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Article ; Online: Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, Hjartåker A, Weiderpass E, Arriola L, Molina-Montes E, Duell EJ, Santiuste C, Alonso de la Torre R, Barricarte Gurrea A, Stocks T, Johansson M, Ljungberg B, Wareham N, Khaw KT, Travis RC, Cross AJ, Murphy N, Riboli E, Scelo G.Int J Cancer. 2015 Oct 15;137(8):1953-66. [Epub 2015 Apr 28]. doi: 10.1002/ijc.29559.

Jay, Raman / Brennan, P / Brenner / Overvad, K / Olsen, A / Tjønneland, A / Boutron-Ruault, M C / Clavel-Chapelon, F / Fagherazzi / Katzke, V / Kühn, T / Boeing, H / Bergmann, M M / Steffen, A / Naska, A / Trichopoulou, A / Trichopoulos, D / Saieva, C / Grioni, S /

Urologic oncology

2017 Volume 35, Issue 3, Page(s) 117

Abstract: Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 to 2010, 477,325 men and women ...

Abstract	Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n = 931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. In multivariate analysis, total alcohol consumption at baseline was inversely associated with renal cancer; the HR and 95% CI for the increasing categories of total alcohol consumption at recruitment vs. the light drinkers category were 0.78 (0.62-0.99), 0.82 (0.64-1.04), 0.70 (0.55-0.90), and 0.91 (0.63-1.30), respectively, (ptrend = 0.001). A similar relationship was observed for average lifetime alcohol consumption and for all renal cancer subsites combined or for renal parenchyma subsite. The trend was not observed in hypertensive individuals and not significant in smokers. In conclusion, moderate alcohol consumption was associated with a decreased risk of renal cancer.
MeSH term(s)	Alcohol Drinking ; Female ; Humans ; Kidney Neoplasms ; Male ; Nutritional Status ; Proportional Hazards Models ; Prospective Studies ; Risk Factors
Language	English
Publishing date	2017-02-01
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2016.12.022
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Zs.A 4817: Show issues

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Article ; Online: First Mixed Fluoro-Chloro Group 4 Organometallics: Synthesis and Spectroscopic and Structural Characterization of [{(C(5)Me(5))ZrF(2)Cl}(4)], [{(C(5)Me(5))HfF(2)Cl}(4)], [(C(5)Me(5))(4)Zr(4)(μ-F)(2)(μ-F(2))(2)(μ-Cl)(2)Cl(4)], [(C(5)Me(5))(4)Hf(4)(μ-F)(2)(μ-F(2))(2)(μ-Cl)(2)Cl(4)], [(C(5)Me(4)Et)(2)ZrClF], and [(C(5)Me(5))(2)HfClF].

Murphy, Eamonn F. / Lübben, Thomas / Herzog, Axel / Roesky, Herbert W. / Demsar, Alojz / Noltemeyer, Mathias / Schmidt, Hans-Georg

Inorganic chemistry

1996 Volume 35, Issue 1, Page(s) 23–29

Abstract: ... and [(C(5)Me(5))(4)Zr(4)(&mgr;-F)(2)(&mgr;-F(2))(2)(&mgr;-Cl)(2)Cl(4)] (3), and 2 and [(C(5)Me(5))(4 ... Tetrameric [{(C(5)Me(5))MF(3)}(4)] (M = Zr, Hf) react smoothly with Me(3)SiCl in CH(2)Cl(2) at room ... temperature to give [{(C(5)Me(5))ZrF(2)Cl}(4)] (1) and [{(C(5)Me(5))HfF(2)Cl}(4)] (2), respectively, in high ...

