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  1. Article ; Online: The assessment of auditory function in CSWS: lessons from long-term outcome.

    Metz-Lutz, Marie-Noëlle

    Epilepsia

    2009  Volume 50 Suppl 7, Page(s) 73–76

    Abstract: In Landau-Kleffner syndrome (LKS), the prominent and often first symptom is auditory verbal agnosia, which may affect nonverbal sounds. It was early suggested that the subsequent decline of speech expression might result from defective auditory analysis ... ...

    Abstract In Landau-Kleffner syndrome (LKS), the prominent and often first symptom is auditory verbal agnosia, which may affect nonverbal sounds. It was early suggested that the subsequent decline of speech expression might result from defective auditory analysis of the patient's own speech. Indeed, despite normal hearing levels, the children behave as if they were deaf, and very rapidly speech expression deteriorates and leads to the receptive aphasia typical of LKS. The association of auditory agnosia more or less restricted to speech with severe language decay prompted numerous studies aimed at specifying the defect in auditory processing and its pathophysiology. Long-term follow-up studies have addressed the issue of the outcome of verbal auditory processing and the development of verbal working memory capacities following the deprivation of phonologic input during the critical period of language development. Based on a review of neurophysiologic and neuropsychological studies of auditory and phonologic disorders published these last 20 years, we discuss the association of verbal agnosia and speech production decay, and try to explain the phonologic working memory deficit in the late outcome of LKS within the Hickok and Poeppel dual-stream model of speech processing.
    MeSH term(s) Agnosia/diagnosis ; Agnosia/physiopathology ; Aphasia, Wernicke/diagnosis ; Cerebral Cortex/physiopathology ; Child ; Cognition Disorders/diagnosis ; Cognition Disorders/physiopathology ; Electroencephalography/statistics & numerical data ; Evoked Potentials, Auditory/physiology ; Humans ; Landau-Kleffner Syndrome/diagnosis ; Landau-Kleffner Syndrome/physiopathology ; Language Development Disorders/diagnosis ; Language Disorders/diagnosis ; Longitudinal Studies ; Memory, Short-Term/physiology ; Sleep/physiology ; Speech Disorders/diagnosis ; Speech Disorders/physiopathology ; Speech Production Measurement ; Temporal Lobe/physiopathology
    Language English
    Publishing date 2009-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/j.1528-1167.2009.02225.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Développement cognitif et troubles des apprentissages

    Metz-Lutz, Marie-Noëlle

    évaluer, comprendre, rééduquer et prendre en charge

    (Collection Neuropsychologie,)

    2004  

    Author's details sous la direction de Marie-Noëlle Metz-Lutz ... [et al.]
    Series title Collection Neuropsychologie,
    MeSH term(s) Communication Disorders ; Child ; Child Development
    Language French
    Size 270 p. :, ill.
    Publisher SOLAL
    Publishing place Marseille
    Document type Book
    ISBN 9782914513647 ; 291451364X
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Article ; Online: What Physiological Changes and Cerebral Traces Tell Us about Adhesion to Fiction During Theater-Watching?

    Metz-Lutz, Marie-Noëlle / Bressan, Yannick / Heider, Nathalie / Otzenberger, Hélène

    Frontiers in human neuroscience

    2010  Volume 4

    Abstract: Live theater is typically designed to alter the state of mind of the audience. Indeed, the perceptual inputs issuing from a live theatrical performance are intended to represent something else, and the actions, emphasized by the writing and staging, are ... ...

