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  1. Article ; Online: Patient Safety Is the First Priority.

    Ota, Takashi / Sato, Kozo / Noguchi, Kenichiro

    JACC. Case reports

    2022  Volume 4, Issue 18, Page(s) 1224

    Language English
    Publishing date 2022-09-21
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2022.05.037
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  2. Article ; Online: Four-dimensional Flow Cardiac MRI for Hemodynamic Assessment of Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy with Multiple Obstructions.

    Suwa, Kenichiro / Sato, Ryota / Iguchi, Keisuke / Maekawa, Yuichiro

    Radiology. Cardiothoracic imaging

    2023  Volume 5, Issue 5, Page(s) e230074

    Abstract: Four-dimensional (4D) flow cardiac MRI can be used to assess hemodynamics in patients with hypertrophic obstructive cardiomyopathy (HOCM) undergoing alcohol septal ablation (ASA). However, to the best of the authors' knowledge, no study has reported on ... ...

    Abstract Four-dimensional (4D) flow cardiac MRI can be used to assess hemodynamics in patients with hypertrophic obstructive cardiomyopathy (HOCM) undergoing alcohol septal ablation (ASA). However, to the best of the authors' knowledge, no study has reported on insufficient or successful ASA evaluated with 4D flow cardiac MRI in HOCM with multiple obstructions. This case report presents a 74-year-old female patient who was diagnosed with HOCM with left ventricular (LV) outflow tract obstruction and midventricular obstruction. Repeat ASA targeting the LV outflow tract the first time and the midventricle the second time was conducted. Four-dimensional flow cardiac MRI performed before ASA, after the first ASA, and after the second ASA showed serial changes in the flow pathway and acceleration at the midventricle. Supplemental material is available for this article. © RSNA, 2023.
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Case Reports
    ISSN 2638-6135
    ISSN (online) 2638-6135
    DOI 10.1148/ryct.230074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Intraoperative transesophageal echocardiography reveals diastolic mitral regurgitation caused by an aortic regurgitation jet.

    Ota, Takashi / Sato, Kozo / Noguchi, Kenichiro / Saito, Shigeru

    Journal of echocardiography

    2022  Volume 21, Issue 3, Page(s) 136–137

    MeSH term(s) Humans ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/etiology ; Mitral Valve Insufficiency/surgery ; Echocardiography, Transesophageal ; Aortic Valve Insufficiency/complications ; Aortic Valve Insufficiency/diagnostic imaging ; Echocardiography ; Mitral Valve/diagnostic imaging
    Language English
    Publishing date 2022-06-24
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2209473-8
    ISSN 1880-344X ; 1349-0222
    ISSN (online) 1880-344X
    ISSN 1349-0222
    DOI 10.1007/s12574-022-00579-4
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  4. Article: Impact of a new dedicated sheath device for tissue sampling of biliary stricture on pathological diagnostic yield: Retrospective study.

    Niiya, Fumitaka / Ishiwatari, Hirotoshi / Sasaki, Keiko / Ishikawa, Kazuma / Sato, Junya / Kishida, Yoshihiro / Imai, Kenichiro / Hotta, Kinichi / Ono, Hiroyuki

    Endoscopy international open

    2024  Volume 12, Issue 4, Page(s) E561–E567

    Abstract: Background and study ... ...

    Abstract Background and study aims
    Language English
    Publishing date 2024-04-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722
    ISSN (online) 2196-9736
    ISSN 2364-3722
    DOI 10.1055/a-2284-9622
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  5. Article ; Online: The association of long working hours and short sleep duration on mental health among Japanese physicians.

    Matsuura, Yushi / Tomooka, Kiyohide / Wada, Hiroo / Sato, Setsuko / Endo, Motoki / Taneda, Kenichiro / Tanigawa, Takeshi

    Industrial health

    2024  

    Abstract: This cross-sectional study investigate the association between long working hours, short sleep duration, and mental health among Japanese physicians. We enrolled 232 Japanese physicians. We used the Brief Job Stress Questionnaire to assess high-stress ... ...

