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  1. Article ; Online: Correction notice: Induction of Temporal Lobe Epilepsy in Mice with Pilocarpine.

    Arshad, Muhammad N / Naegele, Janice R

    Bio-protocol

    2023  Volume 5, Issue 13

    Language English
    Publishing date 2023-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Masterminding Hippocampal Circuits by Transplanting Human GABAergic Interneurons to Treat Temporal Lobe Epilepsy.

    Gupta, Jyoti / Naegele, Janice R

    Epilepsy currents

    2023  Volume 23, Issue 4, Page(s) 268–270

    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2270080-8
    ISSN 1535-7597
    ISSN 1535-7597
    DOI 10.1177/15357597231175010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Aberrant adult neurogenesis in intractable epilepsy: can GABAergic progenitor transplantation normalize this process?

    Arshad, Muhammad N / Naegele, Janice R

    Neural regeneration research

    2023  Volume 19, Issue 7, Page(s) 1419–1420

    Language English
    Publishing date 2023-11-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.387994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction notice: Measurements of Proline and Malondialdehyde Contents and Antioxidant Enzyme Activities in Leaves of Drought Stressed Cotton.

    Arshad, Muhammad N / Naegele, Janice R

    Bio-protocol

    2023  Volume 5, Issue 13

    Language English
    Publishing date 2023-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Forming new connections: Advances in human stem-cell-derived interneuron therapy for treating epilepsy.

    Gupta, Jyoti / Naegele, Janice R

    Neuron

    2023  Volume 111, Issue 6, Page(s) 758–760

    Abstract: Inhibitory interneuron progenitors capable of integrating into epileptic host circuitry hold great potential for correcting network hyperexcitability and reducing seizures in temporal lobe epilepsy. In this issue of Neuron, Zhu and ... ...

    Abstract Inhibitory interneuron progenitors capable of integrating into epileptic host circuitry hold great potential for correcting network hyperexcitability and reducing seizures in temporal lobe epilepsy. In this issue of Neuron, Zhu and colleagues
    MeSH term(s) Humans ; Epilepsy/therapy ; Seizures/therapy ; Epilepsy, Temporal Lobe ; Interneurons/physiology ; Neurons
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2023.02.034
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  6. Article ; Online: Altered connectomes of adult-born granule cells following engraftment of GABAergic progenitors in the mouse hippocampus.

    Arshad, Muhammad N / Pinto, Alejandro / van Praag, Henriette / Naegele, Janice R

    Progress in neurobiology

    2023  Volume 226, Page(s) 102450

    Abstract: Adult neurogenesis occurs in the dentate gyrus (DG) of the rodent hippocampus throughout life, producing new granule cells (GCs) that migrate from a stem cell niche called the subgranular zone (SGZ) into the adjacent granule cell layer (GCL). Seizures ... ...

    Abstract Adult neurogenesis occurs in the dentate gyrus (DG) of the rodent hippocampus throughout life, producing new granule cells (GCs) that migrate from a stem cell niche called the subgranular zone (SGZ) into the adjacent granule cell layer (GCL). Seizures associated with temporal lobe epilepsy alter adult neurogenesis and promote the formation of hyperexcitable circuits. Stem cell therapies for treating intractable seizure disorders are based on the premise that transplantation of GABAergic interneurons will strengthen inhibitory connections within the hippocampus and reduce hyperexcitability. Grafts of medial ganglionic eminence (MGE)-derived fetal GABAergic progenitors into the DG of adult mice with pilocarpine-induced TLE have been shown to suppress spontaneous recurrent seizures. In addition, the transplanted cells formed functional inhibitory synaptic connections with hippocampal neurons, including adult-born GCs. However, it is unknown whether MGE grafts change adult-born GC connectivity. To address this question, we compared the first-order monosynaptic inputs to adult-born GCs in TLE mice with or without MGE-derived interneuron grafts. Here we show that TLE increased excitatory inputs from endogenous hippocampal, entorhinal cortex, and medial septum/diagonal band neurons onto adult-born GCs. In contrast, in TLE mice with grafts, these excitatory inputs were reduced, coinciding with transplanted GABAergic interneuron innervation of adult-born GCs. These findings indicate that GABAergic interneuron transplantation into the dentate gyrus may prevent epilepsy-associated alterations in the connectivity of adult-born GCs.
    MeSH term(s) Mice ; Animals ; Connectome ; Neurons/physiology ; Hippocampus ; Brain ; Interneurons/physiology ; Epilepsy, Temporal Lobe
    Language English
    Publishing date 2023-04-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 185535-9
    ISSN 1873-5118 ; 0301-0082
    ISSN (online) 1873-5118
    ISSN 0301-0082
    DOI 10.1016/j.pneurobio.2023.102450
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  7. Article: Blocking Astrocyte Transformation at the Dysfunctional Blood Brain Barrier.