    Abstract Live theater is typically designed to alter the state of mind of the audience. Indeed, the perceptual inputs issuing from a live theatrical performance are intended to represent something else, and the actions, emphasized by the writing and staging, are the key prompting the adhesion of viewers to fiction, i.e., their belief that it is real. This phenomenon raises the issue of the cognitive processes governing access to a fictional reality during live theater and of their cerebral underpinnings. To get insight into the physiological substrates of adhesion we recreated the peculiar context of watching live drama in a functional magnetic resonance imaging (fMRI) experiment, with simultaneous recording of heart activity. The instants of adhesion were defined as the co-occurrence of theatrical events determined a priori by the stage director and the spectators' offline reports of moments when fiction acted as reality. These data served to specify, for each spectator, individual fMRI time-series, used in a random-effect group analysis to define the pattern of brain response to theatrical events. The changes in this pattern related to subjects' adhesion to fiction, were investigated using a region of interest analysis. The results showed that adhesion to theatrical events correlated with increased activity in the left BA47 and posterior superior temporal sulcus, together with a decrease in dynamic heart rate variability, leading us to discuss the hypothesis of subtle changes in the subjects' state of awareness, enabling them to mentally dissociate physical and mental (drama-viewing) experiences, to account for the phenomenon of adhesion to dramatic fiction.
    Language English
    Publishing date 2010-08-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2425477-0
    ISSN 1662-5161 ; 1662-5161
    ISSN (online) 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2010.00059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Visemic processing in audiovisual discrimination of natural speech: a simultaneous fMRI-EEG study.

    Dubois, Cyril / Otzenberger, Hélène / Gounot, Daniel / Sock, Rudolph / Metz-Lutz, Marie-Noëlle

    Neuropsychologia

    2012  Volume 50, Issue 7, Page(s) 1316–1326

    Abstract: In a noisy environment, visual perception of articulatory movements improves natural speech intelligibility. Parallel to phonemic processing based on auditory signal, visemic processing constitutes a counterpart based on "visemes", the distinctive visual ...

    Abstract In a noisy environment, visual perception of articulatory movements improves natural speech intelligibility. Parallel to phonemic processing based on auditory signal, visemic processing constitutes a counterpart based on "visemes", the distinctive visual units of speech. Aiming at investigating the neural substrates of visemic processing in a disturbed environment, we carried out a simultaneous fMRI-EEG experiment based on discriminating syllabic minimal pairs involving three phonological contrasts, each bearing on a single phonetic feature characterised by different degrees of visual distinctiveness. The contrasts involved either labialisation of the vowels, or place of articulation or voicing of the consonants. Audiovisual consonant-vowel syllable pairs were presented either with a static facial configuration or with a dynamic display of articulatory movements related to speech production. In the sound-disturbed MRI environment, the significant improvement of syllabic discrimination achieved in the dynamic audiovisual modality, compared to the static audiovisual modality was associated with activation of the occipito-temporal cortex (MT+V5) bilaterally, and of the left premotor cortex. While the former was activated in response to facial movements independently of their relation to speech, the latter was specifically activated by phonological discrimination. During fMRI, significant evoked potential responses to syllabic discrimination were recorded around 150 and 250 ms following the onset of the second stimulus of the pairs, whose amplitude was greater in the dynamic compared to the static audiovisual modality. Our results provide arguments for the involvement of the speech motor cortex in phonological discrimination, and suggest a multimodal representation of speech units.
    MeSH term(s) Acoustic Stimulation ; Adolescent ; Adult ; Analysis of Variance ; Brain/blood supply ; Brain/physiology ; Discrimination (Psychology)/physiology ; Electroencephalography ; Evoked Potentials/physiology ; Fatty Acids ; Female ; Humans ; Image Processing, Computer-Assisted ; Indoles ; Magnetic Resonance Imaging ; Male ; Oxygen/blood ; Phonetics ; Photic Stimulation ; Reaction Time ; Speech/physiology ; Time Factors ; Voice ; Young Adult
    Chemical Substances CU 23 ; Fatty Acids ; Indoles ; Oxygen (S88TT14065)
    Language English
    Publishing date 2012-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207151-4
    ISSN 1873-3514 ; 0028-3932
    ISSN (online) 1873-3514
    ISSN 0028-3932
    DOI 10.1016/j.neuropsychologia.2012.02.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Is there an alternative cerebral network associated with enhanced phonological processing in deaf speech-users? An exceptional case.

    Aparicio, Mario / Demont, Elisabeth / Gounot, Daniel / Metz-Lutz, Marie-Noëlle

    Scandinavian journal of psychology

    2009  Volume 50, Issue 5, Page(s) 445–455

    Abstract: Most people born deaf and exposed to oral language show scant evidence of sensitivity to the phonology of speech when processing written language. In this respect they differ from hearing people. However, occasionally, a prelingually deaf person can ... ...

