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  1. Article: A

    Sheikh, Md Abdul Kuddus / Kowal, Dominik / Mahyuddin, Muhammad Haris / Cala', Roberto / Auffray, Etiennette / Witkowski, Marcin Eugeniusz / Makowski, Michal / Drozdowski, Winicjusz / Wang, Hong / Dujardin, Christophe / Cortecchia, Daniele / Birowosuto, Muhammad Danang

    The journal of physical chemistry. C, Nanomaterials and interfaces

    2023  Volume 127, Issue 22, Page(s) 10737–10747

    Abstract: Quantum-well (QW) hybrid organic-inorganic perovskite (HOIP) crystals, e.g., ... ...

    Abstract Quantum-well (QW) hybrid organic-inorganic perovskite (HOIP) crystals, e.g., A
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Journal Article
    ISSN 1932-7447
    ISSN 1932-7447
    DOI 10.1021/acs.jpcc.3c00824
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  2. Article ; Online: T Cells, Interleukin-2 and Systemic Lupus Erythematosus-From Pathophysiology to Therapy.

    Mak, Anselm

    Cells

    2022  Volume 11, Issue 6

    Abstract: The phenotypic and functional complexities of T cells engender complicated and often confusing concepts as to how T cells ignite, accelerate and brake the inflammatory processes involved in systemic lupus erythematosus (SLE), let alone the plasticity of ... ...

    Abstract The phenotypic and functional complexities of T cells engender complicated and often confusing concepts as to how T cells ignite, accelerate and brake the inflammatory processes involved in systemic lupus erythematosus (SLE), let alone the plasticity of T cells that takes place under different immunological contexts. Nevertheless, being one of the prime survival factors of T cells, interleukin (IL)-2 plays a potentially critical role in many immunological scenarios during the pathophysiological process of SLE. Here, the pathophysiology of lupus T cells and current, as well as ongoing, therapeutic approaches of SLE that involve low-dose IL-2 administration will be highlighted. The mechanisms of IL-2 deficiency in SLE pathophysiology, the effects of low-dose IL-2 on T cells and restoration of lupus manifestations in murine SLE models, as well as the efficacy and safety of clinical trials that evaluated low-dose IL-2-containing regimens in patients with SLE will be discussed.
    MeSH term(s) Animals ; Humans ; Interleukin-2 ; Lupus Erythematosus, Systemic ; Mice ; T-Lymphocytes, Regulatory
    Chemical Substances Interleukin-2
    Language English
    Publishing date 2022-03-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11060980
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  3. Article ; Online: Canonical and Non-Canonical Localization of Tight Junction Proteins during Early Murine Cranial Development.

    Mak, Shermin / Hammes, Annette

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: This study investigates the intricate composition and spatial distribution of tight junction complex proteins during early mouse neurulation. The analyses focused on the cranial neural tube, which gives rise to all head structures. Neurulation brings ... ...

    Abstract This study investigates the intricate composition and spatial distribution of tight junction complex proteins during early mouse neurulation. The analyses focused on the cranial neural tube, which gives rise to all head structures. Neurulation brings about significant changes in the neuronal and non-neuronal ectoderm at a cellular and tissue level. During this process, precise coordination of both epithelial integrity and epithelial dynamics is essential for accurate tissue morphogenesis. Tight junctions are pivotal for epithelial integrity, yet their complex composition in this context remains poorly understood. Our examination of various tight junction proteins in the forebrain region of mouse embryos revealed distinct patterns in the neuronal and non-neuronal ectoderm, as well as mesoderm-derived mesenchymal cells. While claudin-4 exhibited exclusive expression in the non-neuronal ectoderm, we demonstrated a neuronal ectoderm specific localization for claudin-12 in the developing cranial neural tube. Claudin-5 was uniquely present in mesenchymal cells. Regarding the subcellular localization, canonical tight junction localization in the apical junctions was predominant for most tight junction complex proteins. ZO-1 (zona occludens protein-1), claudin-1, claudin-4, claudin-12, and occludin were detected at the apical junction. However, claudin-1 and occludin also appeared in basolateral domains. Intriguingly, claudin-3 displayed a non-canonical localization, overlapping with a nuclear lamina marker. These findings highlight the diverse tissue and subcellular distribution of tight junction proteins and emphasize the need for their precise regulation during the dynamic processes of forebrain development. The study can thereby contribute to a better understanding of the role of tight junction complex proteins in forebrain development.
    MeSH term(s) Mice ; Animals ; Tight Junction Proteins/metabolism ; Claudin-4/metabolism ; Claudin-1/metabolism ; Occludin/metabolism ; Claudin-3/metabolism ; Tight Junctions/metabolism ; Zonula Occludens-1 Protein/metabolism ; Claudins/metabolism
    Chemical Substances Tight Junction Proteins ; Claudin-4 ; Claudin-1 ; Occludin ; Claudin-3 ; Zonula Occludens-1 Protein ; Claudins
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031426
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  4. Article ; Online: Physical exercise and systemic lupus erythematosus.