Abstract	Tetrameric [{(C(5)Me(5))MF(3)}(4)] (M = Zr, Hf) react smoothly with Me(3)SiCl in CH(2)Cl(2) at room temperature to give [{(C(5)Me(5))ZrF(2)Cl}(4)] (1) and [{(C(5)Me(5))HfF(2)Cl}(4)] (2), respectively, in high yield. Treatment of [{(C(5)Me(5))MF(3)}(4)] (M = Zr, Hf) with Me(2)AlCl in toluene gives mixtures of 1 and [(C(5)Me(5))(4)Zr(4)(μ-F)(2)(μ-F(2))(2)(μ-Cl)(2)Cl(4)] (3), and 2 and [(C(5)Me(5))(4)Hf(4)(μ-F)(2)(μ-F(2))(2)(μ-Cl)(2)Cl(4)] (4), respectively, in an approximately 1:1 molar ratio. Metallocene type complexes [(C(5)Me(4)Et)(2)ZrCl(2)] and [(C(5)Me(5))(2)HfCl(2)] react with 1 equiv of Me(3)SnF to give [(C(5)Me(4)Et)(2)ZrClF] (5) and [(C(5)Me(5))(2)HfClF] (6), respectively. The complexes 1-6 were characterized by spectroscopic methods ((1)H and (19)F NMR and mass spectroscopy). The solid state structures of 1, 3, and 5 were determined by single-crystal X-ray diffraction analyses.
Language	English
Publishing date	1996-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/ic950822a
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Article ; Online: A highly tuneable inverse emulsion polymerization for the synthesis of stimuli-responsive nanoparticles for biomedical applications.

Murphy, Andrew C / Oldenkamp, Heidi F / Peppas, Nicholas A

Biomaterials science

2024 Volume 12, Issue 7, Page(s) 1707–1715

Abstract: Polymeric nanomaterials have seen widespread use in biomedical applications as they are highly tuneable to achieve the desired stimuli-responsiveness, targeting, biocompatibility, and degradation needed for fields such as drug delivery and biosensing. ... ...

Abstract	Polymeric nanomaterials have seen widespread use in biomedical applications as they are highly tuneable to achieve the desired stimuli-responsiveness, targeting, biocompatibility, and degradation needed for fields such as drug delivery and biosensing. However, adjustments to composition and the introduction of new monomers often necessitate reoptimization of the polymer synthesis to achieve the target parameters. In this study, we explored the use of inverse emulsion polymerization to prepare a library of polymeric nanoparticles with variations in pH and temperature response and examined the impact of overall batch volume and the volume of the aqueous phase on nanoparticle size and composition. We were able to prepare copolymeric nanoparticles using three different nonionic and three different anionic comonomers. Varying the non-ionizable comonomers, acrylamide (AAm), 2-hydroxyethyl methacrylate, and
MeSH term(s)	Emulsions/chemistry ; Polymerization ; Drug Carriers/chemistry ; Hydrogen-Ion Concentration ; Nanoparticles/chemistry ; Polymers/chemistry ; Methacrylates
Chemical Substances	Emulsions ; Drug Carriers ; methacrylic acid (1CS02G8656) ; Polymers ; Methacrylates
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d3bm01765f
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Article ; Online: Development and validation of a chemiluminescent western blot assay for glanders (

Grause, Juanita F / Elschner, Mandy C / Ledesma, Nicholas A / Murphy, Gleeson

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

2024 Volume 36, Issue 2, Page(s) 283–286

Abstract: Glanders, caused ... ...

Abstract	Glanders, caused by
MeSH term(s)	Horses ; Animals ; Glanders/diagnosis ; Burkholderia mallei ; Blotting, Western/veterinary ; Zoonoses ; Complement Fixation Tests/veterinary ; Horse Diseases
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	287603-6
ISSN	1943-4936 ; 1040-6387
ISSN (online)	1943-4936
ISSN	1040-6387
DOI	10.1177/10406387241230292
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Zs.A 3645: Show issues

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Article ; Online: Rianú: Multi-tissue tracking software for increased throughput of engineered cardiac tissue screening.

Murphy, Jack F / Costa, Kevin D / Turnbull, Irene C

Computer methods and programs in biomedicine update

2023 Volume 3

Abstract: Background: The field of tissue engineering has provided valuable three-dimensional species-specific models of the human myocardium in the form of human Engineered Cardiac Tissues (hECTs) and similar constructs. However, hECT systems are often ... ...