    Abstract Most people born deaf and exposed to oral language show scant evidence of sensitivity to the phonology of speech when processing written language. In this respect they differ from hearing people. However, occasionally, a prelingually deaf person can achieve good processing of written language in terms of phonological sensitivity and awareness, and in this respect appears exceptional. We report the pattern of event-related fMRI activation in such a deaf reader while performing a rhyme-judgment on written words with similar spelling endings that do not provide rhyme clues. The left inferior frontal gyrus pars opercularis and the left inferior parietal lobe showed greater activation for this task than for a letter-string identity matching task. This participant was special in this regard, showing significantly greater activation in these regions than a group of hearing participants with a similar level of phonological and reading skill. In addition, SR showed activation in the left mid-fusiform gyrus; a region which did not show task-specific activation in the other respondents. The pattern of activation in this exceptional deaf reader was also unique compared with three deaf readers who showed limited phonological processing. We discuss the possibility that this pattern of activation may be critical in relation to phonological decoding of the written word in good deaf readers whose phonological reading skills are indistinguishable from those of hearing readers.
    MeSH term(s) Adult ; Brain Mapping ; Cerebral Cortex/physiology ; Deafness/physiopathology ; Decision Making/physiology ; Female ; Humans ; Image Processing, Computer-Assisted ; Judgment/physiology ; Language ; Language Tests ; Lipreading ; Magnetic Resonance Imaging ; Male ; Nerve Net/physiology ; Phonetics ; Photic Stimulation ; Psychomotor Performance/physiology ; Reading ; Verbal Behavior/physiology ; Visual Perception/physiology
    Language English
    Publishing date 2009-10
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 219197-0
    ISSN 1467-9450 ; 0036-5564
    ISSN (online) 1467-9450
    ISSN 0036-5564
    DOI 10.1111/j.1467-9450.2009.00749.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Neuropsychological findings in Rolandic epilepsy and Landau-Kleffner syndrome.

    Metz-Lutz, Marie-Noëlle / Filippini, Melissa

    Epilepsia

    2006  Volume 47 Suppl 2, Page(s) 71–75

    Abstract: In an attempt to correlate neuropsychological deficits and various neurophysiological aspects of focal epileptic activity in benign childhood epilepsy, we have reviewed the findings of a longitudinal group study of benign childhood epilepsy with ... ...

    Abstract In an attempt to correlate neuropsychological deficits and various neurophysiological aspects of focal epileptic activity in benign childhood epilepsy, we have reviewed the findings of a longitudinal group study of benign childhood epilepsy with centrotemporal spikes (BCECTS) and several case studies of continuous spike-waves during slow sleep syndrome (CSWS). We first distinguish the temporary neuropsychological impairments often observed in the natural history of BCECTS from the more long-lasting and more specific neuropsychological deficits associated with CSWS, of which the Landau-Kleffner syndrome (LKS) is the most studied clinical form. A series of metabolic findings from (18)FDG-PET studies in BCECTS and CSWS children have shown that specific cognitive impairment is related to increased glucose uptake in cortical areas restricted to the associative cortex coincident with the focus of spike-wave discharges. From recent functional neuroimaging data of three patients recovered from LKS, we address the issue of the pathophysiology of cognitive impairment persisting after complete recovery of epilepsy. Finally, we discuss the reliability of the study of mismatch negativity to address the issue of the early effect of interictal discharges in typical and atypical BCECTS on the auditory cortex and the development of speech processing essential to verbal learning.
    MeSH term(s) Adolescent ; Auditory Cortex/physiopathology ; Child ; Child, Preschool ; Cognition Disorders/diagnosis ; Cognition Disorders/physiopathology ; Electroencephalography/statistics & numerical data ; Epilepsy, Rolandic/diagnosis ; Epilepsy, Rolandic/physiopathology ; Fluorodeoxyglucose F18 ; Humans ; Landau-Kleffner Syndrome/diagnosis ; Landau-Kleffner Syndrome/physiopathology ; Language Development ; Longitudinal Studies ; Neuropsychological Tests/statistics & numerical data ; Positron-Emission Tomography ; Sleep/physiology ; Verbal Learning/physiology
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2006
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/j.1528-1167.2006.00695.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Phonological processing in relation to reading: an fMRI study in deaf readers.