    Mak, Anselm

    Rheumatology (Oxford, England)

    2019  Volume 59, Issue 5, Page(s) 921–922

    MeSH term(s) Cardiovascular Diseases ; Exercise ; Humans ; Lupus Erythematosus, Systemic ; Risk Factors ; Sedentary Behavior
    Language English
    Publishing date 2019-12-18
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kez534
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  5. Article ; Online: The Impact of Vitamin D on the Immunopathophysiology, Disease Activity, and Extra-Musculoskeletal Manifestations of Systemic Lupus Erythematosus.

    Mak, Anselm

    International journal of molecular sciences

    2018  Volume 19, Issue 8

    Abstract: Over the past two decades it has been increasingly recognized that vitamin D, aside from its crucial involvement in calcium and phosphate homeostasis and the dynamics of the musculoskeletal system, exerts its influential impact on the immune system. The ... ...

    Abstract Over the past two decades it has been increasingly recognized that vitamin D, aside from its crucial involvement in calcium and phosphate homeostasis and the dynamics of the musculoskeletal system, exerts its influential impact on the immune system. The mechanistic roles that vitamin D plays regarding immune activation for combating infection, as well as pathologically and mediating autoimmune conditions, have been progressively unraveled. In vitro and in vivo models have demonstrated that the action of vitamin D on various immunocytes is not unidirectional. Rather, how vitamin D affects immunocyte functions depends on the context of the immune response, in the way that its suppressive or stimulatory action offers physiologically appropriate and immunologically advantageous outcomes. In this review, the relationship between various aspects of vitamin D, starting from its adequacy in circulation to its immunological functions, as well as its autoimmune conditions, in particular systemic lupus erythematosus (SLE), a prototype autoimmune condition characterized by immune-complex mediated inflammation, will be discussed. Concurring with other groups of investigators, our group found that vitamin D deficiency is highly prevalent in patients with SLE. Furthermore, the circulating vitamin D levels appear to be correlated with a higher disease activity of SLE as well as extra-musculoskeletal complications of SLE such as fatigue, cardiovascular risk, and cognitive impairment.
    MeSH term(s) Animals ; Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/pathology ; Musculoskeletal Diseases/genetics ; Musculoskeletal Diseases/immunology ; Musculoskeletal Diseases/pathology ; Vitamin D/immunology ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/immunology ; Vitamin D Deficiency/pathology
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2018-08-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19082355
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  6. Article: Assessment of Undernutrition in Pediatric Chronic Kidney Disease - Gaps and Opportunities.

    Iyengar, Arpana / Mak, Robert H

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 866498

    Language English
    Publishing date 2022-05-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.866498
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  7. Article ; Online: Steps for Conducting a Scoping Review.

    Mak, Susanne / Thomas, Aliki

    Journal of graduate medical education

    2022  Volume 14, Issue 5, Page(s) 565–567

    MeSH term(s) Humans ; Internship and Residency ; Evidence-Based Medicine ; Research Design
    Language English
    Publishing date 2022-10-24
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2578612-X
    ISSN 1949-8357 ; 1949-8357
    ISSN (online) 1949-8357
    ISSN 1949-8357
    DOI 10.4300/JGME-D-22-00621.1
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  8. Article ; Online: An Introduction to Scoping Reviews.

    Mak, Susanne / Thomas, Aliki

    Journal of graduate medical education

    2022  Volume 14, Issue 5, Page(s) 561–564

    MeSH term(s) Humans ; Internship and Residency ; Evidence-Based Medicine ; Research Design
    Language English
    Publishing date 2022-10-20
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2578612-X
    ISSN 1949-8357 ; 1949-8357
    ISSN (online) 1949-8357
    ISSN 1949-8357
    DOI 10.4300/JGME-D-22-00620.1
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  9. Article ; Online: Endothelial function and endothelial progenitor cells in systemic lupus erythematosus.