Abstract	Background: The field of tissue engineering has provided valuable three-dimensional species-specific models of the human myocardium in the form of human Engineered Cardiac Tissues (hECTs) and similar constructs. However, hECT systems are often bottlenecked by a lack of openly available software that can collect data from multiple tissues at a time, even in multi-tissue bioreactors, which limits throughput in phenotypic and therapeutic screening applications. Methods: We developed Rianú, an open-source web application capable of simultaneously tracking multiple hECTs on flexible end-posts. This software is operating system agnostic and deployable on a remote server, accessible via a web browser with no local hardware or software requirements. The software incorporates object-tracking capabilities for multiple objects simultaneously, an algorithm for twitch tracing analysis and contractile force calculation, and a data compilation system for comparative analysis within and amongst groups. Validation tests were performed using in-silico and in-vitro experiments for comparison with established methods and interventions. Results: Rianú was able to detect the displacement of the flexible end-posts with a sub-pixel sensitivity of 0.555 px/post (minimum increment in post displacement) and a lower limit of 1.665 px/post (minimum post displacement). Compared to our established reference for contractility assessment, Rianú had a high correlation for all parameters analyzed (ranging from Conclusions: Rianú provides simultaneous tracking of multiple hECTs, expediting the recording and analysis processes, and simplifies time-based intervention studies. It also allows data collection from different formats and has scale-up capabilities proportional to the number of tissues per field of view. These capabilities will enhance throughput of hECTs and similar assays for in-vitro analysis in disease modeling and drug screening applications.
Language	English
Publishing date	2023-05-25
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-9900
ISSN (online)	2666-9900
DOI	10.1016/j.cmpbup.2023.100107
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Article ; Online: High inhaler resistance does not limit successful inspiratory maneuver among patients with asthma or COPD.

Vartiainen, Ville A / Lavorini, Federico / Murphy, Anna C / Rabe, Klaus F

Expert opinion on drug delivery

2023 Volume 20, Issue 3, Page(s) 385–393

Abstract: Introduction: There has been an active discussion on the sustainability of inhaler therapy in respiratory diseases, and it has cast a shadow on pMDIs which rely on propellant with high global warming potential (GWP). DPIs offer a lower GWP and effective ...

Abstract	Introduction: There has been an active discussion on the sustainability of inhaler therapy in respiratory diseases, and it has cast a shadow on pMDIs which rely on propellant with high global warming potential (GWP). DPIs offer a lower GWP and effective alternative, but there has been concern whether all patients can generate sufficient inspiratory effort to disperse the drug. This review focuses on airflow resistance of DPIs and its clinical relevance. Areas covered: For this narrative review, we searched the literature for studies comparing flow patterns with different devices. We also included a section on clinical trials comparing reliever administration with DPI, pMDI with spacer, and nebulizer during exacerbation. Expert opinion: The evidence supports the efficacy of DPIs irrespective of respiratory condition or age of the patient even during acute exacerbations. Air flow resistance does not limit the use of DPIs and the patients were able to generate sufficient inspiratory flow rate with almost any device studied. None of 16 identified clinical trials comparing reliever administration via DPIs to other types of devices during exacerbation or bronchial challenge showed statistically significant difference between the device types in FEV1 recovery. DPIs performed as well as other types of inhaler devices even during asthma or COPD exacerbation.
MeSH term(s)	Humans ; Bronchodilator Agents ; Asthma/drug therapy ; Nebulizers and Vaporizers ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Lung ; Administration, Inhalation ; Metered Dose Inhalers ; Dry Powder Inhalers
Chemical Substances	Bronchodilator Agents
Language	English
Publishing date	2023-02-26
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2167286-6
ISSN	1744-7593 ; 1742-5247
ISSN (online)	1744-7593
ISSN	1742-5247
DOI	10.1080/17425247.2023.2179984
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Zs.A 6012: Show issues

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Article ; Online: Workload for infection prevention and control teams in preventing nosocomial tuberculosis: an underestimated burden.

