Food chemistry

2022 Volume 384, Page(s) 132459

Abstract: A ratiometric fluorescent nanoprobe is developed with a wide color variation for visual determination of spermine (SP) and spermidine (SD) in meat samples. The green emission provided from the combination of yellow emissive quantum dots and blue emissive ...

Abstract	A ratiometric fluorescent nanoprobe is developed with a wide color variation for visual determination of spermine (SP) and spermidine (SD) in meat samples. The green emission provided from the combination of yellow emissive quantum dots and blue emissive carbon dots turns into pink when SP or SD are present. The results show that the developed sensor has good linearity in the range of 0.5-10 and 0.5-80 µM for SP and SD and suitable detection limits were achieved including 0.2 and 2.1 µM for SP and SD. The probe was highly selective in the presence of amino acids and other biogenic amines. RGB indices were extracted to build a combinational logic gate for visual and simultaneous detection of SP and SD. The dual functional logic gate was easy to design and convenient to operate. Finally, a portable sensor was fabricated for visual, rapid and on-site assessment of meat freshness.
MeSH term(s)	Carbon/chemistry ; Fluorescence ; Fluorescent Dyes/chemistry ; Meat ; Penicillins ; Quantum Dots/chemistry ; Spermidine ; Spermine
Chemical Substances	Fluorescent Dyes ; Penicillins ; Spermine (2FZ7Y3VOQX) ; Carbon (7440-44-0) ; Spermidine (U87FK77H25)
Language	English
Publishing date	2022-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2022.132459
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Article: Attenuating

Karimifar, Kiana / Alipanah, Hiva / Solatani Hekmat, Ava / Bigdeli, Mohammad Reza

Basic and clinical neuroscience

2022 Volume 13, Issue 3, Page(s) 357–371

Abstract: Introduction: The death of neurons and cerebral edema are the main consequences of stroke. However, inflammatory processes play key roles in aggravating cerebral damage following a stroke. This study aimed to investigate the effects of Viola odorata ... ...

Abstract	Introduction: The death of neurons and cerebral edema are the main consequences of stroke. However, inflammatory processes play key roles in aggravating cerebral damage following a stroke. This study aimed to investigate the effects of Viola odorata extract (VOE) on the infarct volume (IV), neurologic deficits (ND), and the expression of Methods: The animals were randomly separated into 6 groups: (1) control group, (2) vehicle-treated group, (3) MCAO group, (4) VOE25 group, (5) VOE50 group, and (6) VOE75 group (n= 12). VOE (25, 50, and 75 mg/kg) and distilled water were administered daily for 30 days. Two hours after the last gavage, the rats were exposed to MCAO for 60 minutes. Twenty-four hours later, Results: Viola odorata extract exhibited excellent neuroprotective effects by reducing IV (mainly in the core and subcortex areas), and induced downregulation of Conclusion: Viola odorata could also activate intracellular pathways, reducing the expression of Highlights: A stroke occurs when the blood supply to a part of the brain is interrupted or reduced.Viola odorata extract (VOE) reduced the infarct volumes (IV) in rats' brains 24 h after middle cerebral artery occlusion (MCAO).VOE may decrease Plain language summary: A stroke is a medical condition in which poor blood flow to the brain results in cell death. After an interruption of blood flow, energy stores are rapidly depleted, and complex cellular cascades induce excitotoxic cell death. So far, no effective and specific treatment has been suggested for the stroke. In this study, the neuroprotective effects of the viola odorata extract (VOE) were screened. The V. odorata extract exhibited excellent neuroprotective effects by reducing infarct volume and inducing downregulation of
Language	English
Publishing date	2022-05-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2652444-2
ISSN	2228-7442 ; 2008-126X
ISSN (online)	2228-7442
ISSN	2008-126X
DOI	10.32598/bcn.12.6.2061.1
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Article: Genetic and epigenetic effects on couple adjustment in context of romantic relationship: A scoping systematic review.

Khani, Pouria / Ansari Dezfouli, Mitra / Nasri, Farzad / Rahemi, Maryam / Ahmadloo, Salma / Afkhami, Hamed / Saeidi, Farzane / Tereshchenko, Sergey / Bigdeli, Mohammad Reza / Modarressi, Mohammad Hossein

Frontiers in genetics

2023 Volume 14, Page(s) 1002048

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-01-24
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.1002048
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Article: Inhibitory Effect of

Alipanah, Hiva / Bigdeli, Mohammad Reza / Esmaeili, Mohammad Ali

Iranian journal of pharmaceutical research : IJPR

2018 Volume 17, Issue 1, Page(s) 276–291

Abstract: ... Viola ... ...

Abstract	Viola odorata
Language	English
Publishing date	2018-03-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2578271-X
ISSN	1735-0328 ; 1726-6890
ISSN	1735-0328 ; 1726-6890
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Article ; Online: Effects of nicorandil on neurobehavioral function, BBB integrity, edema and stereological parameters of the brain in the sub-acute phase of stroke in a rat model.