    Mak, Anselm / Chan, Jerry Kok Yen

    Nature reviews. Rheumatology

    2022  Volume 18, Issue 5, Page(s) 286–300

    Abstract: The observations that traditional cardiovascular disease (CVD) risk factors fail to fully account for the excessive cardiovascular mortality in patients with systemic lupus erythematosus (SLE) compared with the general population have prompted in-depth ... ...

    Abstract The observations that traditional cardiovascular disease (CVD) risk factors fail to fully account for the excessive cardiovascular mortality in patients with systemic lupus erythematosus (SLE) compared with the general population have prompted in-depth investigations of non-traditional, SLE-related risk factors that contribute to cardiovascular complications in patients with SLE. Of the various perturbations of vascular physiology, endothelial dysfunction, which is believed to occur in the earliest step of atherosclerosis, has been extensively investigated for its contribution to CVD risk in SLE. Endothelial progenitor cells (EPCs), which play a crucial part in vascular repair, neovascularization and maintenance of endothelial function, are quantitatively and functionally reduced in patients with SLE. Yet, the lack of a unified definition of EPCs, standardization of the quantity and functional assessment of EPCs as well as endothelial function measurement pose challenges to the translation of endothelial function measurements and EPC levels into prognostic markers for CVD in patients with SLE. This Review discusses factors that contribute to CVD in SLE, with particular focus on how endothelial function and EPCs are evaluated currently, and how EPCs are quantitatively and functionally altered in patients with SLE. Potential strategies for the use of endothelial function measurements and EPC quantification as prognostic markers of CVD in patients with SLE, and the limitations of their prognostication potential, are also discussed.
    MeSH term(s) Atherosclerosis ; Endothelial Progenitor Cells/physiology ; Humans ; Lupus Erythematosus, Systemic/epidemiology ; Neovascularization, Pathologic ; Risk Factors
    Language English
    Publishing date 2022-04-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-022-00770-y
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  10. Article ; Online: Unraveling attrition and retention: A qualitative study with rehabilitation professionals.

    Mak, Susanne / Thomas, Aliki / Razack, Saleem / Root, Kelly / Hunt, Matthew

    Work (Reading, Mass.)

    2024  

    Abstract: Background: Health human resources are scarce worldwide. In occupational therapy (OT), physical therapy (PT), and speech-language pathology (S-LP), attrition and retention issues amplify this situation and contribute to the precarity of health systems.!# ...

    Abstract Background: Health human resources are scarce worldwide. In occupational therapy (OT), physical therapy (PT), and speech-language pathology (S-LP), attrition and retention issues amplify this situation and contribute to the precarity of health systems.
    Objective: To investigate the phenomena of attrition and retention with OTs, PTs and S-LPs who stayed in, or left their profession.
    Methods: Cultural-historical activity theory provided the theoretical scaffolding for this interpretive description study. We used purposeful sampling (maximum variation approach) to recruit OTs, PTs, and S-LPs from Quebec, Canada. Individual interviews were conducted with 51 OTs, PTs, and S-LPs from Quebec, Canada, in English or French (2019-2020). Inductive and deductive approaches, and constant comparative techniques were used for data analysis.
    Results: Six themes were developed: 1) characteristics of work that made it meaningful; 2) aspects of work that practitioners appreciate; 3) factors of daily work that weigh on a practitioner; 4) factors that contribute to managing work; 5) relationships with different stakeholders that shape daily work; and 6) perceptions of the profession. Meaningfulness was tied to participants' sense that their values were reflected in their work. Factors outside work shaped participants' work experiences. Recurrent negative experiences led some to leave their profession.
    Conclusion: Findings underscore a critical need to address contributing factors to attrition and retention which are essential to ensuring the availability of OTs, PTs and SLPs for present and future rehabilitation needs.
    Language English
    Publishing date 2024-04-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1394194-x
    ISSN 1875-9270 ; 1051-9815
    ISSN (online) 1875-9270
    ISSN 1051-9815
    DOI 10.3233/WOR-230531
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