Murphy, C / Duffy, F / McCormick, F / O'Donnell, S / Fitzpatrick, F / Humphreys, H

The Journal of hospital infection

2022 Volume 129, Page(s) 115–116

MeSH term(s)	Humans ; Cross Infection/prevention & control ; Workload ; Tuberculosis/epidemiology ; Tuberculosis/prevention & control ; Infection Control ; Hospitals
Language	English
Publishing date	2022-08-09
Publishing country	England
Document type	Letter
ZDB-ID	779366-2
ISSN	1532-2939 ; 0195-6701
ISSN (online)	1532-2939
ISSN	0195-6701
DOI	10.1016/j.jhin.2022.07.017
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Zs.A 1586: Show issues

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Book: Festschrift in honor of Martin C. Mihm, Jr, MD

Mihm, Martin C. / Murphy, George F.

(Journal of cutaneous pathology ; 37, Suppl. 1)

2010

Author's details	guest ed.: George F. Murphy
Series title	Journal of cutaneous pathology ; 37, Suppl. 1
Collection
Language	English
Size	136 S. : Ill., Kt.
Publisher	Wiley-Blackwell
Publishing place	S.l.
Document type	Book
HBZ-ID	HT016319500
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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Zs A 1043 -37,Suppl.1-	not available for loan	Zeitschriften-Lesesaal

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Article ; Online: Updates in neuro-otology.

Murphy, Olwen C / Hac, Nicholas E F / Gold, Daniel R

Current opinion in neurology

2022 Volume 36, Issue 1, Page(s) 36–42

Abstract: Purpose of review: Recent updates with clinical implications in the field of neuro-otology are reviewed.: Recent findings: Important updates relating to several neuro-otologic disorders have been reported in recent years. For benign positional ... ...

Abstract	Purpose of review: Recent updates with clinical implications in the field of neuro-otology are reviewed. Recent findings: Important updates relating to several neuro-otologic disorders have been reported in recent years. For benign positional paroxysmal vertigo (BPPV), we provide updates on the characteristics and features of the short arm variant of posterior canal BPPV. For the acute vestibular syndrome, we report important updates on the use of video-oculography in clinical diagnosis. For autoimmune causes of neuro-otologic symptoms, we describe the clinical and paraclinical features of kelch-like protein 11 encephalitis, a newly-identified antibody associated disorder. For cerebellar ataxia, neuropathy, vestibular areflexia syndrome, we report recent genetic insights into this condition. Summary: This review summarizes important recent updates relating to four hot topics in neuro-otology.
MeSH term(s)	Humans ; Neurotology ; Benign Paroxysmal Positional Vertigo/diagnosis
Language	English
Publishing date	2022-11-15
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	1182686-1
ISSN	1473-6551 ; 1350-7540
ISSN (online)	1473-6551
ISSN	1350-7540
DOI	10.1097/WCO.0000000000001127
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Zs.A 2524: Show issues

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Article ; Online: Development and validation of a chemiluminescent western blot assay for glanders (Burkholderia mallei) serodetection

Grause, Juanita F. / Elschner, Mandy C. / Ledesma, Nicholas A. / Murphy, Gleeson

[Brief report]

2024

Abstract: Glanders, caused by Burkholderia mallei, is a zoonotic disease of equids. Serologic testing for glanders is required by disease-free countries before international movement of equids. The World Organisation for Animal Health Terrestrial Manual recommends ...

Abstract	Glanders, caused by Burkholderia mallei, is a zoonotic disease of equids. Serologic testing for glanders is required by disease-free countries before international movement of equids. The World Organisation for Animal Health Terrestrial Manual recommends the complement fixation test (CFT) for clearance of individual animals for movement, but the CFT is prone to false-positive results. A colorimetric western blot (WB) assay was developed and validated to resolve false-positive CFT results; however, that assay is relatively time-consuming, and the interpretation is subjective. We present here a procedurally similar chemiluminescent WB assay that performs comparably to the validated colorimetric WB assay and offers noticeable benefits of decreased time-to-result and greater ease of interpretation.
Keywords	article ; Text ; ddc:570 ; chemiluminescent assay -- equids -- glanders -- western blot
Subject code	630
Language	English
Publishing date	2024-03-01
Publisher	SAGE Publications
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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