    Aparicio, Mario / Gounot, Daniel / Demont, Elisabeth / Metz-Lutz, Marie-Noëlle

    NeuroImage

    2007  Volume 35, Issue 3, Page(s) 1303–1316

    Abstract: Without special education, early deprivation of auditory speech input, hinders the development of phonological representations and may alter the neural mechanisms of reading. By using fMRI during lexical and rhyming decision tasks, we compared in hearing ...

    Abstract Without special education, early deprivation of auditory speech input, hinders the development of phonological representations and may alter the neural mechanisms of reading. By using fMRI during lexical and rhyming decision tasks, we compared in hearing and pre-lingually deaf subjects the neural activity in functional regions of interest (ROIs) engaged in reading. The results show in deaf readers significantly higher activation in the ROIs relevant to the grapho-phonological route, but also in the posterior medial frontal cortex (pMFC) and the right inferior frontal gyrus (IFG). These adjustments may be interpreted within the dual route model of reading as an alternative strategy, which gives priority to rule-based letter-to-sound conversion. Activation in the right IFG would account for compensation mechanisms based on phonological recoding and inner speech while activation in the posterior medial frontal cortex (pMFC) may relate to the cognitive effort called for by the alternative strategy. Our data suggest that the neural mechanisms of reading are shaped by the auditory experience of speech.
    MeSH term(s) Adult ; Articulation Disorders/complications ; Articulation Disorders/physiopathology ; Brain Mapping ; Cerebral Cortex/physiopathology ; Deafness/complications ; Deafness/physiopathology ; Discrimination (Psychology) ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Phonetics ; Reading ; Speech
    Language English
    Publishing date 2007-04-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2006.12.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Reading disabilities in SLI and dyslexia result from distinct phonological impairments.

    Nithart, Christelle / Demont, Elisabeth / Majerus, Steve / Leybaert, Jacqueline / Poncelet, Martine / Metz-Lutz, Marie-Noëlle

    Developmental neuropsychology

    2009  Volume 34, Issue 3, Page(s) 296–311

    Abstract: Children with specific language impairment (SLI) who show impaired phonological processing are at risk of developing reading disabilities, which raises the question of phonological impairment commonality between developmental dyslexia (DD) and SLI. In ... ...

    Abstract Children with specific language impairment (SLI) who show impaired phonological processing are at risk of developing reading disabilities, which raises the question of phonological impairment commonality between developmental dyslexia (DD) and SLI. In order to distinguish the failing phonological processes in SLI and DD, we investigated the different steps involved in speech processing going from perceptual discrimination through various aspects of phonological memory. Our results show that whereas the memory for sequence is likewise impaired in either disorder, children with SLI have to face additional impairment in phonological discrimination and short-term memory, which may account for even poorer phonological awareness than dyslexics'.
    MeSH term(s) Adolescent ; Analysis of Variance ; Articulation Disorders/complications ; Auditory Perception ; Child ; Developmental Disabilities/physiopathology ; Dyslexia/classification ; Dyslexia/etiology ; Female ; Humans ; Language Development Disorders ; Language Tests ; Male ; Mathematics ; Memory, Short-Term/physiology ; Mental Recall/physiology ; Neuropsychological Tests ; Psycholinguistics ; Risk Factors ; Speech Perception ; Verbal Behavior/physiology
    Language English
    Publishing date 2009
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632665-1
    ISSN 1532-6942 ; 8756-5641
    ISSN (online) 1532-6942
    ISSN 8756-5641
    DOI 10.1080/87565640902801841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Reliability of individual functional MRI brain mapping of language.

    Otzenberger, Hélène / Gounot, Daniel / Marrer, Corinne / Namer, Izzie Jacques / Metz-Lutz, Marie-Noëlle

    Neuropsychology

    2005  Volume 19, Issue 4, Page(s) 484–493

    Abstract: The use of individual brain mapping for a single case study implicitly assumes that the pattern of activation obtained in a single session represents the subject's functional neuroanatomy. It is therefore essential to estimate the potential variability ... ...

