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  1. Article ; Online: A Glycoprotein Mutation That Emerged during the 2013-2016 Ebola Virus Epidemic Alters Proteolysis and Accelerates Membrane Fusion.

    Fels, J Maximilian / Bortz, Robert H / Alkutkar, Tanwee / Mittler, Eva / Jangra, Rohit K / Spence, Jennifer S / Chandran, Kartik

    mBio

    2021  Volume 12, Issue 1

    Abstract: Genomic surveillance of viral isolates during the 2013-2016 Ebola virus epidemic in Western Africa, the largest and most devastating filovirus outbreak on record, revealed several novel mutations. The responsible strain, named Makona, carries an A-to-V ... ...

    Abstract Genomic surveillance of viral isolates during the 2013-2016 Ebola virus epidemic in Western Africa, the largest and most devastating filovirus outbreak on record, revealed several novel mutations. The responsible strain, named Makona, carries an A-to-V substitution at position 82 (A82V) in the glycoprotein (GP), which is associated with enhanced infectivity
    MeSH term(s) Africa, Western ; Amino Acid Substitution/genetics ; Animals ; Cathepsin L/metabolism ; Cell Line ; Chlorocebus aethiops ; Ebolavirus/genetics ; Epidemics ; Hemorrhagic Fever, Ebola/virology ; Humans ; Membrane Fusion/genetics ; Mutation ; Proteolysis ; Vero Cells ; Viral Envelope Proteins/genetics ; Virus Internalization
    Chemical Substances Viral Envelope Proteins ; Cathepsin L (EC 3.4.22.15)
    Language English
    Publishing date 2021-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.03616-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry.

    Fels, J Maximilian / Spence, Jennifer S / Bortz, Robert H / Bornholdt, Zachary A / Chandran, Kartik

    mBio

    2019  Volume 10, Issue 4

    Abstract: Ebola virus (EBOV) causes highly lethal disease outbreaks against which no FDA-approved countermeasures are available. Although many host factors exploited by EBOV for cell entry have been identified, including host cell surface phosphatidylserine ... ...

    Abstract Ebola virus (EBOV) causes highly lethal disease outbreaks against which no FDA-approved countermeasures are available. Although many host factors exploited by EBOV for cell entry have been identified, including host cell surface phosphatidylserine receptors, endosomal cysteine proteases, and the lysosomal cholesterol trafficking protein NPC1, key questions remain. Specifically, late entry steps culminating in viral membrane fusion remain enigmatic. Here, we investigated a set of glycoprotein (GP) mutants previously hypothesized to be entry defective and identified one mutation, R64A, that abolished infection with no apparent impact on GP expression, folding, or viral incorporation. R64A profoundly thermostabilized EBOV GP and rendered it highly resistant to proteolysis
    MeSH term(s) Animals ; Chlorocebus aethiops ; Ebolavirus/genetics ; Ebolavirus/physiology ; Mutation ; Niemann-Pick C1 Protein/genetics ; Vero Cells ; Viral Envelope Proteins/genetics ; Virus Internalization
    Chemical Substances Niemann-Pick C1 Protein ; Viral Envelope Proteins ; envelope glycoprotein, Ebola virus
    Language English
    Publishing date 2019-07-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.01408-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Secretory Carcinoma of the Lacrimal Gland: A Rare Case Report.

    Bortz, John G / Zhang, Paul J L / Eagle, Ralph C / Yong, Jennifer J / Milman, Tatyana

    Ophthalmic plastic and reconstructive surgery

    2018  Volume 34, Issue 5, Page(s) e154–e157

    Abstract: Secretory carcinoma is a salivary gland malignancy that recapitulates secretory carcinoma of the breast, along with its shared ETV6-NTRK3 gene fusion. Characterization of histopathologic, immunohistochemical, and molecular genetic features of this ... ...

    Abstract Secretory carcinoma is a salivary gland malignancy that recapitulates secretory carcinoma of the breast, along with its shared ETV6-NTRK3 gene fusion. Characterization of histopathologic, immunohistochemical, and molecular genetic features of this neoplasm has led to reclassification of a heterogeneous group of salivary gland carcinomas as secretory carcinoma and to identification of this neoplasm in other gland-containing tissues. The authors describe a 52-year-old man who presented with a 2-week history of diplopia and a well-circumscribed right orbital mass. The tumor was resected via lateral orbitotomy approach. Pathologic evaluation demonstrated secretory carcinoma, previously not described in the main lacrimal gland. Recognition of lacrimal gland secretory carcinoma may lead to reappraisal of morphologically similar, but biologically heterogeneous lacrimal gland neoplasms, providing an insight into this tumor's clinical presentation and prognosis. Accurate diagnosis of this malignancy has important management and prognostic implications, particularly with emergence of targeted therapies.
    MeSH term(s) Carcinoma/pathology ; Eye Neoplasms/pathology ; Humans ; Lacrimal Apparatus Diseases/pathology ; Male ; Middle Aged
    Language English
    Publishing date 2018-07-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 632830-1
    ISSN 1537-2677 ; 0740-9303
    ISSN (online) 1537-2677
    ISSN 0740-9303
    DOI 10.1097/IOP.0000000000001173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2159: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article: Neuropsychiatric and memory issues in epilepsy.

    Bortz, Jennifer J

    Mayo Clinic proceedings

    2003  Volume 78, Issue 6, Page(s) 781–787

    Abstract: Epilepsy is an extremely complex disorder characterized by marked variability in clinical presentation, etiology, diagnostic certainty, and therapeutic options. Neuropsychiatric and cognitive concomitant disorders are equally diverse and complex. ... ...