Owjfard, Maryam / Bigdeli, Mohammad Reza / Safari, Anahid / Namavar, Mohammad Reza

Journal of biosciences

2020 Volume 45

Abstract: Blood-brain barrier (BBB) disruption, inflammation, and cell death are the pathogenic mechanisms of cerebral ischemia/reperfusion (I/R) injury. Nicorandil protects ischemic injury via some of these mechanisms. The aim of this study was to investigate the ...

Abstract	Blood-brain barrier (BBB) disruption, inflammation, and cell death are the pathogenic mechanisms of cerebral ischemia/reperfusion (I/R) injury. Nicorandil protects ischemic injury via some of these mechanisms. The aim of this study was to investigate the therapeutic effects of this drug on the brain ischemia after transient middle cerebral artery occlusion (MCAO) and clarify the NF-jB and Nrf2-dependent mechanisms modulated by this drug. Sixty-six rats were randomized into sham, MCAO and MCAO + nicorandil groups with oral gavage for 3 days. Cerebral I/R injury were induced by a transient MCAO for 1 h and neurobehavioral scores were performed for 3 days. In addition to measurement of BBB disruption and brain water content, the total and infarct volume, density, and total number of neurons, non-neurons and dead neurons in the right cortex were estimated by unbiased stereological methods. RT-PCR was performed to analyze the expression levels of NFjB and Nrf2. Although nicorandil treatment in the sub-acute brain ischemia did not have a prominent effect on neurobehavioral function and number of neurons, non-neurons and dead neurons probably through up-regulation of NF-jB, it, however, improved ischemia-induced BBB disruption and brain edema and showed a significant reduction in the infarction volume probably through up-regulation of Nrf2.
MeSH term(s)	Animals ; Behavior, Animal/drug effects ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/pathology ; Brain/drug effects ; Brain/pathology ; Brain/physiopathology ; Brain Edema/drug therapy ; Brain Edema/pathology ; Brain Infarction/drug therapy ; Brain Infarction/physiopathology ; Brain Ischemia/drug therapy ; Brain Ischemia/etiology ; Brain Ischemia/physiopathology ; Disease Models, Animal ; Infarction, Middle Cerebral Artery/complications ; Male ; NF-E2-Related Factor 2/metabolism ; NF-kappa B/metabolism ; Neurons/cytology ; Neurons/drug effects ; Neurons/pathology ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Nicorandil/pharmacology ; Nicorandil/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology ; Reperfusion Injury/physiopathology ; Stroke/drug therapy ; Stroke/etiology ; Stroke/metabolism ; Stroke/pathology
Chemical Substances	NF-E2-Related Factor 2 ; NF-kappa B ; NFE2L2 protein, human ; Neuroprotective Agents ; Nicorandil (260456HAM0)
Language	English
Publishing date	2020-04-28
Publishing country	India
Document type	Journal Article
ZDB-ID	756157-x
ISSN	0973-7138 ; 0250-5991
ISSN (online)	0973-7138
ISSN	0250-5991
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Article ; Online: Effect of Saponin on Cerebral Edema Rate in An Animal Model of Stroke

Elmira Shiri / Mohammad Reza Bigdeli / Akram Eidi / Seyed Pejman Mortazavi

Journal of Mazandaran University of Medical Sciences, Vol 32, Iss 214, Pp 43-

2022 Volume 54

Abstract: Background and purpose: Oxidative stress and neuroinflammation are the main causes of cerebral ischemia. Saponin with steroid or triterpenoid compounds with a sugar part has strong antioxidant and anti-inflammatory properties. The aim of this study was ... ...

Abstract	Background and purpose: Oxidative stress and neuroinflammation are the main causes of cerebral ischemia. Saponin with steroid or triterpenoid compounds with a sugar part has strong antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the effect of saponin on cerebral edema, Bax gene expression level, and ischemic neurological defects. Materials and methods: In this experimental study, 24 male Wistar rats were divided into three groups: sham, stroke, and stroke+saponin. Rats in the stroke+saponin group received intravenous injection of saponin (3mg/kg) 30 minutes before cerebral ischemia. Each group was divided into two subgroups: brain edema (n=5) and gene expression level investigation (n=3). Cerebral ischemia was induced by middle cerebral artery occlusion model. After 24 hrs, we investigated neurological deficits resulting from ischemia (Kruskal-Wallis test), the degree of brain edema, and Bax gene expression levels in the cortex, piriform cortex-amygdala, striatum, and hippocampus (one-way ANOVA). Results: Findings indicated a significant decrease in the score of neurological defects resulting from ischemia, the amount of cerebral edema, and the level of Bax gene expression in stroke+saponin group (P<0.05). Conclusion: This study showed that saponin pretreatment in rats with ischemia-reperfusion injury can be effective in reducing the damage caused by cerebral ischemia.
Keywords	stroke ; cerebral edema ; saponin ; bax ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Mazandaran University of Medical Sciences
Document type	Article ; Online
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Article ; Online: Effect of Dimethyl Fumarate on the Motor Function and Spatial Arrangement of Primary Motor Cortical Neurons in the Sub-Acute Phase of Stroke in a Rat Model.