    Abstract The use of individual brain mapping for a single case study implicitly assumes that the pattern of activation obtained in a single session represents the subject's functional neuroanatomy. It is therefore essential to estimate the potential variability of brain activation in individuals. To this purpose, the authors compared the pattern of activation determined by statistical parametric mapping (SPM 99) in 9 subjects who repeated 3 verbal tasks in 3 separate sessions. In each subject for each task, the authors examined the intersession variability of the volume of activation in a set of regions classically implicated in language processing. Their results show that reproducibility of functional MRI brain mapping for language within subject varies as a function of the activation task and the region of interest for language.
    MeSH term(s) Adult ; Brain/physiology ; Brain Mapping ; Female ; Functional Laterality ; Humans ; Image Processing, Computer-Assisted/methods ; Language ; Language Tests ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Reproducibility of Results ; Verbal Learning
    Language English
    Publishing date 2005-07
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1042412-x
    ISSN 1931-1559 ; 0894-4105
    ISSN (online) 1931-1559
    ISSN 0894-4105
    DOI 10.1037/0894-4105.19.4.484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Unsupervised learning and mapping of active brain functional MRI signals based on hidden semi-Markov event sequence models.

    Faisan, Sylvain / Thoraval, Laurent / Armspach, Jean-Paul / Metz-Lutz, Marie-Noëlle / Heitz, Fabrice

    IEEE transactions on medical imaging

    2005  Volume 24, Issue 2, Page(s) 263–276

    Abstract: In this paper, a novel functional magnetic resonance imaging (fMRI) brain mapping method is presented within the statistical modeling framework of hidden semi-Markov event sequence models (HSMESMs). Neural activation detection is formulated at the voxel ... ...

    Abstract In this paper, a novel functional magnetic resonance imaging (fMRI) brain mapping method is presented within the statistical modeling framework of hidden semi-Markov event sequence models (HSMESMs). Neural activation detection is formulated at the voxel level in terms of time coupling between the sequence of hemodynamic response onsets (HROs) observed in the fMRI signal, and an HSMESM of the hidden sequence of task-induced neural activations. The sequence of HRO events is derived from a continuous wavelet transform (CWT) of the fMRI signal. The brain activation HSMESM is built from the timing information of the input stimulation protocol. The rich mathematical framework of HSMESMs makes these models an effective and versatile approach for fMRI data analysis. Solving for the HSMESM Evaluation and Learning problems enables the model to automatically detect neural activation embedded in a given set of fMRI signals, without requiring any template basis function or prior shape assumption for the fMRI response. Solving for the HSMESM Decoding problem allows to enrich brain mapping with activation lag mapping, activation mode visualizing, and hemodynamic response function analysis. Activation detection results obtained on synthetic and real epoch-related fMRI data demonstrate the superiority of the HSMESM mapping method with respect to a real application case of the statistical parametric mapping (SPM) approach. In addition, the HSMESM mapping method appears clearly insensitive to timing variations of the hemodynamic response, and exhibits low sensitivity to fluctuations of its shape.
    MeSH term(s) Algorithms ; Artificial Intelligence ; Brain/anatomy & histology ; Brain/blood supply ; Brain/physiology ; Brain Mapping/methods ; Cluster Analysis ; Computer Simulation ; Evoked Potentials/physiology ; Humans ; Image Interpretation, Computer-Assisted/methods ; Information Storage and Retrieval/methods ; Magnetic Resonance Imaging/methods ; Markov Chains ; Models, Neurological ; Models, Statistical ; Numerical Analysis, Computer-Assisted ; Pattern Recognition, Automated/methods ; Reproducibility of Results ; Sensitivity and Specificity ; Signal Processing, Computer-Assisted
    Language English
    Publishing date 2005-02-11
    Publishing country United States
    Document type Comparative Study ; Evaluation Studies ; Journal Article
    ZDB-ID 622531-7
    ISSN 1558-254X ; 0278-0062
    ISSN (online) 1558-254X
    ISSN 0278-0062
    DOI 10.1109/tmi.2004.841225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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