    Abstract This cross-sectional study investigate the association between long working hours, short sleep duration, and mental health among Japanese physicians. We enrolled 232 Japanese physicians. We used the Brief Job Stress Questionnaire to assess high-stress status, and the Japanese version of the Center for Epidemiologic Studies Depression scale to assess depressive status. Daily sleep duration (DSD) and weekly working hours (WWHs) were collected using a self-administered questionnaire. Multivariable-adjusted logistic regression analysis was performed to examine the association of the combined categories of DSD and WWHs with high-stress and depressive status. Compared to physicians with WWHs <80 h and DSD ≥6 h, the multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of high-stress status for those with WWHs ≥80 and DSD ≥6, WWHs <80 and DSD <6, and WWHs ≥80 and DSD <6 were 2.76 (0.97-7.87), 3.36 (1.53-7.40), and 3.92 (1.52-10.14), respectively. The respective ORs (CIs) of depressive status were 1.82 (0.42-7.81), 4.03 (1.41-11.53), and 4.69 (1.33-16.62). The results showed that regardless of working long hours or not, physicians with DSD <6 h had significantly higher stress and depressive status, suggesting that not only regulating long working hours but also ensuring adequate sleep duration is important for preventing physicians' mental health.
    Language English
    Publishing date 2024-04-16
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 214185-1
    ISSN 1880-8026 ; 0019-8366
    ISSN (online) 1880-8026
    ISSN 0019-8366
    DOI 10.2486/indhealth.2023-0174
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1404: Show issues Location:
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  6. Article: Advertisement by medical facilities as an opportunity route of APOE genetic testing in Japan: a website analysis.

    Sato, Kenichiro / Niimi, Yoshiki / Ihara, Ryoko / Iwata, Atsushi / Ikeuchi, Takeshi / Iwatsubo, Takeshi

    Journal of community genetics

    2024  Volume 15, Issue 2, Page(s) 195–204

    Abstract: The APOE-ε4 allele(s) is a strong risk factor for Alzheimer's disease (AD). A significant point of access for this allele testing is through services provided by medical facilities in Japan, which advertise out-of-insurance APOE testing on their websites. ...

    Abstract The APOE-ε4 allele(s) is a strong risk factor for Alzheimer's disease (AD). A significant point of access for this allele testing is through services provided by medical facilities in Japan, which advertise out-of-insurance APOE testing on their websites. There is a concern that website advertisements for APOE testing may influence the ability for individuals to adequately self-determine whether to undergo APOE testing. We conducted a cross-sectional survey on medical facility websites in Japan advertising APOE genetic testing. We predefined desirable features for advertisement descriptions based on legal regulations and guidelines published by relevant professional societies and evaluated each website according to these features. We identified 220 medical facilities that had posted advertisements on their websites for the provision of APOE genetic testing, of which 85% were small clinics. Contact information, details, and costs of testing were described in most of the websites. Meanwhile, features such as "explaining APOE as a risk gene," "notes on interpreting APOE results," or "explaining examination methods" (e.g., blood sampling) were described to a variable degree depending on individual facilities. "Notes on genetic testing" or "referring to genetic counseling" were hardly referred to, and specialists with appropriate expertise were considered to participate in clinical practice in approximately one-third of these facilities providing APOE testing services. These website evaluation results showed moderate to substantial reliability between independent raters. These results suggest that self-determination of pursuing out-of-insurance APOE testing at some medical facilities in Japan may possibly be influenced in an inappropriate manner, at least in its entry route of taking the test.
    Language English
    Publishing date 2024-01-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2543127-4
    ISSN 1868-6001 ; 1868-310X
    ISSN (online) 1868-6001
    ISSN 1868-310X
    DOI 10.1007/s12687-024-00697-9
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  7. Article: Successful Systemic Steroid Administration for the Treatment of Edematous Anastomotic Stenosis After the Laparoscopic Augmented Rectangle Technique for Billroth I Reconstruction for Laparoscopic Distal Gastrectomy.