    Naegele, Janice R

    Epilepsy currents

    2015  Volume 15, Issue 2, Page(s) 87–89

    Language English
    Publishing date 2015-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2270080-8
    ISSN 1535-7597
    ISSN 1535-7597
    DOI 10.5698/1535-7597-15.2.87
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Induction of Temporal Lobe Epilepsy in Mice with Pilocarpine.

    Arshad, Muhammad Nauman / Naegele, Janice R

    Bio-protocol

    2020  Volume 10, Issue 4, Page(s) e3533

    Abstract: In the pilocarpine model of temporal lobe epilepsy (TLE) in rodents, systemic injections of pilocarpine induce continuous, prolonged limbic seizures, a condition termed "Status Epilepticus" (SE). With appropriate doses, many inbred strains of mice show ... ...

    Abstract In the pilocarpine model of temporal lobe epilepsy (TLE) in rodents, systemic injections of pilocarpine induce continuous, prolonged limbic seizures, a condition termed "Status Epilepticus" (SE). With appropriate doses, many inbred strains of mice show behavioral seizures within an hour after pilocarpine is injected. With the behavioral scoring system based on a modification of the original Racine scale, one can monitor the seizures behaviorally, as they develop into more prolonged seizures and SE. SE is typically associated with damage to subsets of hippocampal neurons and other structural changes in the hippocampus and generally subsides on its own. However, more precise control of the duration of SE is commonly achieved by injecting a benzodiazepine into the mouse 1 to 3 h after the onset of SE to suppress the seizures. Several days following pilocarpine-induced SE, electrographic and behavioral seizures begin to occur spontaneously. The goal of this protocol is to reliably generate mice that develop spontaneous recurrent seizures (SRS) and show the typical neuropathological changes in the brain characteristic of severe human mesial temporal lobe epilepsy (mTLE), without high mortality. To reduce mortality, multiple subthreshold injections of pilocarpine are administered, which increases the percentage of mice developing SE without concomitant mortality. Precise control of the duration of SE (1 or 3 h) is achieved by suppressing SE with the benzodiazepine Midazolam (Versed). We have found that this protocol is an efficient means for generating mice that subsequently develop characteristics of human mTLE including high-frequency interictal spike and wave activity and SRS. In addition, we and others have shown that this protocol produces mice that show excitotoxic cell death of subsets of hippocampal GABAergic interneurons, particularly in the dentate gyrus and compensatory sprouting of excitatory projections from dentate granule cells (mossy fiber sprouting). Aspects of this protocol have been described in several of our previous publications.
    Language English
    Publishing date 2020-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.3533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Synaptic Sweet Talk: How Do Perineuronal Nets Contribute to Epileptogenesis and Neuroplasticity?

    Naegele, Janice R

    Epilepsy currents

    2015  Volume 16, Issue 1, Page(s) 29–30

    Language English
    Publishing date 2015-07-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2270080-8
    ISSN 1535-7597
    ISSN 1535-7597
    DOI 10.5698/1535-7597-16.1.29
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  10. Article ; Online: CLC-3 Takes a Quantum Leap Toward Understanding Mechanisms of GABA Release.

    Naegele, Janice R

    Epilepsy currents

    2012  Volume 12, Issue 1, Page(s) 17–18

    Language English
    Publishing date 2012-01-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2270080-8
    ISSN 1535-7511 ; 1535-7597
    ISSN (online) 1535-7511
    ISSN 1535-7597
    DOI 10.5698/1535-7511-12.1.17
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