Owjfard, Maryam / Bigdeli, Mohammad Reza / Safari, Anahid / Haghani, Masoud / Namavar, Mohammad Reza

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2021 Volume 30, Issue 4, Page(s) 105630

Abstract: Background: The therapeutic effects of dimethyl fumarate (DMF) in patients with multiple sclerosis and animal models of neurologic disease were reported. The density and the distribution pattern of motor neurons are important in transmitting the signal ... ...

Abstract	Background: The therapeutic effects of dimethyl fumarate (DMF) in patients with multiple sclerosis and animal models of neurologic disease were reported. The density and the distribution pattern of motor neurons are important in transmitting the signal and controlling the movement-related functions. The present study evaluated the effects of DMF treatment on the neurological functions, infarct volume, and spatial distribution of the neurons in the primary motor cortex after cerebral ischemia. Methods: Thirty-three Sprague-Dawley rats were randomly divided into three groups: The sham group underwent surgery without middle cerebral artery occlusion (MCAO) and drug. The vehicle and treatment groups after MCAO received a vehicle or DMF for three consecutive days. Post-stroke neurological and motor functions were assessed. At the end of the third day, the brains were removed, and the cerebral infarct volume was evaluated. We used cresyl violet staining to analyze the density and the spatial arrangement of motor cortical neurons using Voronoi tessellation. Results: Treatment of the brain ischemia for three days with DMF could not significantly reduce the neurological and motor function deficits and infarct volume. However, it reduced the neuronal area and death and preserved their spatial distribution in the normal regular pattern. Conclusion: Cerebral ischemia decreased the neuronal density of the primary motor cortex and changed their distributions to a random pattern. DMF treatment during sub-acute ischemic stroke did not significantly improve the neurological deficit scores. However, it could prevent neuronal swelling and death and preserved the spatial distribution of the cortical neurons in their normal pattern.
MeSH term(s)	Animals ; Behavior, Animal/drug effects ; Cell Death/drug effects ; Dimethyl Fumarate/pharmacology ; Disease Models, Animal ; Infarction, Middle Cerebral Artery/drug therapy ; Infarction, Middle Cerebral Artery/pathology ; Infarction, Middle Cerebral Artery/physiopathology ; Ischemic Stroke/drug therapy ; Ischemic Stroke/pathology ; Ischemic Stroke/physiopathology ; Male ; Motor Activity/drug effects ; Motor Cortex/drug effects ; Motor Cortex/pathology ; Motor Cortex/physiopathology ; Motor Neurons/drug effects ; Motor Neurons/pathology ; Neuroprotective Agents/pharmacology ; Rats, Sprague-Dawley ; Rotarod Performance Test ; Time Factors ; Rats
Chemical Substances	Neuroprotective Agents ; Dimethyl Fumarate (FO2303MNI2)
Language	English
Publishing date	2021-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1131675-5
ISSN	1532-8511 ; 1052-3057
ISSN (online)	1532-8511
ISSN	1052-3057
DOI	10.1016/j.jstrokecerebrovasdis.2021.105630
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Article: The Positive Effect of MiR1 Antagomir on Ischemic Neurological Disorders Via Changing the Expression of Bcl-w and Bad Genes.

Talebi, Anis / Rahnema, Mehdi / Bigdeli, Mohammad Reza

Basic and clinical neuroscience

2020 Volume 11, Issue 6, Page(s) 811–820

Abstract: Introduction: MicroRNAs (miRNAs or miRs) are non-coding RNAs. Studies have shown that miRNAs are expressed aberrantly in stroke. The miR1 enhances ischemic damage, and a previous study has demonstrated that reduction of miR1 level has a neuroprotective ... ...

Abstract	Introduction: MicroRNAs (miRNAs or miRs) are non-coding RNAs. Studies have shown that miRNAs are expressed aberrantly in stroke. The miR1 enhances ischemic damage, and a previous study has demonstrated that reduction of miR1 level has a neuroprotective effect on the Middle Cerebral Artery Occlusion (MCAO). Since apoptosis is one of the important processes in neural protection, the possible effect of miR1 on this pathway has been tested in this study. Post-ischemic administration of miR1 antagomir reduces infarct volume via bcl-w and bad expression. Methods: Rats were divided into four experimental groups: sham, control, positive control, and antagomir treatment group. One hour after MCAO surgery, the rats were received intravenously (Tail vein) 0.1 mL Normal Saline (NS), 0.1 mL rapamycin, and 300 pmol/g miR1 antagomir (soluble in 0.1 mL normal saline) in control, positive control, and treatment group, respectively. Twenty-four hours after reperfusion infarct volume was measured. The expression of miR1, bcl-w, and bad were analyzed using real-time PCR in sham, control, and treated groups. Results: Our results indicate that administration of miR1 antagomir reduces infarct volume significantly, it also decreases miR1 and bad expression while increases bcl-w expression. Conclusion: Understanding the precise neuroprotective mechanism of miR1 antagomir can make it a proper treatment and an innovative approach for stroke therapy.
Language	English
Publishing date	2020-11-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2652444-2
ISSN	2228-7442 ; 2008-126X
ISSN (online)	2228-7442
ISSN	2008-126X
DOI	10.32598/bcn.11.6.324.3
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