    Ito, Tomoaki / Sakurada, Mutsumi / Kushida, Tomoyuki / Tanaka, Kenichiro / Sato, Koichi

    Cureus

    2023  Volume 15, Issue 6, Page(s) e40914

    Abstract: Edematous anastomotic stenosis is a well-known complication following Billroth I anastomosis for distal gastrectomy. Currently, there is no established treatment for this condition. A 54-year-old female patient underwent the augmented rectangle technique ...

    Abstract Edematous anastomotic stenosis is a well-known complication following Billroth I anastomosis for distal gastrectomy. Currently, there is no established treatment for this condition. A 54-year-old female patient underwent the augmented rectangle technique for Billroth I reconstruction after total laparoscopic distal gastrectomy for early gastric cancer. On postoperative day (POD) 9, the patient started vomiting. During the conservative waiting period, edematous anastomotic stenosis was diagnosed using imaging on PODs 11 and 13. Systemic steroid administration was initiated on POD 13, and the drainage volume of the nasogastric tube decreased four days after initiation. The edematous anastomosis stenosis improved, and gastrografin flowed into the duodenum on POD 19. Food intake was started on POD 20. Oral steroid administration was continued after hospital discharge and gradually terminated. Systemic steroid treatment may help improve edematous anastomotic stenosis.
    Language English
    Publishing date 2023-06-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.40914
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  8. Article ; Online: APOE-ε4 allele[s]-associated adverse events reported from placebo arm in clinical trials for Alzheimer's disease

    Kenichiro Sato / Yoshiki Niimi / Ryoko Ihara / Kazushi Suzuki / Atsushi Iwata / Takeshi Iwatsubo

    Frontiers in Dementia, Vol

    implications for anti-amyloid beta therapy

    2024  Volume 2

    Abstract: APOE-ε4 allele[s] is a risk factor for Alzheimer's disease (AD) and Amyloid-Related Imaging Abnormalities (ARIA) in anti-amyloid beta therapy, and is also associated with cerebrovascular risk factors such as hyperlipidemia or atherosclerosis. During AD ... ...

    Abstract APOE-ε4 allele[s] is a risk factor for Alzheimer's disease (AD) and Amyloid-Related Imaging Abnormalities (ARIA) in anti-amyloid beta therapy, and is also associated with cerebrovascular risk factors such as hyperlipidemia or atherosclerosis. During AD clinical trials, APOE-ε4 carriers may experience neuropsychiatric adverse events (AEs) related to these risks, complicating the differentiation of ARIA from cerebrovascular events based on symptoms. This study aimed to examine the hypothetical impact of considering the APOE-ε4 allele's risk for non-ARIA AEs during AD clinical trials. We used data from the Critical Path for Alzheimer's Disease (CPAD) from the placebo arm of randomized controlled trials (RCT) for AD treatment. We determined whether AEs were reported more frequently in APOE-ε4 carriers, quantifying with reporting odds ratio (ROR) using a mixed effect model. We also evaluated the association between ROR levels and the prior probability that an AE is symptomatic ARIA. We analyzed 6,313 patients with AD or mild cognitive impairment in 28 trials. Of the prespecified 35 neuropsychiatric or related AEs, several had a significantly high ROR: “delusion” (ROR = 4.133), “confusional state” (ROR = 1.419), “muscle spasms” (ROR = 9.849), “irritability” (ROR = 12.62), “sleep disorder” (ROR = 2.944), or “convulsion” (ROR = 13.00). However, none remained significant after adjusting for Mini-Mental State Examination scores. There is no strong evidence to suggest that specific neuropsychiatric AEs occur more frequently without drug treatment association among APOE-ε4 carriers. The influence of APOE-ε4 allele[s] on the clinicians' assessment of the likelihood of ARIA during safety monitoring in anti-amyloid beta monoclonal antibody treatment might be unchanged, thus maintaining the current level of awareness of clinicians of AEs.
    Keywords adverse event ; APOE ; Amyloid-Related Imaging Abnormalities ; ARIA ; Alzheimer's disease ; disease-modifying therapy ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Successful ultrathin bronchoscopy with cryobiopsy for diagnosing and removing mucus plugs in allergic bronchopulmonary mycosis mimicking lung cancer.