    Abstract Epilepsy is an extremely complex disorder characterized by marked variability in clinical presentation, etiology, diagnostic certainty, and therapeutic options. Neuropsychiatric and cognitive concomitant disorders are equally diverse and complex. Depression and anxiety, for example, may be preexisting conditions, occur only in peri-ictal or ictal states, or persist as constant interictal phenomena; both place additional burden on memory functions, which are further taxed by the effects of recurrent seizures, temporal lobe insult, and antiseizure medications. Such factors present considerable clinical challenges, particularly in outpatient settings. This article provides an overview of major psychiatric features of epilepsy and of issues regarding the nature of memory deficits in this neurologic population. The importance of identifying and treating potentially reversible causes of memory impairment and related forms of cognitive impairment is emphasized.
    MeSH term(s) Anticonvulsants/adverse effects ; Anxiety/etiology ; Awareness ; Cognition Disorders/etiology ; Depression/etiology ; Epilepsy/complications ; Epilepsy/drug therapy ; Epilepsy/physiopathology ; Fear ; Humans ; Memory Disorders/chemically induced ; Memory Disorders/etiology ; Memory Disorders/physiopathology ; Mental Disorders/chemically induced ; Mental Disorders/etiology ; Mental Disorders/physiopathology ; Psychotic Disorders/etiology
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2003-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.4065/78.6.781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Nurse leader mindfulness meditation program for stress management: a randomized controlled trial.

    Pipe, Teri Britt / Bortz, Jennifer J / Dueck, Amylou / Pendergast, Debra / Buchda, Vicki / Summers, Jay

    The Journal of nursing administration

    2009  Volume 39, Issue 3, Page(s) 130–137

    Abstract: Objective: The aim of this study was to rigorously evaluate a brief stress management intervention for nurse leaders.: Background: Despite the nursing shortage, evidence-based workplace approaches addressing nurse stress have not been well studied.!## ...

    Abstract Objective: The aim of this study was to rigorously evaluate a brief stress management intervention for nurse leaders.
    Background: Despite the nursing shortage, evidence-based workplace approaches addressing nurse stress have not been well studied.
    Methods: Nurse leaders (n = 33) were randomly assigned to brief mindfulness meditation course (MMC) or leadership course (control). Self-report measures of stress were administered at baseline and within 1 week of course completion.
    Results: Among MMC participants, change scores (from baseline to postintervention) on several subscales of the Symptom Checklist 90-Revised showed significantly more improvement in self-reported stress symptoms relative to controls. Mindfulness meditation course participants had significantly more improvement in Positive Symptom Distress Index (P = 0.010; confidence interval [CI] = -0.483 to -0.073) and Global Severity Index (P = 0.019; CI = -0.475 to -0.046) and nearly significantly more improvement in Positive Symptom Total (P = 0.066; CI = -16.66 to 0.581) compared with controls.
    Conclusion: Results support preliminary effectiveness of a 4-week MMC in reducing self-reported stress symptoms among nursing leaders.
    MeSH term(s) Burnout, Professional/prevention & control ; Depression/prevention & control ; Depression/psychology ; Health Knowledge, Attitudes, Practice ; Humans ; Leadership ; Meditation ; Nurses ; Program Development ; Stress, Psychological/epidemiology ; Stress, Psychological/prevention & control ; Stress, Psychological/psychology
    Language English
    Publishing date 2009-03
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 193141-6
    ISSN 1539-0721 ; 1539-073X ; 0002-0443
    ISSN (online) 1539-0721 ; 1539-073X
    ISSN 0002-0443
    DOI 10.1097/NNA.0b013e31819894a0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1008: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article: Neurocysticercosis: nursing perspectives.

    Shulman, Deborah L / Cleary, Barbara B / Bortz, Jennifer J / Sirven, Joseph I / Drazkowski, Joseph F / Zimmerman, Richard S

    The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses

    2003  Volume 34, Issue 5, Page(s) 237–241

    Abstract: Management of neurocysticercosis (NCC) is mostly by means of prevention and antihelminthic medications. We reviewed the role of medical and surgical intervention in patients with NCC lesions. We also identified two patients with isolated NCC lesions to ... ...

    Abstract Management of neurocysticercosis (NCC) is mostly by means of prevention and antihelminthic medications. We reviewed the role of medical and surgical intervention in patients with NCC lesions. We also identified two patients with isolated NCC lesions to determine whether they might be rendered seizure free through surgical removal of the lesion. The two patients, one male and one female, ages 21 and 43 years, respectively, presented with generalized seizures. Electroencephalograms showed focal slowing consistent with the site of the lesion and had failed antiepileptic drug therapy. Magnetic resonance imaging scans showed a distinct single-ring-enhanced lesion in each patient consistent with late-stage NCC. The patients underwent surgery with ultrasonagraphic guidance to remove the cysts. Surgery involved resection of the suspected calcified neurocystic lesion. Both patients have been seizure free since surgery. Patients with a single calcified neurocystic lesion may benefit from surgery for control of seizures. Prospective evaluations are needed to assess the timing of surgery in relation to the stage of the disease. Nurses play a significant role in the primary prevention of this disease and care throughout treatment.
    MeSH term(s) Adult ; Female ; Humans ; Male ; Neurocysticercosis/diagnosis ; Neurocysticercosis/nursing ; Neurocysticercosis/therapy ; Taenia solium/growth & development
    Language English
    Publishing date 2003-04-01
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 632790-4
    ISSN 0888-0395
    ISSN 0888-0395
    DOI 10.1097/01376517-200210000-00003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1501: Show issues Location:
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