    Takigawa, Yuki / Watanabe, Hiromi / Sato, Ken / Goda, Mayu / Inoue, Tomoyoshi / Fujiwara, Miho / Matsuoka, Suzuka / Kudo, Kenichiro / Sato, Akiko / Fujiwara, Keiichi / Shibayama, Takuo

    Respirology case reports

    2024  Volume 12, Issue 4, Page(s) e01359

    Abstract: In patients presenting with abnormal pulmonary nodules, especially those with a history of asthma, allergic bronchopulmonary mycosis should be considered. Eosinophil counts and IgE levels should be checked in such patients. ...

    Abstract In patients presenting with abnormal pulmonary nodules, especially those with a history of asthma, allergic bronchopulmonary mycosis should be considered. Eosinophil counts and IgE levels should be checked in such patients.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2750180-2
    ISSN 2051-3380
    ISSN 2051-3380
    DOI 10.1002/rcr2.1359
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  10. Article ; Online: [Survey on the Current Advertising and Sales of Mucuna pruriens in Consumer-to-consumer Internet Trading in Japan].

    Sato, Kenichiro / Hida, Ayumi / Niimi, Yoshiki / Iwata, Atsushi / Iwatsubo, Takeshi

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2023  Volume 143, Issue 12, Page(s) 1057–1067

    Abstract: Mucuna pruriens (MP) is leguminous plant which contains 5% of L-3,4-dihydroxyphenylalanine (levodopa) in its seeds. It may have a potential to be used as an alternative therapy for Parkinson's disease (PD). Meanwhile, there is a concern in terms of ... ...

    Abstract Mucuna pruriens (MP) is leguminous plant which contains 5% of L-3,4-dihydroxyphenylalanine (levodopa) in its seeds. It may have a potential to be used as an alternative therapy for Parkinson's disease (PD). Meanwhile, there is a concern in terms of public health that MP products can be overused by patients with PD. As an entry for patients with PD to acquire MP products in Japan, they are often purchased via internet auctions or free markets. MP products are not reagrded as 'pharmatheutical' by Japanese law as long as the specific legal requirements on advertisements are met, so that the MP products can be advertised or sold without any permission from the authorities. In this study, we aimed to conduct internet survey as to the complianse status of these legal requirements. Several major internet auction or free market websites in Japan were surveyed in May-June 2023 by the authors, and 1157 MP product pages were examined. We found approximately 30-40% of the MP products were suspected to have potential legal risks in terms of their advertisements in their website descriptions, such as claiming pharmatheutical efficacy or describing pharmatheutical-like dosages. In addition, approximately 30-40% of the MP products also did not refer to cautions not to take MP products excessively because of the levodopa ingredients. Current study suggested the need of careful description of the MP products in the auction or free market websites for the MP products exhibitors or sellers, in order to fullfill legal requirements as well as to prevent MP abuse.
    MeSH term(s) Humans ; Levodopa/therapeutic use ; Mucuna ; Advertising ; Phytotherapy ; Japan ; Parkinson Disease/drug therapy ; Plant Extracts/therapeutic use
    Chemical Substances Levodopa (46627O600J) ; Plant Extracts
    Language Japanese
    Publishing date 2023-10-13
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.23-00145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 643: Show issues Location:
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